JP5634506B2 - 1,2,3−トリアゾロ[4,3−a]ピリジン誘導体ならびに神経障害および精神障害の治療または予防のためのその使用 - Google Patents
1,2,3−トリアゾロ[4,3−a]ピリジン誘導体ならびに神経障害および精神障害の治療または予防のためのその使用 Download PDFInfo
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- JP5634506B2 JP5634506B2 JP2012510160A JP2012510160A JP5634506B2 JP 5634506 B2 JP5634506 B2 JP 5634506B2 JP 2012510160 A JP2012510160 A JP 2012510160A JP 2012510160 A JP2012510160 A JP 2012510160A JP 5634506 B2 JP5634506 B2 JP 5634506B2
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- 0 CN1CCN(*)CC1 Chemical compound CN1CCN(*)CC1 0.000 description 2
- GCDDUUKCLOWKCS-UHFFFAOYSA-N C(c1ccccc1)N(CC1)CCC11c(cccn2)c2OC1 Chemical compound C(c1ccccc1)N(CC1)CCC11c(cccn2)c2OC1 GCDDUUKCLOWKCS-UHFFFAOYSA-N 0.000 description 1
- LSBJNJGTXFNPKC-UHFFFAOYSA-N CC(c1c(C(F)(F)F)c2nnc(CC3CC3)[n]2cc1)OS(c1ccc(C)cc1)=O Chemical compound CC(c1c(C(F)(F)F)c2nnc(CC3CC3)[n]2cc1)OS(c1ccc(C)cc1)=O LSBJNJGTXFNPKC-UHFFFAOYSA-N 0.000 description 1
- CWHCTKAJYQOXMG-UHFFFAOYSA-N CC1(C)CCN(C)CC1 Chemical compound CC1(C)CCN(C)CC1 CWHCTKAJYQOXMG-UHFFFAOYSA-N 0.000 description 1
- KOAJZWITRVNZMC-UHFFFAOYSA-N CC1(C)OC2(CCNCC2)c(cc2)c1cc2F Chemical compound CC1(C)OC2(CCNCC2)c(cc2)c1cc2F KOAJZWITRVNZMC-UHFFFAOYSA-N 0.000 description 1
- GZCJWTQIDUAQRU-UHFFFAOYSA-N CCc(c1nnc(CC2CC2)[n]1cc1)c1Cl Chemical compound CCc(c1nnc(CC2CC2)[n]1cc1)c1Cl GZCJWTQIDUAQRU-UHFFFAOYSA-N 0.000 description 1
- VVQYGKASFOBXOJ-AMGKYWFPSA-N C[C@@H](C1)C1c(c(NN)ncc1)c1OCc1ccccc1 Chemical compound C[C@@H](C1)C1c(c(NN)ncc1)c1OCc1ccccc1 VVQYGKASFOBXOJ-AMGKYWFPSA-N 0.000 description 1
- DAZDFQAHZIEDHT-UHFFFAOYSA-N Clc(cc[n]1c2nnc1CC1CC1)c2I Chemical compound Clc(cc[n]1c2nnc1CC1CC1)c2I DAZDFQAHZIEDHT-UHFFFAOYSA-N 0.000 description 1
- CCQZJWADESNXEW-UHFFFAOYSA-N Clc1c(CN(CC2)CCC2c2ccccc2)ccnc1Cl Chemical compound Clc1c(CN(CC2)CCC2c2ccccc2)ccnc1Cl CCQZJWADESNXEW-UHFFFAOYSA-N 0.000 description 1
- RTDHTTTTYNODCG-UHFFFAOYSA-N FC(Cc1nnc2[n]1ccc(N(CC1)CCC11OCc3ccccc13)c2Cl)(F)F Chemical compound FC(Cc1nnc2[n]1ccc(N(CC1)CCC11OCc3ccccc13)c2Cl)(F)F RTDHTTTTYNODCG-UHFFFAOYSA-N 0.000 description 1
- MYFWXXPPPYPLOB-UHFFFAOYSA-N FC(c(c1nnc(CC2CC2)[n]1cc1)c1Cl)(F)F Chemical compound FC(c(c1nnc(CC2CC2)[n]1cc1)c1Cl)(F)F MYFWXXPPPYPLOB-UHFFFAOYSA-N 0.000 description 1
- KWPHHUZLMZZEKJ-UHFFFAOYSA-N NNc1nccc(I)c1Cl Chemical compound NNc1nccc(I)c1Cl KWPHHUZLMZZEKJ-UHFFFAOYSA-N 0.000 description 1
- WHMBIZKGMOAPON-UHFFFAOYSA-N NNc1nccc(N(CC2)CCC22OCc3c2cccc3)c1Cl Chemical compound NNc1nccc(N(CC2)CCC22OCc3c2cccc3)c1Cl WHMBIZKGMOAPON-UHFFFAOYSA-N 0.000 description 1
- VQRLAQXQUIPXDN-UHFFFAOYSA-N O=C(CC(F)(F)F)NNc1nccc(N(CC2)CCC22OCc3c2cccc3)c1Cl Chemical compound O=C(CC(F)(F)F)NNc1nccc(N(CC2)CCC22OCc3c2cccc3)c1Cl VQRLAQXQUIPXDN-UHFFFAOYSA-N 0.000 description 1
- XZCWHXTYYVOUDV-UHFFFAOYSA-N O=C(CC1CC1)NNc1nccc(I)c1Cl Chemical compound O=C(CC1CC1)NNc1nccc(I)c1Cl XZCWHXTYYVOUDV-UHFFFAOYSA-N 0.000 description 1
