CN1556828A - 具有y形分支的亲水性聚合物衍生物、其制备方法、与药物分子的结合物以及包含该结合物的药物组合物 - Google Patents

具有y形分支的亲水性聚合物衍生物、其制备方法、与药物分子的结合物以及包含该结合物的药物组合物 Download PDF

Info

Publication number
CN1556828A
CN1556828A CNA038011050A CN03801105A CN1556828A CN 1556828 A CN1556828 A CN 1556828A CN A038011050 A CNA038011050 A CN A038011050A CN 03801105 A CN03801105 A CN 03801105A CN 1556828 A CN1556828 A CN 1556828A
Authority
CN
China
Prior art keywords
derivative
conjugate
group
hydroxyl
polyethylene glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA038011050A
Other languages
English (en)
Other versions
CN1243779C (zh
Inventor
������ɽ����
嵇世山
朱德权
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tianjin Jenkem Technology Co Ltd
Jenkem Technology Co Ltd
Original Assignee
Jenkem Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenkem Technology Co Ltd filed Critical Jenkem Technology Co Ltd
Publication of CN1556828A publication Critical patent/CN1556828A/zh
Application granted granted Critical
Publication of CN1243779C publication Critical patent/CN1243779C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及一种由式(I)－(IV)表示的Y形分支的聚乙二醇衍生物。本发明还涉及该衍生物与药物分子形成的结合物以及包含该结合物的药物组合物。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CNB038011050A 2002-03-13 2003-03-12 具有y形分支的亲水性聚合物衍生物、其制备方法、与药物分子的结合物以及包含该结合物的药物组合物 Expired - Lifetime CN1243779C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNPCT/CN02/00147 2002-03-13
CN0200147 2002-03-13

Publications (2)

Publication Number Publication Date
CN1556828A true CN1556828A (zh) 2004-12-22
CN1243779C CN1243779C (zh) 2006-03-01

Family

ID=27792878

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038011050A Expired - Lifetime CN1243779C (zh) 2002-03-13 2003-03-12 具有y形分支的亲水性聚合物衍生物、其制备方法、与药物分子的结合物以及包含该结合物的药物组合物

Country Status (9)

Country Link
US (3) US8003089B2 (zh)
EP (1) EP1496076B1 (zh)
JP (1) JP4272537B2 (zh)
CN (1) CN1243779C (zh)
AT (1) ATE368066T1 (zh)
AU (1) AU2003221291A1 (zh)
DE (1) DE60315145T2 (zh)
ES (1) ES2291620T3 (zh)
WO (1) WO2003076490A1 (zh)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008052428A1 (fr) * 2006-10-24 2008-05-08 Beijing Jenkem Technology Co. Ltd Procédé de preparation et conjugué avec molécule médicinale correspondante
CN101636414B (zh) * 2007-09-04 2012-02-15 厦门伯赛基因转录技术有限公司 聚乙二醇修饰的干扰素α2b及其制备方法和应用
WO2014114262A1 (zh) * 2013-01-28 2014-07-31 天津键凯科技有限公司 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途
CN104109235A (zh) * 2014-05-30 2014-10-22 厦门赛诺邦格生物科技有限公司 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质
CN106750250A (zh) * 2016-12-21 2017-05-31 沈阳化工大学 以氨基酸作为连接臂的聚乙二醇齐墩果酸衍生物及其制备方法和应用
US9700633B2 (en) 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
WO2018177055A1 (zh) * 2017-03-30 2018-10-04 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
CN108659227A (zh) * 2017-03-30 2018-10-16 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
CN109400868A (zh) * 2018-11-30 2019-03-01 吉林化工学院 一种聚乙二醇单苯甲醚化合物的合成方法

