ECSP066856A - Compuestos novedosos como moduladores del receptor opioide - Google Patents
Compuestos novedosos como moduladores del receptor opioideInfo
- Publication number
- ECSP066856A ECSP066856A EC2006006856A ECSP066856A ECSP066856A EC SP066856 A ECSP066856 A EC SP066856A EC 2006006856 A EC2006006856 A EC 2006006856A EC SP066856 A ECSP066856 A EC SP066856A EC SP066856 A ECSP066856 A EC SP066856A
- Authority
- EC
- Ecuador
- Prior art keywords
- new compounds
- opioid
- receiver modulators
- modulators
- opioid receiver
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
Abstract
La presente invención está dirigida a moduladores del receptor opioide de fórmula (I); la invención además se refiere a métodos para la preparación de dichos compuestos, composiciones farmacéuticas que los contienen, y su uso en el tratamiento de trastornos que se pueden mejorar o tratar mediante la formulación de receptores opioide.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55334204P | 2004-03-15 | 2004-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP066856A true ECSP066856A (es) | 2006-11-24 |
Family
ID=34962827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006006856A ECSP066856A (es) | 2004-03-15 | 2006-09-15 | Compuestos novedosos como moduladores del receptor opioide |
Country Status (36)
Country | Link |
---|---|
US (8) | US7741356B2 (es) |
EP (5) | EP3112352B1 (es) |
JP (1) | JP4778954B2 (es) |
KR (1) | KR101166342B1 (es) |
CN (2) | CN102786476B (es) |
AR (2) | AR048269A1 (es) |
AT (1) | ATE516274T1 (es) |
AU (1) | AU2005224091B2 (es) |
BR (1) | BRPI0508820B8 (es) |
CA (1) | CA2560047C (es) |
CR (1) | CR8655A (es) |
CY (3) | CY1111927T1 (es) |
DK (5) | DK2573068T3 (es) |
EC (1) | ECSP066856A (es) |
ES (5) | ES2428008T3 (es) |
HK (4) | HK1099016A1 (es) |
HR (4) | HRP20110694T1 (es) |
HU (2) | HUE029852T2 (es) |
IL (3) | IL178040A (es) |
LT (2) | LT2653465T (es) |
LU (1) | LUC00007I2 (es) |
ME (3) | ME02540B (es) |
MX (1) | MXPA06010642A (es) |
MY (1) | MY146972A (es) |
NL (1) | NL300865I2 (es) |
NO (3) | NO338203B1 (es) |
NZ (1) | NZ549842A (es) |
PH (1) | PH12012501640A1 (es) |
PL (4) | PL1725537T3 (es) |
PT (4) | PT1725537E (es) |
RS (4) | RS51995B (es) |
SI (4) | SI1725537T1 (es) |
TW (1) | TWI361069B (es) |
UA (1) | UA86053C2 (es) |
WO (1) | WO2005090315A1 (es) |
ZA (1) | ZA200608587B (es) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
ATE516274T1 (de) | 2004-03-15 | 2011-07-15 | Janssen Pharmaceutica Nv | Neue verbindungen als modulatoren des opioidrezeptors |
CN1984879B (zh) | 2004-05-14 | 2011-07-27 | 詹森药业有限公司 | 甲酰胺基阿片样化合物 |
JP2008523815A (ja) | 2004-12-15 | 2008-07-10 | エラン ファーマ インターナショナル リミテッド | 認知の改善における使用のためのヒト化アミロイドβ抗体 |
EP1863764A1 (en) * | 2005-03-14 | 2007-12-12 | Janssen Pharmaceutica, N.V. | Process for the preparation of opioid modulators |
