US10329318B2 - Method for the synthesis of phosphorus atom modified nucleic acids - Google Patents

Method for the synthesis of phosphorus atom modified nucleic acids Download PDF

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Publication number
US10329318B2
US10329318B2 US15/608,123 US201715608123A US10329318B2 US 10329318 B2 US10329318 B2 US 10329318B2 US 201715608123 A US201715608123 A US 201715608123A US 10329318 B2 US10329318 B2 US 10329318B2
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Prior art keywords
alkyl
embodiments
moiety
formula
alkenyl
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US15/608,123
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US20180111958A1 (en
Inventor
Takeshi Wada
Mamoru Shimizu
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Wave Life Sciences Pte Ltd
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Wave Life Sciences Pte Ltd
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Priority to US11924508P priority Critical
Priority to PCT/IB2009/007923 priority patent/WO2010064146A2/en
Priority to US201113131591A priority
Priority to US15/167,583 priority patent/US9695211B2/en
Priority to US15/608,123 priority patent/US10329318B2/en
Application filed by Wave Life Sciences Pte Ltd filed Critical Wave Life Sciences Pte Ltd
Assigned to WAVE LIFE SCIENCES LTD. reassignment WAVE LIFE SCIENCES LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WAVE LIFE SCIENCES JAPAN, INC.
Assigned to WAVE LIFE SCIENCES JAPAN, INC. reassignment WAVE LIFE SCIENCES JAPAN, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WADA, TAKESHI, SHIMIZU, MAMORU
Publication of US20180111958A1 publication Critical patent/US20180111958A1/en
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