DE60330322D1 - Arzneimittel-mikroteilchen - Google Patents
Arzneimittel-mikroteilchenInfo
- Publication number
- DE60330322D1 DE60330322D1 DE60330322T DE60330322T DE60330322D1 DE 60330322 D1 DE60330322 D1 DE 60330322D1 DE 60330322 T DE60330322 T DE 60330322T DE 60330322 T DE60330322 T DE 60330322T DE 60330322 D1 DE60330322 D1 DE 60330322D1
- Authority
- DE
- Germany
- Prior art keywords
- microparticles
- medicines
- making
- methods
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
- B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36795702P | 2002-03-26 | 2002-03-26 | |
PCT/US2003/009327 WO2003082247A2 (en) | 2002-03-26 | 2003-03-25 | Drug microparticles |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60330322D1 true DE60330322D1 (de) | 2010-01-14 |
Family
ID=28675427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60330322T Expired - Lifetime DE60330322D1 (de) | 2002-03-26 | 2003-03-25 | Arzneimittel-mikroteilchen |
Country Status (17)
Country | Link |
---|---|
US (6) | US20030224059A1 (de) |
EP (5) | EP2085072A1 (de) |
JP (1) | JP2005531521A (de) |
KR (1) | KR20040098023A (de) |
AT (1) | ATE450252T1 (de) |
AU (2) | AU2003226021B2 (de) |
CA (1) | CA2480377A1 (de) |
DE (1) | DE60330322D1 (de) |
DK (1) | DK1487416T3 (de) |
EA (1) | EA200401252A1 (de) |
ES (1) | ES2334991T3 (de) |
HK (1) | HK1069126A1 (de) |
IL (1) | IL164152A0 (de) |
MX (1) | MXPA04009385A (de) |
NZ (1) | NZ535854A (de) |
PT (1) | PT1487416E (de) |
WO (1) | WO2003082247A2 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2480377A1 (en) | 2002-03-26 | 2003-10-09 | Teva Pharmaceutical Industries Ltd. | Drug microparticles |
AU2003263480A1 (en) * | 2002-09-24 | 2004-04-19 | Ranbaxy Laboratories Limited | Oral pharmaceutical compositions of fenofibrate having high bioavailability |
CN1882313A (zh) * | 2003-02-20 | 2006-12-20 | 特瓦制药工业有限公司 | 药物的薄荷醇溶液 |
US7932365B2 (en) | 2003-11-08 | 2011-04-26 | Pro Thera Biologics, Llc | Preparation and composition of inter-alpha inhibitor proteins from human plasma for therapeutic use |
US20080249076A1 (en) * | 2003-12-03 | 2008-10-09 | Lifecycle Pharma A/S | Pharmaceutical Compositions Comprising Danazol |
US20050202079A1 (en) * | 2004-03-15 | 2005-09-15 | Mylan Pharmaceuticals Inc. | Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation |
US8216610B2 (en) * | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
WO2006020984A2 (en) * | 2004-08-13 | 2006-02-23 | Teva Pharmaceutical Industries Ltd. | Cyclosporin formulations |
AU2005330266A1 (en) * | 2005-03-30 | 2006-10-12 | Teva Pharmaceutical Industries Ltd. | Improved formulations of fenofibrate containing menthol or PEG/poloxamer |
EP1707197A1 (de) | 2005-03-30 | 2006-10-04 | Teva Pharmaceutical Industries Ltd. | Zusammensetzungen, welche Fenofibrat und eine Tensidmischung beinhaltet |
JP2008534586A (ja) * | 2005-03-30 | 2008-08-28 | テバ ファーマシューティカル インダストリーズ リミティド | フェノフィブレートの改良された製剤 |
US20070148233A1 (en) * | 2005-12-28 | 2007-06-28 | Lerner E I | Pharmaceutical formulations of fenofibrate having improved bioavailability |
US20070015833A1 (en) * | 2005-07-18 | 2007-01-18 | Moshe Flashner-Barak | Formulations of fenofibrate containing menthol |
US20070015834A1 (en) * | 2005-07-18 | 2007-01-18 | Moshe Flashner-Barak | Formulations of fenofibrate containing PEG/Poloxamer |
EP3449928A1 (de) | 2005-11-28 | 2019-03-06 | Imaginot Pty Ltd. | Abgabesystem für eine orale therapeutische verbindung |
CN101511170B (zh) * | 2005-12-22 | 2014-03-26 | 奥克伍德药业有限公司 | 可升华持续释放传递系统和其制造方法 |
BRPI0520821A2 (pt) * | 2005-12-28 | 2009-06-30 | Teva Pharma | formulações farmacêuticas de fenofibrato com biodisponibilidade melhorada |
