NL300865I1 - Eluxadoline of een farmaceutisch aanvaardbaar zout ervan - Google Patents
Eluxadoline of een farmaceutisch aanvaardbaar zout ervanInfo
- Publication number
- NL300865I1 NL300865I1 NL300865C NL300865C NL300865I1 NL 300865 I1 NL300865 I1 NL 300865I1 NL 300865 C NL300865 C NL 300865C NL 300865 C NL300865 C NL 300865C NL 300865 I1 NL300865 I1 NL 300865I1
- Authority
- NL
- Netherlands
- Prior art keywords
- eluxadoline
- pharmaceutically acceptable
- acceptable salt
- salt
- pharmaceutically
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
- Steroid Compounds (AREA)
- Amplitude Modulation (AREA)
- Eye Examination Apparatus (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Amplifiers (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55334204P | 2004-03-15 | 2004-03-15 | |
PCT/US2005/008339 WO2005090315A1 (en) | 2004-03-15 | 2005-03-14 | Novel compounds as opioid receptor modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
NL300865I1 true NL300865I1 (nl) | 2017-03-14 |
NL300865I2 NL300865I2 (nl) | 2020-08-17 |
Family
ID=34962827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL300865C NL300865I2 (nl) | 2004-03-15 | 2017-03-10 | Eluxadoline of een farmaceutisch aanvaardbaar zout ervan |
Country Status (36)
Country | Link |
---|---|
US (8) | US7741356B2 (nl) |
EP (5) | EP2653465B1 (nl) |
JP (1) | JP4778954B2 (nl) |
KR (1) | KR101166342B1 (nl) |
CN (2) | CN102786476B (nl) |
AR (2) | AR048269A1 (nl) |
AT (1) | ATE516274T1 (nl) |
AU (1) | AU2005224091B2 (nl) |
BR (1) | BRPI0508820B8 (nl) |
CA (1) | CA2560047C (nl) |
CR (1) | CR8655A (nl) |
CY (3) | CY1111927T1 (nl) |
DK (5) | DK2298744T3 (nl) |
EC (1) | ECSP066856A (nl) |
ES (5) | ES2533176T3 (nl) |
HK (4) | HK1099016A1 (nl) |
HR (4) | HRP20110694T1 (nl) |
HU (2) | HUE029852T2 (nl) |
IL (3) | IL178040A (nl) |
LT (2) | LT2653465T (nl) |
LU (1) | LUC00007I2 (nl) |
ME (3) | ME02540B (nl) |
MX (1) | MXPA06010642A (nl) |
MY (1) | MY146972A (nl) |
NL (1) | NL300865I2 (nl) |
NO (3) | NO338203B1 (nl) |
NZ (1) | NZ549842A (nl) |
PH (1) | PH12012501640B1 (nl) |
PL (4) | PL1725537T3 (nl) |
PT (4) | PT2653465T (nl) |
RS (4) | RS54199B1 (nl) |
SI (4) | SI2298744T1 (nl) |
TW (1) | TWI361069B (nl) |
UA (1) | UA86053C2 (nl) |
WO (1) | WO2005090315A1 (nl) |
ZA (1) | ZA200608587B (nl) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
ES2533176T3 (es) | 2004-03-15 | 2015-04-08 | Janssen Pharmaceutica Nv | Proceso para preparar intermedios de compuestos útiles como moduladores de receptores opioides |
KR101204751B1 (ko) | 2004-05-14 | 2012-11-27 | 얀센 파마슈티카 엔.브이. | 카복사미도 아편유사약물 화합물 |
JP2008523815A (ja) | 2004-12-15 | 2008-07-10 | エラン ファーマ インターナショナル リミテッド | 認知の改善における使用のためのヒト化アミロイドβ抗体 |
EP1863764A1 (en) * | 2005-03-14 | 2007-12-12 | Janssen Pharmaceutica, N.V. | Process for the preparation of opioid modulators |
ATE511502T1 (de) * | 2005-12-14 | 2011-06-15 | Bristol Myers Squibb Co | Arylpropionamid-, arylacrylamid-, arylpropinamid- oder arylmethylharnstoffanaloge als faktor-xia- inhibitoren |
WO2007078990A2 (en) * | 2005-12-23 | 2007-07-12 | Zealand Pharma A/S | Modified lysine-mimetic compounds |
BRPI0710645A2 (pt) | 2006-04-07 | 2012-03-20 | The Procter & Gamble Company | Anticorpos que se ligam à proteína humana tirosina fosfatase beta (hptpbeta) e usos dos mesmos |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
