MX2017001103A - Derivados de indolizina que son aplicables a enfermedades neurodegenerativas. - Google Patents
Derivados de indolizina que son aplicables a enfermedades neurodegenerativas.Info
- Publication number
- MX2017001103A MX2017001103A MX2017001103A MX2017001103A MX2017001103A MX 2017001103 A MX2017001103 A MX 2017001103A MX 2017001103 A MX2017001103 A MX 2017001103A MX 2017001103 A MX2017001103 A MX 2017001103A MX 2017001103 A MX2017001103 A MX 2017001103A
- Authority
- MX
- Mexico
- Prior art keywords
- applicable
- neurodegenerative diseases
- indolizine derivatives
- indolizine
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
La presente invención se relaciona a compuestos de indolizina, y composiciones farmacéuticamente aceptables de los mismos, útiles como antagonistas de P2X7, y para el tratamiento de trastornos relacionados a P2X7.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462031237P | 2014-07-31 | 2014-07-31 | |
PCT/US2015/043090 WO2016019228A1 (en) | 2014-07-31 | 2015-07-31 | Indolizine derivatives which are applicable to neurodegenerative diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017001103A true MX2017001103A (es) | 2017-04-27 |
Family
ID=53785788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017001103A MX2017001103A (es) | 2014-07-31 | 2015-07-31 | Derivados de indolizina que son aplicables a enfermedades neurodegenerativas. |
Country Status (15)
Country | Link |
---|---|
US (2) | US9546166B2 (es) |
EP (1) | EP3174877B1 (es) |
JP (1) | JP6571756B2 (es) |
KR (1) | KR20170033339A (es) |
CN (1) | CN107001356B (es) |
AR (1) | AR101395A1 (es) |
AU (1) | AU2015296210B2 (es) |
BR (1) | BR112017001221A2 (es) |
CA (1) | CA2954681A1 (es) |
ES (1) | ES2927587T3 (es) |
IL (1) | IL250267B (es) |
MX (1) | MX2017001103A (es) |
RU (1) | RU2017105133A (es) |
SG (1) | SG11201700140TA (es) |
WO (1) | WO2016019228A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102010030111A1 (de) | 2009-08-11 | 2011-02-17 | Evonik Degussa Gmbh | Wässrige Silansysteme für den Blankkorrosionsschutz und Korrosionsschutz von Metallen |
AU2016252686B2 (en) | 2015-04-24 | 2019-03-14 | Shionogi & Co., Ltd. | 6-membered heterocyclic derivative and pharmaceutical composition comprising same |
JP2019524747A (ja) | 2016-07-18 | 2019-09-05 | アースローシ セラピューティクス,インク. | 痛風または高尿酸血症に関連する症状を処置または予防するための化合物、組成物、および方法 |
MX2019004107A (es) | 2016-10-17 | 2019-08-05 | Shionogi & Co | Derivado heterociclico nitrogenado biciclico y composicion farmaceutica que lo contiene. |
HRP20231682T1 (hr) | 2017-03-13 | 2024-03-29 | Raqualia Pharma Inc. | Derivati tetrahidrokinolina kao antagonisti p2x7 receptora |
TWI818948B (zh) * | 2018-01-18 | 2023-10-21 | 日商第一三共股份有限公司 | 啉酮衍生物 |
CA3134613A1 (en) | 2019-04-02 | 2020-10-08 | Aligos Therapeutics, Inc. | Compounds targeting prmt5 |
CA3144360A1 (en) * | 2019-07-08 | 2021-01-14 | Tokyo Institute Of Technology | Method for producing insulin-producing cell using dihydroindolizinone derivatives |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19731153A1 (de) * | 1997-07-21 | 1999-01-28 | Basf Ag | 2-(Pyrazolyl- und Triazolyl-3'-oxymethylen)-phenyl-isoxazolone und -triazolone, Verfahren zu ihrer Herstellung und ihre Verwendung |
WO2002009706A1 (en) | 2000-07-27 | 2002-02-07 | Smithkline Beecham Corporation | Agonists of follicle stimulating hormone activity |
CA2641254A1 (en) * | 2006-02-14 | 2007-08-23 | Vertex Pharmaceuticals Incorporated | Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases |
JP2010523668A (ja) * | 2007-04-10 | 2010-07-15 | ハー・ルンドベック・アクチエゼルスカベット | P2x7拮抗薬としてのヘテロアリールアミド類似体 |
CN103298460B (zh) * | 2010-12-14 | 2016-06-01 | 电泳有限公司 | 酪蛋白激酶1δ(CK1δ)抑制剂 |
-
2015