ATE511502T1 (de) * | 2005-12-14 | 2011-06-15 | Bristol Myers Squibb Co | Arylpropionamid-, arylacrylamid-, arylpropinamid- oder arylmethylharnstoffanaloge als faktor-xia- inhibitoren |
JP5473334B2 (ja) * | 2005-12-23 | 2014-04-16 | ジーランド ファーマ アクティーゼルスカブ | 修飾リジン模倣化合物 |
RU2473565C2 (ru) | 2006-04-07 | 2013-01-27 | Аерпио Терапетикс, Инк. | АНТИТЕЛА, СВЯЗЫВАЮЩИЕ ТИРОЗИН ФОСФАТАЗУ БЕТА ЧЕЛОВЕКА (HPTPβ), И ИХ ИСПОЛЬЗОВАНИЕ |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
EP2468724B1 (en) * | 2006-12-21 | 2015-11-18 | Zealand Pharma A/S | Synthesis of pyrrolidine compounds |
JP5702140B2 (ja) * | 2007-07-09 | 2015-04-15 | フリエツクス・フアーマシユーテイカルズ・インコーポレーテツド | 5−({[2−アミノ−3−(4−カルバモイル−2,6−ジメチル−フェニル)−プロピオニル]−[1−(4−フェニル−1h−イミダゾール−2−イル)−エチル]−アミノ}−メチル)−2−メトキシ−安息香酸の新規な結晶及び製造方法 |
JP5889529B2 (ja) | 2007-07-27 | 2016-03-22 | ヤンセン・サイエンシズ・アイルランド・ユーシー | アミロイド原性疾患の処置 |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
TWI468375B (zh) | 2008-10-27 | 2015-01-11 | Janssen Pharmaceutica Nv | 製備經保護之l-丙胺酸衍生物之方法 |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
JP5198220B2 (ja) * | 2008-11-13 | 2013-05-15 | 東ソ−・エフテック株式会社 | アミノ酸誘導体の製造方法 |
MY160399A (en) | 2009-07-06 | 2017-03-15 | Aerpio Therapeutics Inc | Compounds, compositions, and methods for preventing metastasis of cancer cells |
EP2524912A1 (en) | 2011-05-16 | 2012-11-21 | Bionomics Limited | Amine derivatives |
JP6254075B2 (ja) | 2011-05-16 | 2017-12-27 | バイオノミックス リミテッド | カリウムチャネル遮断剤としてのアミン誘導体 |
WO2013056240A1 (en) | 2011-10-13 | 2013-04-18 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
US9447079B2 (en) * | 2013-03-14 | 2016-09-20 | Epizyme, Inc. | PRMT1 inhibitors and uses thereof |
US9675587B2 (en) | 2013-03-14 | 2017-06-13 | Allergan Holdings Unlimited Company | Opioid receptor modulator dosage formulations |
DK2970132T3 (da) | 2013-03-14 | 2020-12-21 | Epizyme Inc | Argininmethyltransferaseinhibitorer og anvendelser deraf |
WO2014144659A1 (en) | 2013-03-14 | 2014-09-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
JP6483148B2 (ja) | 2014-03-14 | 2019-03-13 | エアーピオ セラピューティクス インコーポレイテッド | HPTP−β阻害剤 |
IS2977B (is) | 2015-02-23 | 2017-07-15 | Actavis Group Ptc Ehf. | Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni |
US10702498B2 (en) | 2015-07-09 | 2020-07-07 | The Regents Of The University Of California | MU opioid receptor modulators |
US10314819B2 (en) | 2015-07-23 | 2019-06-11 | Teva Pharmaceuticals International Gmbh | Solid state forms of Eluxadoline |
CN108026032B (zh) * | 2015-09-11 | 2020-09-29 | 株式会社钟化 | 光学活性4-氨基甲酰基-2,6-二甲基苯基丙氨酸衍生物的制造方法 |
KR20180054677A (ko) | 2015-09-23 | 2018-05-24 | 에르피오 세러퓨틱스 인코포레이티드 | Tie-2의 활성화제로 안내압을 치료하는 방법 |
CN105250232B (zh) * | 2015-09-29 | 2018-08-14 | 江苏汇智知识产权服务有限公司 | 一种伊卢多啉肠溶片及其制备方法 |
WO2017114446A1 (zh) * | 2015-12-31 | 2017-07-06 | 苏州晶云药物科技有限公司 | 艾沙度林的新晶型及其制备方法 |
CN107129444B (zh) * | 2016-02-29 | 2018-08-31 | 尚科生物医药(上海)有限公司 | (s)-2-叔丁氧羰基氨基-3-(4-氨甲酰基-2,6-二甲基苯基)丙酸制备方法 |
EP3272741A1 (en) | 2016-07-21 | 2018-01-24 | Euticals S.P.A. | New stable solvate crystalline forms of eluxadoline |
