JP2011080089A5 - - Google Patents
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- Publication number
- JP2011080089A5 JP2011080089A5 JP2011001566A JP2011001566A JP2011080089A5 JP 2011080089 A5 JP2011080089 A5 JP 2011080089A5 JP 2011001566 A JP2011001566 A JP 2011001566A JP 2011001566 A JP2011001566 A JP 2011001566A JP 2011080089 A5 JP2011080089 A5 JP 2011080089A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- polymer
- linear polymer
- soluble linear
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims 182
- 239000003814 drug Substances 0.000 claims 86
- 229940124597 therapeutic agent Drugs 0.000 claims 85
- 238000000034 method Methods 0.000 claims 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 50
- 150000001875 compounds Chemical class 0.000 claims 47
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 39
- 229920000858 Cyclodextrin Polymers 0.000 claims 19
- 125000005647 linker group Chemical group 0.000 claims 16
- 239000002243 precursor Substances 0.000 claims 14
- 239000002202 Polyethylene glycol Substances 0.000 claims 13
- 229920001223 polyethylene glycol Polymers 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 10
- 229940127093 camptothecin Drugs 0.000 claims 9
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 9
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 8
- 229960004853 betadex Drugs 0.000 claims 8
- 125000000524 functional group Chemical group 0.000 claims 8
- 229940024606 amino acid Drugs 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical group CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 239000001116 FEMA 4028 Substances 0.000 claims 5
- 229940034982 antineoplastic agent Drugs 0.000 claims 5
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 5
- 230000002209 hydrophobic effect Effects 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical group C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 229960004679 doxorubicin Drugs 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 229960004768 irinotecan Drugs 0.000 claims 4
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims 3
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 3
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 claims 3
- 229930012538 Paclitaxel Natural products 0.000 claims 3
- 229920000954 Polyglycolide Polymers 0.000 claims 3
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 claims 3
- 150000001266 acyl halides Chemical class 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims 3
- 150000008064 anhydrides Chemical class 0.000 claims 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 3
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 125000000743 hydrocarbylene group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 3
- 230000000269 nucleophilic effect Effects 0.000 claims 3
- 229920001542 oligosaccharide Polymers 0.000 claims 3
- 150000002482 oligosaccharides Chemical group 0.000 claims 3
- 150000007530 organic bases Chemical class 0.000 claims 3
- 229960001592 paclitaxel Drugs 0.000 claims 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims 3
- 229920002643 polyglutamic acid Polymers 0.000 claims 3
- 239000004633 polyglycolic acid Substances 0.000 claims 3
- 239000004626 polylactic acid Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
- 229960000303 topotecan Drugs 0.000 claims 3
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 3
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 2
- 239000005977 Ethylene Substances 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 229920002873 Polyethylenimine Polymers 0.000 claims 2
- 230000018199 S phase Effects 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 230000022131 cell cycle Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 238000000502 dialysis Methods 0.000 claims 2
- 230000002255 enzymatic effect Effects 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 2
- 125000003827 glycol group Chemical group 0.000 claims 2
- 230000007062 hydrolysis Effects 0.000 claims 2
- 238000006460 hydrolysis reaction Methods 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 2
- 238000006116 polymerization reaction Methods 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 229930183010 Amphotericin Natural products 0.000 claims 1
- QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 claims 1
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 229940009444 amphotericin Drugs 0.000 claims 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 239000012867 bioactive agent Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- -1 cofactor Substances 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 claims 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 150000002466 imines Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 238000006068 polycondensation reaction Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000004952 protein activity Effects 0.000 claims 1
- 239000000018 receptor agonist Substances 0.000 claims 1
- 229940044601 receptor agonist Drugs 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 125000002345 steroid group Chemical class 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40885502P | 2002-09-06 | 2002-09-06 | |
| US60/408,855 | 2002-09-06 | ||
| US42283002P | 2002-10-31 | 2002-10-31 | |
| US60/422,830 | 2002-10-31 | ||
| US45199803P | 2003-03-04 | 2003-03-04 | |
| US60/451,998 | 2003-03-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004569982A Division JP2006502301A (ja) | 2002-09-06 | 2003-09-04 | 治療剤配送のためのシクロデキストリン基材重合体 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012004159A Division JP5681646B2 (ja) | 2002-09-06 | 2012-01-12 | 治療剤配送のためのシクロデキストリン基材重合体 |
| JP2014108845A Division JP5934743B2 (ja) | 2002-09-06 | 2014-05-27 | 治療剤配送のためのシクロデキストリン基材重合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011080089A JP2011080089A (ja) | 2011-04-21 |
| JP2011080089A5 true JP2011080089A5 (enExample) | 2012-06-14 |
| JP5586487B2 JP5586487B2 (ja) | 2014-09-10 |
Family
ID=31982363
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004569982A Withdrawn JP2006502301A (ja) | 2002-09-06 | 2003-09-04 | 治療剤配送のためのシクロデキストリン基材重合体 |
| JP2011001566A Expired - Lifetime JP5586487B2 (ja) | 2002-09-06 | 2011-01-06 | 治療剤配送のためのシクロデキストリン基材重合体 |
| JP2012004159A Expired - Lifetime JP5681646B2 (ja) | 2002-09-06 | 2012-01-12 | 治療剤配送のためのシクロデキストリン基材重合体 |
| JP2014108845A Expired - Lifetime JP5934743B2 (ja) | 2002-09-06 | 2014-05-27 | 治療剤配送のためのシクロデキストリン基材重合体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004569982A Withdrawn JP2006502301A (ja) | 2002-09-06 | 2003-09-04 | 治療剤配送のためのシクロデキストリン基材重合体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012004159A Expired - Lifetime JP5681646B2 (ja) | 2002-09-06 | 2012-01-12 | 治療剤配送のためのシクロデキストリン基材重合体 |
| JP2014108845A Expired - Lifetime JP5934743B2 (ja) | 2002-09-06 | 2014-05-27 | 治療剤配送のためのシクロデキストリン基材重合体 |
Country Status (17)
| Country | Link |
|---|---|
| US (20) | US7270808B2 (enExample) |
| EP (4) | EP3332811A1 (enExample) |
| JP (4) | JP2006502301A (enExample) |
| KR (6) | KR20140070676A (enExample) |
| CN (2) | CN102516417B (enExample) |
| AT (1) | ATE533513T1 (enExample) |
| AU (2) | AU2003278764C1 (enExample) |
| BR (2) | BRPI0314042B8 (enExample) |
| CA (1) | CA2497792C (enExample) |
| CY (2) | CY1112362T1 (enExample) |
| ES (3) | ES2377318T3 (enExample) |
| HK (1) | HK1254600A1 (enExample) |
| IL (2) | IL234716A0 (enExample) |
| MX (2) | MXPA05002444A (enExample) |
| PT (2) | PT2277551E (enExample) |
| TW (2) | TWI422379B (enExample) |
| WO (1) | WO2004022099A2 (enExample) |
Families Citing this family (230)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8106098B2 (en) * | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| US7141540B2 (en) | 2001-11-30 | 2006-11-28 | Genta Salus Llc | Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof |
| WO2003059988A2 (en) | 2002-01-14 | 2003-07-24 | The General Hospital Corporation | Biodegradable polyketal polymers and methods for their formation and use |
| CA2492803C (en) | 2002-07-19 | 2013-11-05 | The General Hospital Corporation | Oxime conjugates and methods for their formation and use |
| KR20140070676A (ko) | 2002-09-06 | 2014-06-10 | 인설트 테라페틱스, 인코퍼레이티드 | 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체 |
| BR0315198A (pt) * | 2002-10-09 | 2005-08-30 | Insert Therapeutics Inc | Materiais e composições à base de ciclodextrina e usos relacionados aos mesmos |
| SG129240A1 (en) * | 2003-01-23 | 2007-02-26 | Agency Science Tech & Res | Biodegradable copolymer and nucleic acid delivery system |
| JP4009721B2 (ja) * | 2003-05-23 | 2007-11-21 | 独立行政法人産業技術総合研究所 | イオン結合性ポリマー含有基板、該基板を含有する検出用センサー及び病原菌又は病原菌が生産する毒素の検出方法 |
| AU2004270251B2 (en) * | 2003-09-05 | 2011-03-31 | The General Hospital Corporation | Polyacetal drug conjugates as release system |
| US6960300B2 (en) * | 2003-09-08 | 2005-11-01 | Sami Labs Limited | Process for preparing water soluble diterpenes and their applications |
| US8394365B2 (en) | 2003-09-17 | 2013-03-12 | Nektar Therapeutics | Multi-arm polymer prodrugs |
| CN1852740B (zh) * | 2003-09-17 | 2011-05-11 | 耐科塔医药公司 | 多支链聚合物的药物前体 |
| JP5138938B2 (ja) | 2003-12-19 | 2013-02-06 | プレキシコン インコーポレーテッド | Ｒｅｔ調節剤の開発のための化合物および方法 |
| WO2005103068A2 (en) * | 2004-04-23 | 2005-11-03 | Novexin Limited | Methods and kits for folding proteins in the presence of linear or branched sugar polymers |
| US8128954B2 (en) | 2004-06-07 | 2012-03-06 | California Institute Of Technology | Biodegradable drug-polymer delivery system |
| US7498342B2 (en) * | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| CN101098854B (zh) | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
| EP1807092B1 (en) | 2004-11-05 | 2016-09-07 | The Children's Hospital of Philadelphia | Biodegradable linkers for molecular therapies |
| TW200640493A (en) * | 2005-02-16 | 2006-12-01 | Insert Therapeutics Inc | Cyclodextrin-based polymers for therapeutics delivery |
| PL1866414T3 (pl) | 2005-03-31 | 2012-10-31 | Calando Pharmaceuticals Inc | Inhibitory podjednostki 2 reduktazy rybonukleotydowej i ich zastosowania |
| AU2006272951A1 (en) * | 2005-05-17 | 2007-02-01 | Plexxikon, Inc. | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
| MY153898A (en) * | 2005-06-22 | 2015-04-15 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| WO2007009265A1 (en) * | 2005-07-22 | 2007-01-25 | The Governors Of The University Of Alberta Tec Edmonton | NOVEL β-CYCLODEXTRIN-BASED MOLECULES AND DRUG DELIVERY COMPOSITIONS |
| GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| CA2621275A1 (en) * | 2005-09-07 | 2007-03-15 | Plexxikon, Inc. | 1 , 4 and 1 , 5-disubstituted indole derivatives for use as ppar active compounds |
| CA2621406A1 (en) * | 2005-09-07 | 2007-03-15 | Plexxikon, Inc. | Pparactive compounds |
| CA2621474A1 (en) * | 2005-09-07 | 2007-03-15 | Plexxikon, Inc. | 1,3-disubstituted indole derivatives for use as ppar modulators |
| US20080275139A1 (en) * | 2005-12-19 | 2008-11-06 | Capsutech Ltd. | Cyclodextrin-Containing Polymers and Uses Thereof |
| US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| US8232427B2 (en) | 2006-03-29 | 2012-07-31 | Novartis Ag | Selective hydroxamate based MMP inhibitors |
| US20080027212A1 (en) * | 2006-06-28 | 2008-01-31 | Skinner Keith K | Methods and compositions for improved uptake of biological molecules |
| CA2657258A1 (en) | 2006-07-20 | 2008-01-24 | Novartis Ag | Amino-piperidine derivatives as cetp inhibitors |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| MX2009005780A (es) | 2006-11-30 | 2009-06-10 | Nektar Therapeutics Al Corp | Metodo para preparar un conjugado de polimeros. |
| TW201509433A (zh) * | 2006-12-13 | 2015-03-16 | 斯茹林製藥公司 | 用於醫物傳遞之以環糊精為基之聚合物 |
| WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| RU2009122670A (ru) | 2006-12-21 | 2011-01-27 | Плекссикон, Инк. (Us) | Соединения и способы для модуляции киназ и показания к их применению |
| PE20121126A1 (es) * | 2006-12-21 | 2012-08-24 | Plexxikon Inc | Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa |
| US20080176958A1 (en) | 2007-01-24 | 2008-07-24 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
| MX2009008549A (es) * | 2007-02-09 | 2009-08-18 | Enzon Pharmaceuticals Inc | Tratamiento de canceres resistentes o refractarios con conjugados polimericos de brazos multiples de 7-etil-10-hidroxicamptotecina. |
| PE20090159A1 (es) * | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
| CN104127878A (zh) | 2007-03-14 | 2014-11-05 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| BRPI0812970A2 (pt) | 2007-06-25 | 2019-09-24 | Endocyte Inc | conjugados contendo espaçadores hidrofílicos |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| JP2010533729A (ja) | 2007-07-17 | 2010-10-28 | プレキシコン，インコーポレーテッド | キナーゼ調節のための化合物と方法、及びそのための適応 |
| TW200918099A (en) * | 2007-09-14 | 2009-05-01 | Nitto Denko Corp | Drug carriers |
| EP2194068B1 (en) * | 2007-09-28 | 2013-04-17 | Nanodex INC. | Cyclodextrin compound modified with folic acid, process for production thereof, drug delivery agent for targeting drug delivery system, pharmaceutical composition, and imaging agent |
| EP2200649A4 (en) | 2007-10-19 | 2012-09-26 | Univ California | COMPOSITIONS AND METHODS FOR TREATING CNS INFUSION, PSYCHOSIS, DELIRE, PTSD OR PTSS |
| PL2207775T3 (pl) | 2007-11-05 | 2012-08-31 | Novartis Ag | Pochodne 4-benzyloamino-1-karboksyacylo-piperydyny jako inhibitory CETP użyteczne do leczenia chorób, takich jak hiperlipidemia lub stwardnienie tętnic |
| AU2008333272B2 (en) | 2007-12-03 | 2012-03-29 | Novartis Ag | 1,2-disubstituted-4-benzylamino-pyrrolidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperli pidemia or arteriosclerosis |
| ES2524259T3 (es) | 2008-03-24 | 2014-12-04 | Novartis Ag | Inhibidores de metaloproteinasa de matriz a base de arilsulfonamida |
| EP2269072B1 (en) * | 2008-03-31 | 2017-08-23 | Boston Medical Center Corporation | Predictive marker for topoisomerase i inhibitors |
| JP2011516065A (ja) | 2008-04-04 | 2011-05-26 | カランド ファーマシューティカルズ， インコーポレイテッド | Ｅｐａｓ１阻害剤の組成物および使用 |
| US8158636B2 (en) | 2008-05-19 | 2012-04-17 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| PE20091846A1 (es) * | 2008-05-19 | 2009-12-16 | Plexxikon Inc | DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS |
| US8110576B2 (en) * | 2008-06-10 | 2012-02-07 | Plexxikon Inc. | Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications |
| CN104530052A (zh) * | 2008-06-10 | 2015-04-22 | 普莱希科公司 | 用于激酶调节的5h-吡咯[2,3-b]吡嗪衍生物和其适应症 |
| KR101671537B1 (ko) * | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| ES2915692T3 (es) * | 2008-08-13 | 2022-06-24 | California Inst Of Techn | Nanopartículas portadoras y composiciones, métodos y sistemas relacionados |
| TW201010732A (en) * | 2008-08-29 | 2010-03-16 | Enzon Pharmaceuticals Inc | Method of treating RAS associated cancer |
| US20100068266A1 (en) | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo-modifiable multiple-release state final dosage form |
| US20100068275A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Personalizable dosage form |
| US20100068153A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo activatable final dosage form |
| MX2011003063A (es) | 2008-09-23 | 2011-04-21 | Nektar Therapeutics | Composiciones y metodos para lograr concentraciones terapeuticas de farmaco sostenidas en un individuo. |
| US20100098654A1 (en) * | 2008-10-21 | 2010-04-22 | Fabio Pastorino | Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| EP2359852A4 (en) * | 2008-11-17 | 2015-05-20 | Nat Cancer Ct | NEW CANCERED THERAPY WITH A SUBSTANCE COMPLEX SPECIFICALLY BINDING TO A TUMOR STREAM FACTOR AND ANTITUMIR COMPOUND |
| AR074584A1 (es) * | 2008-12-10 | 2011-01-26 | Mersana Therapeutics Inc | Formulaciones farmaceuticas de conjugados camtotecina-polimero biocompatibles biodegradables |