ATE429902T1 (de) | 2005-12-28 | 2009-05-15 | Teva Pharma | Pharmazeutische formulierungen mit fenofibrat mit verbesserter bioverfügbarkeit |
RU2008142388A (ru) * | 2006-04-03 | 2010-05-10 | Тева Фармасьютикл Индастриес Лтд. (Il) | Микрочастицы лекарственного вещества |
US20100151035A1 (en) * | 2007-03-13 | 2010-06-17 | Sandoz Ag | Pharmaceutical compositions of poorly soluble drugs |
KR100790954B1 (ko) * | 2007-09-13 | 2008-01-04 | 영남대학교 산학협력단 | 이트라코나졸 함유 젤라틴 초미세 미립구 |
CA2726281C (en) | 2008-05-28 | 2023-04-18 | Prothera Biologics, Llc | Preparation and composition of inter-alpha inhibitor proteins from blood |
MX2011006307A (es) * | 2008-12-15 | 2011-10-14 | Banner Pharmacaps Inc | Metodos para aumentar la liberacion y absorcion de agentes activos insolubles en agua. |
CN102292072A (zh) * | 2009-01-26 | 2011-12-21 | 特瓦制药工业有限公司 | 用微粒包衣载体的方法 |
US20120076838A1 (en) | 2009-05-27 | 2012-03-29 | Samyang Biopharmaceuticals Corporation | Poorly soluble drug containing microsphere with improved bioavailabilty and method of preparing the same |
EP2726512B1 (de) | 2011-06-29 | 2017-10-11 | Covidien LP | Auflösung von oxydierter zellulose |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
CA2856520C (en) | 2011-11-23 | 2021-04-06 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
WO2013163453A1 (en) | 2012-04-25 | 2013-10-31 | Spi Pharma, Inc. | Crystalline microspheres and the process for manufacturing the same |
US9271937B2 (en) | 2012-05-31 | 2016-03-01 | Covidien Lp | Oxidized cellulose microspheres |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US9499636B2 (en) | 2012-06-28 | 2016-11-22 | Covidien Lp | Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations |
WO2014039987A2 (en) | 2012-09-09 | 2014-03-13 | Prothera Biologics, Inc. | Treatment of disease using inter-alpha inhibitor proteins |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10413566B2 (en) | 2013-03-15 | 2019-09-17 | Covidien Lp | Thixotropic oxidized cellulose solutions and medical applications thereof |
AU2015264003A1 (en) | 2014-05-22 | 2016-11-17 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
FR3039990B1 (fr) | 2015-08-10 | 2018-07-06 | Rhodia Operations | Procede d'encapsulation |
WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
CA3020153A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
AU2017270580B9 (en) | 2016-05-26 | 2020-01-30 | Allergan, Inc. | Production of rounded salt particles |
US20180056261A1 (en) * | 2016-08-30 | 2018-03-01 | Allergan, Inc. | Method of manufacturing coated beads |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
WO2022155544A1 (en) | 2021-01-15 | 2022-07-21 | Aquestive Therapeutics, Inc. | Prodrug compositions and methods of treatment |
WO2023015183A1 (en) * | 2021-08-02 | 2023-02-09 | Cornell University | Polymer nanoparticles via condensed droplet polymerization |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3089818A (en) | 1960-06-02 | 1963-05-14 | Baxter Laboratories Inc | Water dispersible antibiotics |
DE2246013A1 (de) * | 1972-09-20 | 1974-03-28 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von poroesen tabletten |
JPS5429566B2 (de) | 1974-09-13 | 1979-09-25 | ||
US4900775A (en) | 1988-02-29 | 1990-02-13 | Gaf Chemicals Corporation | Solubilization of complexes of water-insoluble organic compounds by aqueous solutions of polyvinylpyrrolidone |
US5342625A (en) * | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
GB8921710D0 (en) * | 1989-09-26 | 1989-11-08 | Mentholatum Co Ltd | Ibuprofen triturates and topical compositions containing same |
HUT75616A (en) * | 1992-03-17 | 1997-05-28 | Pfizer | Method for prooucing porous delivery devices |
