|
HRP20141228T1
(en)
|
2003-12-19 |
2015-03-13 |
Plexxikon Inc. |
Compounds and methods for development of ret modulators
|
|
BRPI0509369B1
(pt)
|
2004-03-30 |
2021-08-03 |
Vertex Pharmaceuticals Incorporated |
Compostos azaindóis úteis como inibidores de jak e outras proteína cinases e composição farmacêutica
|
|
US7498342B2
(en)
|
2004-06-17 |
2009-03-03 |
Plexxikon, Inc. |
Compounds modulating c-kit activity
|
|
EP1797881B1
(en)
|
2004-09-17 |
2009-04-15 |
Eisai R&D Management Co., Ltd. |
Medicinal composition with improved stability and reduced gelation properties
|
|
AU2006272951A1
(en)
|
2005-05-17 |
2007-02-01 |
Plexxikon, Inc. |
Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
|
|
PT1893612E
(pt)
*
|
2005-06-22 |
2011-11-21 |
Plexxikon Inc |
Derivados de pirrolo [2,3-b]piridina como inibidores de proteína quinase
|
|
CN102127078A
(zh)
|
2005-07-14 |
2011-07-20 |
安斯泰来制药株式会社 |
Janus激酶3的杂环类抑制剂
|
|
KR20080026654A
(ko)
|
2005-07-14 |
2008-03-25 |
아스텔라스세이야쿠 가부시키가이샤 |
헤테로시클릭 야누스 키나제 3 억제제
|
|
US9006240B2
(en)
|
2005-08-02 |
2015-04-14 |
Eisai R&D Management Co., Ltd. |
Method for assay on the effect of vascularization inhibitor
|
|
CN101277720A
(zh)
*
|
2005-09-01 |
2008-10-01 |
卫材R&D管理有限公司 |
崩解性被改善的药物组合物的制备方法
|
|
PL1966202T3
(pl)
|
2005-12-13 |
2012-02-29 |
Incyte Holdings Corp |
Podstawione heteroarylem pirolo[2,3-b]pirydyny i pirolo[2,3-b]pirymidyny jako inhibitory kinazy Janusowej
|
|
EP1973911B1
(en)
|
2006-01-17 |
2016-01-13 |
Vertex Pharmaceuticals Incorporated |
Azaindoles useful for the treatment of (inter alia) proliferative, cardiac, neurodegenerative, autoimmune or inflammatory disorders
|
|
CA2635899A1
(en)
*
|
2006-01-19 |
2007-07-26 |
Osi Pharmaceuticals, Inc. |
Fused heterobicyclic kinase inhibitors
|
|
CA2648303C
(en)
|
2006-04-03 |
2014-07-15 |
Astellas Pharma Inc. |
5-[monocyclic(hetero)arylsubstituted-1,2,4-oxadliazol-3-yl]-(fused heteroaryl substituted) compounds and their use as s1p1 agonists
|
|
CN104706637A
(zh)
|
2006-05-18 |
2015-06-17 |
卫材R&D管理有限公司 |
针对甲状腺癌的抗肿瘤剂
|
|
CN101448827A
(zh)
*
|
2006-05-22 |
2009-06-03 |
阿斯利康(瑞典)有限公司 |
吲哚衍生物
|
|
US7964728B2
(en)
|
2006-07-06 |
2011-06-21 |
Solvay Pharmaceuticals B.V. |
Azaindole derivatives with a combination of partial nicotinic acetyl-choline receptor agonism and dopamine reuptake inhibition
|
|
EA015700B1
(ru)
*
|
2006-07-06 |
2011-10-31 |
Солвей Фармасьютикалс Б.В. |
Азаиндольные производные с сочетанием частичного агонизма к никотиновому ацетилхолиновому рецептору и ингибирования обратного захвата дофамина
|
|
GB0617161D0
(en)
*
|
2006-08-31 |
2006-10-11 |
Vernalis R&D Ltd |
Enzyme inhibitors
|
|
PL2526934T4
(pl)
|
2006-09-22 |
2016-09-30 |
|
Inhibitory kinazy tyrozynowej Brutona
|
|
WO2008063888A2
(en)
*
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
WO2008079909A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
|
WO2008080015A2
(en)
*
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
PE20121126A1
(es)
*
|
2006-12-21 |
2012-08-24 |
Plexxikon Inc |
Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
|
|
MX2009006700A
(es)
|
2006-12-21 |
2009-06-30 |
Vertex Pharma |
Derivados de 5-ciano-4-(pirolo)[2,3b]piridina-3-il)-pirimidinas utiles como inhibidores de proteina-cinasas.
|
|
US8809273B2
(en)
|
2007-03-28 |
2014-08-19 |
Pharmacyclics, Inc. |
Inhibitors of Bruton's tyrosine kinase
|
|
CN101674834B
(zh)
*
|
2007-03-28 |
2013-06-12 |
环状药物公司 |
布鲁顿氏酪氨酸激酶(Bruton's tyrosine kinase)抑制剂
|
|
JP5926487B2
(ja)
|
2007-04-13 |
2016-05-25 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
ErbB療法に耐性である癌を治療するための方法
|
|
GB0710528D0
(en)
*
|
2007-06-01 |
2007-07-11 |
Glaxo Group Ltd |
Novel compounds
|
|
CN103524509B
(zh)
|
2007-06-13 |
2016-03-02 |
因塞特控股公司 |
詹纳斯激酶抑制剂(R)-3-(4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基)-3-环戊基丙腈的盐
|
|
BRPI0814423B1
(pt)
|
2007-07-17 |
2022-04-19 |
Plexxikon, Inc |
Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos
|
|
MX2010001636A
(es)
*
|
2007-08-14 |
2010-03-15 |
Hoffmann La Roche |
Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
|
|
US8476273B2
(en)
|
2007-08-17 |
2013-07-02 |
University Of Maryland, Baltimore |
Small molecule inhibitors of Lck SH2 domain binding
|
|
CA2639416C
(en)
|
2007-09-11 |
2019-12-31 |
F. Hoffmann-La Roche Ag |
Diagnostic test for susceptibility to b-raf kinase inhibitors
|
|
DE102007045919B4
(de)
|
2007-09-26 |
2018-07-05 |
Bayer Intellectual Property Gmbh |
Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
|
|
DE102007045956A1
(de)
|
2007-09-26 |
2009-04-09 |
Bayer Cropscience Ag |
Wirkstoffkombination mit insektiziden und akariziden Eigenschaften
|
|
US8183245B2
(en)
|
2007-10-25 |
2012-05-22 |
Merck Sharp & Dohme Corp. |
Pyrazine substituted pyrrolopyridines as inhibitors of JAK and PDK1
|
|
US8426396B2
(en)
*
|
2008-01-08 |
2013-04-23 |
Shriners Hospitals For Children |
Treatment for achondroplasia
|
|
ES2394759T3
(es)
|
2008-01-08 |
2013-02-05 |
Array Biopharma, Inc. |
Pirrolopiridinas como inhibidores de quinasa
|
|
CA2711741A1
(en)
|
2008-01-09 |
2009-07-16 |
Array Biopharma Inc. |
Pyrazolopyridines as kinase inhibitors
|
|
US20110282056A1
(en)
*
|
2008-01-22 |
2011-11-17 |
Merck Patent Gmbh |
Protein kinase inhibitors and use thereof
|
|
JP5485178B2
(ja)
*
|
2008-02-25 |
2014-05-07 |
エフ.ホフマン−ラ ロシュ アーゲー |
ピロロピラジンキナーゼ阻害剤
|
|
EP2265574A1
(en)
|
2008-02-29 |
2010-12-29 |
Array Biopharma, Inc. |
N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer
|
|
CL2009000447A1
(es)
|
2008-02-29 |
2010-01-04 |
Array Biopharma Inc Y Genentech Inc |
Compuestos derivados de (1h-pirrolo{2,3-b}piridin-5-il)-sulfonamido-benzamida sustituida; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento del cancer, a travez de la inhibicion de raf.
