EA202092492A1 - Способ лечения и композиции, содержащие двойной ингибитор киназ pi3k дельта-гамма и кортикостероид - Google Patents

Способ лечения и композиции, содержащие двойной ингибитор киназ pi3k дельта-гамма и кортикостероид

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Publication number
EA202092492A1
EA202092492A1 EA202092492A EA202092492A EA202092492A1 EA 202092492 A1 EA202092492 A1 EA 202092492A1 EA 202092492 A EA202092492 A EA 202092492A EA 202092492 A EA202092492 A EA 202092492A EA 202092492 A1 EA202092492 A1 EA 202092492A1
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EA
Eurasian Patent Office
Prior art keywords
corticosteroid
delta
gamma
treatment
dual pi3k
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EA202092492A
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English (en)
Inventor
Сваруп Кумар Венката Сатья Ваккаланка
Срикант Висванадха
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Ризен Фармасьютикалз Са
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Application filed by Ризен Фармасьютикалз Са filed Critical Ризен Фармасьютикалз Са
Publication of EA202092492A1 publication Critical patent/EA202092492A1/ru

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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Abstract

Настоящее изобретение относится к способу лечения аутоиммунных, респираторных и/или воспалительных заболеваний или состояний, например астмы, ХОБЛ, ревматоидного артрита и идиопатического фиброза легких (ИФЛ). Предложенный способ включает введение двойного ингибитора PI3K дельта и гамма и кортикостероида. Настоящее изобретение также относится к фармацевтическим композициям, содержащим двойной ингибитор PI3K дельта и гамма и кортикостероид.
EA202092492A 2014-09-03 2015-09-03 Способ лечения и композиции, содержащие двойной ингибитор киназ pi3k дельта-гамма и кортикостероид EA202092492A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN4287CH2014 2014-09-03

Publications (1)

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EA202092492A1 true EA202092492A1 (ru) 2021-07-30

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Application Number Title Priority Date Filing Date
EA202092492A EA202092492A1 (ru) 2014-09-03 2015-09-03 Способ лечения и композиции, содержащие двойной ингибитор киназ pi3k дельта-гамма и кортикостероид
EA201790379A EA038527B1 (ru) 2014-09-03 2015-09-03 Способ лечения респираторного заболевания или состояния, композиции и наборы, содержащие двойной ингибитор киназ pi3k дельта-гамма и кортикостероид

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EA201790379A EA038527B1 (ru) 2014-09-03 2015-09-03 Способ лечения респираторного заболевания или состояния, композиции и наборы, содержащие двойной ингибитор киназ pi3k дельта-гамма и кортикостероид

