DE60315145D1 - Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff - Google Patents

Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff

Info

Publication number
DE60315145D1
DE60315145D1 DE60315145T DE60315145T DE60315145D1 DE 60315145 D1 DE60315145 D1 DE 60315145D1 DE 60315145 T DE60315145 T DE 60315145T DE 60315145 T DE60315145 T DE 60315145T DE 60315145 D1 DE60315145 D1 DE 60315145D1
Authority
DE
Germany
Prior art keywords
hydrophilic
manufacturing
polymer derivative
branch polymer
above connected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60315145T
Other languages
English (en)
Other versions
DE60315145T2 (de
Inventor
Shishan Ji
Dequan Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Jiankai Technology Co Ltd
Original Assignee
Beijing Jiankai Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Jiankai Technology Co Ltd filed Critical Beijing Jiankai Technology Co Ltd
Application granted granted Critical
Publication of DE60315145D1 publication Critical patent/DE60315145D1/de
Publication of DE60315145T2 publication Critical patent/DE60315145T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60315145T 2002-03-13 2003-03-12 Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff Expired - Lifetime DE60315145T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN0200147 2002-03-13
WOPCT/CN02/00147 2002-03-13
PCT/CN2003/000179 WO2003076490A1 (fr) 2002-03-13 2003-03-12 Derive polymere hydrophile a ramification de type y et procede de preparation d'un composite medical contenant le compose precite

Publications (2)

Publication Number Publication Date
DE60315145D1 true DE60315145D1 (de) 2007-09-06
DE60315145T2 DE60315145T2 (de) 2008-04-30

Family

ID=27792878

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60315145T Expired - Lifetime DE60315145T2 (de) 2002-03-13 2003-03-12 Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff

Country Status (9)