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
DE60315145T2 (de) * 2002-03-13 2008-04-30 Beijing Jiankai Technology Co., Ltd. Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff
AU2003253399B2 (en) 2002-09-11 2010-10-14 Fresenius Kabi Deutschland Gmbh Hasylated polypeptides, especially hasylated erythropoietin
DE10326303A1 (de) * 2003-06-11 2004-12-30 Celares Gmbh Reagenzien zur Modifikation von Biopharmazeutika, deren Herstellung und Anwendung
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
GB0329825D0 (en) * 2003-12-23 2004-01-28 Celltech R&D Ltd Biological products
CN101659704A (zh) 2004-03-11 2010-03-03 弗雷泽纽斯卡比德国有限公司 通过还原氨基化制备的羟烷基淀粉和蛋白质的偶联物
CA2606583C (en) * 2005-05-20 2013-09-17 Agency For Science, Technology And Research Aldehyde conjugated flavonoid preparations
US7858080B2 (en) 2005-05-20 2010-12-28 Agency For Science, Technology And Research Aldehyde conjugated flavonoid preparations
US20070092486A1 (en) * 2005-10-21 2007-04-26 Avigenics, Inc. Glycolated and glycosylated poultry derived therapeutic proteins
US20080171696A1 (en) * 2005-10-21 2008-07-17 Avigenics, Inc. Pharmacodynamically enhanced therapeutic proteins
EP2089052A4 (en) * 2006-05-24 2011-02-16 Peg Biosciences POLYETHYLENE GLYCOL-BASED LINK COMPOUNDS AND BIOLOGICALLY ACTIVE CONJUGATES BASED ON SAID COMPOUNDS
CN102827284B (zh) * 2006-11-14 2015-07-29 上海仁会生物制药股份有限公司 带有聚乙二醇基团的Exendin或其类似物及其制剂和用途
EP2192914A4 (en) * 2007-08-20 2014-05-07 Belrose Pharma Inc POLYMER BINDERS CONTAINING PYRIDYL DISULFIDE GROUPS
CA2698396C (en) * 2007-09-04 2014-01-21 Biosteed Gene Expression Tech. Co., Ltd. Interferon alpha2a modified by polyethylene glycol, the preparation and use thereof
EP2070950A1 (en) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkyl starch derivatives and process for their preparation
EP2236521A4 (en) * 2007-12-29 2013-07-10 Biosteed Gene Expression Tech Co Ltd BY POLYETHYLENE GLYCOL OF Y-TYPE MODIFIED G-CSF AND METHOD FOR THE PRODUCTION AND USE THEREOF
CA2720306C (en) * 2008-04-03 2016-03-15 Biosteed Gene Expression Tech. Co., Ltd. Double-stranded polyethylene glycol modified growth hormone, preparation method and application thereof
CN101701068B (zh) * 2009-10-30 2011-09-21 北京化工大学 一种pH响应性的Y型药物输送材料及其制备方法
JP2011105792A (ja) * 2009-11-12 2011-06-02 Japan Science & Technology Agency ブロックコポリマー、ブロックコポリマー−金属錯体複合体、及びそれを用いた中空構造体キャリア
FR2953720B1 (fr) * 2009-12-11 2012-05-11 Oreal Utilisation de derives de benzyloxy-ethylamines comme conservateur,
EP2590678A1 (en) 2010-07-09 2013-05-15 Fresenius Kabi Deutschland GmbH Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
US20140073778A9 (en) 2010-07-09 2014-03-13 Fresenius Kabi Deutschland Gmbh Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
EP2590680A1 (en) 2010-07-09 2013-05-15 Fresenius Kabi Deutschland GmbH Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
CA2804545A1 (en) 2010-07-09 2012-01-12 Fresenius Kabi Deutschland Gmbh Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
JP2014503187A (ja) 2010-10-29 2014-02-13 ノクソン ファーマ エージー 身体からヘプシジンを除去するためのヘプシジン結合核酸の使用
CN103083680B (zh) * 2011-11-07 2014-12-24 北京键凯科技有限公司 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物
WO2013089182A1 (ja) * 2011-12-14 2013-06-20 国立大学法人筑波大学 新規分岐ポリエチレングリコール及びその用途
CN103965458B (zh) * 2013-01-28 2017-02-15 天津键凯科技有限公司 聚乙二醇‑氨基酸寡肽‑达沙替尼结合物及其药物组合物
CN106146325B (zh) * 2015-04-24 2019-01-29 北京键凯科技股份有限公司 一种y型多缩乙二醇衍生物及其制备方法
CN107446908A (zh) * 2016-06-01 2017-12-08 湖南华腾制药有限公司 分支型聚乙二醇修饰的l‑门冬酰胺酶及其制备方法
CN108530637B (zh) * 2017-03-05 2021-03-30 厦门赛诺邦格生物科技股份有限公司 一种单一功能化支化聚乙二醇的制备方法
CN108530642B (zh) * 2017-11-24 2021-01-15 四川大学 可生物降解的三嵌段杂臂星形双亲性高分子材料及其制备方法
CA3193273A1 (en) 2020-08-27 2022-03-03 Enosi Therapeutics Corporation Methods and compositions to treat autoimmune diseases and cancer
CN112898561A (zh) * 2021-01-27 2021-06-04 大连理工大学 马来酰亚胺封端聚苯醚及其制备方法
CN117396537A (zh) * 2022-04-12 2024-01-12 厦门赛诺邦格生物科技股份有限公司 一种非线性聚乙二醇化脂质及其应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756285A (fr) 1969-09-17 1971-03-17 Hoechst Ag Produits de polyoxethylation fluores utilisables pour l'appretage de textiles
GB1361627A (en) * 1970-08-04 1974-07-30 Marumo H Detergent composition
IT956228B (it) * 1972-04-15 1973-10-10 Snia Viscosa Metodo ed additivi per conferire proprieta antistatiche a composi zioni poliammidiche e prodotti poliammidici ottenuti secondo tale metodo e con l impiego di tali additivi
US4520145A (en) * 1982-07-21 1985-05-28 The Boots Company Plc Modified thermosetting imide resins with improved fracture toughness
DE3730797A1 (de) 1987-09-14 1989-03-23 Siegel Rolf Materialien mit nicht-thrombogener oberflaeche
GB2215806B (en) 1988-02-15 1992-02-05 Hakko Co Method of applying a lining to a pipeline
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
JPH0362814A (ja) 1989-07-29 1991-03-18 Nisshinbo Ind Inc 親水性ポリカルボジイミドポリマー、該親水性ポリカルボジイミドポリマーによるパルプ状物及びそれらの製造方法
JP2902201B2 (ja) 1991-03-18 1999-06-07 ストックハウゼン ルイジアナ リミティド 超吸収性ポリマーの残留アクリル酸含量を低下させる方法
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5349001A (en) * 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
US5824701A (en) * 1993-10-20 1998-10-20 Enzon, Inc. Taxane-based prodrugs
US5840900A (en) 1993-10-20 1998-11-24 Enzon, Inc. High molecular weight polymer-based prodrugs
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
WO1997001631A1 (fr) 1995-06-26 1997-01-16 Daiichi Pure Chemicals Co., Ltd. Solution stable de plasmine
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
SI0932399T1 (sl) 1996-03-12 2006-10-31 Pg Txl Co Lp Vodotopna paklitakselna predzdravila
US6258351B1 (en) * 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
CN1164533A (zh) 1997-01-09 1997-11-12 云南汉德技术发展有限公司 一种水溶性抗癌化合物-聚氨基酸紫杉醇酯
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6824766B2 (en) 1998-04-17 2004-11-30 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
WO2001057067A1 (en) 2000-02-04 2001-08-09 Supratek Pharma Inc. Ligand for vascular endothelial growth factor receptor
CN1125097C (zh) 2000-07-05 2003-10-22 天津大学 聚乙二醇支载的紫杉醇或多烯紫杉醇的前药
CN100475269C (zh) 2002-03-05 2009-04-08 北京键凯科技有限公司 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途
DE60315145T2 (de) 2002-03-13 2008-04-30 Beijing Jiankai Technology Co., Ltd. Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff
CN1309763C (zh) 2002-10-31 2007-04-11 日本化药株式会社 喜树碱的高分子衍生物