| US8309530B2 (en) * | 2009-02-04 | 2012-11-13 | Washington State University | Compositions and methods for modulating ghrelin-mediated conditions |
| EP2401225B1 (en) | 2009-02-26 | 2014-10-22 | The Regents of The University of California | A supramolecular approach for preparation of size controllable nanoparticles |
| AR075812A1 (es) | 2009-03-11 | 2011-04-27 | Plexxikon Inc | Derivados de pirrol[2,3-b]piridina como inhibidores de raf quinasa |
| AR076105A1 (es) * | 2009-03-11 | 2011-05-18 | Plexxikon Inc | Derivados pirrol[2,3-b]piridina para inhibir la raf quinasa |
| CA2738573C (en) * | 2009-04-03 | 2013-02-19 | F. Hoffmann-La Roche Ag | Compositions of propane-1 sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and uses thereof |
| TW201041888A (en) * | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| US20120077774A1 (en) * | 2009-05-28 | 2012-03-29 | Cornell University | Compositions and their use for removing cholesterol |
| JP5747432B2 (ja) * | 2009-05-28 | 2015-07-15 | 国立大学法人秋田大学 | ２置換修飾シクロデキストリンおよびこれを用いた核酸検出方法 |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| WO2011031865A1 (en) * | 2009-09-09 | 2011-03-17 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
| EA201200486A1 (ru) * | 2009-09-15 | 2012-08-30 | Серулин Фарма Инк. | Лечение онкологических заболеваний |
| US20120114658A1 (en) * | 2009-09-15 | 2012-05-10 | John Ryan | Treatment of cancer |
| US8460745B2 (en) * | 2009-09-20 | 2013-06-11 | Medtronic Vascular, Inc. | Apparatus and methods for loading a drug eluting medical device |
| JP2013510166A (ja) * | 2009-11-06 | 2013-03-21 | プレキシコン インコーポレーテッド | キナーゼ調節のための化合物、方法およびその適用 |
| EP2501236B1 (en) | 2009-11-18 | 2017-03-29 | Plexxikon Inc. | N-[2-fluoro-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-4-benzenesulfonamide derivatives as Raf protein kinase modulators for the treatment of cancer |
| BR112012012210B8 (pt) * | 2009-11-23 | 2021-05-25 | Cerulean Pharma Inc | conjugado de (cdp)-taxano de polímero contendo ciclodextrina, composição, composição farmacêutica, forma de dosagem, kit e uso de um conjugado de cdp-taxano |
| CA2784393A1 (en) | 2009-12-23 | 2011-06-30 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US20120004195A1 (en) * | 2010-01-19 | 2012-01-05 | Alexandra Glucksmann | Cyclodextrin-based polymers for therapeutic delivery |
| WO2011090940A1 (en) * | 2010-01-19 | 2011-07-28 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
| JP2011190341A (ja) * | 2010-03-15 | 2011-09-29 | Nano Dex Kk | シクロデキストリン化合物 |
| US8207290B2 (en) | 2010-03-26 | 2012-06-26 | Cerulean Pharma Inc. | Methods and systems for generating nanoparticles |
| US8349308B2 (en) | 2010-03-26 | 2013-01-08 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| US20110237686A1 (en) | 2010-03-26 | 2011-09-29 | Cerulean Pharma Inc | Formulations and methods of use |
| US20120064107A1 (en) * | 2010-05-18 | 2012-03-15 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other disease |
| CA2927832C (en) * | 2010-05-18 | 2021-03-23 | Cerulean Pharma Inc. | Cyclodextrin-containing polymer-therapeutic agent conjugates and their use |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US20120213854A1 (en) * | 2010-09-30 | 2012-08-23 | Fetzer Oliver S | Methods of treating a subject and related particles, polymers and compositions |
| EP2857499A1 (en) | 2010-10-01 | 2015-04-08 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| WO2012092339A2 (en) * | 2010-12-28 | 2012-07-05 | The Children's Hospital Of Philadelphia | The design of hydrolytically releasable prodrugs for sustained release nanoparticle formulations |
| US8546521B2 (en) | 2011-01-28 | 2013-10-01 | Cerulean Pharma Inc. | Method for fabricating nanoparticles |
| PE20141360A1 (es) | 2011-02-07 | 2014-10-13 | Plexxikon Inc | Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos. |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US20120302505A1 (en) * | 2011-04-21 | 2012-11-29 | Fetzer Oliver S | Cyclodextrin-based polymers for therapeutic delivery |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| PT3682905T (pt) | 2011-10-03 | 2022-04-07 | Modernatx Inc | Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações |
| ES2923757T3 (es) | 2011-12-16 | 2022-09-30 | Modernatx Inc | Composiciones de ARNm modificado |
| HK1207562A1 (en) | 2012-01-18 | 2016-02-05 | 苏州泰飞尔医药有限公司 | High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions |
| HK1205156A1 (en) * | 2012-01-31 | 2015-12-11 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| WO2013137627A1 (ko) * | 2012-03-13 | 2013-09-19 | 포항공과대학교 산학협력단 | 방출 제어가 가능한 약물 전달 복합체, 및 이의 이용 |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9598503B2 (en) * | 2012-04-18 | 2017-03-21 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| US9827321B2 (en) | 2012-08-14 | 2017-11-28 | The Trustees Of The University Of Pennsylvania | Stabilizing shear-thinning hydrogels |
| JP6318156B2 (ja) | 2012-09-06 | 2018-04-25 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | キナーゼをモジュレートするための化合物および方法、ならびにその指標 |
| WO2014055493A1 (en) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
| EA201590622A1 (ru) | 2012-10-16 | 2015-10-30 | Эндосайт, Инк. | Конъюгаты для доставки лекарственного средства, содержащие не встречающиеся в природе аминокислоты, и способы применения |
| WO2014070233A1 (en) | 2012-10-29 | 2014-05-08 | Boston Medical Center Corporation | Brca1 mutations as predictive markers for topoisomerase i inhibitors |
| PT2922554T (pt) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Arn modificado nas porções terminais |
| WO2014093343A2 (en) * | 2012-12-10 | 2014-06-19 | Massachusetts Institute Of Technology | Multistage nanoparticle drug delivery system for the treatment of solid tumors |
| CN103044349B (zh) * | 2012-12-13 | 2014-05-21 | 浙江大学 | 一种微波辅助纳米铁酸盐制备乙二胺四乙酸酐的方法 |
| ME03000B (me) | 2012-12-21 | 2018-10-20 | Plexxikon Inc | Jedinjenja i metode modulacije kinaze i povezane indikacije |
| JP6309980B2 (ja) * | 2013-02-25 | 2018-04-11 | ユニバーシティ オブ ロチェスター | 抗バイオフィルム剤を制御放出するためのナノ粒子及びその使用方法 |
| US9132097B2 (en) | 2013-03-01 | 2015-09-15 | California Institute Of Technology | Nanoparticles stabilized with nitrophenylboronic acid compositions |
| US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
| US10258698B2 (en) | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US20140302516A1 (en) | 2013-03-14 | 2014-10-09 | University Of Washington Through Its Center For Commercialization | Polymer dot compositions and related methods |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| CN105073747B (zh) | 2013-03-15 | 2017-06-06 | 普莱希科公司 | 杂环化合物及其应用 |
| RU2015149937A (ru) | 2013-05-30 | 2017-07-06 | Плексксикон Инк. | Соединения для модулирования киназы и показания к их применению |
| US20160178610A1 (en) | 2013-08-07 | 2016-06-23 | Friedrich Miescher Institute For Biomedical Research | New screening method for the treatment Friedreich's ataxia |
| CA2923029A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| WO2015066532A1 (en) | 2013-11-01 | 2015-05-07 | Daniel Brady | Two-part accommodating intraocular lens device |
| US9771369B2 (en) | 2014-03-04 | 2017-09-26 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2015179402A1 (en) * | 2014-05-19 | 2015-11-26 | North Carolina State University | Methods of folding a graft copolymer with dual anticancer drugs and related applications |
| CN110478495A (zh) | 2014-06-30 | 2019-11-22 | 塔弗达治疗有限公司 | 靶向缀合物及其颗粒和制剂 |
| WO2016011226A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| EP3171895A1 (en) | 2014-07-23 | 2017-05-31 | Modernatx, Inc. | Modified polynucleotides for the production of intrabodies |
| US10004596B2 (en) | 2014-07-31 | 2018-06-26 | Lensgen, Inc. | Accommodating intraocular lens device |
| ES2774177T3 (es) | 2014-09-15 | 2020-07-17 | Plexxikon Inc | Compuestos heterocíclicos y usos de estos |