PT669128E (pt) * | 1992-11-17 | 2000-06-30 | Yoshitomi Pharmaceutical | Micro-esfera de libertacao sustentada contendo antipsicoticos e processo para produzir a mesma |
IT1264020B (it) * | 1993-01-28 | 1996-09-09 | Recordati Chem Pharm | Procedimento per la preparazione di microgranuli idonei alla sospensione in liquidi |
SI9300504A (en) * | 1993-09-28 | 1995-04-30 | Krka | Process for preparation solid dispersions and deposits of calcium antagonist dihidropyrimidine derivates and pharmaceutical compositions comprising the same |
US5430021A (en) * | 1994-03-18 | 1995-07-04 | Pharmavene, Inc. | Hydrophobic drug delivery systems |
IE75744B1 (en) * | 1995-04-03 | 1997-09-24 | Elan Corp Plc | Controlled release biodegradable micro- and nanospheres containing cyclosporin |
US5766629A (en) * | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
WO1997035584A1 (en) * | 1996-03-25 | 1997-10-02 | Eli Lilly And Company | Method for treating pain |
US6096339A (en) * | 1997-04-04 | 2000-08-01 | Alza Corporation | Dosage form, process of making and using same |
JP2001507701A (ja) * | 1996-12-31 | 2001-06-12 | インヘイル・セラピューティック・システムズ・インコーポレーテッド | 親水性賦形剤を有する疎水性薬剤の溶液を噴霧乾燥するための方法及びその方法によって作製された組成物 |
FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
KR19990001564A (ko) | 1997-06-16 | 1999-01-15 | 유충식 | 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제 |
US6027747A (en) * | 1997-11-11 | 2000-02-22 | Terracol; Didier | Process for the production of dry pharmaceutical forms and the thus obtained pharmaceutical compositions |
US20030059471A1 (en) * | 1997-12-15 | 2003-03-27 | Compton Bruce Jon | Oral delivery formulation |
US6337092B1 (en) * | 1998-03-30 | 2002-01-08 | Rtp Pharma Inc. | Composition and method of preparing microparticles of water-insoluble substances |
US20010038855A1 (en) * | 1998-06-05 | 2001-11-08 | Desjardin Michael A. | Dosage form for administering prescribed dose |
SE9803240D0 (sv) * | 1998-09-24 | 1998-09-24 | Diabact Ab | A pharmaceutical composition having a rapid action |
US6582285B2 (en) * | 2000-04-26 | 2003-06-24 | Elan Pharmainternational Ltd | Apparatus for sanitary wet milling |
US6264987B1 (en) * | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
US20020001617A1 (en) * | 2000-05-26 | 2002-01-03 | Chang-Hyun Lee | Rapidly disintegrating tablet and process for the manufacture thereof |
US6531158B1 (en) * | 2000-08-09 | 2003-03-11 | Impax Laboratories, Inc. | Drug delivery system for enhanced bioavailability of hydrophobic active ingredients |
AU2001287918A1 (en) | 2000-09-20 | 2002-04-02 | Nycomed Pharma As | Preparation of vitamin emulsions and concentrates thereof |
US7276249B2 (en) * | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
MXPA04002446A (es) | 2001-09-26 | 2004-07-23 | Baxter Int | Preparacion de nanoparticulas de tamano de submicras mediante dispersion y remocion de la fase liquida o solvente. |
US6878693B2 (en) * | 2001-09-28 | 2005-04-12 | Solubest Ltd. | Hydrophilic complexes of lipophilic materials and an apparatus and method for their production |
US20030185882A1 (en) * | 2001-11-06 | 2003-10-02 | Vergez Juan A. | Pharmaceutical compositions containing oxybutynin |
CA2480377A1 (en) | 2002-03-26 | 2003-10-09 | Teva Pharmaceutical Industries Ltd. | Drug microparticles |
US20020193386A1 (en) * | 2002-03-28 | 2002-12-19 | Inigo Pfeiffer | Polymorphic form of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-alpha]pyrimidin-4-one and formulations thereof |
US20040121003A1 (en) * | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