CN105777584B (zh) * | 2016-03-28 | 2018-01-02 | 成都伊诺达博医药科技有限公司 | 丙氨酸衍生物的制备方法 |
CN105693554B (zh) * | 2016-04-06 | 2017-08-08 | 成都伊诺达博医药科技有限公司 | 丙氨酸衍生物的制备方法 |
WO2017191650A1 (en) * | 2016-05-03 | 2017-11-09 | Msn Laboratories Private Limited | Process for the preparation of 5-[[[(2s)-2-amino-3-[4-(aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl][(1s)-1-(4-phenyl-1h-imidazol-2-yl)ethyl]amino]methyl-2-methoxybenzoic acid and its polymorphs thereof |
WO2017208156A1 (en) * | 2016-05-30 | 2017-12-07 | Sun Pharmaceutical Industries Limited | A process for the preparation of eluxadoline |
US10822308B2 (en) * | 2016-06-23 | 2020-11-03 | Sun Pharmaceutical Industries Limited | Processes for the preparation of eluxadoline |
WO2018020450A2 (en) | 2016-07-28 | 2018-02-01 | Lupin Limited | Process for the preparation of eluxadoline |
CZ2016548A3 (cs) | 2016-09-07 | 2018-03-14 | Zentiva, K.S. | Pevné formy eluxadolinu |
WO2018047131A1 (en) * | 2016-09-09 | 2018-03-15 | Sun Pharmaceutical Industries Limited | Amorphous eluxadoline |
EP3515434A4 (en) | 2016-09-20 | 2020-02-26 | Sun Pharmaceutical Industries Limited | METHOD FOR PRODUCING ELUXADOLIN |
EP3573958A1 (en) | 2017-01-27 | 2019-12-04 | Quimica Sintetica, S.A. | Eluxadoline crystalline forms and processes for their preparation |
WO2018138272A1 (en) | 2017-01-27 | 2018-08-02 | Quimica Sintetica, S. A. | Eluxadoline crystalline form and process for the preparation thereof |
CN110709096B (zh) | 2017-05-05 | 2023-10-31 | 泽兰德制药公司 | 细胞间隙连接通讯调节剂及其在糖尿病性眼病治疗中的应用 |
WO2019008604A1 (en) | 2017-07-07 | 2019-01-10 | Cipla Limited | NEW FORMS OF MU-OPIOID RECEPTOR AGONIST |
WO2019144805A1 (zh) * | 2018-01-25 | 2019-08-01 | 四川科伦博泰生物医药股份有限公司 | 取代的苯乙胺化合物及其制备方法和用途 |
WO2019197274A1 (en) | 2018-04-09 | 2019-10-17 | Quimica Sintetica, S. A. | Process for the preparation of opioid modulators |
US20210251964A1 (en) | 2018-08-20 | 2021-08-19 | Allergan Holdings Unlimited Company | Polymorphs of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid |
WO2020068653A1 (en) | 2018-09-24 | 2020-04-02 | Aerpio Pharmaceuticals, Inc. | MULTISPECIFIC ANTIBODIES THAT TARGET HPTP - β (VE-PTP) AND VEGF |
PL3659433T3 (pl) * | 2018-11-30 | 2021-11-08 | Phytobiotics Futterzusatzstoffe Gmbh | System analizowania obrazów wydzielin zwierzęcych |
CN111377832A (zh) * | 2018-12-27 | 2020-07-07 | 江苏联昇化学有限公司 | 一种伊卢多啉中间体制备的新方法 |
WO2020223209A1 (en) | 2019-04-29 | 2020-11-05 | Aerpio Pharmaceuticals, Inc. | Tie-2 activators targeting the schlemm's canal |
WO2021198780A1 (en) | 2020-03-30 | 2021-10-07 | Allergan Holdings Unlimited Company | Forms of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid |
IL300110A (en) * | 2020-07-28 | 2023-03-01 | Jazz Pharmaceuticals Ireland Ltd | Chiral synthesis of RAF inhibitors in compressed cyclics |
US11850319B2 (en) | 2020-09-29 | 2023-12-26 | Abl Ip Holding Llc | Techniques for directing ultraviolet energy towards a moving surface |