AR064626A1 (es) * | 2006-12-21 | 2009-04-15 | Wyeth Corp | Sintesis de compuestos de pirrolidina |
CN101730685A (zh) | 2007-07-09 | 2010-06-09 | 詹森药业有限公司 | 5-({[2-氨基-3-(4-氨甲酰基-2,6-二甲基-苯基)-丙酰基]-[1-(4-苯基-1h-咪唑-2-基)-乙基]-氨基}-甲基)-2-甲氧基-苯甲酸的新型晶体及其制备方法 |
EP2182983B1 (en) | 2007-07-27 | 2014-05-21 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases with humanised anti-abeta antibodies |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
TWI468375B (zh) | 2008-10-27 | 2015-01-11 | Janssen Pharmaceutica Nv | 製備經保護之l-丙胺酸衍生物之方法 |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
JP5198220B2 (ja) * | 2008-11-13 | 2013-05-15 | 東ソ−・エフテック株式会社 | アミノ酸誘導体の製造方法 |
MY160399A (en) | 2009-07-06 | 2017-03-15 | Aerpio Therapeutics Inc | Compounds, compositions, and methods for preventing metastasis of cancer cells |
CN103781763B (zh) | 2011-05-16 | 2017-03-22 | 生态学有限公司 | 作为钾通道阻断剂的胺衍生物 |
EP2524912A1 (en) | 2011-05-16 | 2012-11-21 | Bionomics Limited | Amine derivatives |
WO2013056240A1 (en) | 2011-10-13 | 2013-04-18 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
US9675587B2 (en) * | 2013-03-14 | 2017-06-13 | Allergan Holdings Unlimited Company | Opioid receptor modulator dosage formulations |
SI2970132T1 (sl) | 2013-03-14 | 2021-02-26 | Epizyme, Inc. | Inhibitorji argininmetiltransferaze in njihove uporabe |
US9447079B2 (en) * | 2013-03-14 | 2016-09-20 | Epizyme, Inc. | PRMT1 inhibitors and uses thereof |
WO2014144659A1 (en) | 2013-03-14 | 2014-09-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
WO2015138882A1 (en) | 2014-03-14 | 2015-09-17 | Aerpio Therapeutics, Inc. | Hptp-beta inhibitors |
IS2977B (is) | 2015-02-23 | 2017-07-15 | Actavis Group Ptc Ehf. | Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni |
WO2017007695A1 (en) | 2015-07-09 | 2017-01-12 | The Regents Of The University Of California | Mu opioid receptor modulators |
US10314819B2 (en) | 2015-07-23 | 2019-06-11 | Teva Pharmaceuticals International Gmbh | Solid state forms of Eluxadoline |
CN108026032B (zh) * | 2015-09-11 | 2020-09-29 | 株式会社钟化 | 光学活性4-氨基甲酰基-2,6-二甲基苯基丙氨酸衍生物的制造方法 |
BR112018005499A2 (pt) | 2015-09-23 | 2018-10-09 | Aerpio Therapeutics Inc | métodos de tratamento de pressão intraocular com ativadores de tie-2. |
CN105250232B (zh) * | 2015-09-29 | 2018-08-14 | 江苏汇智知识产权服务有限公司 | 一种伊卢多啉肠溶片及其制备方法 |
WO2017114446A1 (zh) * | 2015-12-31 | 2017-07-06 | 苏州晶云药物科技有限公司 | 艾沙度林的新晶型及其制备方法 |
CN107129444B (zh) * | 2016-02-29 | 2018-08-31 | 尚科生物医药(上海)有限公司 | (s)-2-叔丁氧羰基氨基-3-(4-氨甲酰基-2,6-二甲基苯基)丙酸制备方法 |
EP3272741A1 (en) | 2016-07-21 | 2018-01-24 | Euticals S.P.A. | New stable solvate crystalline forms of eluxadoline |
CN105777584B (zh) * | 2016-03-28 | 2018-01-02 | 成都伊诺达博医药科技有限公司 | 丙氨酸衍生物的制备方法 |
CN105693554B (zh) * | 2016-04-06 | 2017-08-08 | 成都伊诺达博医药科技有限公司 | 丙氨酸衍生物的制备方法 |
US20190177281A1 (en) * | 2016-05-03 | 2019-06-13 | Sromovasam THIRUMALAI RAJAN | Process for the preparation of 5-[[[(2s)-2-amino-3-[4-(aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl] [(1s)-1-(4-phenyl-1h-imidazol-2-yl)ethyl]amino] methyl-2-methoxybenzoic acid and its polymorphs thereof |
MA45184A (fr) * | 2016-05-30 | 2019-04-10 | Sun Pharmaceutical Ind Ltd | Procédé de préparation de l'éluxadoline . |
EP3474847B1 (en) * | 2016-06-23 | 2022-09-07 | Sun Pharmaceutical Industries Limited | Processes for the preparation of eluxadoline |
