MX2008014456A - Procedimiento para preparar microesferas para liberacion sostenida que tienen capacidad mejorada de dispersion y capacidad de inyeccion. - Google Patents

Procedimiento para preparar microesferas para liberacion sostenida que tienen capacidad mejorada de dispersion y capacidad de inyeccion.

Info

Publication number
MX2008014456A
MX2008014456A MX2008014456A MX2008014456A MX2008014456A MX 2008014456 A MX2008014456 A MX 2008014456A MX 2008014456 A MX2008014456 A MX 2008014456A MX 2008014456 A MX2008014456 A MX 2008014456A MX 2008014456 A MX2008014456 A MX 2008014456A
Authority
MX
Mexico
Prior art keywords
microspheres
drug
sustained release
syringeability
suspension
Prior art date
Application number
MX2008014456A
Other languages
English (en)
Inventor
Hee-Yong Lee
Jung-Soo Kim
Eun-Ho Shin
Seong-Kyu Kim
Eun-Young Seol
Mi-Jin Baek
Mi-Young Baek
Yeon-Jin Chae
Ho-Il Choi
Original Assignee
Peptron Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peptron Co Ltd filed Critical Peptron Co Ltd
Publication of MX2008014456A publication Critical patent/MX2008014456A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

Se expone un procedimiento de preparar microesferas de liberación sostenida, que tienen un polímero biodegradable como portador y fármaco, usando secado por aspersión; el procedimiento comprende preparar una solución, suspensión o emulsión que contiene un polímero biodegradable, un fármaco y un solvente, secar por dispersión la solución, suspensión o emulsión, y suspender las microesferas secadas por aspersión en una solución acuosa que contiene alcohol polivinílico para remover el solvente residual y aumentar la capacidad hidrófila de la superficie microesférica; el procedimiento hace posible la preparación de microesferas que tienen alta eficiencia de encapsulación de fármaco, no teniendo casi problema de toxicidad debido al solvente residual y teniendo buena capacidad de inyección; las microesferas preparadas de acuerdo con la presente invención liberan una concentración efectiva de un fármaco de manera sostenida durante un período predeterminado, cuando se administran al cuerpo y son útiles por lo tanto en el tratamiento de enfermedades.
MX2008014456A 2006-05-11 2007-05-11 Procedimiento para preparar microesferas para liberacion sostenida que tienen capacidad mejorada de dispersion y capacidad de inyeccion. MX2008014456A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020060042462A KR100722607B1 (ko) 2006-05-11 2006-05-11 분산성 및 주사 투여능이 향상된 서방성 미립구의 제조방법
PCT/KR2007/002339 WO2007133020A1 (en) 2006-05-11 2007-05-11 A process of preparing microspheres for sustained release having improved dispersibility and syringeability

Publications (1)

Publication Number Publication Date
MX2008014456A true MX2008014456A (es) 2009-04-01

Family

ID=38278452

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008014456A MX2008014456A (es) 2006-05-11 2007-05-11 Procedimiento para preparar microesferas para liberacion sostenida que tienen capacidad mejorada de dispersion y capacidad de inyeccion.

Country Status (10)

Country Link
US (2) US20070264341A1 (es)
EP (1) EP2015737B1 (es)
JP (1) JP5191480B2 (es)
KR (1) KR100722607B1 (es)
CN (1) CN101528206B (es)
BR (1) BRPI0712080B1 (es)
ES (1) ES2571855T3 (es)
MX (1) MX2008014456A (es)
RU (1) RU2403017C2 (es)
WO (1) WO2007133020A1 (es)

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Also Published As

Publication number Publication date
RU2403017C2 (ru) 2010-11-10
BRPI0712080B1 (pt) 2021-09-14
WO2007133020A1 (en) 2007-11-22
US20090269414A1 (en) 2009-10-29
ES2571855T3 (es) 2016-05-27
EP2015737B1 (en) 2016-03-23
US9877922B2 (en) 2018-01-30
JP2009536942A (ja) 2009-10-22
CN101528206B (zh) 2012-02-15
EP2015737A4 (en) 2013-01-23
KR100722607B1 (ko) 2007-05-28
EP2015737A1 (en) 2009-01-21
CN101528206A (zh) 2009-09-09
RU2008148817A (ru) 2010-06-20
JP5191480B2 (ja) 2013-05-08
US20070264341A1 (en) 2007-11-15
BRPI0712080A2 (pt) 2012-01-17

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