| CN104274837B (zh) * | 2014-09-18 | 2017-01-11 | 福格森（武汉）生物科技股份有限公司 | 一种尼洛替尼口服制剂 |
| CN104311820B (zh) * | 2014-09-24 | 2017-06-20 | 北京化工大学 | 一种基于多糖接枝聚天冬氨酸苄酯构建可降解药物载体的方法 |
| US10160755B2 (en) | 2015-04-08 | 2018-12-25 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| TWI547308B (zh) * | 2015-06-10 | 2016-09-01 | 聚和國際股份有限公司 | 聚電解質膠囊的製備方法及所製得的聚電解質膠囊 |
| EP3317323B1 (en) | 2015-07-01 | 2021-05-26 | California Institute of Technology | Cationic mucic acid polymer-based delivery systems |
| WO2017006279A1 (en) * | 2015-07-08 | 2017-01-12 | Aten Porus Lifesciences | Cyclodextrin-polymer complexes and compostions and methods of making and using the same |
| CN113679689B (zh) | 2015-07-22 | 2023-09-01 | 日东电工株式会社 | 用于纳米粒冷冻干燥物形式的组合物及方法 |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US11458205B2 (en) | 2015-08-04 | 2022-10-04 | Duke University | Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same |
| HK1255102A1 (zh) | 2015-09-21 | 2019-08-02 | Plexxikon Inc. | 杂环化合物及其应用 |
| CN108473538B (zh) | 2015-10-28 | 2022-01-28 | 塔弗达治疗有限公司 | Sstr靶向缀合物及其颗粒和制剂 |
| US12514872B2 (en) | 2015-11-04 | 2026-01-06 | Duke University | Polycationic polymers for use in treating and detecting cancer |
| AU2016362384B2 (en) | 2015-12-01 | 2021-10-07 | Lensgen, Inc. | Accommodating intraocular lens device |
| US20180271998A1 (en) | 2015-12-04 | 2018-09-27 | Merrimack Pharmaceuticals, Inc. | Disulfide-stabilized fabs |
| EP3389720A1 (en) | 2015-12-18 | 2018-10-24 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
| US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
| EP3405501B1 (en) * | 2016-01-21 | 2023-11-15 | Aten Porus Lifesciences | Cyclodextrin based polymers, methods, compositions and applications thereof |
| WO2017176796A1 (en) | 2016-04-04 | 2017-10-12 | University Of Virginia Patent Foundation | Compositions and methods for preventing and treating disease |
| WO2017210476A1 (en) | 2016-06-01 | 2017-12-07 | Duke University | Nonfouling biosensors |
| CN109715196A (zh) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | 用于促进免疫细胞功能的组合物和方法 |
| EP3512868A4 (en) | 2016-09-14 | 2020-04-15 | Duke University | NANOPARTICLES BASED ON TRIBLOCK POLYPEPTIDE FOR THE DELIVERY OF HYDROPHILIC DRUGS |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| KR20190064600A (ko) | 2016-09-23 | 2019-06-10 | 듀크 유니버시티 | Lcst 거동을 갖는 비구조화된 비-반복적 폴리펩티드 |
| CA3042428A1 (en) | 2016-11-08 | 2018-05-17 | Regeneron Pharmaceuticals, Inc. | Steroids and protein-conjugates thereof |
| WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
| US12447464B2 (en) | 2016-12-22 | 2025-10-21 | Duke University | Polycationic microfibers and methods of using the same |
| JP7193460B2 (ja) | 2016-12-23 | 2022-12-20 | プレキシコン インコーポレーテッド | Ｃｄｋ８調節およびその適応症のための化合物および方法 |
| CA3048785A1 (en) | 2017-01-03 | 2018-07-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto |
| US11648200B2 (en) | 2017-01-12 | 2023-05-16 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
| AU2018247167B2 (en) | 2017-03-28 | 2024-05-16 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto |
| WO2018213320A1 (en) | 2017-05-15 | 2018-11-22 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
| KR20250008984A (ko) | 2017-05-18 | 2025-01-16 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| WO2018226846A1 (en) | 2017-06-07 | 2018-12-13 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| EP3658168A4 (en) | 2017-06-30 | 2021-07-14 | Duke University | ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-RESPONDING BIOPOLYMER NETWORKS |
| US10716858B2 (en) | 2017-06-30 | 2020-07-21 | Massachusetts Institute Of Technology | Branched multi-functional macromonomers and uses thereof |
| WO2019090205A1 (en) | 2017-11-06 | 2019-05-09 | Snap Bio, Inc. | Pim kinase inhibitor compositions, methods, and uses thereof |
| CA3247730A1 (en) | 2017-11-07 | 2025-10-30 | Regeneron Pharmaceuticals, Inc. | Hydrophilic linkers for antibody drug conjugates |
| CN111491982B (zh) | 2017-11-15 | 2023-04-18 | 北卡罗来纳大学查佩尔希尔分校 | 作为抗菌支架的一氧化氮释放型超支化化合物及其相关方法 |
| MA50259A1 (fr) | 2018-01-08 | 2021-07-29 | Regeneron Pharma | Stéroïdes et leurs conjugués-anticorps |
| WO2019147954A1 (en) | 2018-01-26 | 2019-08-01 | Duke University | Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same |
| WO2019173539A1 (en) | 2018-03-06 | 2019-09-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto |
| US11149011B2 (en) | 2018-03-20 | 2021-10-19 | Plexxikon Inc. | Compounds and methods for IDO and TDO modulation, and indications therefor |
| WO2019213150A1 (en) * | 2018-04-30 | 2019-11-07 | Duke University | Stimuli-responsive peg-like polymer-based drug delivery platform |
| WO2019217591A1 (en) | 2018-05-09 | 2019-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-msr1 antibodies and methods of use thereof |
| US20190381188A1 (en) | 2018-06-13 | 2019-12-19 | California Institute Of Technology | Nanoparticles For Crossing The Blood Brain Barrier And Methods Of Treatment Using The Same |
| EP3829622A4 (en) | 2018-08-02 | 2022-05-11 | Duke University | DOUBLE AGONIST FUSION PROTEINS |
| US10988491B2 (en) | 2018-08-17 | 2021-04-27 | Massachusetts Institute Of Technology | Degradable polymers of a cyclic silyl ether and uses thereof |
| WO2020051541A1 (en) | 2018-09-07 | 2020-03-12 | Duke University | Nanoparticulate drug delivery systems |
| JP7645546B2 (ja) | 2018-12-28 | 2025-03-14 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 一酸化窒素放出抗菌性ポリマーおよびそれから製造された足場、ならびにそれに関する方法 |
| CN112512494B (zh) * | 2018-12-29 | 2024-03-15 | 瓦克化学股份公司 | 亲水性的含环糊精的有机硅凝胶 |
| WO2020160382A1 (en) * | 2019-01-31 | 2020-08-06 | Northwestern University | Supramolecular photoprotection of a photosensitizer |
| JP7636646B2 (ja) | 2019-04-09 | 2025-02-27 | オプナ バイオ ソシエテ アノニム | Ｅｐ３００またはｃｂｐの調節のための縮合アジンおよびその適応 |
| EP3972982A1 (en) | 2019-05-20 | 2022-03-30 | Massachusetts Institute of Technology | Boronic ester prodrugs and uses thereof |
| US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
| WO2021113625A1 (en) | 2019-12-06 | 2021-06-10 | Plexxikon Inc. | Compounds and methods for cd73 modulation and indications therefor |
| KR102904096B1 (ko) * | 2019-12-06 | 2025-12-24 | (주) 에이치엔에이파마켐 | 공유결합성 유기 골격체 및 폴리머를 이용한 경피전달용 복합체 |
| WO2021141662A1 (en) | 2020-01-10 | 2021-07-15 | Massachusetts Institute Of Technology | Proteolysis targeting chimeric molecules (protacs) with functional handles and uses thereof |
| CN111443068B (zh) * | 2020-03-06 | 2023-06-27 | 天津大学 | 具有多重刺激响应特性的纯有机室温磷光材料及筛选方法和应用 |
| TW202204354A (zh) | 2020-04-02 | 2022-02-01 | 美商普雷辛肯公司 | 用於ｃｓｋ調節之化合物及方法以及其說明 |
| JP7842698B2 (ja) | 2020-04-23 | 2026-04-08 | オプナ バイオ ソシエテ アノニム | Ｃｄ７３調節のための化合物及び方法並びにそれらの表示 |
| AU2021263383A1 (en) | 2020-04-29 | 2022-11-24 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| NL2025818B1 (en) * | 2020-06-11 | 2022-02-16 | Umc Utrecht Holding Bv | Improved adhesive drug carrier |
| CA3187357A1 (en) * | 2020-06-15 | 2021-12-23 | Nanosynthons Llc | Excipients providing stabilization and enhanced water solubilization and their uses |
| EP4192509A1 (en) | 2020-08-05 | 2023-06-14 | Ellipses Pharma Ltd | Treatment of cancer using a cyclodextrin-containing polymer-topoisomerase inhibitor conjugate and a parp inhibitor |
| WO2022061251A1 (en) | 2020-09-18 | 2022-03-24 | Plexxikon Inc. | Compounds and methods for kras modulation and indications therefor |
| CN112755197B (zh) * | 2020-10-09 | 2023-01-13 | 黑龙江大学 | 一种环糊精药物包合物及其制备方法和应用 |
| WO2022159319A2 (en) * | 2021-01-19 | 2022-07-28 | Mountain Valley Md Inc | A porous aluminum nanoparticulate structure |
| CA3206549A1 (en) | 2021-01-29 | 2022-08-04 | Frederick G. Vogt | Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy |
| CN115160454A (zh) * | 2021-04-01 | 2022-10-11 | 四川大学 | 一种基于聚-β-环糊精与金刚烷主客体作用的超分子多醛化合物及其制备方法 |
| CN113274541A (zh) * | 2021-05-10 | 2021-08-20 | 四川大学 | 一种抗菌型胶原基医用材料及其制备方法 |
| CN117956996A (zh) | 2021-05-11 | 2024-04-30 | Opna 生物公司 | 用于yap/tead调节的化合物和方法及其适应证 |