- 2015-07-31 US US14/814,659 patent/US9546166B2/en active Active
- 2015-07-31 KR KR1020177003586A patent/KR20170033339A/ko unknown
- 2015-07-31 EP EP15747950.2A patent/EP3174877B1/en active Active
- 2015-07-31 SG SG11201700140TA patent/SG11201700140TA/en unknown
- 2015-07-31 CN CN201580050359.2A patent/CN107001356B/zh active Active
- 2015-07-31 ES ES15747950T patent/ES2927587T3/es active Active
- 2015-07-31 JP JP2017505203A patent/JP6571756B2/ja active Active
- 2015-07-31 WO PCT/US2015/043090 patent/WO2016019228A1/en active Application Filing
- 2015-07-31 RU RU2017105133A patent/RU2017105133A/ru unknown
- 2015-07-31 CA CA2954681A patent/CA2954681A1/en active Pending
- 2015-07-31 MX MX2017001103A patent/MX2017001103A/es unknown
- 2015-07-31 AU AU2015296210A patent/AU2015296210B2/en not_active Ceased
- 2015-07-31 BR BR112017001221A patent/BR112017001221A2/pt not_active Application Discontinuation
- 2015-07-31 AR ARP150102464A patent/AR101395A1/es unknown
-
2016
- 2016-12-06 US US15/370,645 patent/US9931324B2/en active Active
-
2017
- 2017-01-25 IL IL250267A patent/IL250267B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
US9546166B2 (en) | 2017-01-17 |
US9931324B2 (en) | 2018-04-03 |
AU2015296210A1 (en) | 2017-02-02 |
KR20170033339A (ko) | 2017-03-24 |
SG11201700140TA (en) | 2017-02-27 |
JP6571756B2 (ja) | 2019-09-04 |
EP3174877B1 (en) | 2022-06-29 |
CA2954681A1 (en) | 2016-02-04 |
US20160031879A1 (en) | 2016-02-04 |
CN107001356B (zh) | 2019-09-03 |
JP2017522347A (ja) | 2017-08-10 |
CN107001356A (zh) | 2017-08-01 |
AR101395A1 (es) | 2016-12-14 |
IL250267A0 (en) | 2017-03-30 |
RU2017105133A (ru) | 2018-08-28 |
WO2016019228A1 (en) | 2016-02-04 |
EP3174877A1 (en) | 2017-06-07 |
ES2927587T3 (es) | 2022-11-08 |
US20170079965A1 (en) | 2017-03-23 |
IL250267B (en) | 2021-05-31 |
AU2015296210B2 (en) | 2019-08-15 |
BR112017001221A2 (pt) | 2017-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG10201804868PA (en) | Compounds for the inhibition of indoleamine-2,3-dioxygenase | |
IL246833A0 (en) | New salts and their pharmaceutical preparations for the treatment of inflammatory disorders | |
MX2016011632A (es) | Derivados de azaspiro como antagonistas de trpm8. | |
MX2017001103A (es) | Derivados de indolizina que son aplicables a enfermedades neurodegenerativas. | |
IL255109A0 (en) | New dihydropyridoisoquinolinones and their pharmaceutical preparations for the treatment of inflammatory disorders | |
GB201402070D0 (en) | Pharmaceutical compositions for the treatment of inflammatory disorders | |
MX2018014114A (es) | Derivados del sobetiroma. | |
HRP20181332T1 (hr) | Derivati benzimidazola i njihovi farmaceutski pripravci, namijenjeni liječenju upalnih poremećaja | |
GB201411241D0 (en) | Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders | |
EP3256438A4 (en) | Compounds, compositions, and methods for the treatment of inflammatory, degenerative, and neurodegenerative diseases | |
MY180844A (en) | Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions | |
EP3169405A4 (en) | Methods, compounds, and compositions for the treatment of musculoskeletal diseases | |
IN2014CH00840A (es) | ||
GB201612043D0 (en) | Composition for treatment of disorders | |
IL252543A0 (en) | Compounds for the treatment of degenerative retinal tissues | |
WO2016083315A8 (en) | Use of ox1r antagonists for the treatment of inflammatory bowel diseases | |
MX2017008655A (es) | Derivados de jasmonato y composiciones de los mismos. | |
PL3164110T3 (pl) | Kompozycje farmaceutyczne do leczenia łuszczycy | |
HRP20181123T1 (hr) | Spojevi 3,4-diamino-6-kloropirazin-2-karboksamida za liječenje bolesti posredovanih s enac | |
GB201714241D0 (en) | Pharmaceutical compositions for the treatment of proteinopathies |