PE20141211A1 - Moduladores receptores de hormonas nucleares - Google Patents
Moduladores receptores de hormonas nuclearesInfo
- Publication number
- PE20141211A1 PE20141211A1 PE2013002048A PE2013002048A PE20141211A1 PE 20141211 A1 PE20141211 A1 PE 20141211A1 PE 2013002048 A PE2013002048 A PE 2013002048A PE 2013002048 A PE2013002048 A PE 2013002048A PE 20141211 A1 PE20141211 A1 PE 20141211A1
- Authority
- PE
- Peru
- Prior art keywords
- ring
- hormone receptor
- nuclear hormone
- receptor modulators
- cyclohepten
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07C49/613—Unsaturated compounds containing a keto groups being part of a ring polycyclic
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- C07C49/643—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system having three rings
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- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
SE REFIERE A COMPUESTOS MODULADORES RECEPTORES DE HORMONA NUCLEARES DE FORMULA (I), DONDE EL ANILLO A ES ARILO OPCIONALMENTE SUSTITUIDO, (C5-C6) CARBOCICLICO SATURADO, ENTRE OTROS; EL ANILLO C ES (C5-C6)CARBOCICLICO SATURADO, HETEROCICLO, ENTRE OTROS; Q Y T SON FORMA INDEPENDIENTE C , N; EL ANILLO B ES UN ANILLO DE SIETE MIEMBROS DONDE: X ES -C(R5)2-, -C(R5)-; -C(=O)-,ENTRE OTROS; R5 ES H, F, ENTRE OTROS; Y ES -C(R5)2C(R5)2-, -O-C(=O)-, ENTRE OTROS; Z ES CR4, N; R1 ES H, BR, CL ,ENTRE OTROS; R2 ES -(CH2)r-ARILO, -(CH2)r-(C3-C6)CICLOALQUILO, ENTRE OTROS; R3 ES H, DEUTERIO, ENTRE OTROS; R4 ES H, (C1-C3)ALQUILO, ENTRE OTROS; m es 1-4; n ES 1-4; r 0-2. SON COMPUESTOS PREFERIDOS (4AR, 11BS)-11B-BENCIL-9-HIDROXI-1,2,4,4 A, 5, 6, 7, 11B-OCTAHIDRO-DIBENZO[A,C]CICLOHEPTEN-3-ONA, (4AS, 11BR)-11B-BENCIL-9-HIDROXI-1,2,4,4 A, 5, 6, 7, 11B-OCTAHIDRO-DIBENZO[A,C]CICLOHEPTEN-3-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ES UTIL EN EL TRATAMIENTO DE CONDICIONES INMUNOLOGICAS Y ONCOLOGICAS.
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AU2009204483B2 (en) | 2008-01-04 | 2014-03-13 | Intellikine, Llc | Certain chemical entities, compositions and methods |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
BR112013017670B1 (pt) | 2011-01-10 | 2022-07-19 | Infinity Pharmaceuticals, Inc | Processos de preparação de isoquinolinonas e formas sólidas de isoquinolinonas |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
TW201422590A (zh) | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
WO2014094357A1 (en) | 2012-12-21 | 2014-06-26 | Abbvie Inc. | Heterocyclic nuclear hormone receptor modulators |
US9643947B2 (en) | 2013-08-28 | 2017-05-09 | Northwestern University | 7-membered fused heterocycles and methods of their synthesis |
US20150320755A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
CN109071537A (zh) * | 2016-03-01 | 2018-12-21 | 科赛普特治疗学股份有限公司 | 用于加强检查点抑制剂的糖皮质激素受体调节剂的应用 |
AU2017281797A1 (en) | 2016-06-24 | 2019-01-24 | Infinity Pharmaceuticals, Inc. | Combination therapies |
KR101849301B1 (ko) * | 2018-01-29 | 2018-04-16 | 전북대학교 산학협력단 | 식나무 추출물을 포함하는 안구 건조증 예방 또는 치료용 조성물 |
US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
CA3132365A1 (en) * | 2019-04-11 | 2020-10-15 | Nicolas Cuniere | Novel synthetic options towards the manufacture of (6r,10s)-10- {4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6h)- pyrimidinyl}- 1-(difluoromethyl)-6-methyl-1,4,7 8,9,10-hexahydro-11,15-(metheno)pyrazolo [4,3-b][1,7]diazacyclotetradecin-5(6h)-one |
KR20220124176A (ko) | 2019-12-06 | 2022-09-13 | 버텍스 파마슈티칼스 인코포레이티드 | 나트륨 채널의 조절제로서의 치환된 테트라하이드로푸란 |
AU2022284886A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
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ATE423555T1 (de) * | 1998-04-06 | 2009-03-15 | Astellas Pharma Inc | Verwendung von beta-3-adrenergen-rezeptoren agonisten in der behandlung von dysurie |
EA007483B1 (ru) * | 1999-04-30 | 2006-10-27 | Пфайзер Продактс Инк. | Применение модулятора рецепторов глюкокортикоидов и агониста рецепторов глюкокортикоидов при получении лекарственного средства |
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UY33957A (es) | 2012-10-31 |
IL228422A0 (en) | 2013-12-31 |
EP2685821A4 (en) | 2014-08-20 |
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BR112013033777A2 (pt) | 2016-09-13 |
DOP2013000208A (es) | 2013-11-15 |
CA2830234A1 (en) | 2012-09-20 |
CR20130500A (es) | 2013-12-13 |
AR085412A1 (es) | 2013-10-02 |
AU2012229952A1 (en) | 2013-04-18 |
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RU2013145912A (ru) | 2015-04-20 |
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JP2014509592A (ja) | 2014-04-21 |
CO6771454A2 (es) | 2013-10-15 |
GT201300214A (es) | 2014-10-17 |
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