| KR20230050084A (ko) * | 2021-10-07 | 2023-04-14 | 주식회사 셀진 | Plga 및 약물을 함유하는 베타-사이클로덱스트린을 포함하는 약물 전달체 |
| MX2024007452A (es) * | 2021-12-15 | 2024-07-09 | Sillajen Inc | Composiciones farmaceuticas que comprenden beta-ciclodextrinas modificadas. |
| EP4469065A1 (en) | 2022-01-28 | 2024-12-04 | Iovance Biotherapeutics, Inc. | Cytokine associated tumor infiltrating lymphocytes compositions and methods |
| CN114470237B (zh) * | 2022-03-21 | 2023-12-19 | 中国科学院长春应用化学研究所 | 一种类病毒结构基因载体、药物递送系统、其制备方法及其应用 |
| CN115006549B (zh) * | 2022-06-16 | 2024-07-05 | 湖南科技大学 | 一种粒径可控及可控降解的酸敏型交联环糊精纳米水凝胶药物递送系统的制备方法 |
| CN115340615B (zh) * | 2022-08-12 | 2023-05-02 | 同济大学 | 一种基于环糊精-氨基酸的荧光分子及其合成方法与应用 |
| CA3263309A1 (en) | 2022-08-22 | 2024-02-29 | Iambic Therapeutics, Inc. | HER2 COMPOUNDS AND MODULATION METHODS |
| IL325907A (en) | 2023-07-13 | 2026-03-01 | Iovance Biotherapeutics Inc | Cytokine encoding lentiviral vectors and uses thereof for making tumor infiltrating lymphocytes |
| WO2026006784A1 (en) | 2024-06-28 | 2026-01-02 | Iovance Biotherapeutics, Inc. | Methods of making tumor reactive peripheral blood lymphocytes (trpbl) |
| CN119345381B (zh) * | 2024-12-23 | 2025-04-18 | 上海华之沃生物医药科技有限公司 | 替曲朵辛偶联物及其制备方法和应用 |
Family Cites Families (246)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2131201A (en) | 1928-08-04 | 1938-09-27 | Gen Motors Corp | Composite clutch |
| US2129408A (en) | 1936-07-02 | 1938-09-06 | Arthur C Davidson | Truck stabilizer |
| US2129401A (en) | 1937-09-09 | 1938-09-06 | Botinger Fred | Flexible utility ladder |
| US2131208A (en) | 1938-02-26 | 1938-09-27 | Union Switch & Signal Co | Remote indication apparatus |
| US3472835A (en) * | 1964-02-12 | 1969-10-14 | American Mach & Foundry | Schardinger dextrins |
| US3454530A (en) * | 1966-03-07 | 1969-07-08 | Leslie C Case | Novel polyols which are reaction products of a monoepoxide and a cyclic monoanhydride |
| US3426011A (en) * | 1967-02-13 | 1969-02-04 | Corn Products Co | Cyclodextrins with anionic properties |
| US3453257A (en) * | 1967-02-13 | 1969-07-01 | Corn Products Co | Cyclodextrin with cationic properties |
| US3654261A (en) * | 1968-06-27 | 1972-04-04 | Cpc International Inc | Quaternary ammonium alkoxide alkoxy polyol compounds |
| USRE32268E (en) * | 1973-03-01 | 1986-10-21 | Strategic Medical Research Corp. | Therapeutic composition and method of therapeutically treating warm blooded animals therewith |
| GB1390479A (en) | 1973-09-05 | 1975-04-16 | I Orch Sinteza Akademii Nauk L | Pharmaceutical composition for treatment of parkinsonism |
| DE2843963A1 (de) | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
| DE2842862A1 (de) * | 1978-10-02 | 1980-04-10 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung von ionen, polaren und/oder lipophilen substanzen in fluessigkeiten |
| CA1190855A (en) | 1980-09-03 | 1985-07-23 | Rolf W. Pfirrmann | Treatment of osteitis |
| JPS58113198A (ja) * | 1981-12-26 | 1983-07-05 | Hidetoshi Tsuchida | シクロデキストリンが結合したポルフイリン化合物 |
| US4570629A (en) | 1982-03-17 | 1986-02-18 | University Of Illinois Foundation | Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressing comprising same |
| JPS58167613A (ja) | 1982-03-26 | 1983-10-03 | Mitsubishi Petrochem Co Ltd | 水溶性シクロデキストリン含有重合体の製造法 |
| EP0092918B1 (en) | 1982-04-22 | 1988-10-19 | Imperial Chemical Industries Plc | Continuous release formulations |
| CA1208558A (en) | 1982-10-07 | 1986-07-29 | Kazuo Kigasawa | Soft buccal |
| US4438253A (en) | 1982-11-12 | 1984-03-20 | American Cyanamid Company | Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same |
| HU191101B (en) * | 1983-02-14 | 1987-01-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu | Process for preparing water-soluble cyclodextrin polymers substituted with ionic groups |
| JPS60501759A (ja) | 1983-07-01 | 1985-10-17 | バテル メモリアル インステイチユ−ト | 生物分解性ポリペプチド及び薬剤の緩慢な放出のためのその使用 |
| US4525495A (en) | 1983-07-22 | 1985-06-25 | The Dow Chemical Company | Mineral filled composites |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4818542A (en) * | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
| US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| GB8416234D0 (en) | 1984-06-26 | 1984-08-01 | Ici Plc | Biodegradable amphipathic copolymers |
| US4625014A (en) * | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
| CH663951A5 (fr) | 1984-10-10 | 1988-01-29 | Nestle Sa | Procede d'enrichissement selectif en acides gras polyinsatures d'un melange contenant des acides gras fractions enrichies obtenues et compositions les contenant. |
| US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
| US4638045A (en) | 1985-02-19 | 1987-01-20 | Massachusetts Institute Of Technology | Non-peptide polyamino acid bioerodible polymers |
| JPH0651725B2 (ja) * | 1985-02-28 | 1994-07-06 | メルシャン株式会社 | 部分メチル化シクロデキストリン及びその製造方法 |
| GB8506792D0 (en) * | 1985-03-15 | 1985-04-17 | Janssen Pharmaceutica Nv | Derivatives of y-cyclodextrin |
| US4841081A (en) * | 1985-10-16 | 1989-06-20 | Osaka Soda Co., Ltd. | Method of optically resolving a racemate or a diastereomeric mixture of glycidyl compound |
| FR2601675B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| ES2058081T3 (es) | 1986-09-05 | 1994-11-01 | American Cyanamid Co | Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos. |
| GB2197720A (en) | 1986-11-20 | 1988-05-25 | Nat Res Dev | Immobilisation of polynucleotides |
| US5166320A (en) * | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| JP2993967B2 (ja) * | 1987-06-17 | 1999-12-27 | インスティテュート・フォー・チャイルド・ヘルス・リサーチ | ダニアレルゲンのクローニング |
| US4877778A (en) * | 1987-07-01 | 1989-10-31 | The Children's Medical Center Corporation | Method of enhancing lipophile transport using cyclodextrin derivatives |
| US4774329A (en) * | 1987-08-04 | 1988-09-27 | American Maize-Products Company | Controlled release agent for cetylpyridinium chloride |
| US4941996A (en) | 1987-10-19 | 1990-07-17 | Minnesota Mining And Manufacturing Company | Inclusion complexes providing second harmonic generation |
| US5760015A (en) | 1988-01-19 | 1998-06-02 | The Trustees Of The University Of Pennsylvania | Cyclodextrin compounds and methods of making and use thereof |
| JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
| JP2614081B2 (ja) | 1988-05-27 | 1997-05-28 | 大塚化学株式会社 | 光学活性β−ラクタム誘導体の製造法 |
| US4887778A (en) | 1988-06-01 | 1989-12-19 | Universal Instruments Corporation | Feeder drive assembly and replaceable section for tape supplying and cover peeling |
| JPH01319502A (ja) * | 1988-06-21 | 1989-12-25 | Showa Denko Kk | シクロデキストリン誘導体及びその製造方法 |
| HU200913B (en) | 1988-07-28 | 1990-09-28 | Ciklodextrin Kutato Fejlesztoe | Process for producing infusion stock-solution containing pharmaceutically active components of bad water solubility |
| MY106598A (en) | 1988-08-31 | 1995-06-30 | Australian Commercial Res & Development Ltd | Compositions and methods for drug delivery and chromatography. |
| US4902788A (en) | 1988-09-29 | 1990-02-20 | Uop | Crosslinked cyclodextrins supported on porous refractory inorganic oxides |
| US5098793A (en) * | 1988-09-29 | 1992-03-24 | Uop | Cyclodextrin films on solid substrates |
| IT1230566B (it) | 1988-10-17 | 1991-10-28 | Vectorpharma Int | Farmaci poco solubili supportati su sostanze polimeriche in forma atta all'aumento della velocita' di dissoluzione |
| US5108921A (en) * | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5688488A (en) * | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| US5424186A (en) * | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| JPH03221505A (ja) | 1990-01-29 | 1991-09-30 | Toppan Printing Co Ltd | シクロデキストリンポリマーの合成方法及びシクロデキストリン膜の製造方法 |
| WO1991013100A1 (en) * | 1990-03-02 | 1991-09-05 | Australian Commercial Research & Development Limited | Cyclodextrin compositions and methods for pharmaceutical and industrial applications |