WO2004075874A1 (en) | 2003-02-28 | 2004-09-10 | Anbics Patents-Licences Ag | Method for treatment and prevention of acute and chronic pseudomonas aeruginosa airway infections with inhalable macrolides |
US20040185108A1 (en) * | 2003-03-18 | 2004-09-23 | Short Robert E. | Method of preparing gas-filled polymer matrix microparticles useful for delivering drug |
EP1680086A2 (de) | 2003-10-10 | 2006-07-19 | LifeCycle Pharma A/S | Feste dosierform mit einem fibrat und einem statin |
ATE388697T1 (de) | 2003-11-21 | 2008-03-15 | Galderma Res & Dev | Sprühbare zusammensetzung zur verabreichung von vitamin d derivaten |
-
2003
- 2003-03-25 CA CA002480377A patent/CA2480377A1/en not_active Abandoned
- 2003-03-25 EP EP09004873A patent/EP2085072A1/de not_active Withdrawn
- 2003-03-25 MX MXPA04009385A patent/MXPA04009385A/es unknown
- 2003-03-25 WO PCT/US2003/009327 patent/WO2003082247A2/en active Application Filing
- 2003-03-25 PT PT03745623T patent/PT1487416E/pt unknown
- 2003-03-25 EP EP09004875A patent/EP2085074A1/de not_active Withdrawn
- 2003-03-25 JP JP2003579785A patent/JP2005531521A/ja active Pending
- 2003-03-25 DK DK03745623.3T patent/DK1487416T3/da active
- 2003-03-25 AU AU2003226021A patent/AU2003226021B2/en not_active Ceased
- 2003-03-25 DE DE60330322T patent/DE60330322D1/de not_active Expired - Lifetime
- 2003-03-25 EA EA200401252A patent/EA200401252A1/ru unknown
- 2003-03-25 US US10/400,100 patent/US20030224059A1/en not_active Abandoned
- 2003-03-25 EP EP03745623A patent/EP1487416B1/de not_active Expired - Lifetime
- 2003-03-25 EP EP09004874A patent/EP2085073A1/de not_active Withdrawn
- 2003-03-25 EP EP09004704A patent/EP2087882A1/de not_active Withdrawn
- 2003-03-25 ES ES03745623T patent/ES2334991T3/es not_active Expired - Lifetime
- 2003-03-25 KR KR10-2004-7015217A patent/KR20040098023A/ko not_active Application Discontinuation
- 2003-03-25 NZ NZ535854A patent/NZ535854A/en unknown
- 2003-03-25 IL IL16415203A patent/IL164152A0/xx unknown
- 2003-03-25 AT AT03745623T patent/ATE450252T1/de not_active IP Right Cessation
-
2005
- 2005-03-31 HK HK05102709.3A patent/HK1069126A1/xx not_active IP Right Cessation
-
2006
- 2006-02-17 US US11/357,757 patent/US20060141052A1/en not_active Abandoned
- 2006-02-17 US US11/357,248 patent/US20060141051A1/en not_active Abandoned
- 2006-02-17 US US11/356,682 patent/US20060141050A1/en not_active Abandoned
-
2008
- 2008-10-17 AU AU2008230007A patent/AU2008230007A1/en not_active Abandoned
-
2009
- 2009-12-10 US US12/635,417 patent/US8663703B2/en not_active Expired - Lifetime
-
2014
- 2014-01-16 US US14/156,714 patent/US9107832B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE450252T1 (de) | 2009-12-15 |
US8663703B2 (en) | 2014-03-04 |
MXPA04009385A (es) | 2005-01-25 |
WO2003082247A2 (en) | 2003-10-09 |
AU2008230007A1 (en) | 2008-11-13 |
EA200401252A1 (ru) | 2005-04-28 |
NZ535854A (en) | 2006-08-31 |
EP2085074A1 (de) | 2009-08-05 |
EP2087882A1 (de) | 2009-08-12 |
US20060141052A1 (en) | 2006-06-29 |
DK1487416T3 (da) | 2010-03-29 |
EP1487416A2 (de) | 2004-12-22 |
WO2003082247A3 (en) | 2004-02-05 |
US20140134256A1 (en) | 2014-05-15 |
US9107832B2 (en) | 2015-08-18 |
CA2480377A1 (en) | 2003-10-09 |
US20100092568A1 (en) | 2010-04-15 |
KR20040098023A (ko) | 2004-11-18 |
EP2085073A1 (de) | 2009-08-05 |
AU2003226021B2 (en) | 2008-07-17 |
PT1487416E (pt) | 2010-01-25 |
HK1069126A1 (en) | 2005-05-13 |
IL164152A0 (en) | 2005-12-18 |
EP1487416B1 (de) | 2009-12-02 |
AU2003226021A1 (en) | 2003-10-13 |
US20060141051A1 (en) | 2006-06-29 |
US20060141050A1 (en) | 2006-06-29 |
US20030224059A1 (en) | 2003-12-04 |
JP2005531521A (ja) | 2005-10-20 |
ES2334991T3 (es) | 2010-03-18 |
EP2085072A1 (de) | 2009-08-05 |
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