MD4496C1 - Analogi carba-nucleozidici 2'-substituiţi pentru tratament antiviral - Google Patents

Analogi carba-nucleozidici 2'-substituiţi pentru tratament antiviral

Info

Publication number
MD4496C1
MD4496C1 MDA20140112A MD20140112A MD4496C1 MD 4496 C1 MD4496 C1 MD 4496C1 MD A20140112 A MDA20140112 A MD A20140112A MD 20140112 A MD20140112 A MD 20140112A MD 4496 C1 MD4496 C1 MD 4496C1
Authority
MD
Moldova
Prior art keywords
nucleoside analogs
antiviral treatment
compounds
substituted carba
carba
Prior art date
Application number
MDA20140112A
Other languages
English (en)
Russian (ru)
Other versions
MD20140112A2 (ro
MD4496B1 (ro
Inventor
Майкл О'Нил Хенрехен Кларк
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of MD20140112A2 publication Critical patent/MD20140112A2/ro
Publication of MD4496B1 publication Critical patent/MD4496B1/ro
Publication of MD4496C1 publication Critical patent/MD4496C1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/30—Vaccines

Abstract

Invenţia se referă la compuşi cu Formula I:,precum şi la compoziţii farmaceutice care conţin compuşi cu Formula I şi metode pentru tratarea infecţiilor cu viruşi Orthomyxoviridae prin administrarea acestor compuşi.Compuşii, compoziţiile şi metodele propuse sunt utile în particular pentru tratamentul infecţiilor cu virusul gripal uman.
MDA20140112A 2012-03-13 2013-03-11 Analogi carba-nucleozidici 2'-substituiţi pentru tratament antiviral MD4496C1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261610411P 2012-03-13 2012-03-13
PCT/US2013/030196 WO2013138236A1 (en) 2012-03-13 2013-03-11 2'- substituted carba-nucleoside analogs for antiviral treatment

Publications (3)

Publication Number Publication Date
MD20140112A2 MD20140112A2 (ro) 2015-02-28
MD4496B1 MD4496B1 (ro) 2017-07-31
MD4496C1 true MD4496C1 (ro) 2018-02-28

Family

ID=47997868

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20140112A MD4496C1 (ro) 2012-03-13 2013-03-11 Analogi carba-nucleozidici 2'-substituiţi pentru tratament antiviral

Country Status (19)

