EP0518930A4 - Cyclodextrin compositions and methods for pharmaceutical and industrial applications - Google Patents

Cyclodextrin compositions and methods for pharmaceutical and industrial applications

Info

Publication number
EP0518930A4
EP0518930A4 EP19910905452 EP91905452A EP0518930A4 EP 0518930 A4 EP0518930 A4 EP 0518930A4 EP 19910905452 EP19910905452 EP 19910905452 EP 91905452 A EP91905452 A EP 91905452A EP 0518930 A4 EP0518930 A4 EP 0518930A4
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical
methods
industrial applications
cyclodextrin compositions
cyclodextrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910905452
Other versions
EP0518930A1 (en
Inventor
John Hewlett Coates
Christopher John Easton
Stephen Frederick Lincoln
Stephen John Z K Kunststofflab. B L Van Eyk
Bruce Lindley May
Michael Lloyd Williams
Susan Elizabeth Brown
Angelo Lepore
Ming-Long Liao
Yin Luo
Vilma Macolino
Deborah Susanne Schiesser
Craig Bernard Whalland
Ian S. C. Mckenzie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Australia Commercial Research and Development Ltd
Original Assignee
Australia Commercial Research and Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Australia Commercial Research and Development Ltd filed Critical Australia Commercial Research and Development Ltd
Publication of EP0518930A1 publication Critical patent/EP0518930A1/en
Publication of EP0518930A4 publication Critical patent/EP0518930A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
EP19910905452 1990-03-02 1991-03-01 Cyclodextrin compositions and methods for pharmaceutical and industrial applications Withdrawn EP0518930A4 (en)

Applications Claiming Priority (26)

Application Number Priority Date Filing Date Title
AU8899/90 1990-03-02
AUPJ889990 1990-03-02
AUPJ899390 1990-03-08
AU8993/90 1990-03-08
AU9344/90 1990-03-28
AUPJ934490 1990-03-28
AUPJ937390 1990-03-29
AU9373/90 1990-03-29
AUPJ975690 1990-04-23
AU9756/90 1990-04-23
AU1538/90 1990-08-03
AUPK153890 1990-08-03
AUPK175590 1990-08-16
AU1755/90 1990-08-16
AU2269/90 1990-09-12
AUPK226990 1990-09-12
AUPK359690 1990-11-29
AU3596/90 1990-11-29
AU3624/90 1990-11-30
AUPK362490 1990-11-30
AUPK428491 1991-01-21
AU4284/91 1991-01-21
AU4603/91 1991-02-14
AUPK460391 1991-02-14
AUPK485691 1991-02-27
AU4856/91 1991-02-27

Publications (2)

Publication Number Publication Date
EP0518930A1 EP0518930A1 (en) 1992-12-23
EP0518930A4 true EP0518930A4 (en) 1993-09-15

Family

ID=27583900

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910905452 Withdrawn EP0518930A4 (en) 1990-03-02 1991-03-01 Cyclodextrin compositions and methods for pharmaceutical and industrial applications

Country Status (2)

Country Link
EP (1) EP0518930A4 (en)
WO (1) WO1991013100A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
EP0630261A4 (en) * 1992-03-11 1996-11-06 Australian Commercial Research New cyclodextrins and new formulated drugs.
AT399718B (en) * 1992-04-16 1995-07-25 Lek Tovarna Farmacevtskih INCLUSION COMPLEXES OF OPTICALLY ACTIVE AND RACEMIC 1,4-DIHYDROPYRIDINES WITH METHYL-BETA-CYCLODEXTRIN OR OTHER CYCLODEXTRINE DERIVATIVES, A METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE DIHYDROPYRIDE-DOMETHYL-DOMETHYL-DOMETHYL-DOMETHYL POWERS
RU2143896C1 (en) * 1993-03-05 2000-01-10 Хексаль Аг Crystalline complex of cyclodextrin with ranitidin hydrochloride, method of preparation thereof, and pharmaceutical compositions containing thereof
FR2705350B1 (en) * 1993-05-13 1995-07-07 Oreal New derivatives of mono (6-amino 6-deoxy) cyclodextrin substituted in position 6 by an alpha-amino acid residue, their preparation process and their uses.
DE4338508A1 (en) * 1993-11-11 1995-05-18 Asta Medica Ag Pharmaceutical preparations containing thioctic acid or dihydroliponic acid in the form of inclusion compounds with cyclodextrins or cyclodextrin derivatives and in the form of granules, chewable or effervescent tablets
FR2713934B1 (en) * 1993-12-22 1996-01-12 Commissariat Energie Atomique Use of amino cyclodextrins for the aqueous solubilization of hydrophobic compounds, in particular of pharmaceutically active molecules.
FR2714067B1 (en) * 1993-12-22 1996-01-12 Commissariat Energie Atomique New cyclodextrin derivatives, usable in particular for solubilizing hydrophobic chemical compounds such as drugs, and their preparation process.
BE1008978A5 (en) * 1994-12-27 1996-10-01 Solvay Adjuvants for vaccines.
HUP9700632A3 (en) * 1997-03-24 1999-10-28 Cyclolab Ciklodextrin Kutato F Pharmaceutical compositions containing propylamine derivative and cyclodextrine and process for producing the same
DE59807775D1 (en) 1997-11-11 2003-05-08 Ceramoptec Inc DETOXIFICATION OF PHARMACEUTICAL ACTIVE SUBSTANCES BY CYCLODEXTRIN OLIGOMERS
KR100247558B1 (en) * 1997-11-24 2000-05-01 김충섭 Iontophoresis using cyclodextrin
EP1035135B1 (en) * 1999-03-05 2004-10-13 Wolff Walsrode AG Regioselectively substituted esters of oligosaccharides and polysaccharides and process for their preparation
DE10018617A1 (en) * 2000-01-13 2001-10-31 Joerg G Moser Cyclodextrin dimers with peptide spacer structures for detoxification of active pharmaceutical ingredients with high potential for side effects
US6869939B2 (en) * 2002-05-04 2005-03-22 Cydex, Inc. Formulations containing amiodarone and sulfoalkyl ether cyclodextrin
SI1374906T1 (en) * 2002-06-17 2007-10-31 Chiesi Farma Spa A process for the preparation of piroxicam: beta-cyclodextrin inclusion compounds
MXPA05002444A (en) * 2002-09-06 2005-09-30 Insert Therapeutics Inc Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto.
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
JP5050191B2 (en) * 2005-11-01 2012-10-17 国立大学法人三重大学 Method for isolating and purifying cyclodextrin derivatives
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
US11020363B2 (en) 2009-05-29 2021-06-01 Cydex Pharmaceuticals, Inc. Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
NZ596515A (en) 2009-05-29 2014-03-28 Cydex Pharmaceuticals Inc Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same
US8492538B1 (en) 2009-06-04 2013-07-23 Jose R. Matos Cyclodextrin derivative salts
JP2011190341A (en) * 2010-03-15 2011-09-29 Nano Dex Kk Cyclodextrin compound
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
GB201608936D0 (en) 2016-05-20 2016-07-06 Polytherics Ltd Novel conjugates and novel conjugating reagents
EP3906263A4 (en) 2019-01-03 2022-08-31 Underdog Pharmaceuticals, Inc. Cyclodextrin dimers, compositions thereof, and uses thereof
AU2021291071A1 (en) 2020-06-18 2023-02-23 Halo Therapeutics Ltd Fatty acid complexes of coronavirus spike protein and their use
WO2022029334A1 (en) 2020-08-07 2022-02-10 Gbiotech S.À.R.L. Combination therapies for treating coronavirus infection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659696A (en) * 1982-04-30 1987-04-21 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its nasal or vaginal use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3565887A (en) * 1968-05-15 1971-02-23 Corn Products Co Unsaturated and long chain esters of cyclodextrin
US3553191A (en) * 1968-05-21 1971-01-05 Cpc International Inc Aminoethyl cyclodextrin and method of making same
US4169079A (en) * 1977-10-24 1979-09-25 Iwao Tabushi Polystyrene based polymers containing cyclodextrin derivatives, metal complexes of the same, and process for the production of the same
HU191101B (en) * 1983-02-14 1987-01-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for preparing water-soluble cyclodextrin polymers substituted with ionic groups
EP0147685B1 (en) * 1983-12-17 1989-04-26 Hoechst Aktiengesellschaft Beta-cyclodextrin and process for its preparation
DE3346123A1 (en) * 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse PHARMACEUTICAL PREPARATIONS OF SUBSTANCES MEDICAL OR UNSTABLE IN WATER AND METHOD FOR THE PRODUCTION THEREOF
HU199444B (en) * 1985-09-10 1990-02-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 7-isopropoxy-isoflavone-cyclodextrene inclusion complex and pharmaceutical compositions therefrom
CA1298290C (en) * 1987-01-09 1992-03-31 Herand M. Markarian Solution ibuprofen complexes, compositions and processes for preparing the same
IT1204725B (en) * 1987-06-17 1989-03-10 Edmond Pharma Srl DIPYRIDAMOL INCLUSION COMPLEXES WITH CYCLODESTRINE
WO1989006536A1 (en) * 1988-01-19 1989-07-27 Moses Judah Folkman Growth inhibiting agent and the use thereof
WO1990001320A1 (en) * 1988-08-15 1990-02-22 American Maize-Products Company Water soluble branched beta cyclodextrin steroid complex
MY106598A (en) * 1988-08-31 1995-06-30 Australian Commercial Res & Development Ltd Compositions and methods for drug delivery and chromatography.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659696A (en) * 1982-04-30 1987-04-21 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its nasal or vaginal use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANGEWANDTE CHEMIE, INT. ED. ENGL. vol. 19, 1980, pages 344 - 362 WOLFRAM SAENGER 'cyclodextrin inclusion compounds in research and industry' *
CHEMICAL PATENTS INDEX, BASIC ABSTRACTS JOURNAL Week 8712, Derwent Publications Ltd., London, GB; AN 82254 *
PATENT ABSTRACTS OF JAPAN vol. 10, no. 262 (C-371)6 September 1986 *
See also references of WO9113100A1 *

Also Published As

Publication number Publication date
EP0518930A1 (en) 1992-12-23
WO1991013100A1 (en) 1991-09-05

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