WO2010024615A3 - 용매교류증발법에 의한 서방출성 미립구의 제조방법 - Google Patents

용매교류증발법에 의한 서방출성 미립구의 제조방법 Download PDF

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Publication number
WO2010024615A3
WO2010024615A3 PCT/KR2009/004820 KR2009004820W WO2010024615A3 WO 2010024615 A3 WO2010024615 A3 WO 2010024615A3 KR 2009004820 W KR2009004820 W KR 2009004820W WO 2010024615 A3 WO2010024615 A3 WO 2010024615A3
Authority
WO
WIPO (PCT)
Prior art keywords
sustained release
manufacturing
solvent flow
release microsphere
microsphere
Prior art date
Application number
PCT/KR2009/004820
Other languages
English (en)
French (fr)
Other versions
WO2010024615A2 (ko
Inventor
임낙현
김성근
김세연
정형준
차경회
Original Assignee
동국제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41722136&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2010024615(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 동국제약 주식회사 filed Critical 동국제약 주식회사
Priority to BRPI0917714A priority Critical patent/BRPI0917714A2/pt
Priority to CN2009801340116A priority patent/CN102137657A/zh
Priority to EP09810220A priority patent/EP2327397A2/en
Priority to MX2011002210A priority patent/MX2011002210A/es
Priority to JP2011524904A priority patent/JP2012501321A/ja
Priority to US13/061,389 priority patent/US20110200679A1/en
Publication of WO2010024615A2 publication Critical patent/WO2010024615A2/ko
Publication of WO2010024615A3 publication Critical patent/WO2010024615A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

본 발명은 지속적으로 약물의 방출을 조절할 수 있는 서방출성 미립구의 제조방법에 관한 것으로, 보다 상세하게는 생분해성 고분자로 이루어진 담체에 약물을 봉입한 미립구를 제조함에 있어 공용매를 사용한 용매교류증발법을 사용함으로써 생리활성물질의 초기 과다방출을 억제하여 체내에서 생리활성물질이 지속적이고 균일하게 방출될 수 있도록 한 서방출성 미립구의 제조방법에 관한 것이다.
PCT/KR2009/004820 2008-08-29 2009-08-28 용매교류증발법에 의한 서방출성 미립구의 제조방법 WO2010024615A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BRPI0917714A BRPI0917714A2 (pt) 2008-08-29 2009-08-28 método para preparar uma microesfera de liberação prolongada, e, microesfera de liberação prolongada
CN2009801340116A CN102137657A (zh) 2008-08-29 2009-08-28 通过溶剂交流蒸发法制备缓释微球的方法
EP09810220A EP2327397A2 (en) 2008-08-29 2009-08-28 Method for manufacturing sustained release microsphere by solvent flow evaporation method
MX2011002210A MX2011002210A (es) 2008-08-29 2009-08-28 Metodo para preparar una microesfera de liberacion sostenida mediante la evaporacion de intra-intercambio de solvente.
JP2011524904A JP2012501321A (ja) 2008-08-29 2009-08-28 溶媒交流蒸発法による徐放性マイクロスフェアの製造方法
US13/061,389 US20110200679A1 (en) 2008-08-29 2009-08-28 Method for manufacturing sustained release microsphere by solvent flow evaporation method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020080085368A KR101113044B1 (ko) 2008-08-29 2008-08-29 용매교류증발법에 의한 서방출성 미립구의 제조방법
KR10-2008-0085368 2008-08-29

Publications (2)

Publication Number Publication Date
WO2010024615A2 WO2010024615A2 (ko) 2010-03-04
WO2010024615A3 true WO2010024615A3 (ko) 2010-06-17

Family

ID=41722136

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/004820 WO2010024615A2 (ko) 2008-08-29 2009-08-28 용매교류증발법에 의한 서방출성 미립구의 제조방법

Country Status (11)