|
|
AU2009222144A1
(en)
|
2008-02-29 |
2009-09-11 |
Array Biopharma Inc. |
Pyrazole [3, 4-b] pyridine Raf inhibitors
|
|
UA103319C2
(en)
|
2008-05-06 |
2013-10-10 |
Глаксосмитклайн Ллк |
Thiazole- and oxazole-benzene sulfonamide compounds
|
|
PE20091846A1
(es)
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
|
US8158636B2
(en)
|
2008-05-19 |
2012-04-17 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
US20110065577A1
(en)
*
|
2008-05-21 |
2011-03-17 |
Basf Se |
Substituted pyridin-4-yl-methyl sulfonamides as fungicides
|
|
CN102046623A
(zh)
*
|
2008-05-28 |
2011-05-04 |
巴斯夫欧洲公司 |
作为杀真菌剂的取代的吡啶-4-基甲基磺酰胺
|
|
EP2313411A1
(en)
*
|
2008-06-10 |
2011-04-27 |
Plexxikon, Inc. |
5h-pyrr0l0 [2,3-b]pyrazine derivatives for kinase modulation, and indications therefor
|
|
US8110576B2
(en)
|
2008-06-10 |
2012-02-07 |
Plexxikon Inc. |
Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications
|
|
AR072008A1
(es)
*
|
2008-06-13 |
2010-07-28 |
Merck & Co Inc |
Compuestos heterobiciclicos como agentes de inhibicion de quinasa p38
|
|
US9447049B2
(en)
|
2010-03-01 |
2016-09-20 |
University Of Tennessee Research Foundation |
Compounds for treatment of cancer
|
|
US20110130384A1
(en)
|
2008-06-25 |
2011-06-02 |
Takeda Pharmaceutical Company Limited |
Amide compound
|
|
CA2730930C
(en)
|
2008-07-16 |
2015-01-13 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
|
|
DE102008052943A1
(de)
|
2008-10-23 |
2010-04-29 |
Merck Patent Gmbh |
Azaindolderivate
|
|
WO2010059771A1
(en)
*
|
2008-11-20 |
2010-05-27 |
Osi Pharmaceuticals, Inc. |
Substituted pyrrolo[2,3-b]-pyridines and-pyrazines
|
|
ES2554375T3
(es)
*
|
2008-11-25 |
2015-12-18 |
University Of Rochester |
Inhibidores de las MLK y métodos de uso
|
|
WO2010065927A2
(en)
*
|
2008-12-05 |
2010-06-10 |
California Institute Of Technology |
Dna-damage-induced proteolysis
|
|
CN110194765A
(zh)
*
|
2009-02-10 |
2019-09-03 |
孟山都技术有限公司 |
用于控制线虫的组合物和方法
|
|
CA2755197A1
(en)
*
|
2009-03-11 |
2010-09-16 |
Plexxikon, Inc. |
Pyrrolo [2, 3-b] pyridine derivatives for the inhibition of raf kinases
|
|
MX2011009489A
(es)
*
|
2009-03-11 |
2011-10-11 |
Plexxikon Inc |
Derivados de pirrolo [2,3-b] piridina para la inhibicion de raf cinasas.
|
|
WO2010111527A1
(en)
*
|
2009-03-26 |
2010-09-30 |
Plexxikon, Inc. |
Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use
|
|
DK2414356T3
(en)
|
2009-04-03 |
2015-12-14 |
Hoffmann La Roche |
PROPAN-1-sulfonic acid {3- [5- (4-CHLORO-PHENYL) -1H-pyrrolo [2,3-b] pyridine-3- carbonyl] -2,4-difluorophenyl) -AMIDSAMMENSÆTNINGER AND USES THEREOF
|
|
TW201041888A
(en)
*
|
2009-05-06 |
2010-12-01 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
AR076920A1
(es)
|
2009-05-22 |
2011-07-20 |
Incyte Corp |
3-(4-(7h-pirrolo(2,3-d)pirimidin-4-il)-1h-pirazol-1-il)octano-o heptano--nitrilo como inhibidores de jak
|
|
MX2011012353A
(es)
|
2009-05-22 |
2011-12-14 |
Incyte Corp |
Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus.
|
|
US20220315555A1
(en)
|
2009-05-26 |
2022-10-06 |
Abbvie Inc. |
Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
KR20170037683A
(ko)
*
|
2009-05-26 |
2017-04-04 |
애브비 아일랜드 언리미티드 컴퍼니 |
암,면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
|
|
US9034875B2
(en)
|
2009-05-26 |
2015-05-19 |
Abbvie Inc. |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
US8546399B2
(en)
|
2009-05-26 |
2013-10-01 |
Abbvie Inc. |
Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
UY32717A
(es)
|
2009-06-17 |
2011-01-31 |
Vertex Pharma |
Inhibidores de la replicación de virus de la gripe
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
US8329724B2
(en)
|
2009-08-03 |
2012-12-11 |
Hoffmann-La Roche Inc. |
Process for the manufacture of pharmaceutically active compounds
|
|
CN102470133B
(zh)
|
2009-08-19 |
2013-08-28 |
卫材R&D管理有限公司 |
含有喹啉衍生物的药物组合物
|
|
IN2012DN01983A
(index.php)
|
2009-08-24 |
2015-07-24 |
Ascepion Pharmaceuticals Inc |
|
|
US20120214811A1
(en)
|
2009-08-28 |
2012-08-23 |
Ignacio Aliagas |
Raf inhibitor compounds and methods of use thereof
|
|
JP2013503189A
(ja)
|
2009-08-28 |
2013-01-31 |
アレイ バイオファーマ、インコーポレイテッド |
Raf阻害化合物およびその使用方法
|
|
CN102858754A
(zh)
|
2009-08-28 |
2013-01-02 |
阵列生物制药公司 |
Raf抑制剂化合物及其使用方法
|
|
EP2470538A1
(en)
*
|
2009-08-28 |
2012-07-04 |
Array Biopharma, Inc. |
Raf inhibitor compounds and methods of use thereof
|
|
JP2013503194A
(ja)
|
2009-08-28 |
2013-01-31 |
アレイ バイオファーマ、インコーポレイテッド |
Rafキナーゼを阻害するための1H−ピラゾロ[3,4−B]ピリジン化合物
|
|
US20120157451A1
(en)
|
2009-08-28 |
2012-06-21 |
Genentech, Inc |
Raf inhibitor compounds and methods of use thereof
|
|
US9249145B2
(en)
|
2009-09-01 |
2016-02-02 |
Incyte Holdings Corporation |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
JP2013508415A
(ja)
|
2009-10-23 |
2013-03-07 |
マンカインド コーポレイション |
癌の免疫療法、および治療の方法
|
|
JP2013510166A
(ja)
*
|
2009-11-06 |
2013-03-21 |
プレキシコン インコーポレーテッド |
キナーゼ調節のための化合物、方法およびその適用
|
|
WO2011060216A1
(en)
|
2009-11-12 |
2011-05-19 |
Concert Pharmaceuticals Inc. |
Substituted azaindoles
|
|
AU2010321883A1
(en)
|
2009-11-18 |
2012-05-31 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
DE102009058280A1
(de)
*
|
2009-12-14 |
2011-06-16 |
Merck Patent Gmbh |
Thiazolderivate
|
|
CA2784393A1
(en)
|
2009-12-23 |
2011-06-30 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
CA2784807C
(en)
*
|
2009-12-29 |
2021-12-14 |
Dana-Farber Cancer Institute, Inc. |
Type ii raf kinase inhibitors
|
|
CN102811723A
(zh)
|
2010-01-06 |
2012-12-05 |
约瑟夫·P·埃里科 |
靶向药物研发的方法和组合物
|
|
US8658170B2
(en)
|
2010-01-06 |
2014-02-25 |
Joseph P. Errico |
Combination therapy with MDM2 and EFGR inhibitors
|
|
CA2789427A1
(en)
|
2010-02-11 |
2011-08-18 |
Vanderbilt University |
Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
|
|
US11084811B2
(en)
|
2010-03-01 |
2021-08-10 |
Oncternal Therapeutics, Inc. |
Compounds for treatment of cancer
|
|
LT3354652T
(lt)
|
2010-03-10 |
2020-09-25 |
Incyte Holdings Corporation |
Piperidin-4-il azetidino dariniai kaip jak1 inhibitoriai
|
|
JP2013529181A
(ja)
|
2010-03-25 |
2013-07-18 |
ザ ジェイ. デヴィッド グラッドストーン インスティテューツ |
神経障害を治療するための組成物および方法
|
|
AU2011239966B2
(en)
*
|
2010-04-16 |
2014-05-08 |
Ac Immune S.A. |
Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
|
|
TWI510487B
(zh)
|
2010-04-21 |
2015-12-01 |
Plexxikon Inc |
用於激酶調節的化合物和方法及其適應症
|
|
US20130059850A1
(en)
*
|
2010-05-06 |
2013-03-07 |
Merck Sharp & Dohme Corp. |
Aza-indole derivatives useful as modulators of faah
|
|
EP2569315A1
(en)
|
2010-05-14 |
2013-03-20 |
OSI Pharmaceuticals, LLC |
Fused bicyclic kinase inhibitors
|
|
AR081039A1
(es)
*
|
2010-05-14 |
2012-05-30 |
Osi Pharmaceuticals Llc |
Inhibidores biciclicos fusionados de quinasa
|
|
PL3205654T3
(pl)
|
2010-05-20 |
2019-08-30 |
Array Biopharma, Inc. |
Związki makrocykliczne jako inhibitory kinazy TRK
|
|
TWI499421B
(zh)
|
2010-05-21 |
2015-09-11 |
Incyte Corp |
Jak抑制劑的局部製劑
|
|
WO2011147764A1
(en)
*
|
2010-05-28 |
2011-12-01 |
N.V. Organon |
Thieno (2, 3b) pyrazine compounds as b - raf inhibitors
|
|
NZ736048A
(en)
|
2010-06-03 |
2019-09-27 |
Pharmacyclics Llc |
The use of inhibitors of bruton’s tyrosine kinase (btk)
|
|
US9593317B2
(en)
|
2010-06-09 |
2017-03-14 |
Bayer Cropscience Nv |
Methods and means to modify a plant genome at a nucleotide sequence commonly used in plant genome engineering
|
|
US8779150B2
(en)
*
|
2010-07-21 |
2014-07-15 |
Hoffmann-La Roche Inc. |
Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide
|
|
CA2806670A1
(en)
|
2010-07-26 |
2012-02-09 |
Biomatrica, Inc. |
Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
|
|
WO2012018639A2
(en)
|
2010-07-26 |
2012-02-09 |
Biomatrica, Inc. |
Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
|
|
US8709419B2
(en)
*
|
2010-08-17 |
2014-04-29 |
Hoffmann-La Roche, Inc. |
Combination therapy
|
|
US20120045433A1
(en)
|
2010-08-17 |
2012-02-23 |
Kapil Dhingra |
Combination therapy
|
|
EP2616467A1
(en)
|
2010-09-13 |
2013-07-24 |
Concert Pharmaceuticals Inc. |
Substituted azaindoles
|
|
SG189471A1
(en)
|
2010-10-29 |
2013-05-31 |
Abbvie Inc |
Solid dispersions containing an apoptosis-inducing agent
|
|
UA113500C2
(xx)
|
2010-10-29 |
2017-02-10 |
|
Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
|
|
KR101236731B1
(ko)
|
2010-11-02 |
2013-02-25 |
한국과학기술원 |
아자인돌 화합물, 이를 포함하는 pi3k 저해제용 약학 조성물 및 pi3k와 연관된 질환 치료용 약학 조성물
|
|
ES2536415T3
(es)
|
2010-11-19 |
2015-05-25 |
Incyte Corporation |
Pirrolopiridinas y pirrolopirimidinas sustituidas heterocíclicas como inhibidores de JAK
|
|
MX344478B
(es)
|
2010-11-19 |
2016-12-16 |
Incyte Holdings Corp |
Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de janus cinasas (jak).