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008052428A1 (fr) * 2006-10-24 2008-05-08 Beijing Jenkem Technology Co. Ltd Procédé de preparation et conjugué avec molécule médicinale correspondante
CN101636414B (zh) * 2007-09-04 2012-02-15 厦门伯赛基因转录技术有限公司 聚乙二醇修饰的干扰素α2b及其制备方法和应用
WO2014114262A1 (zh) * 2013-01-28 2014-07-31 天津键凯科技有限公司 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途
US9700633B2 (en) 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
CN104109235A (zh) * 2014-05-30 2014-10-22 厦门赛诺邦格生物科技有限公司 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质
CN106750250A (zh) * 2016-12-21 2017-05-31 沈阳化工大学 以氨基酸作为连接臂的聚乙二醇齐墩果酸衍生物及其制备方法和应用
CN106750250B (zh) * 2016-12-21 2019-04-23 沈阳化工大学 以氨基酸作为连接臂的聚乙二醇齐墩果酸衍生物及其制备方法和应用
WO2018177055A1 (zh) * 2017-03-30 2018-10-04 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
CN108659227A (zh) * 2017-03-30 2018-10-16 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
US11359089B2 (en) 2017-03-30 2022-06-14 Jenkem Technology Co., Ltd. (Beijing) Method for preparing Y-branched hydrophilic polymer carboxylic acid derivative
CN109400868A (zh) * 2018-11-30 2019-03-01 吉林化工学院 一种聚乙二醇单苯甲醚化合物的合成方法
CN109400868B (zh) * 2018-11-30 2021-01-15 吉林化工学院 一种聚乙二醇单苯甲醚化合物的合成方法