Country Link
US (4) US9481704B2 (ro)
EP (4) EP3210993B1 (ro)
JP (3) JP6242378B2 (ro)
KR (1) KR102068856B1 (ro)
CN (2) CN106749272B (ro)
AU (2) AU2013232378B2 (ro)
CA (1) CA2866381C (ro)
EA (2) EA201791916A1 (ro)
ES (3) ES2878087T3 (ro)
HK (2) HK1207083A1 (ro)
IL (2) IL234586A (ro)
IN (1) IN2014DN08505A (ro)
MD (1) MD4496C1 (ro)
MX (1) MX355267B (ro)
NZ (1) NZ629996A (ro)
PL (1) PL2834258T3 (ro)
PT (1) PT2834258T (ro)
SI (1) SI2834258T1 (ro)
WO (1) WO2013138236A1 (ro)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010064146A2 (en) 2008-12-02 2010-06-10 Chiralgen, Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
IN2012DN00720A (ro) 2009-07-06 2015-06-19 Ontorii Inc
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
RU2014105311A (ru) 2011-07-19 2015-08-27 Уэйв Лайф Сайенсес Пте. Лтд. Способы синтеза функционализованных нуклеиновых кислот
US8633198B1 (en) 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
CA3107640A1 (en) 2011-12-22 2013-06-27 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof and their use in ameliorating or treating a disease or condition associated with viral infections
EA201791916A1 (ru) 2012-03-13 2018-07-31 Джилид Сайэнс, Инк. 2'-замещенные карбануклеозидные аналоги для противовирусного лечения
MX361460B (es) * 2012-03-21 2018-12-06 Alios Biopharma Inc Nucleosidos sustituidos, nucleotidos y analogos de los mismos.
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
PT2872485T (pt) 2012-07-13 2021-03-05 Wave Life Sciences Ltd Grupo auxiliar assimétrico
UA119050C2 (uk) * 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
KR101868128B1 (ko) * 2013-12-11 2018-06-18 난트 홀딩스 아이피, 엘엘씨 인플루엔자 a rna-의존성 rna 폴리머라제의 저분자 저해제
CN106068325B (zh) 2014-01-16 2021-07-09 波涛生命科学有限公司 手性设计
WO2015120237A2 (en) * 2014-02-06 2015-08-13 Riboscience Llc 4'-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza rna replication
WO2015143712A1 (en) * 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
TWI678369B (zh) 2014-07-28 2019-12-01 美商基利科學股份有限公司 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類
EA031726B1 (ru) 2014-09-26 2019-02-28 Рибосайенс Ллк 4'-винилзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк респираторно-синцитиального вируса
BR112017013858A2 (pt) 2014-12-26 2018-02-27 Univ Emory n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos
JP6768796B2 (ja) 2015-09-23 2020-10-14 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ４’−置換ヌクレオシド逆転写酵素阻害剤及びその調製
US10202412B2 (en) 2016-07-08 2019-02-12 Atea Pharmaceuticals, Inc. β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
AU2018257778B2 (en) 2017-04-24 2022-02-17 Cocrystal Pharma, Inc. Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication
WO2019113462A1 (en) 2017-12-07 2019-06-13 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
EP3829719A1 (en) 2018-07-27 2021-06-09 Cocrystal Pharma, Inc. Pyrrolo[2,3-b]pyridin derivatives as inhibitors of influenza virus replication
TW202023566A (zh) 2018-09-10 2020-07-01 美商共結晶製藥公司 流感病毒複製之抑制劑
US20220048897A1 (en) 2018-11-26 2022-02-17 Cocrystal Pharma, Inc. Inhibitors of influenza virus replication
TW202322824A (zh) 2020-02-18 2023-06-16 美商基利科學股份有限公司 抗病毒化合物
US20230181615A1 (en) 2020-03-22 2023-06-15 Inspirmed Corp. Composition of antiviral agent for use in prophylactic or post-exposure treatment of infectious or respiratory diseases
EP4129291A4 (en) * 2020-03-30 2024-04-10 Fujifilm Toyama Chemical Co Ltd CORONAVIRUS INFECTION TREATMENT MEDICATION
CN111956630A (zh) * 2020-08-20 2020-11-20 大连理工大学 一种瑞德西韦供雾化器用的液体制剂、制备方法及其应用
CN117120444A (zh) 2021-04-16 2023-11-24 吉利德科学公司 使用酰胺制备卡巴核苷的方法
KR20240050362A (ko) * 2021-08-20 2024-04-18 시오노기 앤드 컴파니, 리미티드 바이러스 증식 억제 작용을 갖는 뉴클레오사이드 유도체 및 그들의 프로드러그

Citations (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361306A (en) * 1966-03-31 1968-01-02 Merck & Co Inc Aerosol unit dispensing uniform amounts of a medically active ingredient
US3565070A (en) * 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
US3906950A (en) * 1973-04-04 1975-09-23 Isf Spa Inhaling device for powdered medicaments
US4013075A (en) * 1974-07-15 1977-03-22 I.S.F. S.P.A. Inhalers and insufflators having a cutting means
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US4667668A (en) * 1981-07-08 1987-05-26 Aktiebolaget Draco Dosage inhalator
US4668218A (en) * 1985-04-12 1987-05-26 Aktiebolaget Draco Indicating means for a dosage dispensing device
US4805811A (en) * 1985-03-29 1989-02-21 Aktiebolaget Draco Dosage device
US4816570A (en) * 1982-11-30 1989-03-28 The Board Of Regents Of The University Of Texas System Biologically reversible phosphate and phosphonate protective groups
US4955371A (en) * 1989-05-08 1990-09-11 Transtech Scientific, Inc. Disposable inhalation activated, aerosol device for pulmonary medicine
US4968788A (en) * 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
US4995385A (en) * 1989-02-23 1991-02-26 Phidea S.P.A. Inhaler with regular complete emptying of the capsule
US5261538A (en) * 1992-04-21 1993-11-16 Glaxo Inc. Aerosol testing method
US5388571A (en) * 1987-07-17 1995-02-14 Roberts; Josephine A. Positive-pressure ventilator system with controlled access for nebulizer component servicing
US5458135A (en) * 1991-07-02 1995-10-17 Inhale Therapeutic Systems Method and device for delivering aerosolized medicaments
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5544647A (en) * 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator
US5622163A (en) * 1994-11-29 1997-04-22 Iep Group, Inc. Counter for fluid dispensers
US5663159A (en) * 1990-09-14 1997-09-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
US5740794A (en) * 1994-09-21 1998-04-21 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
US6116234A (en) * 1999-02-01 2000-09-12 Iep Pharmaceutical Devices Inc. Metered dose inhaler agitator
WO2000056734A1 (de) * 1999-03-20 2000-09-28 Aventis Cropscience Gmbh Bicyclische heterocyclen, verfahren zu ihrer herstellung und ihre verwendung als herbizide und pharmazeutische mittel
US20040067901A1 (en) * 2001-01-22 2004-04-08 Balkrishen Bhat Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
WO2008089105A2 (en) * 2007-01-12 2008-07-24 Biocryst Pharmaceuticals, Inc. Antiviral nucleoside analogs
WO2008141079A1 (en) * 2007-05-10 2008-11-20 Biocryst Pharmaceuticals, Inc. Tetrahydrofuro [3 4-d] dioxolane compounds for use in the treatment of viral infections and cancer
WO2009132123A1 (en) * 2008-04-23 2009-10-29 Gilead Sciences, Inc. Carba-nucleoside analogs for antiviral treatment
WO2010002877A2 (en) * 2008-07-03 2010-01-07 Biota Scientific Management Bycyclic nucleosides and nucleotides as therapeutic agents
EA201390142A1 (ru) * 2010-09-13 2013-09-30 Джилид Сайэнс, Инк. 2'-фторзамещенные карбануклеозидные аналоги для противовирусного лечения

