SG11201509938YA - 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS - Google Patents

6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

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Publication number
SG11201509938YA
SG11201509938YA SG11201509938YA SG11201509938YA SG11201509938YA SG 11201509938Y A SG11201509938Y A SG 11201509938YA SG 11201509938Y A SG11201509938Y A SG 11201509938YA SG 11201509938Y A SG11201509938Y A SG 11201509938YA SG 11201509938Y A SG11201509938Y A SG 11201509938YA
Authority
SG
Singapore
Prior art keywords
dihydropyrazolo
pyrazin
compounds
allosteric modulators
negative allosteric
Prior art date
Application number
SG11201509938YA
Inventor
Gool Michiel Luc Maria Van
Diego Sergio-Alvar Alonso-De
José Maria Cid-Núñez
Óscar Delgado-González
Annelies Marie Antonius Decorte
Gregor James Macdonald
Antonius Adrianus Hendrikus Petrus Megens
Andrés Avelino Trabanco-Suárez
Aránzazu García-Molina
José Ignacio Andrés-Gil
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SG11201509938YA publication Critical patent/SG11201509938YA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
SG11201509938YA 2013-06-04 2014-06-03 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS SG11201509938YA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP13170447 2013-06-04
EP13173939 2013-06-27
EP14166450 2014-04-29
PCT/EP2014/061478 WO2014195311A1 (en) 2013-06-04 2014-06-03 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Publications (1)

Publication Number Publication Date
SG11201509938YA true SG11201509938YA (en) 2016-01-28

Family

ID=50884400

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201509938YA SG11201509938YA (en) 2013-06-04 2014-06-03 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Country Status (31)

Country Link
US (2) US10106542B2 (en)
EP (1) EP3004107B1 (en)
JP (1) JP6357533B2 (en)
KR (1) KR102223050B1 (en)
CN (2) CN105263935B (en)
AU (1) AU2014276963C1 (en)
BR (1) BR112015029982A2 (en)
CA (1) CA2910507C (en)
CL (1) CL2015003499A1 (en)
CY (1) CY1119499T1 (en)
DK (1) DK3004107T3 (en)
EA (1) EA030426B1 (en)
ES (1) ES2637295T3 (en)
HK (2) HK1216527A1 (en)
HR (1) HRP20171051T1 (en)
HU (1) HUE033057T2 (en)
IL (1) IL242868B (en)
JO (1) JO3368B1 (en)
LT (1) LT3004107T (en)
ME (1) ME02949B (en)
MX (1) MX368861B (en)
MY (1) MY192029A (en)
PH (1) PH12015502685B1 (en)
PL (1) PL3004107T3 (en)
PT (1) PT3004107T (en)
RS (1) RS56128B1 (en)
SG (1) SG11201509938YA (en)
SI (1) SI3004107T1 (en)
TW (2) TWI674264B (en)
UA (1) UA117016C2 (en)
WO (1) WO2014195311A1 (en)

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JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
DK3096790T3 (en) 2014-01-21 2019-10-07 Janssen Pharmaceutica Nv COMBINATIONS INCLUDING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROP GLUTAMATERG SUBTYPE 2 RECEPTOR AND APPLICATION OF THESE
UA127921C2 (en) 2014-01-21 2024-02-14 Янссен Фармацевтика Нв Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
EP3112369A4 (en) * 2014-02-27 2017-09-20 The University of Tokyo Fused pyrazole derivative having autotaxin inhibitory activity
JOP20150177B1 (en) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JOP20150179B1 (en) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
US10967078B2 (en) 2014-12-03 2021-04-06 Janssen Pharmaceutica Nv Radiolabelled mGluR2 PET ligands
AU2015357167B2 (en) 2014-12-03 2020-06-25 Janssen Pharmaceutica Nv 6,7-dihydropyrazolo(1,5-alpha)pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors
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CA2984711C (en) 2015-07-15 2023-08-29 F. Hoffmann-La Roche Ag Ethynyl derivatives as metabotropic glutamate receptor modulators
JP2018154554A (en) * 2015-07-29 2018-10-04 大日本住友製薬株式会社 Condensed pyrazole derivative having novel linker site and pharmaceutical use thereof
US11033641B2 (en) 2015-12-18 2021-06-15 Janssen Pharmaceutica Nv Radiolabelled mGluR2/3 pet ligands
US11045562B2 (en) 2015-12-18 2021-06-29 Janssen Pharmaceutica Nv Radiolabelled mGluR2/3 PET ligands
SI3484889T1 (en) 2016-07-18 2020-11-30 F. Hoffmann-La Roche Ag Ethynyl derivatives
JP6681517B2 (en) 2016-09-27 2020-04-15 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Chroman, isochroman and dihydroisobenzofuran derivatives as mGluR2-negative allosteric modulators, compositions and their use
CN111601811B (en) 2017-11-24 2023-05-05 住友制药株式会社 6, 7-dihydropyrazolo [1,5-a ] pyrazinone derivatives and medical uses thereof
JP7266010B2 (en) * 2019-05-30 2023-04-27 住友ファーマ株式会社 Medicine containing 6,7-dihydropyrazolo[1,5-a]pyrazinone derivative or salt thereof
CA3225285A1 (en) * 2021-07-13 2023-01-19 Alessandro Boezio Pi3k.alpha. inhibitors and methods of use thereof

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