SE9803518D0 - Novel compounds - Google Patents
Novel compoundsInfo
- Publication number
- SE9803518D0 SE9803518D0 SE9803518A SE9803518A SE9803518D0 SE 9803518 D0 SE9803518 D0 SE 9803518D0 SE 9803518 A SE9803518 A SE 9803518A SE 9803518 A SE9803518 A SE 9803518A SE 9803518 D0 SE9803518 D0 SE 9803518D0
- Authority
- SE
- Sweden
- Prior art keywords
- novel compounds
- compounds
- tautomers
- prophylaxis
- enantiomers
- Prior art date
Links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
There are provided novel compounds of formula (I), wherein R<1>, R<2>, R<3>, R<4>, R<5>, A, Q, X, Y and Z are defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and tautomers thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment of prophylaxis of inflammatory disease and pain.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9803518A SE9803518D0 (en) | 1998-10-15 | 1998-10-15 | Novel compounds |
AU14242/00A AU1424200A (en) | 1998-10-15 | 1999-10-11 | Compounds |
PCT/SE1999/001829 WO2000021934A1 (en) | 1998-10-15 | 1999-10-11 | Compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9803518A SE9803518D0 (en) | 1998-10-15 | 1998-10-15 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9803518D0 true SE9803518D0 (en) | 1998-10-15 |
Family
ID=20412958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9803518A SE9803518D0 (en) | 1998-10-15 | 1998-10-15 | Novel compounds |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU1424200A (en) |
SE (1) | SE9803518D0 (en) |
WO (1) | WO2000021934A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7105544B2 (en) | 2001-07-05 | 2006-09-12 | Synaptic Pharmaceutical Corporation | Substituted alkyl amido piperidines |
US7199135B2 (en) | 2001-07-05 | 2007-04-03 | H. Lundbeck A/S | Substituted alkyl amido piperidines |
EP1449841A1 (en) * | 2003-02-19 | 2004-08-25 | Bayer CropScience SA | New fungicidal compounds |
WO2006008193A1 (en) * | 2004-07-23 | 2006-01-26 | Bayer Cropscience Sa | 4-pyridinylethylcarboxamide derivatives useful as fungicides |
EP1741709A1 (en) * | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals |
TWI417095B (en) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of mglur2-receptors |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
CN101801951B (en) | 2007-09-14 | 2013-11-13 | 杨森制药有限公司 | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones |
ES2439291T3 (en) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | 3-Azabicyclo [3.1.0] hexyl derivatives as modulators of metabotropic glutamate receptors |
US8691813B2 (en) | 2008-11-28 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
MX2011011962A (en) | 2009-05-12 | 2012-02-28 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors. |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
ME01573B (en) | 2009-05-12 | 2014-09-20 | Addex Pharma Sa | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
AU2011328195B2 (en) | 2010-11-08 | 2015-04-02 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
JP5852666B2 (en) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of the mGluR2 receptor |
JO3368B1 (en) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
JO3367B1 (en) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
PL3096790T3 (en) | 2014-01-21 | 2020-01-31 | Janssen Pharmaceutica, N.V. | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
KR20200036063A (en) | 2014-01-21 | 2020-04-06 | 얀센 파마슈티카 엔.브이. | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2241724A1 (en) * | 1995-12-29 | 1997-07-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
CZ203698A3 (en) * | 1995-12-29 | 1999-05-12 | Smithkline Beecham Corporation | Antagonist of vitronectin receptor, pharmaceutical composition containing thereof, process of its preparation and use |
ATE261942T1 (en) * | 1996-03-29 | 2004-04-15 | Pfizer | 6-PHENYLPYRIDINE DERIVATIVES |
-
1998
- 1998-10-15 SE SE9803518A patent/SE9803518D0/en unknown
-
1999
- 1999-10-11 AU AU14242/00A patent/AU1424200A/en not_active Abandoned
- 1999-10-11 WO PCT/SE1999/001829 patent/WO2000021934A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2000021934A1 (en) | 2000-04-20 |
AU1424200A (en) | 2000-05-01 |
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