JP2012500855A - Pd−1アンタゴニストおよび感染性疾患を処置するための方法 - Google Patents
Pd−1アンタゴニストおよび感染性疾患を処置するための方法 Download PDFInfo
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- JP2012500855A JP2012500855A JP2011525158A JP2011525158A JP2012500855A JP 2012500855 A JP2012500855 A JP 2012500855A JP 2011525158 A JP2011525158 A JP 2011525158A JP 2011525158 A JP2011525158 A JP 2011525158A JP 2012500855 A JP2012500855 A JP 2012500855A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
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- AIDS & HIV (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9169408P | 2008-08-25 | 2008-08-25 | |
| US9170508P | 2008-08-25 | 2008-08-25 | |
| US9170908P | 2008-08-25 | 2008-08-25 | |
| US9150208P | 2008-08-25 | 2008-08-25 | |
| US61/091,709 | 2008-08-25 | ||
| US61/091,694 | 2008-08-25 | ||
| US61/091,705 | 2008-08-25 | ||
| US61/091,502 | 2008-08-25 | ||
| US14254809P | 2009-01-05 | 2009-01-05 | |
| US61/142,548 | 2009-01-05 | ||
| US16565209P | 2009-04-01 | 2009-04-01 | |
| US61/165,652 | 2009-04-01 | ||
| PCT/US2009/054970 WO2010098788A2 (en) | 2008-08-25 | 2009-08-25 | Pd-i antagonists and methods for treating infectious disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012500855A true JP2012500855A (ja) | 2012-01-12 |
| JP2012500855A5 JP2012500855A5 (enExample) | 2012-10-11 |
Family
ID=41349286
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011525158A Pending JP2012500855A (ja) | 2008-08-25 | 2009-08-25 | Pd−1アンタゴニストおよび感染性疾患を処置するための方法 |
| JP2011525157A Withdrawn JP2012500652A (ja) | 2008-08-25 | 2009-08-25 | 標的化共刺激ポリペプチドおよび癌を処置するための使用方法 |
| JP2011525159A Pending JP2012510429A (ja) | 2008-08-25 | 2009-08-25 | Pd−1アンタゴニストおよびその使用方法 |
| JP2015040548A Pending JP2015129172A (ja) | 2008-08-25 | 2015-03-02 | Pd−1アンタゴニストおよびその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011525157A Withdrawn JP2012500652A (ja) | 2008-08-25 | 2009-08-25 | 標的化共刺激ポリペプチドおよび癌を処置するための使用方法 |
| JP2011525159A Pending JP2012510429A (ja) | 2008-08-25 | 2009-08-25 | Pd−1アンタゴニストおよびその使用方法 |
| JP2015040548A Pending JP2015129172A (ja) | 2008-08-25 | 2015-03-02 | Pd−1アンタゴニストおよびその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20110223188A1 (enExample) |
| EP (4) | EP2328919A2 (enExample) |
| JP (4) | JP2012500855A (enExample) |
| KR (1) | KR20110074850A (enExample) |
| CN (2) | CN102203125A (enExample) |
| AU (1) | AU2009288289B2 (enExample) |
| BR (1) | BRPI0917891A2 (enExample) |
| CA (1) | CA2735006A1 (enExample) |
| EA (1) | EA201170375A1 (enExample) |
| IL (1) | IL211299A (enExample) |
| MX (1) | MX2011002250A (enExample) |
| WO (3) | WO2010098788A2 (enExample) |
| ZA (1) | ZA201101119B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012510429A (ja) * | 2008-08-25 | 2012-05-10 | アンプリミューン、インコーポレーテッド | Pd−1アンタゴニストおよびその使用方法 |
| JP2017525354A (ja) * | 2014-08-08 | 2017-09-07 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 高親和性pd−1薬剤とその使用方法 |
| JP2020534352A (ja) * | 2017-09-07 | 2020-11-26 | キュー バイオファーマ,インコーポレーテッド | コンジュゲーション部位を有するt細胞調節多量体ポリペプチド及びその使用方法 |
Families Citing this family (845)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1234031T (pt) | 1999-11-30 | 2017-06-26 | Mayo Foundation | B7-h1, uma nova molécula imunoregulatória |
| US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
| US7432351B1 (en) | 2002-10-04 | 2008-10-07 | Mayo Foundation For Medical Education And Research | B7-H1 variants |
| SI1781682T1 (sl) | 2004-06-24 | 2013-05-31 | Mayo Foundation For Medical Education And Research | B7-H5, so-stimulatorni polipeptid |
| PT3428191T (pt) | 2004-10-06 | 2024-12-30 | Mayo Found Medical Education & Res | B7-h1 e tratamento do carcinona de células renais |
| US8231872B2 (en) | 2005-04-25 | 2012-07-31 | The Trustees Of Dartmouth College | Regulatory T cell mediator proteins and uses thereof |
| EP2514762B1 (en) | 2007-07-13 | 2015-04-08 | The Johns Hopkins University | B7-DC variants |
| ES2741730T3 (es) | 2008-05-19 | 2020-02-12 | Advaxis Inc | Sistema de administración doble para antígenos heterólogos que comprende una cepa de Listeria recombinante atenuada por la mutación de dal/dat y la deleción de ActA que comprende una molécula de ácido nucleico que codifica una proteína de fusión de listeriolisina O - antígeno prostático específico |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| EP2927240A1 (en) | 2008-08-25 | 2015-10-07 | Amplimmune, Inc. | Compositions of pd-1 antagonists and methods of use |
| WO2010077634A1 (en) | 2008-12-09 | 2010-07-08 | Genentech, Inc. | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| JP5539411B2 (ja) * | 2009-03-04 | 2014-07-02 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 血管新生因子を含む組成物およびその使用方法 |