|
|
ES2701603T3
(es)
|
2010-11-23 |
2019-02-25 |
Abbvie Ireland Unlimited Co |
Métodos de tratamiento que utilizan inhibidores selectivos de Bcl-2
|
|
CA2817629C
(en)
|
2010-11-23 |
2019-08-13 |
Abbvie Inc. |
Salts and crystalline forms of an apoptosis-inducing agent
|
|
US9296811B2
(en)
|
2010-12-02 |
2016-03-29 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Methods for treating a tumor using an antibody that specifically binds HMW-MAA
|
|
US9295669B2
(en)
|
2010-12-14 |
2016-03-29 |
Hoffman La-Roche Inc. |
Combination therapy for proliferative disorders
|
|
WO2012083117A1
(en)
|
2010-12-16 |
2012-06-21 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
WO2012094451A1
(en)
|
2011-01-06 |
2012-07-12 |
Beta Pharma Canada Inc. |
Novel ureas for the treatment and prevention of cancer
|
|
HUE040136T2
(hu)
*
|
2011-02-07 |
2019-02-28 |
Plexxikon Inc |
Vegyületek és eljárások kináz modulációra és azok indikációi
|
|
WO2012109329A2
(en)
|
2011-02-08 |
2012-08-16 |
Children's Medical Center Corporation |
Methods for treatment of melanoma
|
|
US9993480B2
(en)
|
2011-02-18 |
2018-06-12 |
Novartis Pharma Ag |
mTOR/JAK inhibitor combination therapy
|
|
TWI558702B
(zh)
|
2011-02-21 |
2016-11-21 |
普雷辛肯公司 |
醫藥活性物質的固態形式
|
|
EP2686008A1
(en)
*
|
2011-03-15 |
2014-01-22 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Compositions and methods for inhibiting tumor development caused by chemotherapy induced senescence
|
|
EP2694071B1
(en)
*
|
2011-04-01 |
2017-01-04 |
Genentech, Inc. |
Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
WO2012138809A1
(en)
*
|
2011-04-05 |
2012-10-11 |
Dawei Zhang |
Heterocyclic compounds as kinase inhibitors
|
|
US8962650B2
(en)
|
2011-04-18 |
2015-02-24 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
|
EP2707508A4
(en)
*
|
2011-05-10 |
2015-07-29 |
Brunangelo Falini |
BIOMARKERS OF TRICHOLEUCOCYTE LEUKEMIA AND METHODS OF USE THEREOF
|
|
EP2710003A1
(en)
|
2011-05-16 |
2014-03-26 |
OSI Pharmaceuticals, LLC |
Fused bicyclic kinase inhibitors
|
|
AU2012255275B2
(en)
|
2011-05-17 |
2016-01-28 |
Plexxikon Inc. |
Kinase modulation and indications therefor
|
|
JP2014515368A
(ja)
|
2011-05-26 |
2014-06-30 |
第一三共株式会社 |
プロテインキナーゼ阻害剤としての複素環化合物
|
|
ES2841809T3
(es)
|
2011-06-03 |
2021-07-09 |
Eisai R&D Man Co Ltd |
Biomarcadores para pronosticar y evaluar el grado de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
|
|
JP2014516084A
(ja)
*
|
2011-06-10 |
2014-07-07 |
グラクソスミスクライン、インテレクチュアル、プロパティー、リミテッド |
新規化合物
|
|
CN103797010B
(zh)
|
2011-06-20 |
2016-02-24 |
因塞特控股公司 |
作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物
|
|
CA2841080A1
(en)
|
2011-07-13 |
2013-01-17 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
UA117220C2
(uk)
|
2011-08-01 |
2018-07-10 |
Дженентек, Інк. |
Способи лікування раку з використанням антагоністів, що зв'язуються з віссю pd-1, і інгібіторів mek
|
|
UA118010C2
(uk)
*
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
|
EP2741747A1
(en)
|
2011-08-10 |
2014-06-18 |
Novartis Pharma AG |
JAK P13K/mTOR COMBINATION THERAPY
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
|
WO2013029043A1
(en)
*
|
2011-08-25 |
2013-02-28 |
Reaction Biology Corp. |
Selective kinase inhibitors
|
|
CN104053442B
(zh)
|
2011-08-26 |
2017-06-23 |
润新生物公司 |
某些化学实体、组合物及方法
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
CN108794411B
(zh)
|
2011-09-14 |
2022-06-07 |
润新生物公司 |
某些化学实体、组合物及方法
|
|
EP2570127A1
(en)
|
2011-09-16 |
2013-03-20 |
Sanofi |
Compositions and methods for treating cancer using PI3KB beta inhibitor and MAPK pathway inhibitor, including MEK and RAF inhibitors
|
|
MX2014002990A
(es)
|
2011-09-19 |
2014-05-21 |
Genentech Inc |
Tratamientos combinados que comprenden antagonistas de c-met y antagonistas de b-raf.
