MD20140112A2 - Analogi carba-nucleozidici 2'-substituiţi pentru tratamentul antiviral - Google Patents
Analogi carba-nucleozidici 2'-substituiţi pentru tratamentul antiviralInfo
- Publication number
- MD20140112A2 MD20140112A2 MDA20140112A MD20140112A MD20140112A2 MD 20140112 A2 MD20140112 A2 MD 20140112A2 MD A20140112 A MDA20140112 A MD A20140112A MD 20140112 A MD20140112 A MD 20140112A MD 20140112 A2 MD20140112 A2 MD 20140112A2
- Authority
- MD
- Moldova
- Prior art keywords
- nucleoside analogs
- antiviral treatment
- compounds
- substituted carba
- carba
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000009385 viral infection Effects 0.000 abstract 2
- 241000712464 Orthomyxoviridae Species 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/30—Vaccines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Invenţia se referă la compuşi cu Formula I,,precum şi la compoziţii farmaceutice care conţin compuşii cu Formula I şi metode pentru tratarea infecţiilor cu virusul Orthomyxoviridae prin administrarea acestor compuşi.Compuşii, compoziţiile şi metodele propuse sunt utile în particular pentru tratamentul infecţiilor cu virusul gripal uman.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261610411P | 2012-03-13 | 2012-03-13 | |
PCT/US2013/030196 WO2013138236A1 (en) | 2012-03-13 | 2013-03-11 | 2'- substituted carba-nucleoside analogs for antiviral treatment |
Publications (3)
Publication Number | Publication Date |
---|---|
MD20140112A2 true MD20140112A2 (ro) | 2015-02-28 |
MD4496B1 MD4496B1 (ro) | 2017-07-31 |
MD4496C1 MD4496C1 (ro) | 2018-02-28 |
Family
ID=47997868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20140112A MD4496C1 (ro) | 2012-03-13 | 2013-03-11 | Analogi carba-nucleozidici 2'-substituiţi pentru tratament antiviral |
Country Status (19)
Country | Link |
---|---|
US (4) | US9481704B2 (ro) |
EP (4) | EP3932931A1 (ro) |
JP (3) | JP6242378B2 (ro) |
KR (1) | KR102068856B1 (ro) |
CN (2) | CN104185638A (ro) |
AU (2) | AU2013232378B2 (ro) |
CA (1) | CA2866381C (ro) |
EA (2) | EA201791916A1 (ro) |
ES (3) | ES2878087T3 (ro) |
HK (2) | HK1207083A1 (ro) |
IL (2) | IL234586A (ro) |
IN (1) | IN2014DN08505A (ro) |
MD (1) | MD4496C1 (ro) |
MX (1) | MX355267B (ro) |
NZ (1) | NZ629996A (ro) |
PL (1) | PL2834258T3 (ro) |
PT (1) | PT2834258T (ro) |
SI (1) | SI2834258T1 (ro) |
WO (1) | WO2013138236A1 (ro) |
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ES2878087T3 (es) * | 2012-03-13 | 2021-11-18 | Gilead Sciences Inc | Análogos de carba-nucleósido 2-sustituidos para el tratamiento antiviral |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
SG10201804571TA (en) * | 2012-03-21 | 2018-07-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
PT2872485T (pt) | 2012-07-13 | 2021-03-05 | Wave Life Sciences Ltd | Grupo auxiliar assimétrico |
UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
KR101868128B1 (ko) * | 2013-12-11 | 2018-06-18 | 난트 홀딩스 아이피, 엘엘씨 | 인플루엔자 a rna-의존성 rna 폴리머라제의 저분자 저해제 |
KR20230152178A (ko) | 2014-01-16 | 2023-11-02 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
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2013
- 2013-03-11 ES ES18155061T patent/ES2878087T3/es active Active
- 2013-03-11 EP EP21168626.6A patent/EP3932931A1/en active Pending
- 2013-03-11 KR KR1020147028523A patent/KR102068856B1/ko active IP Right Grant
- 2013-03-11 EA EA201791916A patent/EA201791916A1/ru unknown
- 2013-03-11 JP JP2015500493A patent/JP6242378B2/ja active Active
- 2013-03-11 SI SI201330567A patent/SI2834258T1/sl unknown
- 2013-03-11 NZ NZ629996A patent/NZ629996A/en unknown
- 2013-03-11 EA EA201491548A patent/EA028928B9/ru unknown
- 2013-03-11 US US13/793,557 patent/US9481704B2/en active Active
- 2013-03-11 ES ES13712043.2T patent/ES2621217T3/es active Active
- 2013-03-11 CA CA2866381A patent/CA2866381C/en active Active
- 2013-03-11 PT PT137120432T patent/PT2834258T/pt unknown
- 2013-03-11 EP EP18155061.7A patent/EP3351552B1/en active Active
- 2013-03-11 MD MDA20140112A patent/MD4496C1/ro active IP Right Grant
- 2013-03-11 AU AU2013232378A patent/AU2013232378B2/en active Active
- 2013-03-11 WO PCT/US2013/030196 patent/WO2013138236A1/en active Application Filing
- 2013-03-11 EP EP13712043.2A patent/EP2834258B1/en active Active
- 2013-03-11 CN CN201380014318.9A patent/CN104185638A/zh active Pending
- 2013-03-11 ES ES16203290T patent/ES2709071T3/es active Active
- 2013-03-11 EP EP16203290.8A patent/EP3210993B1/en active Active
- 2013-03-11 PL PL13712043T patent/PL2834258T3/pl unknown
- 2013-03-11 MX MX2014011009A patent/MX355267B/es active IP Right Grant
- 2013-03-11 CN CN201611121597.0A patent/CN106749272B/zh active Active
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2014
- 2014-09-11 IL IL234586A patent/IL234586A/en active IP Right Grant
- 2014-10-10 IN IN8505DEN2014 patent/IN2014DN08505A/en unknown
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2015
- 2015-08-11 HK HK15107752.6A patent/HK1207083A1/xx unknown
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2016
- 2016-09-30 US US15/282,492 patent/US20170114086A1/en not_active Abandoned
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2017
- 2017-06-21 JP JP2017121389A patent/JP6525441B2/ja active Active
- 2017-12-18 IL IL256397A patent/IL256397A/en unknown
- 2017-12-19 AU AU2017279590A patent/AU2017279590A1/en not_active Abandoned
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2018
- 2018-02-01 HK HK18115942.7A patent/HK1256856A1/zh unknown
- 2018-06-22 US US16/016,369 patent/US10941177B2/en active Active
- 2018-12-26 JP JP2018242679A patent/JP2019069986A/ja not_active Withdrawn
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2021
- 2021-01-28 US US17/161,065 patent/US11787832B2/en active Active
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