WO2018020450A2 (en) | 2016-07-28 | 2018-02-01 | Lupin Limited | Process for the preparation of eluxadoline |
CZ2016548A3 (cs) | 2016-09-07 | 2018-03-14 | Zentiva, K.S. | Pevné formy eluxadolinu |
WO2018047131A1 (en) * | 2016-09-09 | 2018-03-15 | Sun Pharmaceutical Industries Limited | Amorphous eluxadoline |
WO2018055528A2 (en) * | 2016-09-20 | 2018-03-29 | Sun Pharmaceutical Industries Limited | Processes for the preparation of eluxadoline |
WO2018138272A1 (en) | 2017-01-27 | 2018-08-02 | Quimica Sintetica, S. A. | Eluxadoline crystalline form and process for the preparation thereof |
WO2018138274A1 (en) | 2017-01-27 | 2018-08-02 | Quimica Sintetica, S. A. | Eluxadoline crystalline forms and processes for their preparation |
CN110709096B (zh) | 2017-05-05 | 2023-10-31 | 泽兰德制药公司 | 细胞间隙连接通讯调节剂及其在糖尿病性眼病治疗中的应用 |
WO2019008604A1 (en) | 2017-07-07 | 2019-01-10 | Cipla Limited | NEW FORMS OF MU-OPIOID RECEPTOR AGONIST |
WO2019144805A1 (zh) * | 2018-01-25 | 2019-08-01 | 四川科伦博泰生物医药股份有限公司 | 取代的苯乙胺化合物及其制备方法和用途 |
WO2019197274A1 (en) | 2018-04-09 | 2019-10-17 | Quimica Sintetica, S. A. | Process for the preparation of opioid modulators |
CA3109557A1 (en) | 2018-08-20 | 2020-02-27 | Allergan Holdings Unlimited Company | Polymorphs of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid |
CN113164597A (zh) | 2018-09-24 | 2021-07-23 | 爱尔皮奥制药公司 | 靶向HPTP-β(VE-PTP)和VEGF的多特异性抗体 |
ES2867895T3 (es) * | 2018-11-30 | 2021-10-21 | Phytobiotics Futterzusatzstoffe Gmbh | Sistema para el análisis de imágenes de excrementos de animales |
CN111377832A (zh) * | 2018-12-27 | 2020-07-07 | 江苏联昇化学有限公司 | 一种伊卢多啉中间体制备的新方法 |
EP3962482A4 (en) | 2019-04-29 | 2023-01-11 | EyePoint Pharmaceuticals, Inc. | TIE-2 ACTIVATORS TARGETING THE SCHLEMM CHANNEL |
WO2021198780A1 (en) | 2020-03-30 | 2021-10-07 | Allergan Holdings Unlimited Company | Forms of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid |
IL300110A (en) * | 2020-07-28 | 2023-03-01 | Jazz Pharmaceuticals Ireland Ltd | Chiral synthesis of RAF inhibitors in compressed cyclics |
US20220096676A1 (en) | 2020-09-29 | 2022-03-31 | Abl Ip Holding Llc | Techniques for Directing Ultraviolet Energy Towards a Moving Surface |
US11850319B2 (en) | 2020-09-29 | 2023-12-26 | Abl Ip Holding Llc | Techniques for directing ultraviolet energy towards a moving surface |
CN114163348A (zh) * | 2020-11-27 | 2022-03-11 | 成都泰蓉生物科技有限公司 | 一种氨酰基取代的l-苯丙氨酸的合成方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD142804A3 (de) * | 1977-11-07 | 1980-07-16 | Wagner Guenter | Verfahren zur herstellung von na-alkyl-bzw.na-aryl-sulfonylierten omega-amidinophenyl-alpha-aminoalkylcarbonsaeureamiden |
US4879398A (en) * | 1987-12-31 | 1989-11-07 | Monsanto Company | Process for producing 2,6-disubstituted tyrosine |
SE9402880D0 (sv) | 1994-08-30 | 1994-08-30 | Astra Ab | New peptide derivatives |
UA55381C2 (uk) * | 1995-01-27 | 2003-04-15 | Ново Нордіск А/С | Похідні пептиду (варіанти), що здатні вивільнювати гормон росту, фармацевтична композиція (варіанти), спосіб стимулювання вивільнення гормону росту з гіпофіза, способи підвищення швидкості і темпу росту та виробництва молока або вовни, спосіб лікування нездужань |
US5565568A (en) | 1995-04-06 | 1996-10-15 | Eli Lilly And Company | 2-acylaminopropanamides as tachykinin receptor antagonists |