| AU2010229994B2 (en) | 2009-03-25 | 2016-08-18 | Genentech, Inc. | Anti-FGFR3 antibodies and methods using same |
| KR101495951B1 (ko) | 2009-03-30 | 2015-02-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 리포솜 조성물 |
| CN107252489A (zh) | 2009-04-13 | 2017-10-17 | 法国健康和医学研究院 | Hpv颗粒及其用途 |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| US20130017199A1 (en) * | 2009-11-24 | 2013-01-17 | AMPLIMMUNE ,Inc. a corporation | Simultaneous inhibition of pd-l1/pd-l2 |
| CA2794483C (en) * | 2010-03-26 | 2020-07-07 | Trustees Of Dartmouth College | Vista regulatory t cell mediator protein, vista binding agents and use thereof |
| US20150231215A1 (en) | 2012-06-22 | 2015-08-20 | Randolph J. Noelle | VISTA Antagonist and Methods of Use |
| US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
| HUE058787T2 (hu) * | 2010-05-05 | 2022-09-28 | Univ New York | Staphylococcus aureus leukocidinek, terápiás készítmények és azok felhasználása |
| WO2012138377A2 (en) | 2010-10-01 | 2012-10-11 | Trustees Of The University Of Pennsylvania | The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals |
| US9029315B2 (en) | 2010-11-11 | 2015-05-12 | The University Of Hong Kong | Soluble PD-1 variants, fusion constructs, and uses thereof |
| US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
| WO2012113413A1 (en) | 2011-02-21 | 2012-08-30 | Curevac Gmbh | Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates |
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| CA2840409A1 (en) | 2011-06-28 | 2013-01-03 | Whitehead Institute For Biomedical Research | Using sortases to install click chemistry handles for protein ligation |
| US9416132B2 (en) | 2011-07-21 | 2016-08-16 | Tolero Pharmaceuticals, Inc. | Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors |
| AR087405A1 (es) | 2011-08-01 | 2014-03-19 | Genentech Inc | Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1 e inhibidores de mek |
| BR112014009526B8 (pt) * | 2011-10-17 | 2023-01-17 | Herlev Hospital | Composição de vacina compreendendo pd-l1, kit de partes compreendendo tal composição e uso dos mesmos para tratar ou prevenir câncer |
| EP2825195A4 (en) | 2012-03-12 | 2015-10-07 | Advaxis Inc | INHIBITION OF SUPPRESSOR CELL FUNCTION AFTER TREATMENT WITH A LISTERIAL VACCINE |
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| EP2855528B1 (en) | 2012-05-31 | 2019-06-19 | Genentech, Inc. | Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists |
| TWI677507B (zh) * | 2012-06-22 | 2019-11-21 | 達特茅斯學院基金會 | 新穎之vista-ig構築體及vista-ig用於治療自體免疫、過敏及發炎病症之用途 |
| US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
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- 2009-08-25 JP JP2011525157A patent/JP2012500652A/ja not_active Withdrawn
- 2009-08-25 JP JP2011525159A patent/JP2012510429A/ja active Pending
- 2009-08-25 CN CN2009801423496A patent/CN102203125A/zh active Pending
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012510429A (ja) * | 2008-08-25 | 2012-05-10 | アンプリミューン、インコーポレーテッド | Pd−1アンタゴニストおよびその使用方法 |
| JP2017525354A (ja) * | 2014-08-08 | 2017-09-07 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 高親和性pd−1薬剤とその使用方法 |
| US10800830B2 (en) | 2014-08-08 | 2020-10-13 | The Board Of Trustees Of The Leland Stanford Junior University | High affinity PD-1 agents and methods of use |
| JP2020534352A (ja) * | 2017-09-07 | 2020-11-26 | キュー バイオファーマ,インコーポレーテッド | コンジュゲーション部位を有するt細胞調節多量体ポリペプチド及びその使用方法 |
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| WO2010027828A2 (en) | 2010-03-11 |
| WO2010098788A3 (en) | 2010-12-02 |
| IL211299A0 (en) | 2011-04-28 |
| EP2328919A2 (en) | 2011-06-08 |
| WO2010027827A3 (en) | 2010-05-06 |
| US20110223188A1 (en) | 2011-09-15 |
| EA201170375A1 (ru) | 2012-03-30 |
| WO2010027827A2 (en) | 2010-03-11 |
| ZA201101119B (en) | 2011-10-26 |
| JP2015129172A (ja) | 2015-07-16 |
| AU2009288289A1 (en) | 2010-03-11 |
| CN102203125A (zh) | 2011-09-28 |
| IL211299A (en) | 2014-01-30 |
| JP2012500652A (ja) | 2012-01-12 |
| CN104740610A (zh) | 2015-07-01 |
| EP2328920A2 (en) | 2011-06-08 |
| US20140227262A1 (en) | 2014-08-14 |
| BRPI0917891A2 (pt) | 2015-11-24 |
| EP2662383A1 (en) | 2013-11-13 |
| US20110159023A1 (en) | 2011-06-30 |
| WO2010027828A3 (en) | 2010-08-26 |
| MX2011002250A (es) | 2011-08-17 |
| CA2735006A1 (en) | 2010-03-11 |
| US20110195068A1 (en) | 2011-08-11 |
| EP2324055A2 (en) | 2011-05-25 |
| KR20110074850A (ko) | 2011-07-04 |
| AU2009288289B2 (en) | 2012-11-08 |
| JP2012510429A (ja) | 2012-05-10 |
| WO2010098788A2 (en) | 2010-09-02 |
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