Also Published As

Publication number Publication date
EP1496076A1 (en) 2005-01-12
US20050180946A1 (en) 2005-08-18
US8003089B2 (en) 2011-08-23
US20110243892A1 (en) 2011-10-06
CN1243779C (zh) 2006-03-01
ATE368066T1 (de) 2007-08-15
US20100221213A1 (en) 2010-09-02
DE60315145T2 (de) 2008-04-30
EP1496076A4 (en) 2006-06-21
EP1496076B1 (en) 2007-07-25
WO2003076490A8 (fr) 2004-10-28
JP2005520006A (ja) 2005-07-07
ES2291620T3 (es) 2008-03-01
JP4272537B2 (ja) 2009-06-03
AU2003221291A1 (en) 2003-09-22
DE60315145D1 (de) 2007-09-06
WO2003076490A1 (fr) 2003-09-18

Similar Documents

Publication Publication Date Title
CN1556828A (zh) 具有y形分支的亲水性聚合物衍生物、其制备方法、与药物分子的结合物以及包含该结合物的药物组合物
EP1489125B1 (en) Compound of hydrophilic polymer-polycarboxyl oligopeptide and medicines, medical composite comprising above compound and use of above compound in medicines
US6436386B1 (en) Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
EP1075282B1 (en) Peg-lhrh analog conjugates
JP2013515791A (ja) マルチアームポリエチレングリコール誘導体、マルチアームポリエチレングリコール誘導体と薬物との接合体およびゲル
WO2005121181A1 (fr) Polyethyleneglycol-oligopeptides de type branchement d'arbre multipoint et leurs derives actifs et composes
JP2004527487A5 (zh)
CN100374443C (zh) 亲水性聚合物-雷公藤提取物的结合物及其药物组合物
CN101168594B (zh) 寡肽为骨架的聚乙二醇活性衍生物、其制备方法及与药物分子的结合物
BRPI0913281B1 (pt) método de preparação de derivados de polietilenoglicol, aldeído de alta pureza
CN1252130C (zh) 亲水性聚合物与丹参酮类药物的结合物以及包含该结合物的药物组合物
CN100415801C (zh) 聚乙二醇氨基酸n-内环羰酐活性衍生物及其药物键合物和凝胶
CN1867578B (zh) 亲水性聚合物-黄杨木提取物的结合物及其药物组合物
CN1206257C (zh) 亲水性聚合物－水飞蓟提取物的结合物以及包含该结合物的药物组合物
CN1259314C (zh) 亲水性聚合物－黄酮结合物以及包含该结合物的药物组合物
CN109776787A (zh) 多臂靶向偶联物
CN1756758A (zh) 新型的斑蝥胺和去甲斑蝥胺衍生物及其在医药中的应用
CN117531021A (zh) 一种刺五加苷e-靶向肽偶联物及其应用
CN115819641A (zh) 一种改性硫酸软骨素及其制备方法和药物组合物
CN115869312A (zh) 一种pdc抗肿瘤药物及其制备方法与应用
CN114796240A (zh) 一种自组装手性短肽药物及其制备方法和应用
JPS62263198A (ja) 細胞保護作用を有する環状ペプチド