JP3950170B2 (ja) | 1995-04-13 | 2007-07-25 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | タキキニン受容体アンタゴニスト活性を有する新規な置換されたピペラジン誘導体 |
EP0761220A1 (en) | 1995-08-21 | 1997-03-12 | Eli Lilly And Company | 2-Acylaminopropanamides as growth hormone secretagogues |
WO1997019908A1 (en) | 1995-11-29 | 1997-06-05 | Nihon Nohyaku Co., Ltd. | Phenylalanine derivatives, optically active substances, salts or coordination compounds thereof, and their use as fungicides |
US5792760A (en) | 1997-04-23 | 1998-08-11 | Eli Lilly And Company | Bisindoles as tachykinin receptor antagonists |
IT1304898B1 (it) | 1998-09-08 | 2001-04-05 | Menarini Ricerche Spa | Prodotti con caratteristiche basiche aventi attivita' antagonista sulrecettore nk-1 e loro impiego in preparazioni farmaceutiche |
ATE252546T1 (de) * | 1999-05-28 | 2003-11-15 | Pfizer Prod Inc | 3-(3-hydroxyphenyl)-3-amino-propionamidderivate |
FR2796643B1 (fr) | 1999-07-22 | 2005-04-29 | Sod Conseils Rech Applic | Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique |
GB0021419D0 (en) | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
US20020072017A1 (en) * | 2000-10-19 | 2002-06-13 | Hudnall Phillip Montgomery | Stabilized p-phenylenediamine-type photographic color developers in free base form |
EA006443B1 (ru) | 2000-10-30 | 2005-12-29 | Янссен Фармацевтика Н.В. | Ингибиторы трипептидил пептидазы |
UA76224C2 (en) * | 2001-10-15 | 2006-07-17 | Janssen Pharmaceutica Nv | Substituted 4-phenyl 4-[1h-imidazol-2-yl]-piperidine derivatives and use thereof as selective non-peptide delta-opioid agonists |
US7041681B2 (en) * | 2002-04-29 | 2006-05-09 | Janssen Pharmaceutica N.V. | Compounds as opioid receptor modulators |
ES2533176T3 (es) | 2004-03-15 | 2015-04-08 | Janssen Pharmaceutica Nv | Proceso para preparar intermedios de compuestos útiles como moduladores de receptores opioides |
AU2005243240B2 (en) | 2004-05-03 | 2012-03-15 | Janssen Pharmaceutica N.V. | Novel indole derivatives as selective androgen receptor modulators (SARMS) |
EP1863764A1 (en) * | 2005-03-14 | 2007-12-12 | Janssen Pharmaceutica, N.V. | Process for the preparation of opioid modulators |
-
2005
- 2005-03-14 ES ES12194058.9T patent/ES2533176T3/es active Active
- 2005-03-14 PT PT131734543T patent/PT2653465T/pt unknown
- 2005-03-14 NZ NZ549842A patent/NZ549842A/en not_active IP Right Cessation
- 2005-03-14 SI SI200531771T patent/SI2298744T1/sl unknown
- 2005-03-14 ES ES10182349T patent/ES2428008T3/es active Active
- 2005-03-14 SI SI200531934T patent/SI2573068T1/sl unknown
- 2005-03-14 RS RS20150204A patent/RS54199B1/en unknown
- 2005-03-14 ME MEP-2016-232A patent/ME02540B/me unknown
- 2005-03-14 EP EP13173454.3A patent/EP2653465B1/en active Active
- 2005-03-14 DK DK10182349.0T patent/DK2298744T3/da active
- 2005-03-14 ME MEP-2015-36A patent/ME02221B/me unknown
- 2005-03-14 SI SI200531383T patent/SI1725537T1/sl unknown
- 2005-03-14 PL PL05728171T patent/PL1725537T3/pl unknown
- 2005-03-14 UA UAA200609824A patent/UA86053C2/ru unknown
- 2005-03-14 BR BRPI0508820A patent/BRPI0508820B8/pt not_active IP Right Cessation
- 2005-03-14 ES ES05728171T patent/ES2367576T3/es active Active
- 2005-03-14 DK DK05728171.9T patent/DK1725537T3/da active
- 2005-03-14 EP EP16178050.7A patent/EP3112352B1/en active Active