US20220096676A1 (en) | 2020-09-29 | 2022-03-31 | Abl Ip Holding Llc | Techniques for Directing Ultraviolet Energy Towards a Moving Surface |
CN114163348A (zh) * | 2020-11-27 | 2022-03-11 | 成都泰蓉生物科技有限公司 | 一种氨酰基取代的l-苯丙氨酸的合成方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD142804A3 (de) * | 1977-11-07 | 1980-07-16 | Wagner Guenter | Verfahren zur herstellung von na-alkyl-bzw.na-aryl-sulfonylierten omega-amidinophenyl-alpha-aminoalkylcarbonsaeureamiden |
US4879398A (en) * | 1987-12-31 | 1989-11-07 | Monsanto Company | Process for producing 2,6-disubstituted tyrosine |
SE9402880D0 (sv) | 1994-08-30 | 1994-08-30 | Astra Ab | New peptide derivatives |
IL116923A (en) | 1995-01-27 | 2000-09-28 | Novo Nordisk As | Compounds with growth hormone releasing properties and pharmaceutical compositions containing them |
US5565568A (en) | 1995-04-06 | 1996-10-15 | Eli Lilly And Company | 2-acylaminopropanamides as tachykinin receptor antagonists |
HUP9802036A3 (en) | 1995-04-13 | 1999-06-28 | Aventis Pharmaceuticals Inc Br | Novel substituted piperazine derivatives having tachykinin receptor antagonists activity, process for producing them an pharmaceutical compositions containing them |
AU6772996A (en) | 1995-08-21 | 1997-03-12 | Eli Lilly And Company | 2-acylaminopropanamides as growth hormone secretagogues |
WO1997019908A1 (en) | 1995-11-29 | 1997-06-05 | Nihon Nohyaku Co., Ltd. | Phenylalanine derivatives, optically active substances, salts or coordination compounds thereof, and their use as fungicides |
US5792760A (en) | 1997-04-23 | 1998-08-11 | Eli Lilly And Company | Bisindoles as tachykinin receptor antagonists |
IT1304898B1 (it) | 1998-09-08 | 2001-04-05 | Menarini Ricerche Spa | Prodotti con caratteristiche basiche aventi attivita' antagonista sulrecettore nk-1 e loro impiego in preparazioni farmaceutiche |
PT1055665E (pt) * | 1999-05-28 | 2004-03-31 | Pfizer Prod Inc | Derivados da 3-(3-hidroxifenil)-3-amino-propionamida |
FR2796643B1 (fr) | 1999-07-22 | 2005-04-29 | Sod Conseils Rech Applic | Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique |
GB0021419D0 (en) | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
US20020072017A1 (en) * | 2000-10-19 | 2002-06-13 | Hudnall Phillip Montgomery | Stabilized p-phenylenediamine-type photographic color developers in free base form |
EP1392291B1 (en) | 2000-10-30 | 2007-05-30 | Janssen Pharmaceutica N.V. | Tripeptidyl peptidase inhibitors |
AU2002346994B2 (en) * | 2001-10-15 | 2007-09-06 | Janssen Pharmaceutica N.V. | Novel substituted 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists |
US7041681B2 (en) | 2002-04-29 | 2006-05-09 | Janssen Pharmaceutica N.V. | Compounds as opioid receptor modulators |
ATE516274T1 (de) * | 2004-03-15 | 2011-07-15 | Janssen Pharmaceutica Nv | Neue verbindungen als modulatoren des opioidrezeptors |