| IT1241417B (it) * | 1990-03-06 | 1994-01-14 | Vectorpharma Int | Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione |
| DE4009825A1 (de) * | 1990-03-27 | 1991-10-02 | Consortium Elektrochem Ind | Wasserunloesliche cyclodextrin-polymerisate und verfahren zu deren herstellung |
| US5139687A (en) | 1990-05-09 | 1992-08-18 | The Proctor & Gamble Company | Non-destructive carriers for cyclodextrin complexes |
| JPH0425505A (ja) | 1990-05-21 | 1992-01-29 | Toppan Printing Co Ltd | シクロデキストリンポリマー及びシクロデキストリン膜の製造方法 |
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| FR2665169A1 (fr) | 1990-07-30 | 1992-01-31 | Rhone Poulenc Chimie | Composes d'inclusion de cyclodextrines enfermant des antioxydants phenoliques et leur utilisation dans les polymeres. |
| JPH04106101A (ja) | 1990-08-27 | 1992-04-08 | Showa Denko Kk | シクロデキストリンポリマーおよびその製造方法 |
| DE69103503T2 (de) * | 1990-09-28 | 1995-01-05 | Mercian Corp | Adriamycinderivate. |
| JPH059205A (ja) * | 1990-09-28 | 1993-01-19 | Mercian Corp | 新規なアドリアマイシン誘導体 |
| WO1992006127A1 (en) * | 1990-10-01 | 1992-04-16 | Toppan Printing Co., Ltd. | Cyclodextrin polymer and cyclodextrin film formed therefrom |
| DE69127810T2 (de) * | 1990-11-30 | 1998-03-12 | Toppan Printing Co Ltd | Verfahren zur herstellung eines cyclodextrinderivates und polymer welches darin immobilisiertes cyclodextrin enthält |
| DK0562025T3 (da) | 1990-12-06 | 2001-06-18 | Affymetrix Inc | Forbindelser og deres anvendelse i en binær syntesestrategi |
| US5148854A (en) * | 1990-12-11 | 1992-09-22 | Toshiba Kikai Kabushiki Kaisha | Counting die cast manufactured goods |
| NO180605C (no) * | 1990-12-19 | 2003-08-28 | Geco As | Anordning til vektbelastning av streamerkabel |
| US5330768A (en) | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
| US5714512A (en) | 1991-07-08 | 1998-02-03 | Rhone-Poulenc Rorer, S.A. | Compositions containing taxane derivatives |
| US5698582A (en) | 1991-07-08 | 1997-12-16 | Rhone-Poulenc Rorer S.A. | Compositions containing taxane derivatives |
| US5750561A (en) | 1991-07-08 | 1998-05-12 | Rhone-Poulenc Rorer, S.A. | Compositions containing taxane derivatives |
| JPH06511270A (ja) | 1991-09-06 | 1994-12-15 | コモンウェルス・サイエンティフィック・アンド・インダストリアル・リサーチ・オーガニゼイション | コレステロール濃度を低下させる組成物および方法 |
| NZ244306A (en) | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
| WO1993009176A2 (en) | 1991-10-29 | 1993-05-13 | Clover Consolidated, Limited | Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release |
| US6849462B1 (en) * | 1991-11-22 | 2005-02-01 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
| JP2976154B2 (ja) | 1991-11-27 | 1999-11-10 | コニカ株式会社 | ハロゲン化銀写真感光材料用固形処理剤 |
| JP3221505B2 (ja) | 1992-02-06 | 2001-10-22 | 日本信号株式会社 | 移動体の運行管理装置 |
| US5219980A (en) | 1992-04-16 | 1993-06-15 | Sri International | Polymers biodegradable or bioerodiable into amino acids |
| JPH05331074A (ja) | 1992-05-27 | 1993-12-14 | Nippon Oil & Fats Co Ltd | 薬物運搬体 |
| GB9211268D0 (en) | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| IT1256134B (it) | 1992-09-09 | 1995-11-29 | Luigi Boltri | Sali lipofili contenenti isotopi neutron attivabili e composizioni che li contengono |
| US5482719A (en) * | 1992-10-30 | 1996-01-09 | Guillet; James E. | Drug delivery systems |
| NZ258533A (en) * | 1992-11-30 | 1996-08-27 | Ciba Geigy Ag | Vinyl ester and amide derivatives of a dicarboxylic acid cyclic-oligomeric carbohydrate half ester; use for forming contact lenses, as thickeners, surfactants and lens cleaning agents |
| FR2698543B1 (fr) | 1992-12-02 | 1994-12-30 | Rhone Poulenc Rorer Sa | Nouvelles compositions à base de taxoides. |
| US6537579B1 (en) | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
| US6749868B1 (en) | 1993-02-22 | 2004-06-15 | American Bioscience, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| US6753006B1 (en) | 1993-02-22 | 2004-06-22 | American Bioscience, Inc. | Paclitaxel-containing formulations |
| US5439686A (en) | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
| US6096331A (en) | 1993-02-22 | 2000-08-01 | Vivorx Pharmaceuticals, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
| CA2155947C (en) | 1993-02-22 | 2007-08-21 | Mark W. Grinstaff | Methods for in vivo delivery of biologics and compositions useful therefor |
| US5298410A (en) * | 1993-02-25 | 1994-03-29 | Sterling Winthrop Inc. | Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life |
| HU210922B (en) | 1993-05-24 | 1995-09-28 | Europharmaceuticals Sa | Nimesulide alkali salt cyclodextrin inclusion complexes their preparation and pharmaceutical compositions containing them |
| US5840485A (en) * | 1993-05-27 | 1998-11-24 | Selectide Corporation | Topologically segregated, encoded solid phase libraries |
| TW328535B (en) * | 1993-07-02 | 1998-03-21 | Novartis Ag | Functional photoinitiators and their manufacture |
| JP3288149B2 (ja) | 1993-08-05 | 2002-06-04 | 日本食品化工株式会社 | シクロデキストリンポリマー及びその製造方法 |
| RU2094059C1 (ru) | 1993-08-30 | 1997-10-27 | Московский государственный университет, химический факультет | Способ транспорта нейротропных препаратов в мозг |
| US5616568A (en) * | 1993-11-30 | 1997-04-01 | The Research Foundation Of State University Of New York | Functionalized derivatives of hyaluronic acid |
| US5880154A (en) * | 1994-02-01 | 1999-03-09 | The Board Of Regents Of The University Of Nebraska | Polymeric adamantane analogues |
| TW307775B (en) | 1994-02-15 | 1997-06-11 | Novartis Erfind Verwalt Gmbh | Unsaturated carbohydrate derivatives, polymers thereof and their use |
| MX9504664A (es) | 1994-03-07 | 1997-05-31 | Dow Chemical Co | Conjugados de dendrimeros bioactivos y/o dirigidos. |
| JPH07316205A (ja) | 1994-03-30 | 1995-12-05 | D D S Kenkyusho:Kk | シクロデキストリン誘導体 |
| HU218280B (en) | 1994-04-26 | 2000-07-28 | Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes | |
| US6589736B1 (en) * | 1994-11-22 | 2003-07-08 | The Trustees Of Boston University | Photocleavable agents and conjugates for the detection and isolation of biomolecules |
| US5691316A (en) * | 1994-06-01 | 1997-11-25 | Hybridon, Inc. | Cyclodextrin cellular delivery system for oligonucleotides |
| US5716594A (en) * | 1994-06-06 | 1998-02-10 | The Jmde Trust | Biotin compounds for targetting tumors and sites of infection |
| US5679773A (en) * | 1995-01-17 | 1997-10-21 | Affymax Technologies N.V | Reagants and methods for immobilized polymer synthesis and display |
| US5549974A (en) * | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| US5739386A (en) * | 1994-06-23 | 1998-04-14 | Affymax Technologies N.V. | Photolabile compounds and methods for their use |
| US5776842A (en) | 1994-06-23 | 1998-07-07 | Cellresin Technologies, Llc | Cellulosic web with a contaminant barrier or trap |
| US5494854A (en) | 1994-08-17 | 1996-02-27 | Texas Instruments Incorporated | Enhancement in throughput and planarity during CMP using a dielectric stack containing HDP-SiO2 films |
| JP3699141B2 (ja) | 1994-09-24 | 2005-09-28 | 伸彦 由井 | 超分子構造の生体内分解性医薬高分子集合体及びその調製方法 |
| US5548932A (en) * | 1994-11-08 | 1996-08-27 | Maxcess Technologies, Inc. | Adjustable cable tray support system |
| US5656611A (en) * | 1994-11-18 | 1997-08-12 | Supratek Pharma Inc. | Polynucleotide compositions |
| US6353055B1 (en) * | 1994-11-18 | 2002-03-05 | Supratek Pharma Inc. | Polynucleotide compositions |
| US5847170A (en) | 1995-03-27 | 1998-12-08 | Rhone-Poulenc Rorer, S.A. | Taxoids, their preparation and pharmaceutical compositions containing them |
| US6372780B2 (en) | 1995-03-27 | 2002-04-16 | Aventis Pharma S.A. | Methods of treating cell lines expressing multidrug resistance P-glycoprotein |
| MA23823A1 (fr) | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | Nouveaux taxoides, leur preparation et les compositions qui les contiennent |
| US5728804A (en) * | 1995-06-02 | 1998-03-17 | Research Corporation Technologies, Inc. | Use of cyclodextrins for protein renaturation |
