SG177564A1 - Novel nucleic acid prodrugs and methods of use thereof - Google Patents

Info

Publication number

SG177564A1

SG177564A1 SG2012001301A SG2012001301A SG177564A1 SG 177564 A1 SG177564 A1 SG 177564A1 SG 2012001301 A SG2012001301 A SG 2012001301A SG 2012001301 A SG2012001301 A SG 2012001301A SG 177564 A1 SG177564 A1 SG 177564A1

Authority

SG

Singapore

Prior art keywords

alkyl

och

aryl

nucleic acid

pme

Prior art date

2009-07-06

Links

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• 102000039446 nucleic acids Human genes 0.000 title claims abstract description 285
• 108020004707 nucleic acids Proteins 0.000 title claims abstract description 285
• 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 280
• 229940002612 prodrug Drugs 0.000 title claims abstract description 215
• 239000000651 prodrug Substances 0.000 title claims abstract description 215
• 238000000034 method Methods 0.000 title claims abstract description 144
• 125000000217 alkyl group Chemical group 0.000 claims description 325
• 229910052739 hydrogen Inorganic materials 0.000 claims description 194
• 150000001875 compounds Chemical class 0.000 claims description 189
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• 125000003118 aryl group Chemical group 0.000 claims description 147
• 125000004432 carbon atom Chemical group C* 0.000 claims description 128
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• 125000001072 heteroaryl group Chemical group 0.000 claims description 102
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• 125000003342 alkenyl group Chemical group 0.000 claims description 90
• 125000000304 alkynyl group Chemical group 0.000 claims description 90
• 150000002431 hydrogen Chemical class 0.000 claims description 80
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• 125000005647 linker group Chemical group 0.000 claims description 59
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• OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims description 50
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