AU2002213422A1 - Synthesis of 2-hydroxymethylglutamic acid and congeners thereof - Google Patents

Synthesis of 2-hydroxymethylglutamic acid and congeners thereof

Info

Publication number
AU2002213422A1
AU2002213422A1 AU2002213422A AU1342202A AU2002213422A1 AU 2002213422 A1 AU2002213422 A1 AU 2002213422A1 AU 2002213422 A AU2002213422 A AU 2002213422A AU 1342202 A AU1342202 A AU 1342202A AU 2002213422 A1 AU2002213422 A1 AU 2002213422A1
Authority
AU
Australia
Prior art keywords
hydroxymethylglutamic
congeners
synthesis
acid
hydroxymethylglutamic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002213422A
Inventor
Alan P Kozikowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University filed Critical Georgetown University
Publication of AU2002213422A1 publication Critical patent/AU2002213422A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
AU2002213422A 2000-09-13 2001-09-13 Synthesis of 2-hydroxymethylglutamic acid and congeners thereof Abandoned AU2002213422A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23227500P 2000-09-13 2000-09-13
US60/232,275 2000-09-13
PCT/US2001/042181 WO2002022622A2 (en) 2000-09-13 2001-09-13 Synthesis of 2-hydroxymethylglutamic acid and congeners thereof

Publications (1)

Publication Number Publication Date
AU2002213422A1 true AU2002213422A1 (en) 2002-03-26

Family

ID=22872492

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002213422A Abandoned AU2002213422A1 (en) 2000-09-13 2001-09-13 Synthesis of 2-hydroxymethylglutamic acid and congeners thereof

Country Status (3)

Country Link
US (1) US6599940B2 (en)
AU (1) AU2002213422A1 (en)
WO (1) WO2002022622A2 (en)

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AR059898A1 (en) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv DERIVATIVES OF 3-CIANO-PIRIDONA 1,4-DISUSTITUTED AND ITS USE AS ALLOSTERIC MODULATORS OF MGLUR2 RECEIVERS
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
EA019085B1 (en) 2007-09-14 2014-01-30 Янссен Фармасьютикалз, Инк. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
EP2203439B1 (en) 2007-09-14 2011-01-26 Ortho-McNeil-Janssen Pharmaceuticals, Inc. 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-ý1, 4'¨bipyridinyl-2'-ones
EP2205565B1 (en) * 2007-09-14 2013-04-17 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
EP2220083B1 (en) 2007-11-14 2017-07-19 Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MX2011002042A (en) 2008-09-02 2011-06-20 Ortho Mcneil Janssen Pharm 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors.
MX2011003691A (en) 2008-10-16 2011-09-06 Ortho Mcneil Janssen Pharm Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors.
RU2512283C2 (en) 2008-11-28 2014-04-10 Янссен Фармасьютикалз, Инк. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
EA020671B1 (en) 2009-05-12 2014-12-30 Янссен Фармасьютикалз, Инк. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF mGluR2 RECEPTORS
CN102439008B (en) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,3-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
JP5852666B2 (en) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of the mGluR2 receptor
US9271967B2 (en) 2010-11-08 2016-03-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
JP5852665B2 (en) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of the mGluR2 receptor
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
MY182627A (en) 2014-01-21 2021-01-27 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
ES2860298T3 (en) 2014-01-21 2021-10-04 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators of metabotropic glutamatergic receptor subtype 2 and their use

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DE3810973A1 (en) * 1988-03-31 1989-10-12 Bayer Ag 1- (N-FORMYLAMINO) -2,4-DICYANOBUTANE AND A METHOD FOR THE PRODUCTION THEREOF
AU8534291A (en) 1990-08-10 1992-03-02 G.D. Searle & Co. Renal-selective angiotensin ii antagonists for treatment of hypertension
US5190922A (en) 1991-06-04 1993-03-02 Abbott Laboratories Terminally modified tri-, tetra- and pentapeptide anaphylatoxin receptor ligands
JPH0532697A (en) 1991-07-31 1993-02-09 Teijin Ltd Synthetic human osteocalcin and production thereof
CZ286106B6 (en) 1992-05-20 2000-01-12 Northwestern University Derivatives of gamma-aminobutyric acid, process and intermediates for their preparation, their use and pharmaceutical preparation in which they are comprised
US5686565A (en) 1992-10-08 1997-11-11 Scios Inc. Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
US5362899A (en) 1993-09-09 1994-11-08 Affymax Technologies, N.V. Chiral synthesis of alpha-aminophosponic acids
US5880096A (en) 1994-02-02 1999-03-09 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5780589A (en) 1994-11-30 1998-07-14 The United States Of America As Represented By The Department Of Health And Human Services Ultraselective opioidmimetic peptides and pharmacological and therapeutic uses thereof
US5744451A (en) 1995-09-12 1998-04-28 Warner-Lambert Company N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
US6200969B1 (en) 1996-09-12 2001-03-13 Idun Pharmaceuticals, Inc. Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
US6133409A (en) 1996-12-19 2000-10-17 Aventis Pharmaceuticals Products Inc. Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
DE69728164D1 (en) 1996-12-27 2004-04-22 Boehringer Ingelheim Ca Ltd PEPTIDOMIMETIC INHIBITORS FROM THE PROTEASE OF THE HUMAN CYTOMEGALOVIRUS
US6133018A (en) 1997-06-02 2000-10-17 Celgro Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
US6242422B1 (en) 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases

Also Published As

Publication number Publication date
US20020147362A1 (en) 2002-10-10
WO2002022622A3 (en) 2003-04-17
US6599940B2 (en) 2003-07-29
WO2002022622A2 (en) 2002-03-21

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