- 2005-03-14 DK DK13173454.3T patent/DK2653465T3/da active
- 2005-03-14 PT PT121940589T patent/PT2573068E/pt unknown
- 2005-03-14 EP EP05728171A patent/EP1725537B1/en active Active
- 2005-03-14 WO PCT/US2005/008339 patent/WO2005090315A1/en active Application Filing
- 2005-03-14 JP JP2007503986A patent/JP4778954B2/ja not_active Expired - Fee Related
- 2005-03-14 RS RS20130371A patent/RS52933B/en unknown
- 2005-03-14 RS RS20110446A patent/RS51995B/en unknown
- 2005-03-14 CN CN201210277845.6A patent/CN102786476B/zh not_active Expired - Fee Related
- 2005-03-14 ES ES13173454.3T patent/ES2596434T3/es active Active
- 2005-03-14 KR KR1020067021231A patent/KR101166342B1/ko active IP Right Grant
- 2005-03-14 CA CA2560047A patent/CA2560047C/en active Active
- 2005-03-14 ME MEP-2013-97A patent/ME01601B/me unknown
- 2005-03-14 US US11/079,647 patent/US7741356B2/en active Active
- 2005-03-14 SI SI200532091A patent/SI2653465T1/sl unknown
- 2005-03-14 EP EP12194058.9A patent/EP2573068B9/en active Active
- 2005-03-14 EP EP10182349.0A patent/EP2298744B1/en active Active
- 2005-03-14 AT AT05728171T patent/ATE516274T1/de active
- 2005-03-14 TW TW094107612A patent/TWI361069B/zh not_active IP Right Cessation
- 2005-03-14 DK DK16178050.7T patent/DK3112352T3/en active
- 2005-03-14 PL PL12194058T patent/PL2573068T3/pl unknown
- 2005-03-14 MX MXPA06010642A patent/MXPA06010642A/es active IP Right Grant
- 2005-03-14 AU AU2005224091A patent/AU2005224091B2/en not_active Ceased
- 2005-03-14 CN CN200580014571XA patent/CN1950342B/zh not_active Expired - Fee Related
- 2005-03-14 PL PL13173454T patent/PL2653465T3/pl unknown
- 2005-03-14 MY MYPI20051060A patent/MY146972A/en unknown
- 2005-03-14 LT LTEP13173454.3T patent/LT2653465T/lt unknown
- 2005-03-14 RS RS20160843A patent/RS55122B1/sr unknown
- 2005-03-14 HU HUE13173454A patent/HUE029852T2/en unknown
- 2005-03-14 PT PT05728171T patent/PT1725537E/pt unknown
- 2005-03-14 PL PL10182349T patent/PL2298744T3/pl unknown
- 2005-03-14 DK DK12194058.9T patent/DK2573068T3/en active
- 2005-03-14 ES ES16178050T patent/ES2705077T3/es active Active
- 2005-03-14 PT PT101823490T patent/PT2298744E/pt unknown
- 2005-03-15 AR ARP050101007A patent/AR048269A1/es active IP Right Grant
-
2006
- 2006-09-12 IL IL178040A patent/IL178040A/en active IP Right Grant
- 2006-09-15 EC EC2006006856A patent/ECSP066856A/es unknown
- 2006-09-25 CR CR8655A patent/CR8655A/es unknown
- 2006-10-13 NO NO20064660A patent/NO338203B1/no not_active IP Right Cessation
- 2006-10-13 ZA ZA2006/08587A patent/ZA200608587B/en unknown
-
2007
- 2007-05-28 HK HK07105593.3A patent/HK1099016A1/xx not_active IP Right Cessation
- 2007-10-17 HK HK07111210.4A patent/HK1105967A1/xx not_active IP Right Cessation
- 2007-10-24 US US11/877,747 patent/US7786158B2/en active Active
-
2010
- 2010-07-19 US US12/838,825 patent/US8344011B2/en active Active
-
2011
- 2011-09-19 HK HK11109830.2A patent/HK1155726A1/xx not_active IP Right Cessation
- 2011-09-28 HR HR20110694T patent/HRP20110694T1/hr unknown
- 2011-10-10 CY CY20111100967T patent/CY1111927T1/el unknown
-
2012
- 2012-08-14 PH PH12012501640A patent/PH12012501640B1/en unknown
- 2012-11-30 US US13/690,041 patent/US8609709B2/en active Active
-
2013
- 2013-02-26 IL IL224908A patent/IL224908A/en active IP Right Grant
