AR064626A1 - Sintesis de compuestos de pirrolidina - Google Patents
Sintesis de compuestos de pirrolidinaInfo
- Publication number
- AR064626A1 AR064626A1 ARP070105792A ARP070105792A AR064626A1 AR 064626 A1 AR064626 A1 AR 064626A1 AR P070105792 A ARP070105792 A AR P070105792A AR P070105792 A ARP070105792 A AR P070105792A AR 064626 A1 AR064626 A1 AR 064626A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- formula
- compound
- atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Se proporcionan métodos para la preparacion de ciertos compuestos de pirrolidona sustituidos, formas de hidrocloruro del ácido (2S,4R)-1-(2-aminoacetil)-4-benzamidopirrolidina-2-carboxílico, y métodos para preparar y usar estas formas. Reivindicacion 1: Un método para preparar un compuesto de formula (1) o una sal del mismo, en la que uno de R1 y R2 es hidrogeno o alquilo C1-6 y el otro es -C(O)R5; donde R5 se elige entre: arilo C6-10 opcionalmente sustituido; heteroarilo opcionalmente sustituido incluyendo de 5-10 átomos; alquilo C1-20 opcionalmente sustituido; haloalquilo C1-20 opcionalmente sustituido; aralquilo C7-12 opcionalmente sustituido; heteroaralquilo opcionalmente sustituido incluyendo de 6-12 átomos; cicloalquilo C3-10 opcionalmente sustituido; y cicloalquenilo C3-10 opcionalmente sustituido; W es alquileno C1-6; y R3 y R4 pueden ser iguales o diferentes y cada uno de ellos se elige independientemente entre hidrogeno, alquilo C1-6 opcionalmente sustituido, -C(O)OR6 y -C(O)R9; donde R6 es alquilo C1-20 opcionalmente sustituido; y donde R9 se elige entre hidrogeno; arilo C6-10 opcionalmente sustituido; heteroarilo opcionalmente sustituido incluyendo de 5-10 átomos; alquilo C1-20 opcionalmente sustituido; cicloalquilo C3-10 opcionalmente sustituido; y heterocicloalquilo opcionalmente sustituido incluyendo de 5-10 átomos; comprendiendo el método: convertir un compuesto de formula (2) o una sal del mismo: en la que: R7 se elige entre hidrogeno y alquilo C1-6 opcionalmente sustituido; en un compuesto de formula (3) o una sal del mismo: y, cuando R7 en la formula (3) es alquilo C1-6 opcionalmente sustituido, hacer reaccionar el compuesto de formula (3) con un hidroxido de metal u otra base adecuada para proporcionar un compuesto de formula (1) o una sal del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87629006P | 2006-12-21 | 2006-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR064626A1 true AR064626A1 (es) | 2009-04-15 |
Family
ID=39470360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070105792A AR064626A1 (es) | 2006-12-21 | 2007-12-20 | Sintesis de compuestos de pirrolidina |
Country Status (9)
Country | Link |
---|---|
US (4) | US20080188545A1 (es) |
EP (2) | EP2468724B1 (es) |
AR (1) | AR064626A1 (es) |
DK (1) | DK2468724T3 (es) |
ES (1) | ES2558856T3 (es) |
PE (1) | PE20081400A1 (es) |
PL (1) | PL2468724T3 (es) |
TW (1) | TW200833660A (es) |
WO (1) | WO2008079266A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1966130T3 (pl) | 2005-12-23 | 2014-05-30 | Zealand Pharma As | Zmodyfikowane związki mimetyczne lizyny |
EP2468724B1 (en) | 2006-12-21 | 2015-11-18 | Zealand Pharma A/S | Synthesis of pyrrolidine compounds |
CN101863817A (zh) * | 2009-06-09 | 2010-10-20 | 大连凯飞精细化工有限公司 | (2s,4r)-4-氨基吡咯啉-1,2-二羧酸-1-叔丁酯-2-甲酯盐酸盐的制法 |
CN103333094B (zh) * | 2013-06-19 | 2015-05-13 | 广东肇庆星湖生物科技股份有限公司 | 一种脯氨酸结晶精制的工艺方法 |
EP3618847B1 (en) | 2017-05-05 | 2021-04-07 | Zealand Pharma A/S | Gap junction intercellular communication modulators and their use for the treatment of diabetic eye disease |
CN112142823B (zh) * | 2019-06-28 | 2022-08-05 | 深圳翰宇药业股份有限公司 | 一种zp-1609的合成方法 |