Country Link
US (3) US8003089B2 (de)
EP (1) EP1496076B1 (de)
JP (1) JP4272537B2 (de)
CN (1) CN1243779C (de)
AT (1) ATE368066T1 (de)
AU (1) AU2003221291A1 (de)
DE (1) DE60315145T2 (de)
ES (1) ES2291620T3 (de)
WO (1) WO2003076490A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
WO2003076490A1 (fr) * 2002-03-13 2003-09-18 Beijing Jiankai Technology Co., Ltd. Derive polymere hydrophile a ramification de type y et procede de preparation d'un composite medical contenant le compose precite
MXPA05002591A (es) 2002-09-11 2005-09-20 Fresenius Kabi Gmbh Derivados de almidon de hidroxialquilo.
DE10326303A1 (de) * 2003-06-11 2004-12-30 Celares Gmbh Reagenzien zur Modifikation von Biopharmazeutika, deren Herstellung und Anwendung
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
GB0329825D0 (en) * 2003-12-23 2004-01-28 Celltech R&D Ltd Biological products
AR048035A1 (es) 2004-03-11 2006-03-22 Fresenius Kabi De Gmbh Conjugados de almidon de hidroxialquilo y una proteina, preparados por aminacion reductora
EP1888651B1 (de) * 2005-05-20 2014-07-30 Agency for Science, Technology and Research Zubereitungen auf basis von aldehydkonjugierten flavonoiden
US7858080B2 (en) 2005-05-20 2010-12-28 Agency For Science, Technology And Research Aldehyde conjugated flavonoid preparations
JP2009514814A (ja) * 2005-10-21 2009-04-09 シナジェバ・バイオファーマ・コーポレイション グリコール化およびグリコシル化された家禽類由来の治療用たんぱく質
US20080171696A1 (en) * 2005-10-21 2008-07-17 Avigenics, Inc. Pharmacodynamically enhanced therapeutic proteins
US20090285780A1 (en) * 2006-05-24 2009-11-19 Chyi Lee Peg linker compounds and biologically active conjugates thereof
CN101168594B (zh) * 2006-10-24 2011-07-27 北京键凯科技有限公司 寡肽为骨架的聚乙二醇活性衍生物、其制备方法及与药物分子的结合物
CN102827284B (zh) 2006-11-14 2015-07-29 上海仁会生物制药股份有限公司 带有聚乙二醇基团的Exendin或其类似物及其制剂和用途
JP2010536986A (ja) * 2007-08-20 2010-12-02 エンゾン ファーマシューティカルズ，インコーポレーテッド ピリジルジスルフィド部分を含有するポリマーリンカー
US8597635B2 (en) 2007-09-04 2013-12-03 Biosteed Gene Expression Tech. Co., Ltd. Interferon alpha-2B modified by polyethylene glycol and methods of preparation thereof
EP2196475B1 (de) * 2007-09-04 2012-06-06 Biosteed Gene Expression Tech. CO., LTD. Polyethylenglykolmodifiziertes interferon alpha 2a, verfahren für dessen synthese und anwendung
EP2070950A1 (de) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
WO2009086656A1 (zh) * 2007-12-29 2009-07-16 Biosteed Gene Expression Tech. Co., Ltd. Y型聚乙二醇修饰的g-csf及其制备方法和应用
RU2488598C2 (ru) * 2008-04-03 2013-07-27 Биостид Джене Експрешен Тек. Ко., Лтд. Гормон роста, модифицированный двухцепочечным полиэтиленгликолем, способ его получения и применение
CN101701068B (zh) * 2009-10-30 2011-09-21 北京化工大学 一种pH响应性的Y型药物输送材料及其制备方法
JP2011105792A (ja) * 2009-11-12 2011-06-02 Japan Science & Technology Agency ブロックコポリマー、ブロックコポリマー−金属錯体複合体、及びそれを用いた中空構造体キャリア
FR2953720B1 (fr) 2009-12-11 2012-05-11 Oreal Utilisation de derives de benzyloxy-ethylamines comme conservateur,
CA2804545A1 (en) 2010-07-09 2012-01-12 Fresenius Kabi Deutschland Gmbh Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
US20140073778A9 (en) 2010-07-09 2014-03-13 Fresenius Kabi Deutschland Gmbh Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
EP2590680A1 (de) 2010-07-09 2013-05-15 Fresenius Kabi Deutschland GmbH Konjugate mit hydroxyalkylstärke und einem zytotoxischen mittel sowie verfahren zu ihrer herstellung
US20130217871A1 (en) 2010-07-09 2013-08-22 Helmut Knoller Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation
EP2633053A1 (de) 2010-10-29 2013-09-04 Noxxon Pharma AG Verwendung von hepcidinbindenden nukleinsäuren für den abbau von hepcidin im körper
CN103083680B (zh) * 2011-11-07 2014-12-24 北京键凯科技有限公司 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物
EP2792698A4 (de) * 2011-12-14 2015-12-23 Univ Tsukuba Neuartiges verzweigtes polyethylenglykol und verwendung davon