- 2013-08-22 HR HRP20130800TT patent/HRP20130800T1/hr unknown
- 2013-09-27 HK HK13111031.3A patent/HK1184432A1/xx not_active IP Right Cessation
- 2013-10-03 US US14/045,008 patent/US8772325B2/en active Active
- 2013-11-14 IL IL229444A patent/IL229444A/en active IP Right Grant
-
2014
- 2014-04-11 AR ARP140101566A patent/AR095848A2/es unknown
- 2014-05-20 US US14/282,828 patent/US9205076B2/en active Active
-
2015
- 2015-03-18 HR HRP20150305TT patent/HRP20150305T1/hr unknown
- 2015-10-12 US US14/880,597 patent/US9700542B2/en active Active
-
2016
- 2016-05-30 NO NO20160916A patent/NO20160916A1/no not_active Application Discontinuation
- 2016-10-12 HR HRP20161331TT patent/HRP20161331T1/hr unknown
- 2016-10-12 CY CY20161101019T patent/CY1118096T1/el unknown
-
2017
- 2017-02-23 NO NO2017007C patent/NO2017007I1/no unknown
- 2017-03-01 LT LTPA2017005C patent/LTC1725537I2/lt unknown
- 2017-03-01 LU LU00007C patent/LUC00007I2/fr unknown
- 2017-03-02 HU HUS1700010C patent/HUS1700010I1/hu unknown
- 2017-03-08 CY CY2017008C patent/CY2017008I1/el unknown
- 2017-03-10 NL NL300865C patent/NL300865I2/nl unknown
- 2017-06-07 US US15/616,358 patent/US10213415B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NL301106I1 (nl) | Cenobamaat of een farmaceutisch aanvaardbaar zout daarvan | |
NL300865I1 (nl) | Eluxadoline of een farmaceutisch aanvaardbaar zout ervan | |
NL301177I2 (nl) | tecovirimat of een farmaceutisch aanvaardbaar zout daarvan | |
NL301209I1 (nl) | capmatinib of een farmaceutisch aanvaardbaar zout daarvan | |
NL301003I2 (nl) | Sotagliflozin of een farmaceutisch aanvaardbaar zout daarvan | |
NL300993I2 (nl) | Apalutamide of een farmaceutisch aanvaardbaar zout daarvan | |
NL350108I2 (nl) | Isofetamid of een zout daarvan | |
FIC20240007I1 (fi) | Gefapiksantti tai sen farmaseuttisesti hyväksyttävä suola | |
NL300640I2 (nl) | Alogliptine of een farmaceutisch aanvaardbaar zout daarvan | |
NL301158I2 (nl) | Relugolix of een zout daarvan | |
NL301256I2 (nl) | cedazuridine, of een farmaceutisch aanvaardbaar zout daarvan | |
NL301037I2 (nl) | Solriamfetol of een farmaceutisch aanvaardbaar zout daarvan, bij voorkeur het hydrochloridezout daarvan | |
NL350091I2 (nl) | Cyantraniliprole of een zout daarvan | |
NL301202I1 (nl) | Linzagolix, of een farmaceutisch aanvaardbaar zout daarvan, zoals linzagolix choline | |
NL301042I1 (nl) | Trifaroteen, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
NL301166I2 (nl) | Avacopan of een farmaceutisch aanvaardbaar zout daarvan | |
NL301150I2 (nl) | setmelanotide, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
NL301071I2 (nl) | alpelisib of een farmaceutisch aanvaardbaar zout ervan | |
NL301049I2 (nl) | crisaborole, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
FIC20210017I1 (fi) | Kabotegraviiri tai sen farmaseuttisesti hyväksyttävä suola tai solvaatti | |
NO2019027I1 (no) | kobicistat eller et farmasøytisk akseptabelt salt derav | |
NL300974I2 (nl) | Binimetinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout of solvaat | |
NL300863I2 (nl) | Palbociclib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
NL300703I2 (nl) | Simeprevir, of een farmaceutisch aanvaardbaar zout daarvan, waaronder simeprevirnatrium. | |
NL300913I2 (nl) | Cariprazine, optioneel in de vorm van een zout, waaronder cariprazine hydrochloride |