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US (2) US10786504B2 (ru)
EP (2) EP3188759B1 (ru)
JP (3) JP6559775B2 (ru)
KR (1) KR20170044203A (ru)
CN (2) CN113332439A (ru)
AU (2) AU2015310545B2 (ru)
BR (1) BR112017004163A2 (ru)
CA (1) CA2958988A1 (ru)
CL (1) CL2017000512A1 (ru)
CY (1) CY1123075T1 (ru)
DK (1) DK3188759T3 (ru)
EA (2) EA202092492A1 (ru)
ES (1) ES2802202T3 (ru)
HR (1) HRP20200968T1 (ru)
HU (1) HUE049480T2 (ru)
IL (2) IL250918B (ru)
LT (1) LT3188759T (ru)
MX (2) MX2017002878A (ru)
PH (1) PH12017500378A1 (ru)
PL (1) PL3188759T3 (ru)
PT (1) PT3188759T (ru)
RS (1) RS60450B1 (ru)
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CN116492351B (zh) * 2023-03-13 2024-03-12 香港大学深圳医院 氯替泼诺在制备治疗早发性卵巢功能不全及卵巢响应匮乏药物中的应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018774A (en) 1976-02-13 1977-04-19 E. R. Squibb & Sons, Inc. Steroidal [16α,17-d]isoxazolidines
SE8106165L (sv) 1981-10-19 1983-04-20 Atlas Copco Ab Forfarande for bergbultning och bergbult
GB0415747D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
UA119314C2 (uk) 2008-01-04 2019-06-10 Інтеллікіне Ллк Спосіб отримання похідних ізохінолінону (варіанти)
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US11058699B2 (en) 2008-07-01 2021-07-13 Wisconsin Alumni Research Foundation Method and compositions for inhibition of double stranded DNA viruses
EP2411003A4 (en) * 2009-03-24 2012-10-17 Univ Singapore USE OF ARTEMISININE DERIVATIVES IN THE TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE BRONCHO-PNEUMOPATHY (COPD)
AU2010294598B2 (en) 2009-09-11 2016-09-01 Chiesi Farmaceutici S.P.A. Pregnane derivatives condensed in the 16, 17 position with an n-substituted isoxazolidine ring as anti-inflammatory agents
AU2010316780B2 (en) * 2009-11-05 2015-07-16 Rhizen Pharmaceuticals Sa Novel benzopyran kinase modulators
AU2011210640A1 (en) * 2010-01-28 2012-06-07 The Johns Hopkins University Compositions and methods for reversing corticosteroid resistance or treating respiratory infections
US10231976B2 (en) * 2010-02-08 2019-03-19 Prairie Pharmaceuticals LLC Methods for the use of progestogen as a glucocorticoid sensitizer
SG10201600179RA (en) 2011-01-10 2016-02-26 Infinity Pharmaceuticals Inc Processes for preparing isoquinolinones and solid forms of isoquinolinones
KR101956937B1 (ko) 2011-03-15 2019-03-11 키에시 파르마슈티시 엣스. 피. 에이. 이속사졸리딘 유도체
ES2710874T3 (es) * 2011-05-04 2019-04-29 Rhizen Pharmaceuticals S A Compuestos novedosos como moduladores de proteína cinasas
WO2013173901A1 (en) 2012-05-22 2013-11-28 Atlas Copco Canada Inc. Rock bolt and method of installing a rock bolt
CN111904962A (zh) * 2012-11-08 2020-11-10 理森制药股份公司 含有PDE4抑制剂和PI3 δ或双重PI3 δ-γ激酶抑制剂的药物组合物
CN204282361U (zh) 2014-12-11 2015-04-22 湖南科技大学 一种带钢丝网的软土地基充气锚杆

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BR112017004163A2 (pt) 2017-12-05
KR20170044203A (ko) 2017-04-24
CN106714842B (zh) 2021-07-02
AU2015310545B2 (en) 2020-10-22
PH12017500378A1 (en) 2017-07-17
WO2016035032A1 (en) 2016-03-10
SI3188759T1 (sl) 2020-08-31
EP3188759B1 (en) 2020-04-01
JP2019172708A (ja) 2019-10-10
AU2021200051A1 (en) 2021-02-18
IL280686A (en) 2021-03-25
MX2020011472A (es) 2020-12-07
EA038527B1 (ru) 2021-09-10
EA201790379A1 (ru) 2017-06-30
SG11201701499YA (en) 2017-03-30
CN113332439A (zh) 2021-09-03
IL250918B (en) 2021-02-28
US10786504B2 (en) 2020-09-29
ES2802202T3 (es) 2021-01-15
JP6559775B2 (ja) 2019-08-14
PL3188759T3 (pl) 2020-11-02
CY1123075T1 (el) 2021-10-29
MX2017002878A (es) 2017-05-30
CL2017000512A1 (es) 2017-11-03
HUE049480T2 (hu) 2020-09-28
CN106714842A (zh) 2017-05-24
JP2021191804A (ja) 2021-12-16
JP2017525739A (ja) 2017-09-07
RS60450B1 (sr) 2020-07-31
US20170281630A1 (en) 2017-10-05
NZ729419A (en) 2021-08-27
EP3701950A1 (en) 2020-09-02
HRP20200968T1 (hr) 2020-10-16
DK3188759T3 (da) 2020-06-29
EP3188759A1 (en) 2017-07-12
PT3188759T (pt) 2020-07-02
SG10202100596SA (en) 2021-02-25
US20210030757A1 (en) 2021-02-04
AU2015310545A1 (en) 2017-03-16
CA2958988A1 (en) 2016-03-10
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