CN1243779C - 具有y形分支的亲水性聚合物衍生物、其制备方法、与药物分子的结合物以及包含该结合物的药物组合物 - Google Patents

具有y形分支的亲水性聚合物衍生物、其制备方法、与药物分子的结合物以及包含该结合物的药物组合物 Download PDF

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CN1243779C
CN1243779C CNB038011050A CN03801105A CN1243779C CN 1243779 C CN1243779 C CN 1243779C CN B038011050 A CNB038011050 A CN B038011050A CN 03801105 A CN03801105 A CN 03801105A CN 1243779 C CN1243779 C CN 1243779C
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derivative
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binding substances
hydroxyl
polyoxyethylene glycol
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CN1556828A (zh
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嵇世山
朱德权
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Tianjin Jenkem Technology Co Ltd
Jenkem Technology Co Ltd
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BEIJING JIANKAI SCIENCE AND TECHNOLOGY Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

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  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Materials For Medical Uses (AREA)
CNB038011050A 2002-03-13 2003-03-12 具有y形分支的亲水性聚合物衍生物、其制备方法、与药物分子的结合物以及包含该结合物的药物组合物 Expired - Lifetime CN1243779C (zh)

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CNPCT/CN02/00147 2002-03-13
CN0200147 2002-03-13

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CN1556828A CN1556828A (zh) 2004-12-22
CN1243779C true CN1243779C (zh) 2006-03-01

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US (3) US8003089B2 (enExample)
EP (1) EP1496076B1 (enExample)
JP (1) JP4272537B2 (enExample)
CN (1) CN1243779C (enExample)
AT (1) ATE368066T1 (enExample)
AU (1) AU2003221291A1 (enExample)
DE (1) DE60315145T2 (enExample)
ES (1) ES2291620T3 (enExample)
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Cited By (15)

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WO2009030066A1 (en) 2007-09-04 2009-03-12 Biosteed Gene Expression Tech. Co., Ltd. Polyethylene glycol modified interferon alpha 2b and preparation method and applicatioins thereof
WO2009030065A1 (zh) 2007-09-04 2009-03-12 Biosteed Gene Expression Tech. Co., Ltd. 聚乙二醇修饰的干扰素α2a及其制备方法和应用
WO2009086656A1 (zh) * 2007-12-29 2009-07-16 Biosteed Gene Expression Tech. Co., Ltd. Y型聚乙二醇修饰的g-csf及其制备方法和应用
WO2009121210A1 (zh) 2008-04-03 2009-10-08 厦门伯赛基因转录技术有限公司 双链聚乙二醇修饰的生长激素及其制备方法和应用
CN101701068B (zh) * 2009-10-30 2011-09-21 北京化工大学 一种pH响应性的Y型药物输送材料及其制备方法
CN103083680A (zh) * 2011-11-07 2013-05-08 北京键凯科技有限公司 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物
CN103965458A (zh) * 2013-01-28 2014-08-06 天津键凯科技有限公司 聚乙二醇-氨基酸寡肽-达沙替尼结合物及其药物组合物
CN104109235A (zh) * 2014-05-30 2014-10-22 厦门赛诺邦格生物科技有限公司 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质
CN106750250A (zh) * 2016-12-21 2017-05-31 沈阳化工大学 以氨基酸作为连接臂的聚乙二醇齐墩果酸衍生物及其制备方法和应用
CN108530642A (zh) * 2017-11-24 2018-09-14 四川大学 可生物降解的三嵌段杂臂星形双亲性高分子材料及其制备方法
CN108530637A (zh) * 2017-03-05 2018-09-14 厦门赛诺邦格生物科技股份有限公司 一种单一功能化支化聚乙二醇的制备方法
WO2018177055A1 (zh) 2017-03-30 2018-10-04 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
WO2023198083A1 (zh) 2022-04-12 2023-10-19 厦门赛诺邦格生物科技股份有限公司 一种含有叔胺的非线性聚乙二醇化脂质及其应用
WO2024022237A1 (zh) 2022-07-28 2024-02-01 厦门赛诺邦格生物科技股份有限公司 一种含氨基酸残基的三臂聚乙二醇衍生物
EP4656202A1 (en) 2023-02-09 2025-12-03 Xie, Yanhui Treatment of atopic dermatitis with polyethylene glycol-modified interleukin 2, glucocorticoid and hyaluronic acid