EP3904339A1 (en) * | 2020-04-28 | 2021-11-03 | Esteve Pharmaceuticals, S.A. | Alkylaminoproline derivatives as alfa-2-delta-1 blockers |
JP2024506331A (ja) | 2021-02-10 | 2024-02-13 | ブルイエ・セラピューティクス・アー・ペー・エス | 腎臓疾患の処置または予防において使用するためのダネガプチド |
WO2023118366A1 (en) | 2021-12-22 | 2023-06-29 | Breye Therapeutics Aps | Gap junction modulators and their use for the treatment of age-related macular degeneration |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5784223A (en) | 1980-11-13 | 1982-05-26 | Nissan Motor Co Ltd | Vibration absorber of vehicle |
US4462943A (en) | 1980-11-24 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Carboxyalkyl amino acid derivatives of various substituted prolines |
ATE22692T1 (de) | 1981-08-03 | 1986-10-15 | Squibb & Sons Inc | Phosphonamidate verbindungen. |
US4514391A (en) | 1983-07-21 | 1985-04-30 | E. R. Squibb & Sons, Inc. | Hydroxy substituted peptide compounds |
US4560506A (en) | 1984-05-25 | 1985-12-24 | E. R. Squibb & Sons, Inc. | Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides |
IL76345A (en) * | 1984-09-12 | 1988-12-30 | Usv Pharma Corp | Proline derivatives and antihypertensive and anti-glaucoma pharmaceutical preparations containing the same |
JPS61148198A (ja) * | 1984-12-22 | 1986-07-05 | Ajinomoto Co Inc | 新規トリペプチド化合物および甘味剤 |
EP0254032A3 (en) | 1986-06-20 | 1990-09-05 | Schering Corporation | Neutral metalloendopeptidase inhibitors in the treatment of hypertension |
EP0566157A1 (en) | 1986-06-20 | 1993-10-20 | Schering Corporation | Neutral metalloendopeptidase inhibitors in the treatment of hypertension |
US4849525A (en) * | 1987-09-21 | 1989-07-18 | E. R. Squibb & Sons, Inc. | Phosphinylcycloalkylcarbonyl and phosphinylcycloalkenylcarbonyl dipeptides |
US5120859A (en) * | 1989-09-22 | 1992-06-09 | Genentech, Inc. | Chimeric amino acid analogues |
FR2700166B1 (fr) * | 1993-01-07 | 1995-02-17 | Rhone Poulenc Rorer Sa | Dérivés de pyrrolidine, leur préparation et les médicaments les contenant. |
EP0739204A4 (en) | 1993-11-09 | 2000-03-15 | Merck & Co Inc | PIPERIDINE, PYRROLIDINE AND HEXAHYDRO-1H-AZEPINE SUPPORT THE RELEASE OF THE GROWTH HORMONE |
DE4408531A1 (de) | 1994-03-14 | 1995-09-28 | Hoechst Ag | PNA-Synthese unter Verwendung einer gegen schwache Säuren labilen Amino-Schutzgruppe |
US5491164A (en) | 1994-09-29 | 1996-02-13 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
AU2722297A (en) | 1996-04-03 | 1997-10-22 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
WO1998010653A1 (en) | 1996-09-13 | 1998-03-19 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
BR9712544B1 (pt) | 1996-10-18 | 2013-10-22 | Inibidores de proteases de serina, composição farmacêutica compreendendo os mesmos e seus usos | |
AU5599898A (en) | 1996-12-12 | 1998-07-03 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
AU758160B2 (en) | 1997-08-22 | 2003-03-20 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives |
US6242422B1 (en) | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
DE60041584D1 (de) | 1999-07-28 | 2009-04-02 | Aventis Pharma Inc | Substituierte oxoazaheterozyclische verbindungen |
US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
JP4898044B2 (ja) | 1999-10-14 | 2012-03-14 | キュリス,インコーポレイテッド | ヘッジホッグシグナル伝達経路のメディエーター、それらと関連する組成物及び利用 |
WO2001034594A1 (en) | 1999-11-12 | 2001-05-17 | Guilford Pharmaceuticals, Inc. | Dipeptidyl peptidase iv inhibitors and methods of making and using dipeptidyl peptidase iv inhibitors |
WO2001062775A2 (en) | 2000-02-23 | 2001-08-30 | Zealand Pharma A/S | Novel antiarrhythmic peptides |
JP2003529594A (ja) | 2000-03-31 | 2003-10-07 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | Aβタンパク質産生の阻害剤としてのサクシノイルアミノ複素環 |