EP1753749B1 (en) * | 2004-05-03 | 2014-07-30 | Janssen Pharmaceutica NV | Novel indole derivatives as selective androgen receptor modulators (sarms) |
EP1863764A1 (en) * | 2005-03-14 | 2007-12-12 | Janssen Pharmaceutica, N.V. | Process for the preparation of opioid modulators |
-
2005
- 2005-03-14 AT AT05728171T patent/ATE516274T1/de active
- 2005-03-14 UA UAA200609824A patent/UA86053C2/ru unknown
- 2005-03-14 PL PL05728171T patent/PL1725537T3/pl unknown
- 2005-03-14 SI SI200531383T patent/SI1725537T1/sl unknown
- 2005-03-14 RS RS20110446A patent/RS51995B/en unknown
- 2005-03-14 BR BRPI0508820A patent/BRPI0508820B8/pt not_active IP Right Cessation
- 2005-03-14 ME MEP-2016-232A patent/ME02540B/me unknown
- 2005-03-14 ES ES10182349T patent/ES2428008T3/es active Active
- 2005-03-14 SI SI200532091A patent/SI2653465T1/sl unknown
- 2005-03-14 RS RS20130371A patent/RS52933B/en unknown
- 2005-03-14 EP EP16178050.7A patent/EP3112352B1/en active Active
- 2005-03-14 EP EP05728171A patent/EP1725537B1/en active Active
- 2005-03-14 WO PCT/US2005/008339 patent/WO2005090315A1/en active Application Filing
- 2005-03-14 CN CN201210277845.6A patent/CN102786476B/zh not_active Expired - Fee Related
- 2005-03-14 PL PL13173454T patent/PL2653465T3/pl unknown
- 2005-03-14 MX MXPA06010642A patent/MXPA06010642A/es active IP Right Grant
- 2005-03-14 JP JP2007503986A patent/JP4778954B2/ja not_active Expired - Fee Related
- 2005-03-14 ES ES16178050T patent/ES2705077T3/es active Active
- 2005-03-14 ES ES13173454.3T patent/ES2596434T3/es active Active
- 2005-03-14 ME MEP-2015-36A patent/ME02221B/me unknown
- 2005-03-14 MY MYPI20051060A patent/MY146972A/en unknown
- 2005-03-14 RS RS20150204A patent/RS54199B1/en unknown
- 2005-03-14 ME MEP-2013-97A patent/ME01601B/me unknown
- 2005-03-14 PT PT05728171T patent/PT1725537E/pt unknown
- 2005-03-14 CA CA2560047A patent/CA2560047C/en active Active
- 2005-03-14 DK DK12194058.9T patent/DK2573068T3/en active
- 2005-03-14 CN CN200580014571XA patent/CN1950342B/zh not_active Expired - Fee Related
- 2005-03-14 DK DK05728171.9T patent/DK1725537T3/da active
- 2005-03-14 EP EP10182349.0A patent/EP2298744B1/en active Active
- 2005-03-14 LT LTEP13173454.3T patent/LT2653465T/lt unknown
- 2005-03-14 ES ES05728171T patent/ES2367576T3/es active Active
- 2005-03-14 TW TW094107612A patent/TWI361069B/zh not_active IP Right Cessation
- 2005-03-14 SI SI200531934T patent/SI2573068T1/sl unknown
- 2005-03-14 NZ NZ549842A patent/NZ549842A/en not_active IP Right Cessation
- 2005-03-14 EP EP12194058.9A patent/EP2573068B9/en active Active
- 2005-03-14 PL PL12194058T patent/PL2573068T3/pl unknown
- 2005-03-14 US US11/079,647 patent/US7741356B2/en active Active
- 2005-03-14 EP EP13173454.3A patent/EP2653465B1/en active Active
- 2005-03-14 KR KR1020067021231A patent/KR101166342B1/ko active IP Right Grant
- 2005-03-14 DK DK16178050.7T patent/DK3112352T3/en active
- 2005-03-14 DK DK13173454.3T patent/DK2653465T3/da active