WO2014114262A1 (zh) * 2013-01-28 2014-07-31 天津键凯科技有限公司 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途
CN103965458B (zh) * 2013-01-28 2017-02-15 天津键凯科技有限公司 聚乙二醇‑氨基酸寡肽‑达沙替尼结合物及其药物组合物
US9700633B2 (en) 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
CN104109235B (zh) * 2014-05-30 2017-07-18 厦门赛诺邦格生物科技股份有限公司 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质
CN106146325B (zh) * 2015-04-24 2019-01-29 北京键凯科技股份有限公司 一种y型多缩乙二醇衍生物及其制备方法
CN107446908A (zh) * 2016-06-01 2017-12-08 湖南华腾制药有限公司 分支型聚乙二醇修饰的l‑门冬酰胺酶及其制备方法
CN106750250B (zh) * 2016-12-21 2019-04-23 沈阳化工大学 以氨基酸作为连接臂的聚乙二醇齐墩果酸衍生物及其制备方法和应用
CN108530637B (zh) * 2017-03-05 2021-03-30 厦门赛诺邦格生物科技股份有限公司 一种单一功能化支化聚乙二醇的制备方法
CN108659227B (zh) 2017-03-30 2020-11-06 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
WO2018177055A1 (zh) * 2017-03-30 2018-10-04 北京键凯科技股份有限公司 一种y型分支的亲水性聚合物羧酸衍生物的制备方法
CN108530642B (zh) * 2017-11-24 2021-01-15 四川大学 可生物降解的三嵌段杂臂星形双亲性高分子材料及其制备方法
CN109400868B (zh) * 2018-11-30 2021-01-15 吉林化工学院 一种聚乙二醇单苯甲醚化合物的合成方法
CA3193273A1 (en) 2020-08-27 2022-03-03 Enosi Therapeutics Corporation Methods and compositions to treat autoimmune diseases and cancer
CN112898561A (zh) * 2021-01-27 2021-06-04 大连理工大学 马来酰亚胺封端聚苯醚及其制备方法
CN117355558A (zh) * 2022-04-12 2024-01-05 厦门赛诺邦格生物科技股份有限公司 一种氮支化非线性聚乙二醇化脂质及其应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756285A (fr) * 1969-09-17 1971-03-17 Hoechst Ag Produits de polyoxethylation fluores utilisables pour l'appretage de textiles
GB1361627A (en) * 1970-08-04 1974-07-30 Marumo H Detergent composition
IT956228B (it) * 1972-04-15 1973-10-10 Snia Viscosa Metodo ed additivi per conferire proprieta antistatiche a composi zioni poliammidiche e prodotti poliammidici ottenuti secondo tale metodo e con l impiego di tali additivi
US4520145A (en) * 1982-07-21 1985-05-28 The Boots Company Plc Modified thermosetting imide resins with improved fracture toughness
DE3730797A1 (de) 1987-09-14 1989-03-23 Siegel Rolf Materialien mit nicht-thrombogener oberflaeche
GB2215806B (en) 1988-02-15 1992-02-05 Hakko Co Method of applying a lining to a pipeline
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
JPH0362814A (ja) * 1989-07-29 1991-03-18 Nisshinbo Ind Inc 親水性ポリカルボジイミドポリマー、該親水性ポリカルボジイミドポリマーによるパルプ状物及びそれらの製造方法
JP2902201B2 (ja) * 1991-03-18 1999-06-07 ストックハウゼン ルイジアナ リミティド 超吸収性ポリマーの残留アクリル酸含量を低下させる方法
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5349001A (en) * 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
US5840900A (en) * 1993-10-20 1998-11-24 Enzon, Inc. High molecular weight polymer-based prodrugs
US5824701A (en) * 1993-10-20 1998-10-20 Enzon, Inc. Taxane-based prodrugs
US5643575A (en) * 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5879923A (en) * 1995-06-26 1999-03-09 Daiichi Pure Chemicals Co., Ltd. Stable plasmin solution
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
CN101028259A (zh) * 1996-03-12 2007-09-05 Pg－Txl有限公司 水溶性紫杉醇产品
US6258351B1 (en) * 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
CN1164533A (zh) 1997-01-09 1997-11-12 云南汉德技术发展有限公司 一种水溶性抗癌化合物-聚氨基酸紫杉醇酯
US6824766B2 (en) * 1998-04-17 2004-11-30 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
US6153655A (en) * 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
CA2399022A1 (en) 2000-02-04 2001-08-09 Supratek Pharma Inc. Ligand for vascular endothelial growth factor receptor
CN1125097C (zh) 2000-07-05 2003-10-22 天津大学 聚乙二醇支载的紫杉醇或多烯紫杉醇的前药
CN100475269C (zh) 2002-03-05 2009-04-08 北京键凯科技有限公司 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途
WO2003076490A1 (fr) 2002-03-13 2003-09-18 Beijing Jiankai Technology Co., Ltd. Derive polymere hydrophile a ramification de type y et procede de preparation d'un composite medical contenant le compose precite
CN1309763C (zh) 2002-10-31 2007-04-11 日本化药株式会社 喜树碱的高分子衍生物

