EA201590721A1 - Фармацевтические композиции, содержащие ингибитор pde4 и ингибитор pi3-дельта или двойной ингибитор pi3-дельта-гамма киназы - Google Patents
Фармацевтические композиции, содержащие ингибитор pde4 и ингибитор pi3-дельта или двойной ингибитор pi3-дельта-гамма киназыInfo
- Publication number
- EA201590721A1 EA201590721A1 EA201590721A EA201590721A EA201590721A1 EA 201590721 A1 EA201590721 A1 EA 201590721A1 EA 201590721 A EA201590721 A EA 201590721A EA 201590721 A EA201590721 A EA 201590721A EA 201590721 A1 EA201590721 A1 EA 201590721A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitor
- delta
- pharmaceutical compositions
- pde4
- double
- Prior art date
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Organic Chemistry (AREA)
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Abstract
Настоящее изобретение относится к способу лечения аутоиммунного, респираторного и/или воспалительного заболевания или состояния (например, псориаза, ревматоидного артрита, астмы, ХОБЛ). Указанный способ включает введение ингибитора PI3K-дельта или двойного ингибитора PI3K-дельта-гамма и ингибитора PDE4. Настоящее изобретение также относится к фармацевтическим композициям, содержащим ингибитор PI3K-дельта или двойной ингибитор PI3K-дельта-гамма и ингибитор PDE4.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2762CH2012 | 2012-11-08 | ||
IN4688CH2012 | 2012-11-08 | ||
PCT/IB2013/059983 WO2014072937A1 (en) | 2012-11-08 | 2013-11-07 | Pharmaceutical compositions containing a pde4 inhibitor and a pi3 delta or dual pi3 delta-gamma kinase inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201590721A1 true EA201590721A1 (ru) | 2015-09-30 |
EA035391B1 EA035391B1 (ru) | 2020-06-05 |
Family
ID=54188815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201590721A EA035391B1 (ru) | 2012-11-08 | 2013-11-07 | Фармацевтические композиции, содержащие ингибитор pde4 и ингибитор pi3-дельта или двойной ингибитор pi3-дельта-гамма киназы |
Country Status (9)
Country | Link |
---|---|
US (4) | US9737521B2 (ru) |
EP (1) | EP2916868B1 (ru) |
JP (2) | JP6434416B2 (ru) |
KR (2) | KR20210010958A (ru) |
CN (2) | CN104870017B (ru) |
CA (1) | CA2889905A1 (ru) |
EA (1) | EA035391B1 (ru) |
HK (1) | HK1214159A1 (ru) |
WO (1) | WO2014072937A1 (ru) |
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US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
NZ613219A (en) | 2008-01-04 | 2014-11-28 | Intellikine Llc | Heterocyclic containing entities, compositions and methods |
CN105801550B (zh) | 2009-11-05 | 2019-06-14 | 理森制药股份公司 | 新型苯并吡喃激酶调节剂 |
UA115767C2 (uk) | 2011-01-10 | 2017-12-26 | Інфініті Фармасьютікалз, Інк. | Способи отримання ізохінолінонів і тверді форми ізохінолінонів |
EA024842B9 (ru) * | 2011-05-04 | 2017-08-31 | Ризен Фармасьютикалз Са | Соединения в качестве модуляторов протеинкиназы pi3k |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
NZ707366A (en) | 2012-11-07 | 2018-11-30 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors and their use in therapy |
KR20210010958A (ko) * | 2012-11-08 | 2021-01-28 | 리젠 파마슈티컬스 소시에떼 아노님 | Pde4 억제제 및 pi3 델타 또는 이중 pi3 델타-감마 키나아제 억제제를 함유하는 약제학적 조성물 |
DK2994465T3 (en) | 2013-05-10 | 2018-10-08 | Karus Therapeutics Ltd | HISTONDEACETYLASE INHIBITORS UNKNOWN |
WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
US20150320754A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
EA202092492A1 (ru) * | 2014-09-03 | 2021-07-30 | Ризен Фармасьютикалз Са | Способ лечения и композиции, содержащие двойной ингибитор киназ pi3k дельта-гамма и кортикостероид |
GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
CN105548393A (zh) * | 2015-12-14 | 2016-05-04 | 成都百裕制药股份有限公司 | 一种检测阿普斯特原料中杂质含量的方法 |
CN109219450A (zh) | 2016-01-11 | 2019-01-15 | 玛丽女王伦敦大学 | 在癌症治疗中用于递送病毒的PI3K P-δ110抑制剂 |
GB201602527D0 (en) * | 2016-02-12 | 2016-03-30 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
KR20190033526A (ko) | 2016-06-24 | 2019-03-29 | 인피니티 파마슈티칼스, 인코포레이티드 | 병용 요법 |
EP3412294A1 (en) * | 2017-06-08 | 2018-12-12 | Universite De Fribourg | Hdac1/2 activator for promoting and/or accelerating myelination and/or remyelination |
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WO2020106754A1 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
WO2021119482A1 (en) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
EP4255418A1 (en) * | 2020-12-01 | 2023-10-11 | Reverspah LLC | Methods and compositions for treating chronic obstructive pulmonary disease, asthma, pneumonia, bronchitis, cystic fibrosis and pulmonary edema |
CN117222413A (zh) * | 2021-02-10 | 2023-12-12 | 同润生物医药(上海)有限公司 | 治疗肿瘤的方法和组合 |
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2013
- 2013-11-07 KR KR1020217001956A patent/KR20210010958A/ko not_active Application Discontinuation
- 2013-11-07 CN CN201380063816.2A patent/CN104870017B/zh not_active Expired - Fee Related
- 2013-11-07 US US14/441,758 patent/US9737521B2/en active Active
- 2013-11-07 KR KR1020157013518A patent/KR20150079745A/ko active Application Filing
- 2013-11-07 CA CA2889905A patent/CA2889905A1/en not_active Abandoned
- 2013-11-07 WO PCT/IB2013/059983 patent/WO2014072937A1/en active Application Filing
- 2013-11-07 CN CN202010719781.5A patent/CN111904962A/zh active Pending
- 2013-11-07 EP EP13795866.6A patent/EP2916868B1/en active Active
- 2013-11-07 JP JP2015541279A patent/JP6434416B2/ja not_active Expired - Fee Related
- 2013-11-07 EA EA201590721A patent/EA035391B1/ru unknown
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2016
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2017
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2018
- 2018-06-20 US US16/013,607 patent/US10413532B2/en not_active Expired - Fee Related
- 2018-08-29 JP JP2018160208A patent/JP7030656B2/ja active Active
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Publication number | Publication date |
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US10058539B2 (en) | 2018-08-28 |
HK1214159A1 (zh) | 2016-07-22 |
EA035391B1 (ru) | 2020-06-05 |
KR20210010958A (ko) | 2021-01-28 |
US9737521B2 (en) | 2017-08-22 |
CN111904962A (zh) | 2020-11-10 |
WO2014072937A1 (en) | 2014-05-15 |
US10413532B2 (en) | 2019-09-17 |
EP2916868A1 (en) | 2015-09-16 |
JP6434416B2 (ja) | 2018-12-05 |
US20190083475A1 (en) | 2019-03-21 |
CA2889905A1 (en) | 2014-05-15 |
US20170319558A1 (en) | 2017-11-09 |
CN104870017A (zh) | 2015-08-26 |
CN104870017B (zh) | 2020-08-14 |
US20150272936A1 (en) | 2015-10-01 |
JP2015536973A (ja) | 2015-12-24 |
KR20150079745A (ko) | 2015-07-08 |
JP2018203760A (ja) | 2018-12-27 |
US11065236B2 (en) | 2021-07-20 |
EP2916868B1 (en) | 2022-05-11 |
JP7030656B2 (ja) | 2022-03-07 |
US20200237735A1 (en) | 2020-07-30 |
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