Country Link
US (1) US20110200679A1 (ko)
EP (1) EP2327397A2 (ko)
JP (1) JP2012501321A (ko)
KR (1) KR101113044B1 (ko)
CN (1) CN102137657A (ko)
BR (1) BRPI0917714A2 (ko)
CL (1) CL2011000393A1 (ko)
CO (1) CO6341545A2 (ko)
MX (1) MX2011002210A (ko)
RU (1) RU2011111714A (ko)
WO (1) WO2010024615A2 (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120011344A (ko) * 2010-07-21 2012-02-08 에스케이케미칼주식회사 고분자 미립구의 제조방법 및 그 방법에 의해 제조된 고분자 미립구
CN102755627B (zh) * 2012-01-31 2014-04-02 赛乐医药科技(上海)有限公司 一种戈舍瑞林缓释植入剂的制备方法
US9393211B2 (en) * 2013-03-15 2016-07-19 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
US9636308B2 (en) 2013-03-15 2017-05-02 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
WO2014169816A1 (zh) * 2013-04-18 2014-10-23 山东绿叶制药有限公司 戈舍瑞林缓释微球药物组合物
US20160175313A1 (en) * 2013-08-06 2016-06-23 Dongkook Pharmaceutical Co., Ltd., Entecavir microspheres and pharmaceutical composition for parenteral administration containing same
JP6238401B2 (ja) * 2013-10-28 2017-11-29 日本化薬株式会社 生理活性ペプチド徐放性微粒子及びその製造方法
KR101695440B1 (ko) * 2014-09-12 2017-01-11 주식회사 고려비엔피 불화퀴놀론계 항생제를 담지한 생분해성 고분자 미립구형 서방출 제제의 제조방법
KR101779846B1 (ko) 2015-08-31 2017-10-10 주식회사 티케이케미칼 나노다공성을 갖는 서방성 미분말과 그 제조방법
KR101961848B1 (ko) * 2016-08-25 2019-03-25 영진약품 주식회사 C18:1, c18:1(oh) 또는 c18:2의 장쇄 지방산이 포함된 오일류를 포함한 방출억제제를 적용한 서방출성 마이크로스피어 및 이의 제조방법
UA127018C2 (uk) * 2017-01-31 2023-03-15 Веру Інк. КОМПОЗИЦІЇ ТА СПОСОБИ ТРИВАЛОГО ВИВІЛЬНЕННЯ АНТАГОНІСТІВ ГОНАДОТРОПІН-ВИВІЛЬНЯЮЧОГО ГОРМОНА (GnRH)
KR102142026B1 (ko) * 2017-05-31 2020-08-06 주식회사 대웅제약 방출제어가 용이한 서방성 약물 미립자의 제조방법
KR102047983B1 (ko) * 2017-11-30 2019-11-22 주식회사 지투지바이오 안전성 및 저장 안정성이 향상된 생분해성 미립구의 제조방법
US20210161917A1 (en) * 2018-04-18 2021-06-03 Inventage Lab Inc. Composition for subcutaneous injection, containing deoxycholic acid, and preparation method therefor
WO2019203543A1 (ko) * 2018-04-18 2019-10-24 (주)인벤티지랩 데옥시콜린산을 포함하는 피하 주사용 조성물 및 이의 제조 방법
AU2019401868B2 (en) * 2018-12-17 2023-07-27 G2Gbio, Inc. Sustained-release injection comprising deslorelin, and preparation method therefor
AU2022391391A1 (en) * 2021-11-18 2024-05-09 Inventage Lab Inc. Method for preparing microparticles containing poorly soluble drugs
CN114668729B (zh) * 2022-02-25 2023-09-29 浙江圣兆药物科技股份有限公司 一种曲普瑞林缓释制剂的连续化生产方法
WO2024122991A1 (ko) * 2022-12-05 2024-06-13 (주)인벤티지랩 복합 수상 용액를 이용한 마이크로 입자에 잔류하는 유기 용매의 제거 방법

Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0877033A1 (en) * 1997-05-08 1998-11-11 Amarnath Maitra A process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles
US20040056372A1 (en) * 2000-02-09 2004-03-25 Masayuki Yokoyama Production process for polymeric micelle charged therein with drug and polymeric micelle composition
KR100754352B1 (ko) * 1999-05-24 2007-08-31 소너스파머슈티칼즈인코포레이티드 난용성 약물용 에멀젼 부형제의 제조방법

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US5366734A (en) 1981-02-16 1994-11-22 Zeneca Limited Continuous release pharmaceutical compositions
TW448055B (en) 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
KR100433061B1 (ko) 2001-09-12 2004-05-28 김시환 휴대용 멀티 표시장치
WO2003055470A1 (fr) * 2001-12-26 2003-07-10 Takeda Chemical Industries, Ltd. Nouvelle microsphere et son procede de production
KR100709015B1 (ko) * 2002-11-13 2007-04-18 (주)아모레퍼시픽 지속적 약물방출이 가능한 고분자 미립구 및 그 제조방법
WO2005058472A2 (en) * 2003-12-19 2005-06-30 Scf Technologies A/S Systems for preparing fine particles and other substances
TW200529890A (en) * 2004-02-10 2005-09-16 Takeda Pharmaceutical Sustained-release preparations
KR100816065B1 (ko) * 2006-11-27 2008-03-24 동국제약 주식회사 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0877033A1 (en) * 1997-05-08 1998-11-11 Amarnath Maitra A process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles
KR100754352B1 (ko) * 1999-05-24 2007-08-31 소너스파머슈티칼즈인코포레이티드 난용성 약물용 에멀젼 부형제의 제조방법
US20040056372A1 (en) * 2000-02-09 2004-03-25 Masayuki Yokoyama Production process for polymeric micelle charged therein with drug and polymeric micelle composition

Also Published As

Publication number Publication date
MX2011002210A (es) 2011-06-24
CN102137657A (zh) 2011-07-27
RU2011111714A (ru) 2012-10-10
US20110200679A1 (en) 2011-08-18
JP2012501321A (ja) 2012-01-19
BRPI0917714A2 (pt) 2016-02-16
CL2011000393A1 (es) 2011-08-19
WO2010024615A2 (ko) 2010-03-04
EP2327397A2 (en) 2011-06-01
KR20100026384A (ko) 2010-03-10
CO6341545A2 (es) 2011-11-21
KR101113044B1 (ko) 2012-02-27

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