EP1276717A2 (en) | 2000-04-17 | 2003-01-22 | Idun Pharmaceuticals, Inc. | Inhibitors of the ice/ced-3 family of cysteine proteases |
WO2001083517A1 (en) | 2000-05-03 | 2001-11-08 | Tularik Inc. | Stat4 and stat6 binding dipeptide derivatives |
US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
AU2001276988B2 (en) | 2000-07-21 | 2007-01-25 | Dendreon Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
EP1301527A2 (en) | 2000-07-21 | 2003-04-16 | Corvas International, Inc. | Peptides as ns3-serine protease inhibitors of hepatitis c virus |
US20040060568A1 (en) | 2000-10-13 | 2004-04-01 | Henryk Dudek | Hedgehog antagonists, methods and uses related thereto |
FR2816838B1 (fr) * | 2000-11-17 | 2004-12-03 | Oreal | Utilisation de derives de l'acide 2-oxothiazolidine- 4-carboxylique comme agents prodesquamants |
JP2005506295A (ja) | 2001-02-22 | 2005-03-03 | ジーランド ファーマ アクティーゼルスカブ | 細胞間連絡促進化合物の新規医薬使用 |
EP1408986B1 (en) | 2001-05-08 | 2008-09-24 | Yale University | Proteomimetic compounds and methods |
MXPA04007163A (es) | 2002-01-23 | 2004-10-29 | Schering Corp | Compuestos de prolina como inhibidores de la proteasa serina ns3 para utilizarse en el tratamiento de la infeccion por el virus de la hepatitis c. |
WO2003072528A2 (en) | 2002-02-08 | 2003-09-04 | Idun Pharmaceuticals, Inc. | (substituted)acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
JP4541882B2 (ja) | 2002-07-02 | 2010-09-08 | ノバルティス アーゲー | Smacタンパク質のアポトーシスタンパク質阻害物質(iap)との結合に対するペプチド阻害剤 |
US20050256171A1 (en) * | 2002-07-26 | 2005-11-17 | Altana Pharma A G | Pyrrolidine derivatives as tryptase inhibitors |
WO2004020599A2 (en) | 2002-08-29 | 2004-03-11 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
US7632858B2 (en) | 2002-11-15 | 2009-12-15 | Bristol-Myers Squibb Company | Open chain prolyl urea-related modulators of androgen receptor function |
KR20050118708A (ko) | 2003-04-03 | 2005-12-19 | 메르크 파텐트 게엠베하 | 혈전-색전 질환의 치료에서 응고 인자 xa의 저해제로서사용하기 위한피롤리디노-1,2-디카르복시-1-(페닐아미드)-2-(4-(3-옥소-모르폴리노-4-일)-페닐아미드) 유도체 및 관련화합물 |
WO2004099134A2 (en) | 2003-05-05 | 2004-11-18 | Prosidion Ltd. | Glutaminyl based dp iv-inhibitors |
SI21507A (sl) * | 2003-05-16 | 2004-12-31 | LEK farmacevtska dru�ba d.d. | Postopek za pripravo spojin z ace inhibitornim delovanjem |
RS20060259A (en) | 2003-10-14 | 2008-08-07 | Intermune Inc., | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication |
CN1528745A (zh) | 2003-10-21 | 2004-09-15 | 山东大学 | 吡咯烷类基质金属蛋白酶抑制剂及其制备方法 |
JP2007525521A (ja) | 2004-02-27 | 2007-09-06 | シェーリング コーポレイション | C型肝炎ウイルスns3セリンプロテアーゼのインヒビターとしてのシクロブテンジオン基含有化合物 |
SI1725537T1 (sl) * | 2004-03-15 | 2011-11-30 | Janssen Pharmaceutica Nv | Nove spojine kot modulatorji opioidnih receptorjev |
EA012389B1 (ru) | 2004-03-30 | 2009-10-30 | Интермун, Инк. | Макроциклические соединения в качестве ингибиторов вирусной репликации |
EP1604977A1 (en) | 2004-06-02 | 2005-12-14 | Faust Pharmaceuticals | CIS pyrrolidinyl derivatives and their uses |
BRPI0513426A (pt) | 2004-07-16 | 2007-11-27 | Gilead Sciences Inc | processo de preparação de amino ácidos úteis na preparação de moduladores de receptores de peptìdeos |
US7820699B2 (en) | 2005-04-27 | 2010-10-26 | Hoffmann-La Roche Inc. | Cyclic amines |
PL1966130T3 (pl) * | 2005-12-23 | 2014-05-30 | Zealand Pharma As | Zmodyfikowane związki mimetyczne lizyny |
EP2468724B1 (en) | 2006-12-21 | 2015-11-18 | Zealand Pharma A/S | Synthesis of pyrrolidine compounds |
-
2007
- 2007-12-20 EP EP12159851.0A patent/EP2468724B1/en active Active
- 2007-12-20 ES ES12159851.0T patent/ES2558856T3/es active Active
