TWI674264B - ６，７－二氫吡唑并［１，５－ａ］吡－４（５Ｈ）－酮化合物及其作為ＭＧＬＵＲ２受體之負異位調節劑之用途 - Google Patents

６，７－二氫吡唑并［１，５－ａ］吡－４（５Ｈ）－酮化合物及其作為ＭＧＬＵＲ２受體之負異位調節劑之用途 Download PDF

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TWI674264B
TWI674264B TW107116714A TW107116714A TWI674264B TW I674264 B TWI674264 B TW I674264B TW 107116714 A TW107116714 A TW 107116714A TW 107116714 A TW107116714 A TW 107116714A TW I674264 B TWI674264 B TW I674264B
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pyridine
methyl
dihydropyrazolo
disorders
compound
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TW107116714A
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TW201835084A (zh
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賽吉歐艾爾法 阿隆索迪牙哥
荷西 西迪努奈茲
歐斯卡 戴蓋多貢沙雷茲
安納利斯 戴寇堤
麥可 梵
葛雷格 麥可當努
安多尼斯 麥根斯
安德烈斯 崔班科蘇阿雷茲
艾倫札魯 葛西亞莫里納
荷塞 安德斯吉爾
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比利時商健生藥品公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Materials Engineering (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
TW107116714A 2013-06-04 2014-05-30 ６，７－二氫吡唑并［１，５－ａ］吡－４（５Ｈ）－酮化合物及其作為ＭＧＬＵＲ２受體之負異位調節劑之用途 TWI674264B (zh)

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??13170447.0 2013-06-04
EP13170447 2013-06-04
EP13173939 2013-06-27
??13173939.3 2013-06-27
??14166450.8 2014-04-29
EP14166450 2014-04-29

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TW201835084A TW201835084A (zh) 2018-10-01
TWI674264B true TWI674264B (zh) 2019-10-11

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TW103118917A TWI632144B (zh) 2013-06-04 2014-05-30 ６，７－二氫吡唑并［１，５－ａ］吡－４（５Ｈ）－酮化合物及其作為ＭＧＬＵＲ２受體之負異位調節劑之用途
TW107116714A TWI674264B (zh) 2013-06-04 2014-05-30 ６，７－二氫吡唑并［１，５－ａ］吡－４（５Ｈ）－酮化合物及其作為ＭＧＬＵＲ２受體之負異位調節劑之用途

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US (2) US10106542B2 (uk)
EP (1) EP3004107B1 (uk)
JP (1) JP6357533B2 (uk)
KR (1) KR102223050B1 (uk)
CN (2) CN105263935B (uk)
AU (1) AU2014276963C1 (uk)
BR (1) BR112015029982A2 (uk)
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RS (1) RS56128B1 (uk)
SG (1) SG11201509938YA (uk)
SI (1) SI3004107T1 (uk)
TW (2) TWI632144B (uk)
UA (1) UA117016C2 (uk)
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NZ722385A (en) 2014-01-21 2019-11-29 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
CN109999025A (zh) 2014-01-21 2019-07-12 詹森药业有限公司 包括代谢型谷氨酸能受体亚型2的正别构调节物或正位激动剂的组合及其用途
JP6513075B2 (ja) * 2014-02-27 2019-05-15 国立大学法人 東京大学 オートタキシン阻害活性を有する縮合ピラゾール誘導体
JOP20150179B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
WO2016087487A1 (en) 2014-12-03 2016-06-09 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
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PL3519416T3 (pl) 2016-09-27 2021-09-06 Merck Sharp & Dohme Corp. Pochodne chromanu, izochromanu i dihydroizobenzofuranu jako ujemne allosteryczne modulatory mglur2, ich kompozycje i zastosowanie
US11633395B2 (en) * 2017-11-24 2023-04-25 Sumitomo Pharma Co., Ltd. Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor
JP7266010B2 (ja) * 2019-05-30 2023-04-27 住友ファーマ株式会社 ６，７－ジヒドロピラゾロ［１，５－ａ］ピラジノン誘導体又はその塩を含有する医薬
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