EP1233671A4 - Compositions and methods for drug delivery using amphiphile binding molecules - Google Patents

Compositions and methods for drug delivery using amphiphile binding molecules

Info

Publication number
EP1233671A4
EP1233671A4 EP00982310A EP00982310A EP1233671A4 EP 1233671 A4 EP1233671 A4 EP 1233671A4 EP 00982310 A EP00982310 A EP 00982310A EP 00982310 A EP00982310 A EP 00982310A EP 1233671 A4 EP1233671 A4 EP 1233671A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
drug delivery
binding molecules
amphiphile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00982310A
Other languages
German (de)
French (fr)
Other versions
EP1233671A1 (en
Inventor
Jon A Wolff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arrowhead Madison Inc
Original Assignee
Mirus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirus Corp filed Critical Mirus Corp
Publication of EP1233671A1 publication Critical patent/EP1233671A1/en
Publication of EP1233671A4 publication Critical patent/EP1233671A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
EP00982310A 1999-11-29 2000-11-29 Compositions and methods for drug delivery using amphiphile binding molecules Withdrawn EP1233671A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16783699P 1999-11-29 1999-11-29
US167836P 1999-11-29
PCT/US2000/032612 WO2001037665A1 (en) 1999-11-29 2000-11-29 Compositions and methods for drug delivery using amphiphile binding molecules

Publications (2)

Publication Number Publication Date
EP1233671A1 EP1233671A1 (en) 2002-08-28
EP1233671A4 true EP1233671A4 (en) 2005-11-02

Family

ID=22609038

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00982310A Withdrawn EP1233671A4 (en) 1999-11-29 2000-11-29 Compositions and methods for drug delivery using amphiphile binding molecules

Country Status (2)

Country Link
EP (1) EP1233671A4 (en)
WO (1) WO2001037665A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509323B1 (en) 1998-07-01 2003-01-21 California Institute Of Technology Linear cyclodextrin copolymers
US7091192B1 (en) 1998-07-01 2006-08-15 California Institute Of Technology Linear cyclodextrin copolymers
US7375096B1 (en) 1998-12-04 2008-05-20 California Institute Of Technology Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network
TWI321054B (en) 2000-12-19 2010-03-01 California Inst Of Techn Compositions containing inclusion complexes
IL161733A0 (en) * 2001-11-02 2005-11-20 Insert Therapeutics Inc Methods and compositions for therapeutic use of rna interference
US20030224055A1 (en) * 2002-05-28 2003-12-04 Lewis David L. Compositions and processes for inhibiting gene expression using polynucleotides
FR2842106B1 (en) * 2002-07-11 2006-07-14 Centre Nat Rech Scient AQUEOUS DISPERSIONS OF NANOMETRIC OR MICROMETRIC PARTICLES FOR THE ENCAPSULATION OF CHEMICAL COMPOUNDS
KR20120104412A (en) 2002-09-06 2012-09-20 인설트 테라페틱스, 인코퍼레이티드 Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
EP1549269A4 (en) 2002-10-09 2010-10-06 Cerulean Pharma Inc Cyclodextrin-based materials, compositions and uses related thereto
JP2010516625A (en) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド Polymer-drug conjugates with tether groups for controlled drug delivery
EP2438908A1 (en) 2010-10-11 2012-04-11 Vectum Pharma, S.L. Anchoring compositions for topical applications
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001418A1 (en) * 1998-07-02 2000-01-13 Genzyme Corporation Transgene expression in polarized cells
WO2001015755A2 (en) * 1999-09-01 2001-03-08 Genecure Pte Ltd Methods and compositions for delivery of pharmaceutical agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5650096A (en) * 1994-12-09 1997-07-22 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
US5965434A (en) * 1994-12-29 1999-10-12 Wolff; Jon A. Amphipathic PH sensitive compounds and delivery systems for delivering biologically active compounds
US5942634A (en) * 1997-05-09 1999-08-24 Genzyme Corporation Cationic amphiphiles for cell transfections

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001418A1 (en) * 1998-07-02 2000-01-13 Genzyme Corporation Transgene expression in polarized cells
WO2001015755A2 (en) * 1999-09-01 2001-03-08 Genecure Pte Ltd Methods and compositions for delivery of pharmaceutical agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CROYLE MA ET AL: "Beta cyclodextrins enhance gene delivery to the intestine", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE BIOACTIVE MATERIALS, vol. 24, 1997, pages 675 - 676, XP002122911, ISSN: 1022-0178 *
FREEMAN D J ET AL: "THE INFLUENCE OF SODIUM GLYCOCHOLATE AND OTHER ADDITIVES ON THE IN VIVO TRANSFECTION OF PLASMID DNA IN THE LUNGS", PHARMACOLOGICAL RESEARCH, ACADEMIC PRESS, LONDON, GB, vol. 13, no. 2, 1 February 1996 (1996-02-01), pages 202 - 209, XP000646438, ISSN: 1043-6618 *
HABUS I ET AL: "SYNTHESIS, HYBRIDIZATION PROPERTIES, NUCLEASE STABILITY, AND ADAMANTANE CONJUGATES. CELLULAR UPTAKE OF THE OLIGONUCLEOTIDE-AMINO- CYCLODEXTRINS AND", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 6, no. 4, 1 July 1995 (1995-07-01), pages 327 - 331, XP000517222, ISSN: 1043-1802 *
See also references of WO0137665A1 *

Also Published As

Publication number Publication date
EP1233671A1 (en) 2002-08-28
WO2001037665A1 (en) 2001-05-31

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020612

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

A4 Supplementary search report drawn up and despatched

Effective date: 20050919

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 48/00 A

Ipc: 7C 12N 15/88 B

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20051202