SE9803518D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SE9803518D0
SE9803518D0 SE9803518A SE9803518A SE9803518D0 SE 9803518 D0 SE9803518 D0 SE 9803518D0 SE 9803518 A SE9803518 A SE 9803518A SE 9803518 A SE9803518 A SE 9803518A SE 9803518 D0 SE9803518 D0 SE 9803518D0
Authority
SE
Sweden
Prior art keywords
novel compounds
compounds
tautomers
prophylaxis
enantiomers
Prior art date
Application number
SE9803518A
Other languages
Swedish (sv)
Inventor
Stephen Connolly
David Cox
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Priority to SE9803518A priority Critical patent/SE9803518D0/en
Publication of SE9803518D0 publication Critical patent/SE9803518D0/en
Priority to AU14242/00A priority patent/AU1424200A/en
Priority to PCT/SE1999/001829 priority patent/WO2000021934A1/en

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

There are provided novel compounds of formula (I), wherein R<1>, R<2>, R<3>, R<4>, R<5>, A, Q, X, Y and Z are defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and tautomers thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment of prophylaxis of inflammatory disease and pain.
SE9803518A 1998-10-15 1998-10-15 Novel compounds SE9803518D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE9803518A SE9803518D0 (en) 1998-10-15 1998-10-15 Novel compounds
AU14242/00A AU1424200A (en) 1998-10-15 1999-10-11 Compounds
PCT/SE1999/001829 WO2000021934A1 (en) 1998-10-15 1999-10-11 Compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9803518A SE9803518D0 (en) 1998-10-15 1998-10-15 Novel compounds

Publications (1)

Publication Number Publication Date
SE9803518D0 true SE9803518D0 (en) 1998-10-15

Family

ID=20412958

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9803518A SE9803518D0 (en) 1998-10-15 1998-10-15 Novel compounds

Country Status (3)

Country Link
AU (1) AU1424200A (en)
SE (1) SE9803518D0 (en)
WO (1) WO2000021934A1 (en)

Families Citing this family (21)

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US7105544B2 (en) 2001-07-05 2006-09-12 Synaptic Pharmaceutical Corporation Substituted alkyl amido piperidines
US7199135B2 (en) 2001-07-05 2007-04-03 H. Lundbeck A/S Substituted alkyl amido piperidines
EP1449841A1 (en) * 2003-02-19 2004-08-25 Bayer CropScience SA New fungicidal compounds
WO2006008193A1 (en) * 2004-07-23 2006-01-26 Bayer Cropscience Sa 4-pyridinylethylcarboxamide derivatives useful as fungicides
EP1741709A1 (en) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals
TWI417095B (en) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of mglur2-receptors
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
CN101801951B (en) 2007-09-14 2013-11-13 杨森制药有限公司 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones
ES2439291T3 (en) 2008-09-02 2014-01-22 Janssen Pharmaceuticals, Inc. 3-Azabicyclo [3.1.0] hexyl derivatives as modulators of metabotropic glutamate receptors
US8691813B2 (en) 2008-11-28 2014-04-08 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
MX2011011962A (en) 2009-05-12 2012-02-28 Janssen Pharmaceuticals Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors.
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ME01573B (en) 2009-05-12 2014-09-20 Addex Pharma Sa 1,2,4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
US9271967B2 (en) 2010-11-08 2016-03-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
AU2011328195B2 (en) 2010-11-08 2015-04-02 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
JP5852666B2 (en) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of the mGluR2 receptor
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
PL3096790T3 (en) 2014-01-21 2020-01-31 Janssen Pharmaceutica, N.V. Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
KR20200036063A (en) 2014-01-21 2020-04-06 얀센 파마슈티카 엔.브이. Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2241724A1 (en) * 1995-12-29 1997-07-10 Smithkline Beecham Corporation Vitronectin receptor antagonists
CZ203698A3 (en) * 1995-12-29 1999-05-12 Smithkline Beecham Corporation Antagonist of vitronectin receptor, pharmaceutical composition containing thereof, process of its preparation and use
ATE261942T1 (en) * 1996-03-29 2004-04-15 Pfizer 6-PHENYLPYRIDINE DERIVATIVES

Also Published As

Publication number Publication date
WO2000021934A1 (en) 2000-04-20
AU1424200A (en) 2000-05-01

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