BRPI1012870B8 - derivados de 1,2,4-triazolo[4,3-a]piridina e seu uso como moduladores alostericos positivos de receptores de mglur2 e composição farmacêutica - Google Patents

derivados de 1,2,4-triazolo[4,3-a]piridina e seu uso como moduladores alostericos positivos de receptores de mglur2 e composição farmacêutica

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Publication number
BRPI1012870B8
BRPI1012870B8 BRPI1012870A BRPI1012870A BRPI1012870B8 BR PI1012870 B8 BRPI1012870 B8 BR PI1012870B8 BR PI1012870 A BRPI1012870 A BR PI1012870A BR PI1012870 A BRPI1012870 A BR PI1012870A BR PI1012870 B8 BRPI1012870 B8 BR PI1012870B8
Authority
BR
Brazil
Prior art keywords
mglur2
triazolo
pyridine derivatives
positive allosteric
allosteric modulators
Prior art date
Application number
BRPI1012870A
Other languages
English (en)
Inventor
Avelino Trabanco-Suarez Andrés
Oehlrich Daniel
John Tresadern Gary
James Macdonald Gregor
Maria Cid-Nunez José
Antonio Vega Ramiro Juan
Original Assignee
Addex Pharmaceuticals Sa
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Addex Pharmaceuticals Sa, Janssen Pharmaceuticals Inc filed Critical Addex Pharmaceuticals Sa
Publication of BRPI1012870A2 publication Critical patent/BRPI1012870A2/pt
Publication of BRPI1012870B1 publication Critical patent/BRPI1012870B1/pt
Publication of BRPI1012870B8 publication Critical patent/BRPI1012870B8/pt

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

derivados de 1,2,4-triazolo[4,3-a]piridina e seu uso como modulares alostéricos positivos de receptores de mglur2. a presente invenção refere-se a novos derivados de triazolo[4,3-a]piridina de fórmula (i) em que todos os radicais são como definido nas reivindicações. os compostos de acordo com a invenção são moduladores alostéricos positivos do subtipo 2 do receptor de glutamato metabotrópico ("mglur2"), que são úteis para o tratamento ou prevenção de distúrbios neurológicos e psiquiátricos associados com disfunção de glutamato e doenças em que o sub- tipo mglur2 de receptores metabotrópicos esta envolvido. a invenção & também direcionada a composições farmacêuticas compreendendo tais compostos, a processos para preparar tais compostos e composições, e ao uso de tais compostos para a prevenção ou tratamento de distúrbios neurológicos e psiquiátricos e doenças em que mglur2 esta envolvido.
BRPI1012870A 2009-05-12 2010-05-11 derivados de 1,2,4-triazolo[4,3-a]piridina e seu uso como moduladores alostericos positivos de receptores de mglur2 e composição farmacêutica BRPI1012870B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09160059.3 2009-05-12
EP09160059 2009-05-12
PCT/EP2010/002910 WO2010130424A1 (en) 2009-05-12 2010-05-11 1,2,3-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders

Publications (3)

Publication Number Publication Date
BRPI1012870A2 BRPI1012870A2 (pt) 2016-04-05
BRPI1012870B1 BRPI1012870B1 (pt) 2020-10-13
BRPI1012870B8 true BRPI1012870B8 (pt) 2021-05-25

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BRPI1012870A BRPI1012870B8 (pt) 2009-05-12 2010-05-11 derivados de 1,2,4-triazolo[4,3-a]piridina e seu uso como moduladores alostericos positivos de receptores de mglur2 e composição farmacêutica

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US (4) US8937060B2 (pt)
EP (1) EP2430022B1 (pt)
JP (1) JP5634506B2 (pt)
KR (1) KR101753826B1 (pt)
CN (1) CN102439008B (pt)
AR (1) AR076861A1 (pt)
AU (1) AU2010246609B2 (pt)
BR (1) BRPI1012870B8 (pt)
CA (1) CA2760741C (pt)
CL (1) CL2011002838A1 (pt)
CY (1) CY1114718T1 (pt)
DK (1) DK2430022T3 (pt)
EA (1) EA020672B1 (pt)
ES (1) ES2440001T3 (pt)
HK (1) HK1169405A1 (pt)
HR (1) HRP20131122T1 (pt)
IL (1) IL215912A (pt)
JO (1) JO2907B1 (pt)
ME (1) ME01573B (pt)
MX (1) MX2011011964A (pt)
MY (1) MY161325A (pt)
NZ (1) NZ596078A (pt)
PL (1) PL2430022T3 (pt)
PT (1) PT2430022E (pt)
RS (1) RS53075B (pt)
SG (2) SG10201402250TA (pt)
SI (1) SI2430022T1 (pt)
SM (1) SMT201400003B (pt)
TW (1) TWI468406B (pt)
UA (1) UA108070C2 (pt)
WO (1) WO2010130424A1 (pt)
ZA (1) ZA201107834B (pt)

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SMT201400003B (it) 2014-03-07
US20160067245A1 (en) 2016-03-10
BRPI1012870A2 (pt) 2016-04-05
ME01573B (me) 2014-09-20
ZA201107834B (en) 2012-12-27
DK2430022T3 (da) 2013-12-02
EA201190303A1 (ru) 2012-06-29
AU2010246609A1 (en) 2011-11-17
US20120184525A1 (en) 2012-07-19
NZ596078A (en) 2013-06-28
MY161325A (en) 2017-04-14
CN102439008A (zh) 2012-05-02
KR101753826B1 (ko) 2017-07-04
UA108070C2 (uk) 2015-03-25
CA2760741C (en) 2018-05-01
EP2430022B1 (en) 2013-11-20
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ES2440001T3 (es) 2014-01-27
MX2011011964A (es) 2012-02-23
US10071095B2 (en) 2018-09-11
AR076861A1 (es) 2011-07-13
TW201100416A (en) 2011-01-01
EP2430022A1 (en) 2012-03-21
US8937060B2 (en) 2015-01-20
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BRPI1012870B1 (pt) 2020-10-13
AU2010246609B2 (en) 2013-09-05
CL2011002838A1 (es) 2012-04-09
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PL2430022T3 (pl) 2014-02-28
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WO2010130424A1 (en) 2010-11-18
IL215912A (en) 2015-02-26
US20170333426A1 (en) 2017-11-23
CA2760741A1 (en) 2010-11-18
PT2430022E (pt) 2013-12-26
JP2012526737A (ja) 2012-11-01
HRP20131122T1 (hr) 2013-12-20
EA020672B1 (ru) 2014-12-30
HK1169405A1 (en) 2013-01-25
CN102439008B (zh) 2015-04-29
TWI468406B (zh) 2015-01-11
RS53075B (en) 2014-04-30
JP5634506B2 (ja) 2014-12-03
IL215912A0 (en) 2012-01-31
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US20150141403A1 (en) 2015-05-21

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