| US6667293B1 (en) | 1995-09-12 | 2003-12-23 | Hybridon, Inc. | Use of cyclodextrins to modulate gene expression with reduced immunostimulatory response |
| PL189698B1 (pl) | 1996-03-12 | 2005-09-30 | Pg Txl Co | Kompozycja farmaceutyczna zawierająca lek przeciwnowotworowy i jej zastosowania |
| US6441025B2 (en) | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| DE19612768A1 (de) | 1996-03-29 | 1997-10-02 | Basf Ag | Cyclodextringruppen enthaltende Polymere, Verfahren zu ihrer Herstellung und ihre Verwendung |
| JP3830198B2 (ja) | 1996-03-29 | 2006-10-04 | 東光薬品工業株式会社 | 超分子構造高分子集合体を用いた皮膚透過性インドメタシン外用剤 |
| JPH11514388A (ja) * | 1996-04-03 | 1999-12-07 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | シクロデキストリン化合物ならびにその製造法および使用 |
| DE19629494A1 (de) | 1996-07-09 | 1998-01-15 | Schering Ag | Pseudopolyrotaxane |
| US5844030A (en) * | 1996-07-09 | 1998-12-01 | Andros; Nicholas | Charged ion cleaning devices and cleaning system |
| US6232434B1 (en) * | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| US5770645A (en) | 1996-08-02 | 1998-06-23 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| WO1998020967A1 (en) | 1996-11-14 | 1998-05-22 | Affymetrix, Inc. | Chemical amplification for the synthesis of patterned arrays |
| JPH10158195A (ja) | 1996-11-28 | 1998-06-16 | Res Inst For Prod Dev | 配位結合を利用した薬物−高分子複合体製剤の調製方法 |
| US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
| HUP9700632A3 (en) | 1997-03-24 | 1999-10-28 | Cyclolab Ciklodextrin Kutato F | Pharmaceutical compositions containing propylamine derivative and cyclodextrine and process for producing the same |
| AU7124598A (en) * | 1997-04-18 | 1998-11-13 | Access Pharmaceuticals, Inc. | Polymer-platinum compounds |
| JP2001524097A (ja) | 1997-04-23 | 2001-11-27 | ユニバーシティ オブ オタゴ | 眼用組成物の制御放出 |
| NZ500694A (en) | 1997-04-30 | 2001-09-28 | Univ Minnesota | Use of chimeric mutational vector (CMV), a macromolecule and a ligand for cell surface receptor adhesion molecule (clatherin) in gene therapy; the CMV vector derived from REC2 homologous pairing with Ustilago maydis |
| US5990237A (en) | 1997-05-21 | 1999-11-23 | Shearwater Polymers, Inc. | Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines |
| JP2002506436A (ja) * | 1997-06-13 | 2002-02-26 | ザ ジョンズ ホプキンス ユニバーシティー | 治療用ナノスフェア |
| DE19726186A1 (de) | 1997-06-20 | 1998-12-24 | Boehringer Ingelheim Int | Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen |
| JPH11100401A (ja) * | 1997-07-30 | 1999-04-13 | Kikkoman Corp | 環状オリゴ糖及びそれを含むレトロウイルス性疾患の予防または治療剤 |
| US6410342B1 (en) * | 1997-08-19 | 2002-06-25 | Pharmacopeia, Inc. | Method and apparatus for controlled photoelution |
| NZ503334A (en) * | 1997-09-15 | 2002-05-31 | Genetic Immunity Llc | A gene delivering complex having a vector with a specific affinity for a foreign genetic material and a second site having a specific affinity for a receptor on an antigen presenting cell |
| WO1999030727A1 (en) | 1997-12-17 | 1999-06-24 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US6383811B2 (en) | 1997-12-30 | 2002-05-07 | Mirus Corporation | Polyampholytes for delivering polyions to a cell |
| GB9801109D0 (en) | 1998-01-20 | 1998-03-18 | Pfizer | Cyclodextrin compositions |
| AU755239B2 (en) * | 1998-02-11 | 2002-12-05 | University Of Houston, The | Method and apparatus for chemical and biochemical reactions using photo-generated reagents |
| IT1298732B1 (it) | 1998-03-13 | 2000-02-02 | Recordati Chem Pharm | Composizioni farmaceutiche orali assumibili senza liquidi,contenenti complessi di inclusione |
| US6048736A (en) | 1998-04-29 | 2000-04-11 | Kosak; Kenneth M. | Cyclodextrin polymers for carrying and releasing drugs |
| WO1999061062A1 (en) | 1998-05-29 | 1999-12-02 | Massachusetts Institute Of Technology | Cyclodextrin complexes |
| US6509323B1 (en) | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
| US7091192B1 (en) | 1998-07-01 | 2006-08-15 | California Institute Of Technology | Linear cyclodextrin copolymers |
| US6261583B1 (en) | 1998-07-28 | 2001-07-17 | Atrix Laboratories, Inc. | Moldable solid delivery system |
| US6703381B1 (en) | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
| JP2003530297A (ja) | 1998-10-16 | 2003-10-14 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ， リプリゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Ｖｉｐアンタゴニストを用いる併用療法 |
| US7375096B1 (en) | 1998-12-04 | 2008-05-20 | California Institute Of Technology | Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network |
| WO2000033885A1 (en) | 1998-12-04 | 2000-06-15 | California Institute Of Technology | Supramolecular complexes containing therapeutic agents |
| WO2000038715A2 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | Use of an integrin antagonist and radiation in the treatment of neoplasia |
| US6740643B2 (en) * | 1999-01-21 | 2004-05-25 | Mirus Corporation | Compositions and methods for drug delivery using amphiphile binding molecules |
| FR2789685B1 (fr) * | 1999-02-15 | 2001-05-04 | Univ Lille Sciences Tech | Procede de fabrication de polymeres solubles et insolubles a base de cyclodextrine(s) et/ou de derives de cyclodextrine(s) et polymeres solubles a base de cyclodextrine(s) et/ou de derives de cyclodextrine(s) |
| AUPP913999A0 (en) * | 1999-03-12 | 1999-04-01 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
| FR2792942B1 (fr) | 1999-04-29 | 2001-06-08 | Commissariat Energie Atomique | Cyclodextrines amphiphiles, leur preparation et leur utilisation pour solubiliser des systemes organises et incorporer des molecules hydrophobes |
| EP1102784A4 (en) | 1999-06-07 | 2009-12-30 | Mirus Bio Corp | A CONNECTION WITH A LABILES DISULFIDE TIE |
| EP1102785B1 (en) | 1999-06-07 | 2013-02-13 | Arrowhead Research Corporation | COMPOSITIONS FOR DRUG DELIVERY USING pH SENSITIVE MOLECULES |
| US6309633B1 (en) | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
| US6420378B1 (en) | 1999-10-15 | 2002-07-16 | Supergen, Inc. | Inhibition of abnormal cell proliferation with camptothecin and combinations including the same |
| EP1233671A4 (en) | 1999-11-29 | 2005-11-02 | Mirus Corp | COMPOSITIONS AND METHODS OF DISPOSING MEDICAMENTS USING AMPHIPHILIC BINDING MOLECULARS |
| SK282717B6 (sk) | 2000-03-10 | 2002-11-06 | �Stav Experiment�Lnej Farmakol�Gie Sav | Spôsob prípravy ultravysokomolekulových hyalurónanov |
| US20010041706A1 (en) | 2000-03-24 | 2001-11-15 | Synold Timothy W. | Blockade of taxane metabolism |
| WO2001074401A2 (en) * | 2000-03-31 | 2001-10-11 | Supergen, Inc. | Camptothecin complexes |
| JP2001288097A (ja) | 2000-04-07 | 2001-10-16 | Pg-Txl Co Lp | 水溶性パクリタキセル誘導体 |
| CA2410632A1 (en) | 2000-06-22 | 2001-12-27 | David S. Garvey | Nitrosated and nitrosylated taxanes, compositions and methods of use |
| US6664228B1 (en) | 2000-08-10 | 2003-12-16 | Ceramoptec Industries, Inc. | Photoselective marking of biological targets |
| AU2001279164A1 (en) * | 2000-08-01 | 2002-02-13 | Oregon Health And Science University | Mammalian dna binding membrane-associated protein-encoding gene and uses |
| TWI321054B (en) * | 2000-12-19 | 2010-03-01 | California Inst Of Techn | Compositions containing inclusion complexes |
| CA2435287A1 (en) | 2001-01-17 | 2002-07-25 | Zycos Inc. | Nucleic acid delivery formulations |
| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| US6828392B2 (en) | 2001-08-28 | 2004-12-07 | Carlsberg A/S | Hydroxy and amine functionalized resins |
| WO2003020305A1 (en) | 2001-08-30 | 2003-03-13 | Baylor College Of Medecine | Methionine restriction for cancer therapy |
| US20030049203A1 (en) | 2001-08-31 | 2003-03-13 | Elmaleh David R. | Targeted nucleic acid constructs and uses related thereto |
| JP2005527639A (ja) | 2001-11-02 | 2005-09-15 | インサート セラピューティクス インコーポレイテッド | Ｒｎａ干渉の治療的利用のための方法及び組成物 |
| US20040063654A1 (en) | 2001-11-02 | 2004-04-01 | Davis Mark E. | Methods and compositions for therapeutic use of RNA interference |