|
|
US9174984B2
(en)
*
|
2011-10-24 |
2015-11-03 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Chemical compounds
|
|
EP2822935B1
(en)
|
2011-11-17 |
2019-05-15 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-jun-n-terminal kinase (jnk)
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
JP5868521B2
(ja)
|
2011-12-31 |
2016-02-24 |
ベイジーン リミテッド |
Rafキナーゼ阻害剤としての縮合三環式化合物
|
|
WO2013109142A1
(en)
|
2012-01-16 |
2013-07-25 |
Stichting Het Nederlands Kanker Instituut |
Combined pdk and mapk/erk pathway inhibition in neoplasia
|
|
CN102603734A
(zh)
*
|
2012-01-19 |
2012-07-25 |
盛世泰科生物医药技术(苏州)有限公司 |
一种蛋白激酶抑制剂及其应用
|
|
WO2013112950A2
(en)
|
2012-01-25 |
2013-08-01 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
US9358235B2
(en)
|
2012-03-19 |
2016-06-07 |
Plexxikon Inc. |
Kinase modulation, and indications therefor
|
|
US9216170B2
(en)
|
2012-03-19 |
2015-12-22 |
Hoffmann-La Roche Inc. |
Combination therapy for proliferative disorders
|
|
RU2014143242A
(ru)
*
|
2012-03-28 |
2016-05-20 |
Ньюропор Терапис, Инк. |
Производные фенилмочевины и фенилкарбаматов в качестве ингибиторов агрегации белка
|
|
WO2013163109A1
(en)
*
|
2012-04-23 |
2013-10-31 |
Genentech, Inc. |
Intermediates and processes for preparing compounds
|
|
TW201406761A
(zh)
|
2012-05-18 |
2014-02-16 |
Incyte Corp |
做爲jak抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
|
|
WO2013176970A1
(en)
*
|
2012-05-22 |
2013-11-28 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
|
|
US10077474B2
(en)
*
|
2012-05-29 |
2018-09-18 |
Abbott Molecular, Inc. |
Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
|
|
US9150570B2
(en)
*
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
RU2014149684A
(ru)
|
2012-05-31 |
2016-07-20 |
Ф. Хоффманн-Ля Рош Аг |
Производные аминохиназолина и пиридопиримидина
|
|
EP2854859B1
(en)
|
2012-06-04 |
2026-02-25 |
Pharmacyclics LLC |
Crystalline forms of a bruton's tyrosine kinase inhibitor
|
|
JP2015522037A
(ja)
|
2012-07-03 |
2015-08-03 |
ラシオファルム ゲーエムベーハー |
ベムラフェニブコリン塩の固体形態
|
|
EP3550031A1
(en)
|
2012-07-24 |
2019-10-09 |
Pharmacyclics, LLC |
Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
|
|
EP2882748A4
(en)
*
|
2012-08-07 |
2015-06-17 |
Aurigene Discovery Tech Ltd |
5- (1H-PYRAZOL-4-YL-) 1H-PYRROLO- [2,3-B-] PYRIDINE DERIVATIVES AS A KINASE INHIBITOR
|
|
SG10201708494QA
(en)
|
2012-08-17 |
2017-11-29 |
Hoffmann La Roche |
Combination therapies for melanoma comprising administering cobimetinib and vemurafinib
|
|
TWI601725B
(zh)
*
|
2012-08-27 |
2017-10-11 |
加拓科學公司 |
取代的氮雜吲哚化合物及其鹽、組合物和用途
|
|
CN103626765B
(zh)
*
|
2012-08-27 |
2016-08-10 |
广东东阳光药业有限公司 |
取代的氮杂吲哚化合物及其盐、组合物和用途
|
|
US10227357B2
(en)
|
2012-09-06 |
2019-03-12 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
EP2897618B1
(en)
|
2012-09-24 |
2021-11-17 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
CN103613591B
(zh)
*
|
2012-09-29 |
2016-04-13 |
上海科州药物研发有限公司 |
作为cMet抑制剂的化合物及其制备方法和用途
|
|
EP2912036A1
(en)
|
2012-10-04 |
2015-09-02 |
Pfizer Limited |
Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors
|
|
AU2013328824B2
(en)
*
|
2012-10-08 |
2018-04-05 |
Atriva Therapeutics Gmbh |
MEK inhibitors in the treatment of virus diseases
|
|
WO2014063068A1
(en)
|
2012-10-18 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
WO2014063061A1
(en)
|
2012-10-19 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
US10000483B2
(en)
|
2012-10-19 |
2018-06-19 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
|
|
EP2916838B1
(en)
|
2012-11-12 |
2019-03-13 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
IL297429A
(en)
|
2012-11-15 |
2022-12-01 |
Incyte Holdings Corp |
Sustained release dosage forms of roxolitinib
|
|
MA38183A1
(fr)
|
2012-11-15 |
2017-03-31 |
Pharmacyclics Inc |
Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase
|
|
US9260426B2
(en)
*
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
|
EP2934572A4
(en)
|
2012-12-20 |
2016-11-23 |
Biomatrica Inc |
FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
|
|
LT2935248T
(lt)
|
2012-12-21 |
2018-04-10 |
Plexxikon Inc. |
Kinazės moduliavimo junginiai ir būdai bei indikacijos
|
|
EP2937337A4
(en)
|
2012-12-21 |
2016-06-22 |
Eisai R&D Man Co Ltd |
AMORPHIC FORM OF CHINOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
|
|
US9278950B2
(en)
|
2013-01-14 |
2016-03-08 |
Incyte Corporation |
Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
|
|
PT2945939T
(pt)
|
2013-01-15 |
2020-06-08 |
Incyte Holdings Corp |
Compostos tiazole e piridina carboxamidas úteis como inibidores das quinases pim
|
|
US20140357636A1
(en)
*
|
2013-02-21 |
2014-12-04 |
Wayne Rothbaum |
Treatment of Skeletal-Related Disorders
|
|
HK1211235A1
(en)
|
2013-02-22 |
2016-05-20 |
霍夫曼-拉罗奇有限公司 |
Methods of treating cancer and preventing drug resistance
|
|
KR102246652B1
(ko)
*
|
2013-03-05 |
2021-04-29 |
유니버시티 오브 테네시 리서치 파운데이션 |
암 치료용 화합물
|
|
HRP20211922T1
(hr)
|
2013-03-06 |
2022-03-04 |
Incyte Holdings Corporation |
Postupci i intermedijeri za pripravu jak inhibitora
|
|
US20140275082A1
(en)
|
2013-03-14 |
2014-09-18 |
Abbvie Inc. |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
WO2014159353A1
(en)
|
2013-03-14 |
2014-10-02 |
Ratiopharm Gmbh |
Solid state forms of vemurafenib hydrochloride
|
|
JP2016516682A
(ja)
|
2013-03-15 |
2016-06-09 |
サノフイ |
癌細胞の耐性を克服するための、pi3kベータ阻害剤およびraf阻害剤を含む抗腫瘍組成物
|
|
US20160143910A1
(en)
|
2013-03-15 |
2016-05-26 |
Constellation Pharmaceuticals, Inc. |
Methods of treating cancer and preventing cancer drug resistance
|
|
WO2014145051A1
(en)
|
2013-03-15 |
2014-09-18 |
Jiazhong Zhang |
Heterocyclic compounds and uses thereof
|
|
US20140303121A1
(en)
|
2013-03-15 |
2014-10-09 |
Plexxikon Inc. |
Heterocyclic compounds and uses thereof
|
|
US9206188B2
(en)
*
|
2013-04-18 |
2015-12-08 |
Arrien Pharmaceuticals Llc |
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
|
|
RU2658601C2
(ru)
|
2013-05-14 |
2018-06-21 |
Эйсай Ар Энд Ди Менеджмент Ко., Лтд. |
Биомаркер для прогнозирования и оценки чувствительности субъектов с раком эндометрия к соединениям ленватиниба
|
|
JP2016520131A
(ja)
|
2013-05-30 |
2016-07-11 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
キナーゼ調節のための化合物、およびその適応
|
|
EP3632208A1
(en)
|
2013-06-13 |
2020-04-08 |
Biomatrica, INC. |
Cell stabilization
|
|
EP3013797B1
(en)
|
2013-06-28 |
2018-01-03 |
BeiGene, Ltd. |
Fused tricyclic amide compounds as multiple kinase inhibitors
|
|
CN105530931B
(zh)
*
|
2013-07-12 |
2019-11-08 |
皮拉马尔企业有限公司 |
用于治疗黑素瘤的药物组合
|
|
WO2015017812A1
(en)
|
2013-08-02 |
2015-02-05 |
Pharmacyclics, Inc. |
Methods for the treatment of solid tumors
|
|
PE20160223A1
(es)
|
2013-08-07 |
2016-04-27 |
Incyte Corp |
Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1
|
|
JP6429292B2
(ja)
|
2013-08-12 |
2018-11-28 |
ファーマサイクリックス エルエルシー |
Her2増幅性癌の処置のための方法
|
|
PE20160532A1
(es)
|
2013-08-23 |
2016-05-21 |
Incyte Corp |
Compuesto de carboxamida de furo y tienopiridina utiles como inhibidores de cinasas pim
|
|
WO2015041534A1
(en)
|