Also Published As

Publication number Publication date
CN1243779C (zh) 2006-03-01
US20110243892A1 (en) 2011-10-06
WO2003076490A1 (fr) 2003-09-18
EP1496076A1 (de) 2005-01-12
DE60315145T2 (de) 2008-04-30
US20050180946A1 (en) 2005-08-18
EP1496076B1 (de) 2007-07-25
JP2005520006A (ja) 2005-07-07
WO2003076490A8 (fr) 2004-10-28
US8003089B2 (en) 2011-08-23
JP4272537B2 (ja) 2009-06-03
AU2003221291A1 (en) 2003-09-22
US20100221213A1 (en) 2010-09-02
CN1556828A (zh) 2004-12-22
ATE368066T1 (de) 2007-08-15
ES2291620T3 (es) 2008-03-01
EP1496076A4 (de) 2006-06-21

Similar Documents

Publication Publication Date Title
DE60315145D1 (de) Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff
ATE478840T1 (de) 3-aminoazetidinderivate enthaltende pharmazeutische zusammensetzungen, diese derivate und deren herstellung
DE602004027888D1 (de) Anti-cd70 antikörper-arzneimittelkonjugate und ihr
EE200200357A (et) Ravimaine suurenenud kontsentratsioone andvad farmatseutilised kompositsioonid
DE60001546D1 (de) Liponsaürederivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
DE60330322D1 (de) Arzneimittel-mikroteilchen
WO2007100902A3 (en) Acryloyloxyethylphosphorylcholine containing polymer conjugates and their preparation
NO20015584L (no) Langtidsvarende insulintropiske peptider og konjugater samt anvendelse for fremstilling av medikamenter for behandling
FR2764889B1 (fr) Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2852957B1 (fr) Nouveaux derives d'imidazo-pyridine et leur utilisation en tant que medicament
ATE345775T1 (de) Zusammensetzungen zur verabreichung von arzneimittelkombinationen
BRPI0510004A (pt) artigo de manufatura, métodos para administrar uma composição terapêutica a um epitélio de um indivìduo, para tratar uma condição mediada por micróbio de um epitélio de um indivìduo, para melhorar um sintoma de uma condição e para prevenir uma condição, e, uso de composto tipo peg pma
DE69815094D1 (de) 2-(iminoethyl)-aminophenyl - derivate, deren herstellung, deren verwendung als medikamente und diese enthaltende pharmazeutische zubereitungen
FR2884252B1 (fr) Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90
ATE422356T1 (de) Pharmazeutische zubereitungen
ATE493127T1 (de) Verwendung von levo-ornidazol zur herstellung eines antiparasitären infektionswirkstoffs
BR0209276A (pt) Uso da azitromicina para a preparação de um medicamento para tratamento de doenças inflamatórias não infecciosas
WO2006023497A3 (en) Intranasal delivery of antipsychotic drugs
PT1401405E (pt) Composicoes farmaceuticas orais com biodisponibilidade melhorada
DE60229287D1 (de) Pharmazeutische zubereitung zur oralen verwendung von heparin und seinen derivaten
FR2842808B1 (fr) Nouveaux derives d'arylimidazoles, leur preparation et leurs applications therapeutiques
ATE256134T1 (de) Sulfatierte phosphatidylinositole, ihre herstellung und verwendung
EA200602199A1 (ru) Композиции, содержащие глюкозаминогликан и нестероидное противовоспалительное средство
ATE402172T1 (de) Thioetherderivate, deren herstellung und verwendung als pharmazeutische mittel
ATE367373T1 (de) Aminosäurediamide in nicht-alpha-stellung, die sich als adjuvantien für die verabreichung biologisch aktiver mittel eignen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition