IS2977B - Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni - Google Patents
Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíniInfo
- Publication number
- IS2977B IS2977B IS9062A IS9062A IS2977B IS 2977 B IS2977 B IS 2977B IS 9062 A IS9062 A IS 9062A IS 9062 A IS9062 A IS 9062A IS 2977 B IS2977 B IS 2977B
- Authority
- IS
- Iceland
- Prior art keywords
- eluxadoline
- synthesis
- preparation
- intermediates useful
- intermediates
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- QFNHIDANIVGXPE-FNZWTVRRSA-N eluxadoline Chemical compound C1=C(C(O)=O)C(OC)=CC=C1CN(C(=O)[C@@H](N)CC=1C(=CC(=CC=1C)C(N)=O)C)[C@@H](C)C1=NC(C=2C=CC=CC=2)=CN1 QFNHIDANIVGXPE-FNZWTVRRSA-N 0.000 title 1
- 229960002658 eluxadoline Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/06—Oxalic acid
- C07C55/07—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IS9062A IS2977B (is) | 2015-02-23 | 2015-02-23 | Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni |
| ES16707564T ES2761821T3 (es) | 2015-02-23 | 2016-02-22 | Proceso para la preparación de intermedios útiles en la síntesis de eluxadolina |
| EP16707564.7A EP3262030B1 (en) | 2015-02-23 | 2016-02-22 | Process for the preparation of intermediates useful in the synthesis of eluxadoline |
| US15/552,639 US10472329B2 (en) | 2015-02-23 | 2016-02-22 | Process for the preparation of intermediates useful in the synthesis of Eluxadoline |
| PCT/IS2016/050003 WO2016135756A1 (en) | 2015-02-23 | 2016-02-22 | Process for the preparation of intermediates useful in the synthesis of eluxadoline |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IS9062A IS2977B (is) | 2015-02-23 | 2015-02-23 | Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS2977B true IS2977B (is) | 2017-07-15 |
Family
ID=55453245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS9062A IS2977B (is) | 2015-02-23 | 2015-02-23 | Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10472329B2 (is) |
| EP (1) | EP3262030B1 (is) |
| ES (1) | ES2761821T3 (is) |
| IS (1) | IS2977B (is) |
| WO (1) | WO2016135756A1 (is) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018198101A2 (en) * | 2017-04-25 | 2018-11-01 | Sun Pharmaceutical Industries Limited | Processes for the preparation of crystalline form of eluxadoline |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040132788A1 (en) | 1999-10-11 | 2004-07-08 | Chabrier De Lassauniere Pierre-Etienne | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| US7291641B2 (en) * | 1999-10-11 | 2007-11-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| CA2417204A1 (en) | 2000-08-01 | 2002-02-07 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R | Imidazolyl derivatives |
| WO2004071448A2 (en) | 2003-02-12 | 2004-08-26 | Transtech Pharma Inc. | Substituted azole derivatives as inhibitors of protein tyrosine phosphatases |
| LT2653465T (lt) | 2004-03-15 | 2016-09-12 | Janssen Pharmaceutica Nv | Opioidinio receptoriaus moduliatoriai |
| US7618981B2 (en) * | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| JP4836280B2 (ja) | 2004-06-18 | 2011-12-14 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 癌を治療するためのキネシンスピンドルタンパク質（ｋｓｐ）阻害剤としてのｎ−（１−（１−ベンジル−４−フェニル−１ｈ−イミダゾール−２−イル）−２，２−ジメチルプロピル）ベンズアミド誘導体および関連化合物 |
| BRPI0607792A2 (pt) | 2005-03-14 | 2009-06-13 | Janssen Pharmaceutica Nv | processo para a preparação de moduladores de opióides |
| MD20140037A2 (ro) | 2011-10-26 | 2014-08-31 | Pfizer Limited | Derivaţi de (4-fenilimidazol-2-il)etilamină utili ca modulatori ai canalului de sodiu |
-
2015
- 2015-02-23 IS IS9062A patent/IS2977B/is unknown
-
2016
- 2016-02-22 WO PCT/IS2016/050003 patent/WO2016135756A1/en not_active Ceased
- 2016-02-22 EP EP16707564.7A patent/EP3262030B1/en active Active
- 2016-02-22 US US15/552,639 patent/US10472329B2/en active Active
- 2016-02-22 ES ES16707564T patent/ES2761821T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016135756A1 (en) | 2016-09-01 |
| EP3262030B1 (en) | 2019-09-11 |
| EP3262030A1 (en) | 2018-01-03 |
| ES2761821T3 (es) | 2020-05-21 |
| US10472329B2 (en) | 2019-11-12 |
| US20180029994A1 (en) | 2018-02-01 |
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