2013-09-20 |
2015-03-26 |
Stichting Het Nederlands Kanker Instituut |
P90rsk in combination with raf/erk/mek
|
|
WO2015041533A1
(en)
|
2013-09-20 |
2015-03-26 |
Stichting Het Nederlands Kanker Instituut |
Rock in combination with mapk-pathway
|
|
CA2925124A1
(en)
|
2013-09-30 |
2015-04-02 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
CA2927917C
(en)
|
2013-10-18 |
2022-08-09 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of proliferative diseases
|
|
JP6491202B2
(ja)
|
2013-10-18 |
2019-03-27 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
サイクリン依存性キナーゼ7(cdk7)の多環阻害剤
|
|
AU2014348752C1
(en)
|
2013-11-13 |
2019-11-21 |
Vertex Pharmaceuticals Incorporated |
Methods of preparing inhibitors of influenza viruses replication
|
|
SG10201804026WA
(en)
|
2013-11-13 |
2018-06-28 |
Vertex Pharma |
Inhibitors of influenza viruses replication
|
|
CA2930584A1
(en)
|
2013-11-15 |
2015-05-21 |
The Wistar Institute Of Anatomy And Biology |
Ebna1 inhibitors and their method of use
|
|
WO2015075749A1
(en)
*
|
2013-11-22 |
2015-05-28 |
Laurus Labs Private Limited |
Novel processes for the preparation of vemurafenib
|
|
CZ2013943A3
(cs)
|
2013-11-27 |
2015-06-03 |
Zentiva, K.S. |
Krystalické formy vemurafenibu
|
|
CN104710417B
(zh)
*
|
2013-12-11 |
2020-09-08 |
上海科州药物研发有限公司 |
氮杂吲哚类衍生物及其合成方法
|
|
CA3240745A1
(en)
*
|
2013-12-20 |
2015-06-25 |
Biomed Valley Discoveries, Inc. |
Cancer treatment using combinations of erk and raf inhibitors
|
|
CN104739823A
(zh)
*
|
2013-12-28 |
2015-07-01 |
复旦大学附属华山医院 |
淫羊藿素在制备维罗非尼增敏剂中的用途
|
|
EP3094736A4
(en)
|
2014-01-14 |
2017-10-25 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
|
|
WO2015134536A1
(en)
|
2014-03-04 |
2015-09-11 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
JP2017509336A
(ja)
|
2014-03-20 |
2017-04-06 |
ファーマサイクリックス エルエルシー |
ホスホリパーゼcガンマ2及び耐性に関連した変異
|
|
WO2015156674A2
(en)
|
2014-04-10 |
2015-10-15 |
Stichting Het Nederlands Kanker Instituut |
Method for treating cancer
|
|
US20180228907A1
(en)
|
2014-04-14 |
2018-08-16 |
Arvinas, Inc. |
Cereblon ligands and bifunctional compounds comprising the same
|
|
WO2015164614A1
(en)
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Janus kinase inhibitors and uses thereof
|
|
US9862688B2
(en)
|
2014-04-23 |
2018-01-09 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged janus kinase inhibitors and uses thereof
|
|
WO2015171833A1
(en)
*
|
2014-05-06 |
2015-11-12 |
The Regents Of The University Of California |
Wound healing using braf inhibitors
|
|
WO2015178770A1
(en)
|
2014-05-19 |
2015-11-26 |
Stichting Het Nederlands Kanker Instituut |
Compositions for cancer treatment
|
|
WO2015181628A1
(en)
*
|
2014-05-27 |
2015-12-03 |
Eisai R&D Management Co., Ltd. |
Treatment of acute myeloid leukemia with an hck inhibitor
|
|
WO2015184305A1
(en)
|
2014-05-30 |
2015-12-03 |
Incyte Corporation |
TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
|
|
TW201613916A
(en)
|
2014-06-03 |
2016-04-16 |
Gilead Sciences Inc |
TANK-binding kinase inhibitor compounds
|
|
US10064404B2
(en)
|
2014-06-10 |
2018-09-04 |
Biomatrica, Inc. |
Stabilization of thrombocytes at ambient temperatures
|
|
CN106659788A
(zh)
*
|
2014-06-13 |
2017-05-10 |
基因泰克公司 |
治疗和预防癌症耐药性的方法
|
|
EP3154589A1
(en)
|
2014-06-13 |
2017-04-19 |
Genentech, Inc. |
Methods of treating and preventing cancer drug resistance
|
|
US20170114323A1
(en)
|
2014-06-19 |
2017-04-27 |
Whitehead Institute For Biomedical Research |
Uses of kinase inhibitors for inducing and maintaining pluripotency
|
|
CN105777756B
(zh)
*
|
2014-07-02 |
2019-03-01 |
广东东阳光药业有限公司 |
杂芳化合物及其在药物中的应用
|
|
AR101106A1
(es)
|
2014-07-02 |
2016-11-23 |
Pharmacyclics Llc |
Inhibidores de tirosina quinasa de bruton
|
|
WO2016010897A1
(en)
|
2014-07-14 |
2016-01-21 |
Incyte Corporation |
Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
|
|
US9580418B2
(en)
|
2014-07-14 |
2017-02-28 |
Incyte Corporation |
Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
|
|
PL3169361T3
(pl)
|
2014-07-15 |
2019-11-29 |
Hoffmann La Roche |
Kompozycje do leczenia nowotworu z użyciem związków antagonistycznych wiązania osi pd-1 i inhibitorów mek
|
|
EP3174539A4
(en)
|
2014-08-01 |
2017-12-13 |
Pharmacyclics, LLC |
Inhibitors of bruton's tyrosine kinase
|
|
EP3193877A4
(en)
|
2014-08-07 |
2018-04-04 |
Pharmacyclics LLC |
Novel formulations of a bruton's tyrosine kinase inhibitor
|
|
BR112017002827B1
(pt)
|
2014-08-28 |
2023-04-18 |
Eisai R&D Management Co., Ltd |
Derivado de quinolina altamente puro e método para produção do mesmo
|
|
JP6832846B2
(ja)
|
2014-09-15 |
2021-02-24 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
ヘテロ環化合物およびその用途
|
|
MX2017003930A
(es)
|
2014-09-26 |
2017-06-30 |
Gilead Sciences Inc |
Derivados de aminotriazina utiles como compuestos inhibidores de la cinasa de union a tank.
|
|
CA2963091A1
(en)
|
2014-10-06 |
2016-04-14 |
Dana-Farber Cancer Institute, Inc. |
Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
|
|
US10611765B2
(en)
|
2014-11-06 |
2020-04-07 |
Ohio State Innovation Foundation |
Pyrrolopyrimidine derivatives as Mps1/TTK kinase inhibitors
|
|
EP3223817A4
(en)
*
|
2014-11-29 |
2018-05-30 |
Shilpa Medicare Limited |
Substantially pure vemurafenib and its salts
|
|
HK1245260A1
(zh)
|
2014-12-23 |
2018-08-24 |
Dana-Farber Cancer Institute, Inc. |
细胞周期蛋白依赖性激酶7(cdk7)的抑制剂
|
|
CN107257800B
(zh)
*
|
2014-12-23 |
2020-06-30 |
达纳-法伯癌症研究所股份有限公司 |
通过双功能分子诱导靶蛋白降解的方法
|
|
US9694084B2
(en)
|
2014-12-23 |
2017-07-04 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
CN107427505A
(zh)
|
2015-02-25 |
2017-12-01 |
卫材R&D管理有限公司 |
用于抑制喹啉衍生物的苦味的方法
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
KR20250020678A
(ko)
|
2015-03-04 |
2025-02-11 |
머크 샤프 앤드 돔 엘엘씨 |
암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
|
|
CN107427521B
(zh)
|
2015-03-27 |
2021-08-03 |
达纳-法伯癌症研究所股份有限公司 |
细胞周期蛋白依赖性激酶的抑制剂
|
|
US10160755B2
(en)
|
2015-04-08 |
2018-12-25 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
CZ2015250A3
(cs)
|
2015-04-14 |
2016-10-26 |
Zentiva, K.S. |
Amorfní formy vemurafenibu
|
|
ES2923943T3
(es)
|
2015-05-06 |
2022-10-03 |
Plexxikon Inc |
Síntesis de un compuesto que modula cinasas
|
|
MY192352A
(en)
|
2015-05-06 |
2022-08-17 |
Plexxikon Inc |
Solid forms of a compound modulating kinases
|
|
EP3294717B1
(en)
|
2015-05-13 |
2020-07-29 |
Vertex Pharmaceuticals Inc. |
Methods of preparing inhibitors of influenza viruses replication
|
|
MA42422A
(fr)
|
2015-05-13 |
2018-05-23 |
Vertex Pharma |
Inhibiteurs de la réplication des virus de la grippe
|
|
JP6771491B2
(ja)
|
2015-05-14 |
2020-10-21 |
ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー |
Ebna1阻害剤およびその使用方法
|
|
CA2986920C
(en)
|
2015-05-22 |
2023-03-21 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
CA2986739C
(en)
|
2015-05-22 |
2023-03-14 |
Plexxikon Inc. |
Plx-8394 or plx-7904 for use in the treatment of braf-v600-related diseases
|
|
US9540347B2
(en)
|
2015-05-29 |
2017-01-10 |
Incyte Corporation |