- 2005-03-14 RS RS20160843A patent/RS55122B1/sr unknown
- 2005-03-14 DK DK10182349.0T patent/DK2298744T3/da active
- 2005-03-14 HU HUE13173454A patent/HUE029852T2/en unknown
- 2005-03-14 PT PT101823490T patent/PT2298744E/pt unknown
- 2005-03-14 PT PT131734543T patent/PT2653465T/pt unknown
- 2005-03-14 SI SI200531771T patent/SI2298744T1/sl unknown
- 2005-03-14 ES ES12194058.9T patent/ES2533176T3/es active Active
- 2005-03-14 PL PL10182349T patent/PL2298744T3/pl unknown
- 2005-03-14 PT PT121940589T patent/PT2573068E/pt unknown
- 2005-03-14 AU AU2005224091A patent/AU2005224091B2/en not_active Ceased
- 2005-03-15 AR ARP050101007A patent/AR048269A1/es active IP Right Grant
-
2006
- 2006-09-12 IL IL178040A patent/IL178040A/en active IP Right Grant
- 2006-09-15 EC EC2006006856A patent/ECSP066856A/es unknown
- 2006-09-25 CR CR8655A patent/CR8655A/es unknown
- 2006-10-13 NO NO20064660A patent/NO338203B1/no not_active IP Right Cessation
- 2006-10-13 ZA ZA2006/08587A patent/ZA200608587B/en unknown
-
2007
- 2007-05-28 HK HK07105593.3A patent/HK1099016A1/xx not_active IP Right Cessation
- 2007-10-17 HK HK07111210.4A patent/HK1105967A1/xx not_active IP Right Cessation
- 2007-10-24 US US11/877,747 patent/US7786158B2/en active Active
-
2010
- 2010-07-19 US US12/838,825 patent/US8344011B2/en active Active
-
2011
- 2011-09-19 HK HK11109830.2A patent/HK1155726A1/xx not_active IP Right Cessation
- 2011-09-28 HR HR20110694T patent/HRP20110694T1/hr unknown
- 2011-10-10 CY CY20111100967T patent/CY1111927T1/el unknown
-
2012
- 2012-08-14 PH PH12012501640A patent/PH12012501640A1/en unknown
- 2012-11-30 US US13/690,041 patent/US8609709B2/en active Active
-
2013
- 2013-02-26 IL IL224908A patent/IL224908A/en active IP Right Grant
- 2013-08-22 HR HRP20130800TT patent/HRP20130800T1/hr unknown
- 2013-09-27 HK HK13111031.3A patent/HK1184432A1/xx not_active IP Right Cessation
- 2013-10-03 US US14/045,008 patent/US8772325B2/en active Active
- 2013-11-14 IL IL229444A patent/IL229444A/en active IP Right Grant
-
2014
- 2014-04-11 AR ARP140101566A patent/AR095848A2/es unknown
- 2014-05-20 US US14/282,828 patent/US9205076B2/en active Active
-
2015
- 2015-03-18 HR HRP20150305TT patent/HRP20150305T1/hr unknown
- 2015-10-12 US US14/880,597 patent/US9700542B2/en active Active
-
2016
- 2016-05-30 NO NO20160916A patent/NO20160916A1/no not_active Application Discontinuation
- 2016-10-12 HR HRP20161331TT patent/HRP20161331T1/hr unknown
- 2016-10-12 CY CY20161101019T patent/CY1118096T1/el unknown
-
2017
- 2017-02-23 NO NO2017007C patent/NO2017007I2/no unknown
- 2017-03-01 LT LTPA2017005C patent/LTC1725537I2/lt unknown
- 2017-03-01 LU LU00007C patent/LUC00007I2/fr unknown
- 2017-03-02 HU HUS1700010C patent/HUS1700010I1/hu unknown
- 2017-03-08 CY CY2017008C patent/CY2017008I2/el unknown
- 2017-03-10 NL NL300865C patent/NL300865I2/nl unknown
