TW200950805A - Dual variable domain immunoglobulins and uses thereof - Google Patents

Dual variable domain immunoglobulins and uses thereof Download PDF

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Publication number
TW200950805A
TW200950805A TW98114240A TW98114240A TW200950805A TW 200950805 A TW200950805 A TW 200950805A TW 98114240 A TW98114240 A TW 98114240A TW 98114240 A TW98114240 A TW 98114240A TW 200950805 A TW200950805 A TW 200950805A
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TW
Taiwan
Prior art keywords
seq
acid sequence
amino acid
binding
chain amino
Prior art date
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TW98114240A
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English (en)
Chinese (zh)
Inventor
Tariq Ghayur
Edward B Reilly
Andrew Phillips
Randy L Bell
ying-chun Li
Hua Ying
Susan E Morgan-Lappe
Gillian A Kingsbury
Jieyi Wang
Suzanne M Norvell
jun-jian Liu
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Abbott Lab
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Application filed by Abbott Lab filed Critical Abbott Lab
Publication of TW200950805A publication Critical patent/TW200950805A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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