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CN101168594B (zh) * 2006-10-24 2011-07-27 北京键凯科技有限公司 寡肽为骨架的聚乙二醇活性衍生物、其制备方法及与药物分子的结合物
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WO2012004006A1 (en) 2010-07-09 2012-01-12 Fresenius Kabi Deutschland Gmbh Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
EP2590680A1 (en) 2010-07-09 2013-05-15 Fresenius Kabi Deutschland GmbH Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
EP2633053A1 (en) 2010-10-29 2013-09-04 Noxxon Pharma AG Use of hepcidin binding nucleic acids for depletion of hepcidin from the body
EP2792698A4 (en) * 2011-12-14 2015-12-23 Univ Tsukuba NOVEL BRANCHED POLYETHYLENE GLYCOL AND USE THEREOF
US9700633B2 (en) 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
WO2014114262A1 (zh) * 2013-01-28 2014-07-31 天津键凯科技有限公司 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途
CN106146325B (zh) * 2015-04-24 2019-01-29 北京键凯科技股份有限公司 一种y型多缩乙二醇衍生物及其制备方法
CN107446908A (zh) * 2016-06-01 2017-12-08 湖南华腾制药有限公司 分支型聚乙二醇修饰的l‑门冬酰胺酶及其制备方法
CN108659227B (zh) 2017-03-30 2020-11-06 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
CN109400868B (zh) * 2018-11-30 2021-01-15 吉林化工学院 一种聚乙二醇单苯甲醚化合物的合成方法
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WO2009030065A1 (zh) 2007-09-04 2009-03-12 Biosteed Gene Expression Tech. Co., Ltd. 聚乙二醇修饰的干扰素α2a及其制备方法和应用
CN101636411B (zh) * 2007-09-04 2013-01-09 厦门伯赛基因转录技术有限公司 聚乙二醇修饰的干扰素α2a及其制备方法和应用
WO2009030066A1 (en) 2007-09-04 2009-03-12 Biosteed Gene Expression Tech. Co., Ltd. Polyethylene glycol modified interferon alpha 2b and preparation method and applicatioins thereof
US8530417B2 (en) 2007-12-29 2013-09-10 Biosteed Gene Expression Tech Co. Ltd. Y-shaped polyethylene glycol modified G-CSF, the preparation and use thereof
WO2009086656A1 (zh) * 2007-12-29 2009-07-16 Biosteed Gene Expression Tech. Co., Ltd. Y型聚乙二醇修饰的g-csf及其制备方法和应用
WO2009121210A1 (zh) 2008-04-03 2009-10-08 厦门伯赛基因转录技术有限公司 双链聚乙二醇修饰的生长激素及其制备方法和应用
CN101701068B (zh) * 2009-10-30 2011-09-21 北京化工大学 一种pH响应性的Y型药物输送材料及其制备方法
CN103083680B (zh) * 2011-11-07 2014-12-24 北京键凯科技有限公司 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物
CN103083680A (zh) * 2011-11-07 2013-05-08 北京键凯科技有限公司 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物
CN103965458A (zh) * 2013-01-28 2014-08-06 天津键凯科技有限公司 聚乙二醇-氨基酸寡肽-达沙替尼结合物及其药物组合物
CN103965458B (zh) * 2013-01-28 2017-02-15 天津键凯科技有限公司 聚乙二醇‑氨基酸寡肽‑达沙替尼结合物及其药物组合物
CN104109235A (zh) * 2014-05-30 2014-10-22 厦门赛诺邦格生物科技有限公司 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质
CN106750250A (zh) * 2016-12-21 2017-05-31 沈阳化工大学 以氨基酸作为连接臂的聚乙二醇齐墩果酸衍生物及其制备方法和应用
CN106750250B (zh) * 2016-12-21 2019-04-23 沈阳化工大学 以氨基酸作为连接臂的聚乙二醇齐墩果酸衍生物及其制备方法和应用
CN108530637A (zh) * 2017-03-05 2018-09-14 厦门赛诺邦格生物科技股份有限公司 一种单一功能化支化聚乙二醇的制备方法
CN108530637B (zh) * 2017-03-05 2021-03-30 厦门赛诺邦格生物科技股份有限公司 一种单一功能化支化聚乙二醇的制备方法
WO2018177055A1 (zh) 2017-03-30 2018-10-04 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
CN108530642A (zh) * 2017-11-24 2018-09-14 四川大学 可生物降解的三嵌段杂臂星形双亲性高分子材料及其制备方法
CN108530642B (zh) * 2017-11-24 2021-01-15 四川大学 可生物降解的三嵌段杂臂星形双亲性高分子材料及其制备方法
WO2023198083A1 (zh) 2022-04-12 2023-10-19 厦门赛诺邦格生物科技股份有限公司 一种含有叔胺的非线性聚乙二醇化脂质及其应用
WO2024022237A1 (zh) 2022-07-28 2024-02-01 厦门赛诺邦格生物科技股份有限公司 一种含氨基酸残基的三臂聚乙二醇衍生物
EP4656202A1 (en) 2023-02-09 2025-12-03 Xie, Yanhui Treatment of atopic dermatitis with polyethylene glycol-modified interleukin 2, glucocorticoid and hyaluronic acid

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