Pyridineamine compounds useful as Pim kinase inhibitors
|
|
WO2016200851A1
(en)
*
|
2015-06-09 |
2016-12-15 |
Abbvie Inc. |
Nuclear receptor modulators
|
|
CA2986441A1
(en)
|
2015-06-12 |
2016-12-15 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
|
EP3311841B1
(en)
|
2015-06-16 |
2021-07-28 |
PRISM BioLab Co., Ltd. |
Anticancer agent
|
|
BR112018000808A2
(pt)
|
2015-07-16 |
2018-09-04 |
Array Biopharma Inc |
compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase
|
|
CA3217238A1
(en)
*
|
2015-07-20 |
2017-01-26 |
Genzyme Corporation |
Colony stimulating factor-1 receptor (csf-1r) inhibitors
|
|
WO2017019804A2
(en)
|
2015-07-28 |
2017-02-02 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
AU2016298175B2
(en)
|
2015-07-28 |
2022-01-06 |
University Of Iowa Research Foundation |
Compositions and methods of treating cancer
|
|
RU2718048C2
(ru)
|
2015-08-20 |
2020-03-30 |
Эйсай Ар Энд Ди Менеджмент Ко., Лтд. |
Противоопухолевое терапевтическое средство
|
|
TWI734699B
(zh)
|
2015-09-09 |
2021-08-01 |
美商英塞特公司 |
Pim激酶抑制劑之鹽
|
|
EP4019515A1
(en)
|
2015-09-09 |
2022-06-29 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
AU2016328619B2
(en)
|
2015-09-21 |
2020-07-16 |
Opna Bio SA |
Heterocyclic compounds and uses thereof
|
|
WO2017059251A1
(en)
|
2015-10-02 |
2017-04-06 |
Incyte Corporation |
Heterocyclic compounds useful as pim kinase inhibitors
|
|
US9890163B2
(en)
|
2015-10-15 |
2018-02-13 |
Princeton Drug Discovery Inc |
Inhibitors of protein kinases
|
|
TN2018000138A1
(en)
|
2015-10-26 |
2019-10-04 |
Array Biopharma Inc |
Point mutations in trk inhibitor-resistant cancer and methods relating to the same
|
|
KR102702851B1
(ko)
|
2015-11-19 |
2024-09-05 |
제넨테크, 인크. |
B-raf 억제제 및 면역 체크포인트 억제제를 사용하여 암을 치료하는 방법
|
|
US9938273B2
(en)
|
2015-12-07 |
2018-04-10 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
KR102589056B1
(ko)
|
2015-12-08 |
2023-10-12 |
바이오매트리카 인코포레이티드 |
적혈구 침강 속도의 감소
|
|
RU2018120366A
(ru)
|
2015-12-14 |
2020-01-16 |
Рэд.Ком, Ллс |
Модульные цифровая камера и сотовый телефон
|
|
EP3394044A1
(en)
|
2015-12-17 |
2018-10-31 |
Gilead Sciences, Inc. |
Tank-binding kinase inhibitor compounds
|
|
US10513528B2
(en)
*
|
2016-02-25 |
2019-12-24 |
Taxis Pharmaceuticals, Inc. |
Synthetic processes and intermediates
|
|
ES2904615T3
(es)
|
2016-03-16 |
2022-04-05 |
Plexxikon Inc |
Compuestos y métodos para la modulación de quinasas e indicaciones al respecto
|
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
|
PH12018502124B1
(en)
|
2016-04-04 |
2024-04-12 |
Loxo Oncology Inc |
Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
|
|
RS65988B1
(sr)
|
2016-04-04 |
2024-10-31 |
Loxo Oncology Inc |
Postupak lečenja pedijatrijskih karcinoma
|
|
CA3018406A1
(en)
|
2016-04-15 |
2017-10-19 |
Genentech, Inc. |
Diagnostic and therapeutic methods for cancer
|
|
ES2952056T3
(es)
|
2016-05-18 |
2023-10-26 |
Loxo Oncology Inc |
Preparación de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida
|
|
RU2768479C2
(ru)
*
|
2016-06-13 |
2022-03-24 |
Хемоцентрикс, Инк. |
Способы лечения рака поджелудочной железы
|
|
WO2017223565A1
(en)
|
2016-06-24 |
2017-12-28 |
University Of Iowa Research Foundation |
Compositions and methods of treating melanoma
|
|
JP6911062B2
(ja)
|
2016-07-01 |
2021-07-28 |
フェルミオン オサケ ユキチュア |
ベムラフェニブの新規な製造方法
|
|
WO2018013597A1
(en)
|
2016-07-12 |
2018-01-18 |
Revolution Medicines, Inc. |
2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
|
|
US10669278B2
(en)
|
2016-09-16 |
2020-06-02 |
Helmholtz Zentrum Muenchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) |
TRAF 6 inhibitors
|
|
TW201815766A
(zh)
|
2016-09-22 |
2018-05-01 |
美商普雷辛肯公司 |
用於ido及tdo調節之化合物及方法以及其適應症
|
|
JOP20190077A1
(ar)
|
2016-10-10 |
2019-04-09 |
Array Biopharma Inc |
مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
|
|
TWI704148B
(zh)
*
|
2016-10-10 |
2020-09-11 |
美商亞雷生物製藥股份有限公司 |
作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
|
|
EP3308773A1
(en)
|
2016-10-11 |
2018-04-18 |
Recordati Industria Chimica E Farmaceutica SPA |
Formulations of cysteamine and cysteamine derivatives
|
|
US11672801B2
(en)
|
2016-10-19 |
2023-06-13 |
United States Government As Represented By The Department Of Veterans Affairs |
Compositions and methods for treating cancer
|
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
|
JP7013464B2
(ja)
|
2016-11-23 |
2022-02-15 |
ケモセントリックス, インコーポレイテッド |
巣状分節性糸球体硬化症を治療する方法
|
|
WO2018109668A1
(en)
|
2016-12-15 |
2018-06-21 |
Nestec Sa |
Compositions and methods that modulate phosphorus or enzymes in a companion animal
|
|
US11173211B2
(en)
|
2016-12-23 |
2021-11-16 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides
|
|
EP3558991A2
(en)
*
|
2016-12-23 |
2019-10-30 |
Plexxikon Inc. |
Compounds and methods for cdk8 modulation and indications therefor
|
|
EP3558994A4
(en)
*
|
2016-12-23 |
2021-05-12 |
Arvinas Operations, Inc. |
COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF FAST ACCELERATED FIBROSARCOMA POLYPEPTIDES
|
|
JP7300394B2
(ja)
*
|
2017-01-17 |
2023-06-29 |
ヘパリジェニックス ゲーエムベーハー |
肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害
|
|
WO2018136663A1
(en)
|
2017-01-18 |
2018-07-26 |
Array Biopharma, Inc. |
Ret inhibitors
|
|
WO2018136661A1
(en)
|
2017-01-18 |
2018-07-26 |
Andrews Steven W |
SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS
|
|
BR112019014527A2
(pt)
|
2017-01-23 |
2020-02-27 |
Revolution Medicines, Inc. |
Compostos de piridina como inibidores de shp2 alostéricos
|
|
CN117327075A
(zh)
|
2017-01-23 |
2024-01-02 |
锐新医药公司 |
作为变构shp2抑制剂的二环化合物
|
|
IL312367A
(en)
|
2017-01-31 |
2024-06-01 |
Arvinas Operations Inc |
Cereblon ligands and bifunctional compounds comprising the same
|
|
CN110072528B
(zh)
|
2017-02-08 |
2022-04-26 |
卫材R&D管理有限公司 |
治疗肿瘤的药物组合物
|
|
JP7341060B2
(ja)
|
2017-02-10 |
2023-09-08 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
Mapk経路の活性化に関連付けられる癌の処置のための方法及び医薬組成物
|
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
|
EP3601326A4
(en)
|
2017-03-20 |
2020-12-16 |
The Broad Institute, Inc. |
COMPOUNDS AND METHODS OF REGULATING INSULIN SECRETION
|
|
US10577366B2
(en)
|
2017-03-20 |
2020-03-03 |
Plexxikon Inc. |
Crystalline forms of a compound that inhibits bromodomain
|
|
WO2018183762A1
(en)
*
|
2017-03-29 |
2018-10-04 |
United States Government As Represented By The Department Of Veterans Affairs |
Methods and compositions for treating cancer
|
|
CA3058183A1
(en)
|
2017-03-30 |
2018-10-04 |
Taxis Pharmaceuticals, Inc. |
Synthetic processes and synthetic intermediates towardthe production of txa709
|
|
TW201902517A
(zh)
*
|
2017-04-28 |
2019-01-16 |
美商石英醫療公司 |
Raf降解結合物化合物
|
|
WO2018210661A1
(en)
*
|
2017-05-15 |
2018-11-22 |
Basf Se |
Heteroaryl compounds as agrochemical fungicides
|
|
CN110831597A
(zh)
|
2017-05-16 |
2020-02-21 |
卫材R&D管理有限公司 |
肝细胞癌的治疗
|
|
PT3624796T
(pt)
|
2017-05-19 |
2025-06-02 |
Nflection Therapeutics Inc |
Compostos de pirrolopiridina-anilina para tratamento de distúrbios dérmicos
|
|
CA3063535A1
(en)
|
2017-05-19 |