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5388572A (en) 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
KR100905221B1 (ko) * 2000-10-18 2009-07-01 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한변형된 뉴클레오시드
GB0112617D0 (en) * 2001-05-23 2001-07-18 Hoffmann La Roche Antiviral nucleoside derivatives
WO2003062256A1 (en) * 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
JP4398631B2 (ja) 2002-07-12 2010-01-13 富山化学工業株式会社 新規なピラジン誘導体またはその塩並びにそれらを含有する抗ウイルス剤
US20050196382A1 (en) 2002-09-13 2005-09-08 Replicor, Inc. Antiviral oligonucleotides targeting viral families
CN101084232A (zh) * 2004-10-19 2007-12-05 里普利科股份有限公司 抗病毒寡核苷酸
WO2010036407A2 (en) * 2008-05-15 2010-04-01 Biocryst Pharmaceuticals, Inc. Antiviral nucleoside analogs
US8455451B2 (en) * 2009-09-21 2013-06-04 Gilead Sciences, Inc. 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
CN102596979B (zh) * 2009-09-21 2014-12-10 吉里德科学公司 用于制备1’-取代碳核苷类似物的方法和中间体
LT2480552T (lt) * 2009-09-21 2017-02-10 Gilead Sciences, Inc. 2'-fluoru pakeisti karbanukleozidų analogai, skirti antivirusiniam gydymui
SG186830A1 (en) 2010-07-22 2013-02-28 Gilead Sciences Inc Methods and compounds for treating paramyxoviridae virus infections
EA201791916A1 (ru) 2012-03-13 2018-07-31 Джилид Сайэнс, Инк. 2'-замещенные карбануклеозидные аналоги для противовирусного лечения