- RWWYURXCQMYLRT-UHFFFAOYSA-N S=C1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12 Chemical compound S=C1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12 RWWYURXCQMYLRT-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09160059.3 | 2009-05-12 | ||
| EP09160059 | 2009-05-12 | ||
| PCT/EP2010/002910 WO2010130424A1 (en) | 2009-05-12 | 2010-05-11 | 1,2,3-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526737A JP2012526737A (ja) | 2012-11-01 |
| JP2012526737A5 JP2012526737A5 (enExample) | 2014-10-09 |
| JP5634506B2 true JP5634506B2 (ja) | 2014-12-03 |
Family
ID=41429238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510160A Active JP5634506B2 (ja) | 2009-05-12 | 2010-05-11 | 1,2,3−トリアゾロ[4,3−a]ピリジン誘導体ならびに神経障害および精神障害の治療または予防のためのその使用 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US8937060B2 (enExample) |
| EP (1) | EP2430022B1 (enExample) |
| JP (1) | JP5634506B2 (enExample) |
| KR (1) | KR101753826B1 (enExample) |
| CN (1) | CN102439008B (enExample) |
| AR (1) | AR076861A1 (enExample) |
| AU (1) | AU2010246609B2 (enExample) |
| BR (1) | BRPI1012870B8 (enExample) |
| CA (1) | CA2760741C (enExample) |
| CL (1) | CL2011002838A1 (enExample) |
| CY (1) | CY1114718T1 (enExample) |
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| EA (1) | EA020672B1 (enExample) |
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| HR (1) | HRP20131122T1 (enExample) |
| IL (1) | IL215912A (enExample) |
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| NZ (1) | NZ596078A (enExample) |
| PL (1) | PL2430022T3 (enExample) |
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| RS (1) | RS53075B (enExample) |
| SG (2) | SG176021A1 (enExample) |
| SI (1) | SI2430022T1 (enExample) |
| SM (1) | SMT201400003B (enExample) |
| TW (1) | TWI468406B (enExample) |
| UA (1) | UA108070C2 (enExample) |
| WO (1) | WO2010130424A1 (enExample) |
| ZA (1) | ZA201107834B (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| CN101848893B (zh) | 2007-09-14 | 2012-06-06 | 奥梅-杨森制药有限公司 | 1,3-二取代的4-(芳基-x-苯基)-1h-吡啶-2-酮 |
| EP2203439B1 (en) * | 2007-09-14 | 2011-01-26 | Ortho-McNeil-Janssen Pharmaceuticals, Inc. | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-ý1, 4'¨bipyridinyl-2'-ones |
| AU2008297877C1 (en) | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
| CN101861316B (zh) * | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| MX2011002042A (es) | 2008-09-02 | 2011-06-20 | Ortho Mcneil Janssen Pharm | Derivados de 3-azabiciclo[3.1.o]hexilo como moduladores de los receptores del glutamato metabotropico. |
| ES2466341T3 (es) | 2008-10-16 | 2014-06-10 | Janssen Pharmaceuticals, Inc. | Derivados de indol y benzomorfolina como moduladores de receptores de glutamato metabotrópicos |
| WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
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