- 2007-12-20 WO PCT/US2007/026002 patent/WO2008079266A2/en active Application Filing
- 2007-12-20 US US12/005,118 patent/US20080188545A1/en not_active Abandoned
- 2007-12-20 PL PL12159851T patent/PL2468724T3/pl unknown
- 2007-12-20 EP EP07867854A patent/EP2074087A2/en not_active Withdrawn
- 2007-12-20 DK DK12159851.0T patent/DK2468724T3/en active
- 2007-12-20 AR ARP070105792A patent/AR064626A1/es unknown
- 2007-12-21 TW TW096149203A patent/TW200833660A/zh unknown
-
2008
- 2008-01-02 PE PE2008000034A patent/PE20081400A1/es not_active Application Discontinuation
-
2010
- 2010-01-19 US US12/690,043 patent/US20100249207A1/en not_active Abandoned
-
2012
- 2012-08-23 US US13/593,110 patent/US8927590B2/en active Active
-
2014
- 2014-12-16 US US14/572,262 patent/US9469609B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20080188545A1 (en) | 2008-08-07 |
PL2468724T3 (pl) | 2016-05-31 |
US20130053344A1 (en) | 2013-02-28 |
DK2468724T3 (en) | 2016-02-22 |
EP2074087A2 (en) | 2009-07-01 |
US20100249207A1 (en) | 2010-09-30 |
WO2008079266A3 (en) | 2008-11-06 |
EP2468724B1 (en) | 2015-11-18 |
US20150322007A1 (en) | 2015-11-12 |
TW200833660A (en) | 2008-08-16 |
ES2558856T3 (es) | 2016-02-09 |
EP2468724A1 (en) | 2012-06-27 |
WO2008079266A2 (en) | 2008-07-03 |
US9469609B2 (en) | 2016-10-18 |
US8927590B2 (en) | 2015-01-06 |
PE20081400A1 (es) | 2008-10-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR064626A1 (es) | Sintesis de compuestos de pirrolidina | |
ES2524045T3 (es) | Nuevas amidas y tioamidas heteroaromáticas como plaguicidas | |
CO5580815A2 (es) | Derivados de adamantana, procesos para su preparacion y composiciones farmaceuticas que los contienen | |
PE20120911A1 (es) | Derivados de prolina como inhibidores de catepsina | |
AR056764A1 (es) | Aminopirimidinas utiles como inhibidores de quinasa | |
UY27317A1 (es) | Resolución de sal quiral | |
AR044874A1 (es) | Derivados de 4- cianopirazol-3 - carboxamida, su preparacion y su aplicacion en terapeutica | |
PE20040164A1 (es) | Mimeticos de glucocorticoides, procedimientos para su preparacion y composiciones farmaceuticas | |
ES2422204T3 (es) | Novedosos derivados de imidazolidin-2-ona como moduladores selectivos de receptor de andrógenos (SARMS) | |
PE20071100A1 (es) | Derivados de azepinoindol como agentes farmaceuticos | |
IN2012DN04853A (es) | ||
AR058546A1 (es) | Derivados de 2- adamantilurea como inhibidores selectivos de 11 beta - hsd1 | |
AR049401A1 (es) | Aza-biciclononanos | |
EA200970510A1 (ru) | Гетеромоноциклическое соединение и его применение | |
AR086590A1 (es) | Compuestos de ciclohexanona y herbicidas que los comprenden | |
PE20060570A1 (es) | Compuestos de quinazolina e isoquinolina piperidilo sustituidos como inhibidores de fosfodiesterasa pde-10 | |
AR053652A1 (es) | Derivados de indol como inhibidores de proteina quinasas. composiciones farmaceuticas | |
ES2531324T3 (es) | Intermedio para producir un derivado de gamma-aminoácido bicíclico | |
HN2005000239A (es) | Derivados de tetrahidroisoquinolilsulfonamidas, su preparacion y su utilizacion en terapeutica | |
PE20100144A1 (es) | Compuestos quimicos 293 | |
AR059184A1 (es) | Derivados de sulfonamidas, su preparacion y su aplicacion en tarapeutica | |
AR059296A1 (es) | Compuesto de l-tartrato de s-zopiclona y proceso para resolver los enantiomeros de zopiclona. | |
AR062797A1 (es) | Derivados de piperidina como inhibidores de renina, composiciones farmaceuticas. | |
CO5700747A2 (es) | Piperidinas novedosas como moduladores de quimoquina (ccr) | |
CO5570702A2 (es) | N-sulfonilo-4-metileneamino-3-hidroxilo-2-piridonas como agente antimicrobiano |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |