JP2005520006A5 - - Google Patents

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Publication number
JP2005520006A5
JP2005520006A5 JP2003574704A JP2003574704A JP2005520006A5 JP 2005520006 A5 JP2005520006 A5 JP 2005520006A5 JP 2003574704 A JP2003574704 A JP 2003574704A JP 2003574704 A JP2003574704 A JP 2003574704A JP 2005520006 A5 JP2005520006 A5 JP 2005520006A5
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JP
Japan
Prior art keywords
group
hydroxyl
derivative
derivative according
polyethylene glycol
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Application number
JP2003574704A
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English (en)
Japanese (ja)
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JP2005520006A (ja
JP4272537B2 (ja
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Priority claimed from PCT/CN2003/000179 external-priority patent/WO2003076490A1/zh
Publication of JP2005520006A publication Critical patent/JP2005520006A/ja
Publication of JP2005520006A5 publication Critical patent/JP2005520006A5/ja
Application granted granted Critical
Publication of JP4272537B2 publication Critical patent/JP4272537B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2003574704A 2002-03-13 2003-03-12 Ｙ型分鎖親水性ポリマー誘導体、それらの調製方法、前記誘導体および薬剤分子の結合生成物、ならびに前記結合生成物を含む医薬組成物 Expired - Fee Related JP4272537B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN0200147 2002-03-13
PCT/CN2003/000179 WO2003076490A1 (en) 2002-03-13 2003-03-12 Hydrophilic polymer derivate with y type branch and preparation method of it medical composite comprising above compound

Publications (3)

Publication Number Publication Date
JP2005520006A JP2005520006A (ja) 2005-07-07
JP2005520006A5 true JP2005520006A5 (enExample) 2008-04-24
JP4272537B2 JP4272537B2 (ja) 2009-06-03

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003574704A Expired - Fee Related JP4272537B2 (ja) 2002-03-13 2003-03-12 Ｙ型分鎖親水性ポリマー誘導体、それらの調製方法、前記誘導体および薬剤分子の結合生成物、ならびに前記結合生成物を含む医薬組成物

Country Status (9)

Country Link
US (3) US8003089B2 (enExample)
EP (1) EP1496076B1 (enExample)
JP (1) JP4272537B2 (enExample)
CN (1) CN1243779C (enExample)
AT (1) ATE368066T1 (enExample)
AU (1) AU2003221291A1 (enExample)
DE (1) DE60315145T2 (enExample)
ES (1) ES2291620T3 (enExample)
WO (1) WO2003076490A1 (enExample)

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CN101701068B (zh) * 2009-10-30 2011-09-21 北京化工大学 一种pH响应性的Y型药物输送材料及其制备方法
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US20140073778A9 (en) 2010-07-09 2014-03-13 Fresenius Kabi Deutschland Gmbh Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
EP2590677A1 (en) 2010-07-09 2013-05-15 Fresenius Kabi Deutschland GmbH Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
EP2590678A1 (en) 2010-07-09 2013-05-15 Fresenius Kabi Deutschland GmbH Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
EP2590680A1 (en) 2010-07-09 2013-05-15 Fresenius Kabi Deutschland GmbH Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
JP2014503187A (ja) 2010-10-29 2014-02-13 ノクソン ファーマ エージー 身体からヘプシジンを除去するためのヘプシジン結合核酸の使用
CN103083680B (zh) * 2011-11-07 2014-12-24 北京键凯科技有限公司 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物
JP5999659B2 (ja) * 2011-12-14 2016-09-28 国立大学法人 筑波大学 新規分岐ポリエチレングリコール及びその用途
WO2014114262A1 (zh) * 2013-01-28 2014-07-31 天津键凯科技有限公司 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途
US9700633B2 (en) 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
CN103965458B (zh) * 2013-01-28 2017-02-15 天津键凯科技有限公司 聚乙二醇‑氨基酸寡肽‑达沙替尼结合物及其药物组合物
CN104109235B (zh) * 2014-05-30 2017-07-18 厦门赛诺邦格生物科技股份有限公司 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质
CN106146325B (zh) * 2015-04-24 2019-01-29 北京键凯科技股份有限公司 一种y型多缩乙二醇衍生物及其制备方法
CN107446908A (zh) * 2016-06-01 2017-12-08 湖南华腾制药有限公司 分支型聚乙二醇修饰的l‑门冬酰胺酶及其制备方法
CN106750250B (zh) * 2016-12-21 2019-04-23 沈阳化工大学 以氨基酸作为连接臂的聚乙二醇齐墩果酸衍生物及其制备方法和应用
CN108530637B (zh) * 2017-03-05 2021-03-30 厦门赛诺邦格生物科技股份有限公司 一种单一功能化支化聚乙二醇的制备方法
WO2018177055A1 (zh) * 2017-03-30 2018-10-04 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
CN108659227B (zh) * 2017-03-30 2020-11-06 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
CN108530642B (zh) * 2017-11-24 2021-01-15 四川大学 可生物降解的三嵌段杂臂星形双亲性高分子材料及其制备方法
CN109400868B (zh) * 2018-11-30 2021-01-15 吉林化工学院 一种聚乙二醇单苯甲醚化合物的合成方法
JP2023541816A (ja) 2020-08-27 2023-10-04 イノージ・セラピューティクス・コーポレイション 自己免疫性疾患および癌を治療するための方法および組成物
CN112898561A (zh) * 2021-01-27 2021-06-04 大连理工大学 马来酰亚胺封端聚苯醚及其制备方法
EP4509544A4 (en) 2022-04-12 2025-07-02 Xiamen Sinopeg Biotech Co Ltd NONLINEAR PEGYLATED LIPID CONTAINING TERTIARY AMINE AND ITS APPLICATION
CN117510828A (zh) 2022-07-28 2024-02-06 厦门赛诺邦格生物科技股份有限公司 一种含氨基酸残基的三臂聚乙二醇衍生物
JP2026505416A (ja) 2023-02-09 2026-02-13 シェ、ヤンホイ ポリエチレングリコール修飾インターロイキン２、グルココルチコイドおよびヒアルロン酸によるアトピー性皮膚炎の治療

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