2018-11-22 |
Nflection Therapeutics, Inc. |
Fused heteroaromatic-aniline compounds for treatment of dermal disorders
|
|
US10428067B2
(en)
|
2017-06-07 |
2019-10-01 |
Plexxikon Inc. |
Compounds and methods for kinase modulation
|
|
IL305317B2
(en)
|
2017-06-30 |
2025-11-01 |
Univ California |
Compositions and methods for modulating hair growth
|
|
BR112019028235B1
(pt)
|
2017-07-25 |
2024-04-30 |
Plexxikon, Inc. |
Composições e seus métodos de preparação
|
|
CN109384785B
(zh)
*
|
2017-08-10 |
2021-09-28 |
浙江海正药业股份有限公司 |
吡咯并吡啶酮类衍生物、其制备方法及其在医药上的用途
|
|
AU2018329925B2
(en)
|
2017-09-08 |
2025-05-29 |
F. Hoffmann-La Roche Ag |
Diagnostic and therapeutic methods for cancer
|
|
TWI791053B
(zh)
|
2017-10-10 |
2023-02-01 |
美商亞雷生物製藥股份有限公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
|
|
TWI876442B
(zh)
|
2017-10-10 |
2025-03-11 |
美商絡速藥業公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
|
|
CN111417389A
(zh)
|
2017-10-11 |
2020-07-14 |
坎莫森特里克斯公司 |
Ccr2拮抗剂对局灶性节段性肾小球硬化症的治疗
|
|
KR20200070295A
(ko)
|
2017-10-12 |
2020-06-17 |
레볼루션 메디슨즈, 인크. |
알로스테릭 shp2 억제제로서의 피리딘, 피라진 및 트리아진 화합물
|
|
JP7675519B2
(ja)
|
2017-10-13 |
2025-05-13 |
オプナ バイオ ソシエテ アノニム |
キナーゼを調節するための化合物の固体形態
|
|
MY203853A
(en)
|
2017-10-26 |
2024-07-22 |
Xynomic Pharmaceuticals Inc |
Crystalline salts of a b-raf kinase inhibitor
|
|
JP7175309B2
(ja)
|
2017-10-27 |
2022-11-18 |
プレキシコン インコーポレーテッド |
キナーゼを調節する化合物の製剤
|
|
AR113922A1
(es)
|
2017-12-08 |
2020-07-01 |
Incyte Corp |
Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
|
|
EP3724189B1
(en)
|
2017-12-15 |
2023-10-04 |
Revolution Medicines, Inc. |
Polycyclic compounds as allosteric shp2 inhibitors
|
|
JP7416716B2
(ja)
|
2017-12-28 |
2024-01-17 |
トラクト ファーマシューティカルズ インコーポレイテッド |
円柱上皮幹細胞のための幹細胞培養系およびそれに関連した使用法
|
|
CA3087972C
(en)
|
2018-01-18 |
2023-01-10 |
Array Biopharma Inc. |
Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
|
|
TW201938169A
(zh)
|
2018-01-18 |
2019-10-01 |
美商亞雷生物製藥股份有限公司 |
作為RET激酶抑制劑之經取代吡唑并[3,4-d]嘧啶化合物
|
|
CN111971286B
(zh)
|
2018-01-18 |
2023-04-14 |
阿雷生物药品公司 |
作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物
|
|
EP3746429B1
(en)
|
2018-01-30 |
2022-03-09 |
Incyte Corporation |
Processes for preparing (1-(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
|
|
IL276353B2
(en)
|
2018-01-31 |
2024-02-01 |
Heparegenix Gmbh |
Protein kinase MKK4 inhibitors for regeneration or reduction or prevention of hepatocyte death
|
|
EP3752200A1
(en)
|
2018-02-13 |
2020-12-23 |
Vib Vzw |
Targeting minimal residual disease in cancer with rxr antagonists
|
|
WO2019183145A1
(en)
|
2018-03-20 |
2019-09-26 |
Plexxikon Inc. |
Compounds and methods for ido and tdo modulation, and indications therefor
|
|
BR112020019814A2
(pt)
|
2018-03-30 |
2021-01-05 |
Incyte Corporation |
Tratamento de hidradenite supurativa usando inibidores jak
|
|
US11634408B2
(en)
|
2018-04-05 |
2023-04-25 |
Beth Israel Deaconess Medical Center, Inc. |
Aryl hydrocarbon receptor modulators and uses thereof
|
|
EP3560516A1
(en)
*
|
2018-04-27 |
2019-10-30 |
Bergen Teknologioverforing AS |
Combination therapy including beta-sitosterol in combination with at least one of a braf inhibitor, a mek inhibitor or an erk inhibitor and methods and use thereof
|
|
WO2019222470A1
(en)
|
2018-05-17 |
2019-11-21 |
The Wistar Institute |
Ebna1 inhibitor crystalline forms, and methods of preparing and using same
|
|
GB201808321D0
(en)
*
|
2018-05-21 |
2018-07-11 |
Univ College Dublin Nat Univ Ireland Dublin |
Compositions and uses thereof
|
|
RU2687107C1
(ru)
*
|
2018-06-18 |
2019-05-07 |
федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" |
Ингибитор braf киназы n-(3-(5-(4-хлорофенил)-1h-пиразоло[3,4-b]пиридин-3-карбонил)-2,4-дифторофенил) пропан-1-сульфонамид
|
|
WO2019243315A1
(en)
|
2018-06-21 |
2019-12-26 |
Heparegenix Gmbh |
Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
|
|
JP7590185B2
(ja)
|
2018-06-25 |
2024-11-26 |
ダナ-ファーバー キャンサー インスティテュート, インコーポレイテッド |
Taireファミリーキナーゼインヒビターおよびそれらの使用
|
|
GB2612522B
(en)
*
|
2018-07-06 |
2023-08-02 |
The Regents Of The Univ Of Colorado A Body Corporate Existing Under The Laws Of The State Of Colorad |
Genetically encoded system for constructing and detecting biologically active agents
|
|
BR112020026003A2
(pt)
|
2018-07-16 |
2021-03-23 |
Heparegenix Gmbh |
inibidores de proteína quinase para promover a regeneração do fígado ou reduzir ou prevenir a morte de hepatócitos
|
|
JP7317938B2
(ja)
*
|
2018-07-19 |
2023-07-31 |
シェンチェン リンファン バイオテック カンパニー,リミティド |
アザインドール誘導体とFGFR及びC-Met阻害剤としてのその使用
|
|
KR102653681B1
(ko)
|
2018-07-31 |
2024-04-03 |
록쏘 온콜로지, 인코포레이티드 |
(s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제
|
|
US11964988B2
(en)
|
2018-09-10 |
2024-04-23 |
Array Biopharma Inc. |
Fused heterocyclic compounds as RET kinase inhibitors
|
|
EP3860598B1
(en)
|
2018-10-03 |
2023-09-06 |
Jyväskylän Yliopisto |
Vemurafenib and salts thereof for use in the treatment of enteroviral infections
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
EP3867409A1
(en)
|
2018-10-16 |
2021-08-25 |
Novartis AG |
Tumor mutation burden alone or in combination with immune markers as biomarkers for predicting response to targeted therapy
|
|
KR20210130701A
(ko)
|
2018-11-16 |
2021-11-01 |
캘리포니아 인스티튜트 오브 테크놀로지 |
Erk 저해제 및 이의 용도
|
|
CA3120352A1
(en)
|
2018-11-20 |
2020-05-28 |
Nflection Therapeutics, Inc. |
Thienyl-aniline compounds for treatment of dermal disorders
|
|
US12378240B2
(en)
|
2018-11-20 |
2025-08-05 |
Nflection Therapeutics, Inc. |
Naphthyridinone-aniline compounds for treatment of dermal disorders
|
|
JP7406264B2
(ja)
|
2018-11-20 |
2023-12-27 |
エヌフレクション セラピューティクス インコーポレイテッド |
皮膚障害の処置のためのシアノアリール-アニリン化合物
|
|
AU2019392502A1
(en)
*
|
2018-12-03 |
2021-07-22 |
Merck Patent Gmbh |
4-heteroarylcarbonyl-N-(phenyl or heteroaryl) piperidine-1-carboxamides as inhibitors of tankyrases
|
|
WO2020131674A1
(en)
|
2018-12-19 |
2020-06-25 |
Array Biopharma Inc. |
7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer
|
|
JP2022515198A
(ja)
|
2018-12-19 |
2022-02-17 |
アレイ バイオファーマ インコーポレイテッド |
FGFRチロシンキナーゼの阻害剤としての置換ピラゾロ[1,5-a]ピリジン化合物
|
|
EP3902542A4
(en)
|
2018-12-28 |
2022-09-07 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 and uses thereof
|
|
LT3924340T
(lt)
*
|
2019-02-11 |
2025-03-10 |
Merck Patent Gmbh |
Indazolil-izoksazolo dariniai, skirti ligų, tokių kaip vėžys, gydymui
|
|
WO2020168197A1
(en)
|
2019-02-15 |
2020-08-20 |
Incyte Corporation |
Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
|
|
US11472791B2
(en)
|
2019-03-05 |
2022-10-18 |
Incyte Corporation |
Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
|
|
WO2020205560A1
(en)
|
2019-03-29 |
2020-10-08 |
Incyte Corporation |
Sulfonylamide compounds as cdk2 inhibitors
|
|
JP7636646B2
(ja)
|
2019-04-09 |
2025-02-27 |
オプナ バイオ ソシエテ アノニム |
Ep300またはcbpの調節のための縮合アジンおよびその適応
|
|
US11447494B2
(en)
|
2019-05-01 |
2022-09-20 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
US11440914B2
(en)
|
2019-05-01 |
