MX2010010525A - Inhibidores de metaloproteasa de matriz basados en aril-sulfonamida. - Google Patents

Inhibidores de metaloproteasa de matriz basados en aril-sulfonamida.

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Publication number
MX2010010525A
MX2010010525A MX2010010525A MX2010010525A MX2010010525A MX 2010010525 A MX2010010525 A MX 2010010525A MX 2010010525 A MX2010010525 A MX 2010010525A MX 2010010525 A MX2010010525 A MX 2010010525A MX 2010010525 A MX2010010525 A MX 2010010525A
Authority
MX
Mexico
Prior art keywords
mmp
arylsulfonamide
based matrix
matrix metalloprotease
metalloprotease inhibitors
Prior art date
Application number
MX2010010525A
Other languages
English (en)
Inventor
Claus Ehrhardt
Michael Shultz
Ruben Alberto Tommasi
Pascal Rigollier
Olivier Rogel
Leslie Wighton Mcquire
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2010010525A publication Critical patent/MX2010010525A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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Abstract

La presente invención proporciona un compuesto de la fórmula (I): (ver fórmulas (I)) este compuesto es inhibidor de MMP-2, y/o MMP-8, y/o MMP-9, y/o MMP-12 y/o MMP-13 y, por consiguiente, se puede emplear para el tratamiento de un trastorno o de una enfermedad caracterizada por una actividad anormal de MMP-2, y/o MMP-8, y/o MMP-9, y/o MMP12 y/o MMP-13. De conformidad con lo anterior, el compuesto de la fórmula (I) se puede utilizar en el tratamiento de los trastornos o las enfermedades mediadas por MMP-2, y/o MMP-8, y/o MMP-9, y/o MMP-12, y/o MMP-13. Finalmente, la presente invención también proporciona una composición farmacéutica.
MX2010010525A 2008-03-24 2009-03-23 Inhibidores de metaloproteasa de matriz basados en aril-sulfonamida. MX2010010525A (es)

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EP2268612A1 (en) 2011-01-05
EP2268612B1 (en) 2014-08-20
US8975439B2 (en) 2015-03-10
US20150045398A1 (en) 2015-02-12
AU2009228765B2 (en) 2012-05-31
US20120258954A1 (en) 2012-10-11
PT2268612E (pt) 2014-11-13
US20130096105A1 (en) 2013-04-18
AU2009228765A1 (en) 2009-10-01
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CN102036953B (zh) 2015-05-06
CA2719457C (en) 2017-05-02
EA020114B1 (ru) 2014-08-29
PL2268612T3 (pl) 2015-02-27
JP2011517446A (ja) 2011-06-09
CN102036953A (zh) 2011-04-27
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US9822092B2 (en) 2017-11-21
US8362063B2 (en) 2013-01-29
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