| US20030134824A1 (en) | 2001-11-12 | 2003-07-17 | Ronald Breslow | Beta-cyclodextrin dimers and phthalocyanines and uses thereof |
| US7141540B2 (en) * | 2001-11-30 | 2006-11-28 | Genta Salus Llc | Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof |
| US6527887B1 (en) * | 2002-01-18 | 2003-03-04 | Mach I, Inc. | Polymeric cyclodextrin nitrate esters |
| EP2316468A1 (en) * | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
| CA2476769A1 (en) * | 2002-02-22 | 2003-09-04 | Insert Therapeutics, Inc. | Carbohydrate-modified polymers, compositions and uses related thereto |
| WO2003105828A1 (en) | 2002-06-14 | 2003-12-24 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| EP1521769B1 (de) | 2002-07-09 | 2015-09-09 | Dömling, Alexander | Tubulysinkonjugate |
| EP1531757B1 (en) | 2002-07-19 | 2016-09-07 | Omeros Corporation | Biodegradable triblock copolymers, synthesis methods therefor, and hydrogels and biomaterials made there from |
| EP1562627A4 (en) | 2002-08-23 | 2006-11-02 | Mclean Hospital Corp | CORTICOSTEROID CONJUGATES AND ITS USES |
| US20050271615A1 (en) | 2002-08-30 | 2005-12-08 | Doron Shabat | Self-immolative dendrimers releasing many active moieties upon a single activating event |
| KR20140070676A (ko) | 2002-09-06 | 2014-06-10 | 인설트 테라페틱스, 인코퍼레이티드 | 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체 |
| CA2818071C (en) | 2002-09-06 | 2015-08-18 | Cerulean Pharma Inc. | Modified cyclodextrin ring compounds having exactly two hydroxyl moieties substituted with an amino acid for therapeutics delivery |
| US20040047835A1 (en) | 2002-09-06 | 2004-03-11 | Cell Therapeutics, Inc. | Combinatorial drug therapy using polymer drug conjugates |
| BR0315198A (pt) * | 2002-10-09 | 2005-08-30 | Insert Therapeutics Inc | Materiais e composições à base de ciclodextrina e usos relacionados aos mesmos |
| JP2006504743A (ja) | 2002-10-09 | 2006-02-09 | コーザン バイオサイエンシス インコーポレイテッド | 治療製剤 |
| CA2502870C (en) | 2002-10-31 | 2011-07-26 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight derivatives of camptothecins |
| EP2305813A3 (en) | 2002-11-14 | 2012-03-28 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
| US7550470B2 (en) | 2002-12-11 | 2009-06-23 | Merck & Co. Inc. | Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors |
| US7601332B2 (en) | 2003-01-27 | 2009-10-13 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| US7358262B2 (en) | 2003-01-29 | 2008-04-15 | Whitehead Institute For Biomedical Research | Identification of genotype-selective anti-tumor agents |
| CN1216057C (zh) | 2003-03-28 | 2005-08-24 | 贵州省生物研究所 | 喜树碱类似物的衍生物及其制备方法 |
| RS20150135A1 (sr) | 2003-05-30 | 2015-08-31 | Genentech Inc. | Tretman sa anti-vegf antitelima |
| EP1525890A1 (en) | 2003-10-02 | 2005-04-27 | Complex Biosystems GmbH | Protein-Proteophore complexes |
| CA2547934C (en) | 2004-02-19 | 2013-05-21 | Abbott Laboratories | Methods of using gamma cyclodextrin to control blood glucose and insulin secretion |
| AU2005250484B2 (en) | 2004-06-04 | 2011-08-11 | Genentech, Inc. | EGFR mutations |
| CN101098854B (zh) | 2004-07-23 | 2012-12-05 | 恩多塞特公司 | 二价连接体及其轭合物 |
| ES2374828T3 (es) | 2004-12-15 | 2012-02-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Combinaciones de agentes terapéuticos para el tratamiento del cáncer. |
| TW200640493A (en) | 2005-02-16 | 2006-12-01 | Insert Therapeutics Inc | Cyclodextrin-based polymers for therapeutics delivery |
| CN103169729A (zh) | 2005-02-18 | 2013-06-26 | 阿布拉科斯生物科学有限公司 | 治疗剂的组合和给予方式以及联合治疗 |
| KR20080003322A (ko) | 2005-02-24 | 2008-01-07 | 엘란 파마 인터내셔널 리미티드 | 도세탁셀 및 이의 유사체의 나노입자 배합물 |
| PL1866414T3 (pl) * | 2005-03-31 | 2012-10-31 | Calando Pharmaceuticals Inc | Inhibitory podjednostki 2 reduktazy rybonukleotydowej i ich zastosowania |
| SI1913157T2 (sl) | 2005-06-28 | 2017-02-28 | Genentech, Inc. | EGFR in KRAS mutacije za napoved bolnikovega odziva na zdravljenje z EGFR inhibitorjem |
| JP4994618B2 (ja) | 2005-08-11 | 2012-08-08 | 学校法人北里研究所 | Ｔｓ−１／カンプトテシン類による化学放射線療法 |
| US8143236B2 (en) | 2005-12-13 | 2012-03-27 | Bionumerik Pharmaceuticals, Inc. | Chemoprotective methods |
| EP1996612A4 (en) | 2006-03-03 | 2010-10-20 | Univ Kingston | COMPOSITIONS FOR THE TREATMENT OF CANCER |
| KR100917809B1 (ko) | 2006-05-22 | 2009-09-18 | 에스케이케미칼주식회사 | 우수한 저장안정성을 갖는 도세탁셀 함유 주사제 조성물 |
| US20100112077A1 (en) | 2006-11-06 | 2010-05-06 | Abraxis Bioscience, Llc | Nanoparticles of paclitaxel and albumin in combination with bevacizumab against cancer |
| TW201509433A (zh) | 2006-12-13 | 2015-03-16 | 斯茹林製藥公司 | 用於醫物傳遞之以環糊精為基之聚合物 |
| US20080176958A1 (en) * | 2007-01-24 | 2008-07-24 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
| WO2008148080A2 (en) | 2007-05-24 | 2008-12-04 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of [5(s)-(2'-hydroxyethoxy)-20(s)-camptothecin] |
| FR2918279B1 (fr) | 2007-07-05 | 2010-10-22 | Aventis Pharma Sa | Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan |
| AU2008338526A1 (en) | 2007-12-14 | 2009-06-25 | Immune Disease Institute, Inc. | Treatment and prevention of HIV infection |
| JP2011516065A (ja) | 2008-04-04 | 2011-05-26 | カランド ファーマシューティカルズ， インコーポレイテッド | Ｅｐａｓ１阻害剤の組成物および使用 |
| TW201010732A (en) | 2008-08-29 | 2010-03-16 | Enzon Pharmaceuticals Inc | Method of treating RAS associated cancer |
| WO2010043050A1 (en) | 2008-10-16 | 2010-04-22 | Celator Pharmaceuticals Corporation | Combinations of a liposomal water-soluble camptothecin with cetuximab or bevacizumab |
| BRPI1014854A2 (pt) | 2009-03-30 | 2016-05-03 | Cerulean Pharma Inc | "conjugados polímero-agente, partículas, composições, e métodos de uso relacionados" |
| US20120114658A1 (en) | 2009-09-15 | 2012-05-10 | John Ryan | Treatment of cancer |
| US20130029909A1 (en) | 2009-09-15 | 2013-01-31 | John Ryan | Treatment of cancer |
| US20110245201A1 (en) | 2009-09-15 | 2011-10-06 | John Ryan | Treatment of cancer |
| EA201200486A1 (ru) | 2009-09-15 | 2012-08-30 | Серулин Фарма Инк. | Лечение онкологических заболеваний |
| BR112012012210B8 (pt) | 2009-11-23 | 2021-05-25 | Cerulean Pharma Inc | conjugado de (cdp)-taxano de polímero contendo ciclodextrina, composição, composição farmacêutica, forma de dosagem, kit e uso de um conjugado de cdp-taxano |
| WO2011090940A1 (en) | 2010-01-19 | 2011-07-28 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
| US9062094B2 (en) | 2010-01-22 | 2015-06-23 | Ascendis Pharma As | Dipeptide-based prodrug linkers for aliphatic amine-containing drugs |
| US8207290B2 (en) | 2010-03-26 | 2012-06-26 | Cerulean Pharma Inc. | Methods and systems for generating nanoparticles |
| CA2927832C (en) | 2010-05-18 | 2021-03-23 | Cerulean Pharma Inc. | Cyclodextrin-containing polymer-therapeutic agent conjugates and their use |
| US20120213854A1 (en) | 2010-09-30 | 2012-08-23 | Fetzer Oliver S | Methods of treating a subject and related particles, polymers and compositions |
| EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
| US9279812B2 (en) | 2011-09-12 | 2016-03-08 | Universiteit Gent | Neuregulin-1-based prognosis and therapeutic stratification of colorectal cancer |
| WO2013059651A1 (en) | 2011-10-21 | 2013-04-25 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Bifunctional compounds |
| HK1214128A1 (zh) | 2012-10-05 | 2016-07-22 | Bluelink Pharmaceuticals, Inc. | 癌症的治療 |
-
2003
- 2003-09-04 KR KR1020147014132A patent/KR20140070676A/ko not_active Ceased
- 2003-09-04 EP EP17209803.0A patent/EP3332811A1/en not_active Withdrawn
- 2003-09-04 PT PT101848844T patent/PT2277551E/pt unknown
- 2003-09-04 ES ES03770286T patent/ES2377318T3/es not_active Expired - Lifetime
- 2003-09-04 AU AU2003278764A patent/AU2003278764C1/en not_active Expired
- 2003-09-04 KR KR1020167024300A patent/KR101857900B1/ko not_active Expired - Lifetime
- 2003-09-04 BR BRPI0314042A patent/BRPI0314042B8/pt not_active IP Right Cessation
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