MXPA04002446A - Preparacion de nanoparticulas de tamano de submicras mediante dispersion y remocion de la fase liquida o solvente. - Google Patents

Preparacion de nanoparticulas de tamano de submicras mediante dispersion y remocion de la fase liquida o solvente.

Info

Publication number
MXPA04002446A
MXPA04002446A MXPA04002446A MXPA04002446A MXPA04002446A MX PA04002446 A MXPA04002446 A MX PA04002446A MX PA04002446 A MXPA04002446 A MX PA04002446A MX PA04002446 A MXPA04002446 A MX PA04002446A MX PA04002446 A MXPA04002446 A MX PA04002446A
Authority
MX
Mexico
Prior art keywords
solvent
preparation
liquid phase
submicron sized
sized nanoparticles
Prior art date
Application number
MXPA04002446A
Other languages
English (en)
Inventor
Narayanan Krishnaswamy
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/964,273 external-priority patent/US20060003012A9/en
Application filed by Baxter Int filed Critical Baxter Int
Publication of MXPA04002446A publication Critical patent/MXPA04002446A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion se refiere a un proceso para preparar nanoparticulas de tamano de submicras de un compuesto poco soluble en agua sonicandolo para evaporar una porcion de la fase organica, o por Iiofilizacion de una dispersion o microdispersion de un sistema de fase multiple que tiene una fase organica y una fase acuosa, teniendo la fase organica el compuesto poco soluble en agua en la misma. El metodo es utilizado de preferencia para preparar nanoparticulas de un compuesto farmaceuticamente activo poco soluble en agua adecuado para la administracion in vivo, particularmente por medio de rutas parenterales.
MXPA04002446A 2001-09-26 2002-09-25 Preparacion de nanoparticulas de tamano de submicras mediante dispersion y remocion de la fase liquida o solvente. MXPA04002446A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/964,273 US20060003012A9 (en) 2001-09-26 2001-09-26 Preparation of submicron solid particle suspensions by sonication of multiphase systems
US10/183,035 US6835396B2 (en) 2001-09-26 2002-06-26 Preparation of submicron sized nanoparticles via dispersion lyophilization
PCT/US2002/030447 WO2003026611A2 (en) 2001-09-26 2002-09-25 Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal

Publications (1)

Publication Number Publication Date
MXPA04002446A true MXPA04002446A (es) 2004-07-23

Family

ID=26878679

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04002446A MXPA04002446A (es) 2001-09-26 2002-09-25 Preparacion de nanoparticulas de tamano de submicras mediante dispersion y remocion de la fase liquida o solvente.

Country Status (10)

Country Link
US (1) US8722091B2 (es)
EP (1) EP1429749A2 (es)
JP (1) JP2005504090A (es)
CN (1) CN1558755A (es)
AU (1) AU2002337692B2 (es)
BR (1) BR0212833A (es)
CA (1) CA2461349C (es)
IL (1) IL160570A0 (es)
MX (1) MXPA04002446A (es)
WO (1) WO2003026611A2 (es)

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EP1429749A2 (en) 2004-06-23
CN1558755A (zh) 2004-12-29
CA2461349A1 (en) 2003-04-03
US20050013868A1 (en) 2005-01-20
WO2003026611A3 (en) 2003-07-03
IL160570A0 (en) 2004-07-25
CA2461349C (en) 2011-11-29
WO2003026611A2 (en) 2003-04-03
JP2005504090A (ja) 2005-02-10
US8722091B2 (en) 2014-05-13
BR0212833A (pt) 2004-10-13

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