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: JIANKAI SCIENCE AND TECHNOLOGY CO., LTD., BEIJING

Free format text: FORMER OWNER: JIANKAI SCIENCE AND TECHNOLOGY CO., LTD., BEIJING

Effective date: 20080815

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20080815

Address after: C, building 2, international science and Technology Pioneer Park, No. four information road, Beijing, Haidian District, China: 100085

Co-patentee after: JENKEM TECHNOLOGY Co.,Ltd. (TIANJIN)

Patentee after: JENKEM TECHNOLOGY Co.,Ltd. (BEIJING)

Address before: C, building 2, international science and Technology Pioneer Park, No. four information road, Beijing, Haidian District, China: 100085

Patentee before: JENKEM TECHNOLOGY Co.,Ltd. (BEIJING)

PE01 Entry into force of the registration of the contract for pledge of patent right

Effective date of registration: 20091202

Pledge (preservation): Pledge

PC01 Cancellation of the registration of the contract for pledge of patent right

Date of cancellation: 20110401

Granted publication date: 20060301

Pledgee: Bank of China Limited by Share Ltd. Beijing subbranch

Pledgor: JENKEM TECHNOLOGY Co.,Ltd. (BEIJING)|JENKEM TECHNOLOGY Co.,Ltd. (TIANJIN)

Registration number: 2009110000662

PE01 Entry into force of the registration of the contract for pledge of patent right

Denomination of invention: Hydrophili polymer derirative having Y shaped branch, its preparation method, combined object with medicine molecule and medical compositon containing combined object

Effective date of registration: 20110629

Granted publication date: 20060301

Pledgee: Zhongguancun Beijing science and technology Company limited by guarantee

Pledgor: JENKEM TECHNOLOGY Co.,Ltd. (BEIJING)|JENKEM TECHNOLOGY Co.,Ltd. (TIANJIN)

Registration number: 2011990000250

PC01 Cancellation of the registration of the contract for pledge of patent right

Date of cancellation: 20120607

Granted publication date: 20060301

Pledgee: Zhongguancun Beijing science and technology Company limited by guarantee

Pledgor: JENKEM TECHNOLOGY Co.,Ltd. (BEIJING)|JENKEM TECHNOLOGY Co.,Ltd. (TIANJIN)

Registration number: 2011990000250

CP03 Change of name, title or address

Address after: 100192 Beijing, Haidian District West Road, No. 66 Dongsheng science and Technology Park, building C1, floor 3

Patentee after: JENKEM TECHNOLOGY Co.,Ltd. (BEIJING)

Patentee after: JENKEM TECHNOLOGY Co.,Ltd. (TIANJIN)

Address before: Haidian District, Beijing, China No. 2 on the road to the international information technology park C building, level Four

Patentee before: JENKEM TECHNOLOGY Co.,Ltd. (BEIJING)

Patentee before: JENKEM TECHNOLOGY Co.,Ltd. (TIANJIN)

CP03 Change of name, title or address
EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20041222

Assignee: BIOSTEED GENE TRANSFORMATION TECH Co.,Ltd.

Assignor: JENKEM TECHNOLOGY Co.,Ltd. (BEIJING)|JENKEM TECHNOLOGY Co.,Ltd. (TIANJIN)

Contract record no.: 2017990000181

Denomination of invention: Hydrophili polymer derirative having Y shaped branch, its preparation method, combined object with medicine molecule and medical compositon containing combined object

Granted publication date: 20060301

License type: Exclusive License

Record date: 20170516

EE01 Entry into force of recordation of patent licensing contract
CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20060301