NZ706506A - Heterocyclic compounds and uses thereof - Google Patents

Heterocyclic compounds and uses thereof

Info

Publication number
NZ706506A
NZ706506A NZ706506A NZ70650610A NZ706506A NZ 706506 A NZ706506 A NZ 706506A NZ 706506 A NZ706506 A NZ 706506A NZ 70650610 A NZ70650610 A NZ 70650610A NZ 706506 A NZ706506 A NZ 706506A
Authority
NZ
New Zealand
Prior art keywords
heterocyclic compounds
chemical entities
kinase
activity
phosphatidylinositide
Prior art date
Application number
NZ706506A
Other languages
English (en)
Inventor
Liansheng Li
Christian Rommel
Pingda Ren
Katrina Chan
Yi Liu
Troy Edward Wilson
Original Assignee
Intellikine Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intellikine Llc filed Critical Intellikine Llc
Publication of NZ706506A publication Critical patent/NZ706506A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/109—Neutrons
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    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1007—Arrangements or means for the introduction of sources into the body
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
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NZ706506A 2009-07-15 2010-07-15 Heterocyclic compounds and uses thereof NZ706506A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/503,776 US8193182B2 (en) 2008-01-04 2009-07-15 Substituted isoquinolin-1(2H)-ones, and methods of use thereof
NZ619727A NZ619727A (en) 2009-07-15 2010-07-15 Heterocyclic compounds and uses thereof

Publications (1)

Publication Number Publication Date
NZ706506A true NZ706506A (en) 2016-11-25

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
NZ706506A NZ706506A (en) 2009-07-15 2010-07-15 Heterocyclic compounds and uses thereof
NZ597595A NZ597595A (en) 2009-07-15 2010-07-15 Heterocyclic compounds and uses therof
NZ619727A NZ619727A (en) 2009-07-15 2010-07-15 Heterocyclic compounds and uses thereof

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NZ619727A NZ619727A (en) 2009-07-15 2010-07-15 Heterocyclic compounds and uses thereof

Country Status (33)

Country Link
US (13) US8193182B2 (en:Method)
EP (4) EP3441392B1 (en:Method)
JP (2) JP5944313B2 (en:Method)
KR (1) KR101680406B1 (en:Method)
CN (3) CN106188059B (en:Method)
AU (1) AU2010274075B2 (en:Method)
BR (1) BR112012000968B8 (en:Method)
CA (1) CA2768307C (en:Method)
CY (2) CY1116424T1 (en:Method)
DK (1) DK2456444T3 (en:Method)
ES (1) ES2538853T3 (en:Method)
FI (1) FIC20210039I1 (en:Method)
HR (1) HRP20150586T1 (en:Method)
HU (1) HUS2100048I1 (en:Method)
IL (2) IL217181A (en:Method)
IN (1) IN2012DN00943A (en:Method)
LT (1) LTPA2021526I1 (en:Method)
LU (1) LUC00237I2 (en:Method)
MX (3) MX2012000626A (en:Method)
MY (2) MY175979A (en:Method)
NL (1) NL301140I2 (en:Method)
NO (1) NO2021047I1 (en:Method)
NZ (3) NZ706506A (en:Method)
PH (2) PH12015502432A1 (en:Method)
PL (1) PL2456444T3 (en:Method)
PT (1) PT2456444E (en:Method)
RU (2) RU2582676C3 (en:Method)
SG (2) SG10201503886WA (en:Method)
SI (1) SI2456444T1 (en:Method)
SM (1) SMT201500141B (en:Method)
UA (2) UA121192C2 (en:Method)
WO (1) WO2011008302A1 (en:Method)
ZA (1) ZA201200254B (en:Method)

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US20170281614A1 (en) 2017-10-05
US20160031886A1 (en) 2016-02-04
MY168762A (en) 2018-12-04
US20090312319A1 (en) 2009-12-17
US20180098983A1 (en) 2018-04-12
EP3441392B1 (en) 2021-12-15
JP5944313B2 (ja) 2016-07-05
RU2012105071A (ru) 2013-08-20
RU2582676C3 (ru) 2022-01-17
US20250170122A1 (en) 2025-05-29
US8785456B2 (en) 2014-07-22
US20190290636A1 (en) 2019-09-26
JP2016210781A (ja) 2016-12-15
PL2456444T3 (pl) 2015-08-31
IL243932A (en) 2016-11-30
RU2016110024A (ru) 2018-11-23
US20220265637A1 (en) 2022-08-25
NL301140I2 (nl) 2021-11-15
CN109912599B (zh) 2021-11-02
IN2012DN00943A (en:Method) 2015-04-10
CN106188059A (zh) 2016-12-07
WO2011008302A1 (en) 2011-01-20
NL301140I1 (en:Method) 2021-11-03
IL243932A0 (en) 2016-04-21
RU2582676C2 (ru) 2016-04-27
CN102711767B (zh) 2016-08-03
CY1116424T1 (el) 2017-02-08
CN102711767A (zh) 2012-10-03
LTPA2021526I1 (en:Method) 2021-12-10
RU2016110024A3 (en:Method) 2019-09-10
CA2768307A1 (en) 2011-01-20
US9216982B2 (en) 2015-12-22
KR20120097479A (ko) 2012-09-04
AU2010274075B2 (en) 2015-01-22
KR101680406B1 (ko) 2016-11-29
MY175979A (en) 2020-07-19
BR112012000968B8 (pt) 2021-05-25
PH12020550450A1 (en) 2021-06-07
CN106188059B (zh) 2019-02-01
CY2021034I2 (el) 2022-03-24
CA2768307C (en) 2018-02-13
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BR112012000968A8 (pt) 2017-12-26
JP6158395B2 (ja) 2017-07-05

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