2022-09-13 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
MA56047A
(fr)
*
|
2019-05-29 |
2022-04-06 |
Ifm Due Inc |
Composés et compositions destinés au traitement d'états pathologiques associés à une activité de sting
|
|
KR20220016090A
(ko)
*
|
2019-05-31 |
2022-02-08 |
포천 파마슈티컬즈, 엘티디. |
단백질 키나제 억제제로서 치환된 피롤로 [2, 3-b] 피리딘 및 피라졸로 [3,4-b] 피리딘 유도체
|
|
US20220340561A1
(en)
|
2019-07-29 |
2022-10-27 |
Heparegenix Gmbh |
Heteroaryl-substituted pyrazolo-pyridine protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
|
|
CR20220066A
(es)
|
2019-08-14 |
2022-11-28 |
Incyte Corp |
Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2
|
|
WO2021067749A2
(en)
*
|
2019-10-02 |
2021-04-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for the treatment of osteoarthritis
|
|
US11851426B2
(en)
|
2019-10-11 |
2023-12-26 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
CN111004210A
(zh)
*
|
2019-10-23 |
2020-04-14 |
中山大学 |
化合物单晶及其制备方法
|
|
WO2021113492A1
(en)
|
2019-12-06 |
2021-06-10 |
Schrödinger, Inc. |
Cyclic compounds and methods of using same
|
|
US12509444B2
(en)
|
2019-12-06 |
2025-12-30 |
Plexxikon Inc. |
Compounds and methods for CD73 modulation and indications therefor
|
|
KR20220119094A
(ko)
|
2019-12-19 |
2022-08-26 |
아비나스 오퍼레이션스, 인코포레이티드 |
안드로겐 수용체의 표적화된 분해를 위한 화합물 및 방법
|
|
IL294214B1
(en)
|
2019-12-27 |
2025-12-01 |
Schr?Dinger Inc |
Cyclic compounds and methods of using same
|
|
JP2023509760A
(ja)
|
2020-01-08 |
2023-03-09 |
シンシス セラピューティクス,インコーポレイテッド |
Alk5阻害剤複合体およびその使用
|
|
AU2021207236A1
(en)
*
|
2020-01-15 |
2022-08-11 |
Heparegenix Gmbh |
3-benzoyl-1h-pyrrolo[2,3-b]pyridine derivatives as MKK4 inhibitors for treating liver diseases
|
|
CN114981241B
(zh)
*
|
2020-01-17 |
2024-11-19 |
大邱庆北尖端医疗产业振兴财团 |
新型化合物及其制备方法和用途
|
|
EP4097234A1
(en)
|
2020-01-28 |
2022-12-07 |
Université de Strasbourg |
Antisense oligonucleotide targeting linc00518 for treating melanoma
|
|
CN115515591B
(zh)
*
|
2020-04-15 |
2024-09-27 |
派拉米德生物科学公司 |
用于制备酪氨酸受体激酶抑制剂的方法
|
|
US11807626B2
(en)
|
2020-04-23 |
2023-11-07 |
Opna Bio SA |
Compounds and methods for CD73 modulation and indications therefor
|
|
JP2023524465A
(ja)
|
2020-04-29 |
2023-06-12 |
プレキシコン インコーポレイティド |
複素環式化合物の合成
|
|
KR102841083B1
(ko)
*
|
2020-05-04 |
2025-07-31 |
아주대학교산학협력단 |
톨-유사 수용체 7/9 억제 기능이 있는 길항성 소분자 화합물
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
US11529335B2
(en)
|
2020-07-31 |
2022-12-20 |
University Of Iowa Research Foundation |
Compositions and methods for treating cancer
|
|
WO2022040512A1
(en)
|
2020-08-21 |
2022-02-24 |
Plexxikon Inc. |
Combinational drug anticancer therapies
|
|
WO2022047145A1
(en)
|
2020-08-28 |
2022-03-03 |
Arvinas Operations, Inc. |
Rapidly accelerating fibrosarcoma protein degrading compounds and associated methods of use
|
|
CN116490507A
(zh)
|
2020-09-10 |
2023-07-25 |
薛定谔公司 |
用于治疗癌症的杂环包缩合cdc7激酶抑制剂
|
|
US20240360154A1
(en)
*
|
2020-09-23 |
2024-10-31 |
Genfleet Therapeutics (Shanghai) Inc. |
Aroyl substituted tricyclic compound, preparation method therefor and use thereof
|
|
CN114478528A
(zh)
*
|
2020-10-28 |
2022-05-13 |
劲方医药科技(上海)有限公司 |
芳甲酰取代的三环化合物及其制法和用途
|
|
CA3198254A1
(en)
*
|
2020-11-17 |
2022-05-27 |
Haohan TAN |
Substituted pyrrolo [2, 3-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors
|
|
WO2022125524A1
(en)
*
|
2020-12-07 |
2022-06-16 |
Lieber Institute, Inc. |
Compounds for inhibiting inositol hexakisphosphate kinase (ip6k) and methods of use thereof
|
|
EP4234558A4
(en)
*
|
2020-12-07 |
2024-10-23 |
Zhejiang Longcharm Bio-Tech Pharma. Co., Ltd. |
PYRROLOPYRIDINE COMPOUND AND APPLICATION THEREOF
|
|
JP2024500919A
(ja)
|
2020-12-23 |
2024-01-10 |
ジェンザイム・コーポレーション |
重水素化コロニー刺激因子-1受容体(csf-1r)阻害剤
|
|
EP4284804A1
(en)
|
2021-01-26 |
2023-12-06 |
Schrödinger, Inc. |
Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders
|
|
CN112574200B
(zh)
*
|
2021-02-26 |
2021-06-11 |
安润医药科技(苏州)有限公司 |
Btk和/或btk的突变体c481s的小分子抑制剂
|
|
CN115073469B
(zh)
*
|
2021-03-15 |
2023-12-22 |
药雅科技(上海)有限公司 |
吡咯并嘧啶类化合物作为激酶抑制剂的制备及其应用
|
|
CN117321418A
(zh)
|
2021-03-18 |
2023-12-29 |
诺华股份有限公司 |
癌症生物标志物及其使用方法
|
|
TW202300150A
(zh)
|
2021-03-18 |
2023-01-01 |
美商薛定諤公司 |
環狀化合物及其使用方法
|
|
TW202304890A
(zh)
*
|
2021-04-14 |
2023-02-01 |
美商百歐克斯製藥公司 |
Klk5雙環雜芳香族抑制劑
|
|
US12371667B2
(en)
|
2021-05-13 |
2025-07-29 |
Washington University |
Enhanced methods for inducing and maintaining naive human pluripotent stem cells
|
|
KR102635126B1
(ko)
|
2021-05-27 |
2024-02-13 |
한국과학기술연구원 |
엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 피롤로피리미딘 유도체 및 이들의 용도
|
|
US11981671B2
(en)
|
2021-06-21 |
2024-05-14 |
Incyte Corporation |
Bicyclic pyrazolyl amines as CDK2 inhibitors
|
|
US20250042895A1
(en)
*
|
2021-10-06 |
2025-02-06 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Inhibitors of ulk1 and methods of use
|
|
US12310950B2
(en)
|
2021-11-23 |
2025-05-27 |
Nflection Therapeutics, Inc. |
Formulations of pyrrolopyridine-aniline compounds
|
|
US11976073B2
(en)
|
2021-12-10 |
2024-05-07 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
CN116768896A
(zh)
*
|
2022-03-15 |
2023-09-19 |
劲方医药科技(上海)有限公司 |
Btk抑制剂的晶型及其酸式盐和其酸式盐的晶型
|
|
US20250186439A1
(en)
*
|
2022-03-16 |
2025-06-12 |
The Children's Medical Center Corporation |
Pyk2 inhibition modulates immune cell function
|
|
KR102710574B1
(ko)
*
|
2022-03-28 |
2024-09-27 |
주식회사 비엔에이치리서치 |
약물의 전기생리학적 스크리닝 방법
|
|
WO2024003350A1
(en)
|
2022-06-30 |
2024-01-04 |
Universite De Strasbourg |
Combination therapy for melanoma
|
|
CN115141197B
(zh)
*
|
2022-07-27 |
2024-03-26 |
安徽医科大学 |
一种3-芳杂环取代苯基衍生物及其制备方法与用途
|
|
WO2024033381A1
(en)
|
2022-08-10 |
2024-02-15 |
Vib Vzw |
Inhibition of tcf4/itf2 in the treatment of cancer
|
|
EP4584258A1
(en)
|
2022-09-07 |
2025-07-16 |
Arvinas Operations, Inc. |
Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use
|
|
AU2023387127A1
(en)
*
|
2022-11-25 |
2025-06-19 |
Xenolis Pte. Ltd. |
Nucleic acid aptamer
|
|
CN116768886B
(zh)
*
|
2022-12-26 |
2025-09-16 |
安徽医科大学 |
N-(4-(1H-吡咯并[2,3-b]吡啶-5-基)苯基)酰胺衍生物及制备与用途
|
|
CN115991705B
(zh)
*
|
2022-12-26 |
2025-04-08 |
安徽医科大学 |
3-(1H吡咯并[2,3-b]吡啶-5-基)苯甲酰基衍生物及其制备与应用
|
|
EP4656193A1
(en)
|
2023-04-06 |
2025-12-03 |
Eisai R&D Management Co., Ltd. |
Pharmaceutical composition for treating tumors
|
|
AU2024304014A1
(en)
|
2023-06-13 |
2026-01-29 |
Synthis Therapeutics, Inc. |
Anti-cd5 antibodies and their uses
|
|
CN117105936B
(zh)
*
|
2023-08-24 |
2025-01-24 |
遵义医科大学 |
一种作为FLT3抑制剂的咪唑并[1,2-a]吡啶化合物及其制备方法和用途
|
|
WO2025059027A1
(en)
|
2023-09-11 |
2025-03-20 |
Schrödinger, Inc. |
Cyclopenta[e]pyrazolo[1,5-a]pyrimidine derivatives as malt1 inhibitors
|
|
WO2025097025A1
(en)
*
|
2023-11-03 |
2025-05-08 |
Evommune, Inc. |
Protein kinase c (pkc) theta inhibitor compounds
|
|
WO2025146444A1
(en)
|
2024-01-03 |
2025-07-10 |
Bayer Aktiengesellschaft |
Darolutamide in combination with braf and mek inhibitors for melanoma treatment
|
|
WO2026019990A1
(en)
|
2024-07-18 |
2026-01-22 |
Genentech, Inc. |
Methods of treating cancer with anti-ccr8/anti-cd3 bispecific antibodies
|