Patent Citations (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3361306A (en) * 1966-03-31 1968-01-02 Merck & Co Inc Aerosol unit dispensing uniform amounts of a medically active ingredient
US3565070A (en) * 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
US3906950A (en) * 1973-04-04 1975-09-23 Isf Spa Inhaling device for powdered medicaments
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US4013075A (en) * 1974-07-15 1977-03-22 I.S.F. S.P.A. Inhalers and insufflators having a cutting means
US4667668A (en) * 1981-07-08 1987-05-26 Aktiebolaget Draco Dosage inhalator
US4816570A (en) * 1982-11-30 1989-03-28 The Board Of Regents Of The University Of Texas System Biologically reversible phosphate and phosphonate protective groups
US4805811A (en) * 1985-03-29 1989-02-21 Aktiebolaget Draco Dosage device
US4668218A (en) * 1985-04-12 1987-05-26 Aktiebolaget Draco Indicating means for a dosage dispensing device
US4968788A (en) * 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
US5388571A (en) * 1987-07-17 1995-02-14 Roberts; Josephine A. Positive-pressure ventilator system with controlled access for nebulizer component servicing
US4995385A (en) * 1989-02-23 1991-02-26 Phidea S.P.A. Inhaler with regular complete emptying of the capsule
US4955371A (en) * 1989-05-08 1990-09-11 Transtech Scientific, Inc. Disposable inhalation activated, aerosol device for pulmonary medicine
US5792756A (en) * 1990-09-14 1998-08-11 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
US5663159A (en) * 1990-09-14 1997-09-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
US5458135A (en) * 1991-07-02 1995-10-17 Inhale Therapeutic Systems Method and device for delivering aerosolized medicaments
US5775320A (en) * 1991-07-02 1998-07-07 Inhale Therapeutic Systems Method and device for delivering aerosolized medicaments
US5261538A (en) * 1992-04-21 1993-11-16 Glaxo Inc. Aerosol testing method
US5785049A (en) * 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US5740794A (en) * 1994-09-21 1998-04-21 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5544647A (en) * 1994-11-29 1996-08-13 Iep Group, Inc. Metered dose inhalator
US5622163A (en) * 1994-11-29 1997-04-22 Iep Group, Inc. Counter for fluid dispensers
US6116234A (en) * 1999-02-01 2000-09-12 Iep Pharmaceutical Devices Inc. Metered dose inhaler agitator
WO2000056734A1 (de) * 1999-03-20 2000-09-28 Aventis Cropscience Gmbh Bicyclische heterocyclen, verfahren zu ihrer herstellung und ihre verwendung als herbizide und pharmazeutische mittel
US20040067901A1 (en) * 2001-01-22 2004-04-08 Balkrishen Bhat Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
WO2008089105A2 (en) * 2007-01-12 2008-07-24 Biocryst Pharmaceuticals, Inc. Antiviral nucleoside analogs
WO2008141079A1 (en) * 2007-05-10 2008-11-20 Biocryst Pharmaceuticals, Inc. Tetrahydrofuro [3 4-d] dioxolane compounds for use in the treatment of viral infections and cancer
WO2009132123A1 (en) * 2008-04-23 2009-10-29 Gilead Sciences, Inc. Carba-nucleoside analogs for antiviral treatment
WO2009132135A1 (en) * 2008-04-23 2009-10-29 Gilead Sciences, Inc. 1' -substituted carba-nucleoside analogs for antiviral treatment
WO2010002877A2 (en) * 2008-07-03 2010-01-07 Biota Scientific Management Bycyclic nucleosides and nucleotides as therapeutic agents
EA201390142A1 (ru) * 2010-09-13 2013-09-30 Джилид Сайэнс, Инк. 2'-фторзамещенные карбануклеозидные аналоги для противовирусного лечения

Non-Patent Citations (23)

* Cited by examiner, † Cited by third party
Title
Bundgaard Hans, „Design and Aplication of Prodrugs" in Textbook of Drug Design and Development (1991), P. Krogsgaard-Larsen and H. Bundgaard, Eds. Harwood Academic Publishers, p. 113-191 *
Carbohydrate Research , 2001, 331(1), 77-82 *
Carryer. Journal of Allergy, 21, 282-287, 1950 *
de Farquhar et al. (1983) J. Pharm. Sci. 72: 324 *
Denyer J. Medicine Pulmonary Drug Delivery 2010, 23 Supp 1, S1 -S10 *
Goodman and Gilman, 10th edition, 2001 *
Handbook of Pharmaceutical Excipient (1986) *
Hedlund et al. Viruses 2010, 2, 1766-1781 *
J. Chem. Soc. Perkin Trans. 1 1984, 2, 229-38 *
J. Chem. Soc. Perkin Trans. 1 1985, 3, 621-30 *
J. Chem. Soc. Perkin Trans. 1 1999, 20, 2929-2936 *
J. Med. Chem. 1986, 29 (11), 2231 - 2235 *
Kuzik, J. Pediatrie 2007, 266 *
Memoli et al. Drug Discovery Today 2008, 13, 590-595 *
Morris J. Allergy Clin. Immunol., 75 (1 Pt) 1-13, 1985 *
Nucleosides & Nucleotides 1996, 15 (1-3), 793-807 *
Organic Letters 2001, 3 (6), 839-842 *
Paquette, Leo A. Principles of Modern Heterocyclic Chemistry (W.A. Benjamin, New York, 1968), deosebit detaliat capitolele 1, 3, 4, 6, 7, şi 9 *
Protective Groups in Organic Chemistry, Theodora W. Greene (John Wiley & Sons, Inc., New York, 1991 *
Remington’s Pharmaceutical Sciences (Mack Publishing Co., Easton, PA) *
Tetrahedron Letters 1994, 35 (30), 5339-42; Heterocycles 1992, 34 (3), 569-74 *
The Chemistry of Heterocyclic Compounds, A Series of Monographs (John Wiley & Sons, New York, 1950 to present), în mod deosebit volumele 13, 14, 16, 19 şi 28; J. Am. Chem. Soc. (1960) 82:5566 *
US Pharmacopeia Capitolul 601 *

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