- 2017-06-07 US US15/616,358 patent/US10213415B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP066856A (es) | Compuestos novedosos como moduladores del receptor opioide | |
CO6450612A2 (es) | Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750 | |
UY28752A1 (es) | Agentes terapeuticos | |
BRPI0910182B8 (pt) | composto de fórmula (i), composição farmacêutica e uso de um composto | |
CR10243A (es) | "bencimidazoles 2-sustituidos como modulares de receptor de androgeno selectivos" | |
UY29058A1 (es) | Compuestos de isoindolona y su uso como potenciadores del receptor metabotropico de glutamato | |
DOP2009000133A (es) | Derivados de indol como agonistas de los receptores s1p1 | |
CL2011001263A1 (es) | Compuestos derivados de pirimidinonas opcionalmente sustituidas; composicion farmaceutica que los comprende; y su uso como inhibidores de fosfodiesterasa 1 (pde1) para el tratamiento de enfermedades que involucran trastornos de la trayectoria intracelular del receptor de dopamina d1 como parkinson, alzheimer, depresion, enfermedad bipolar, hipertension, glaucoma. | |
AR054786A1 (es) | (6-fluor-benzol(1,3) dioxolil)-morfolin-4-il-metanomas, moduladoras del receptor cb1 | |
UY32648A (es) | Nuevos derivados de pirimidina y su uso en el tratamiento de enfermedades | |
ECSP109903A (es) | Derivados de pirazinona y su uso en el tratamiento de enfermedades pulmonares | |
CL2011002837A1 (es) | Compuestos derivados de 1,2,4-triazolo[4,3-a]piridina, moduladores alostericos positivos de receptores mglur2; composicion farmaceutica; proceso para prepararla; y su uso en el tratamiento o la prevencion de un trastorno del sistema nervioso central tal como la ansiedad, esquizofrenia y migraña, entre otros. | |
CL2011002103A1 (es) | Compuestos derivados de indazol; procedimiento de preparacion; compuesto intermediario; composicion farmaceutica y combinacion que los comprende; y uso para tratar una afeccion para la que esta indicado un antagonista del receptor ccr4. | |
EA200970967A1 (ru) | Оксадиазол замещенные производные индазола для применения в качестве агонистов сфингозин 1-фосфата (sip) | |
EA201070327A1 (ru) | Катехоламиновые производные и их пролекарства | |
CR10497A (es) | Derivados de piperazinilo utiles en el tratamiento de enfermedades mediadas por el receptor gpr38 | |
CR10682A (es) | Compuestos de tiazol pirazolopirimidina | |
UY30572A1 (es) | N-(1-ftalazin-1-il-piperidin-4-il)-amidas como moduladores del receptor ep2 | |
UY31922A (es) | Compuestos | |
EA201190017A1 (ru) | Аминоэфирные производные алкалоидов и их медицинские композиции | |
EA201100161A1 (ru) | Производные хинуклидина карбоната и их медицинские композиции | |
UY29798A1 (es) | Derivados de carboxamida como antagonistas del receptor muscarínico | |
UY28839A1 (es) | Agentes terapeuticos | |
ECSP088584A (es) | Nuevos derivados de benzimidazol como inhibidores del receptor vanilloide 1 (vrl) | |
CO6351723A2 (es) | Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1 |