CO6341545A2 - Metodo para elaborar una microesfera de liberacion sostenida mediante un metodo de la evaporacion de solvente - Google Patents
Metodo para elaborar una microesfera de liberacion sostenida mediante un metodo de la evaporacion de solventeInfo
- Publication number
- CO6341545A2 CO6341545A2 CO11023782A CO11023782A CO6341545A2 CO 6341545 A2 CO6341545 A2 CO 6341545A2 CO 11023782 A CO11023782 A CO 11023782A CO 11023782 A CO11023782 A CO 11023782A CO 6341545 A2 CO6341545 A2 CO 6341545A2
- Authority
- CO
- Colombia
- Prior art keywords
- release
- microphase
- developing
- sustained
- solvent evaporation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Abstract
La presente invención se relaciona a un método para preparar una microesfera de liberación sostenida que puede controlar la liberación a largo plazo de un fármaco. Más particularmente, como la preparación de una microesfera en la cual un fármaco se carga en un portador que comprende un polímero biodegradable, la presente invención se relaciona a un método para preparar una microesfera de liberación sostenida en donde se utiliza un método de evaporación de intra-intercambio de solvente por medio de cosolvente para suprimir la liberación repentina inicial de la sustancia fisiológicamente activa, para liberar la sustancia fisiológicamente activa en el cuerpo continua y uniformemente.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020080085368A KR101113044B1 (ko) | 2008-08-29 | 2008-08-29 | 용매교류증발법에 의한 서방출성 미립구의 제조방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6341545A2 true CO6341545A2 (es) | 2011-11-21 |
Family
ID=41722136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO11023782A CO6341545A2 (es) | 2008-08-29 | 2011-02-28 | Metodo para elaborar una microesfera de liberacion sostenida mediante un metodo de la evaporacion de solvente |
Country Status (11)
Country | Link |
---|---|
US (1) | US20110200679A1 (es) |
EP (1) | EP2327397A2 (es) |
JP (1) | JP2012501321A (es) |
KR (1) | KR101113044B1 (es) |
CN (1) | CN102137657A (es) |
BR (1) | BRPI0917714A2 (es) |
CL (1) | CL2011000393A1 (es) |
CO (1) | CO6341545A2 (es) |
MX (1) | MX2011002210A (es) |
RU (1) | RU2011111714A (es) |
WO (1) | WO2010024615A2 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20120011344A (ko) * | 2010-07-21 | 2012-02-08 | 에스케이케미칼주식회사 | 고분자 미립구의 제조방법 및 그 방법에 의해 제조된 고분자 미립구 |
CN102755627B (zh) * | 2012-01-31 | 2014-04-02 | 赛乐医药科技(上海)有限公司 | 一种戈舍瑞林缓释植入剂的制备方法 |
US9393211B2 (en) * | 2013-03-15 | 2016-07-19 | Oakwood Laboratories LLC | High drug load buprenorphine microspheres and method of producing same |
US9636308B2 (en) | 2013-03-15 | 2017-05-02 | Oakwood Laboratories LLC | High drug load buprenorphine microspheres and method of producing same |
PL2987484T3 (pl) * | 2013-04-18 | 2019-07-31 | Shandong Luye Pharmaceutical Co., Ltd. | Kompozycja farmaceutyczna mikrosfery o przedłużonym uwalnianiu gosereliny |
MX2016001607A (es) * | 2013-08-06 | 2016-06-06 | Dong Kook Pharm Co Ltd | Microesferas de entecavir y composicion farmaceutica para administracion parenteral que contiene las mismas. |
JP6238401B2 (ja) * | 2013-10-28 | 2017-11-29 | 日本化薬株式会社 | 生理活性ペプチド徐放性微粒子及びその製造方法 |
KR101695440B1 (ko) * | 2014-09-12 | 2017-01-11 | 주식회사 고려비엔피 | 불화퀴놀론계 항생제를 담지한 생분해성 고분자 미립구형 서방출 제제의 제조방법 |
KR101779846B1 (ko) | 2015-08-31 | 2017-10-10 | 주식회사 티케이케미칼 | 나노다공성을 갖는 서방성 미분말과 그 제조방법 |
KR101961848B1 (ko) * | 2016-08-25 | 2019-03-25 | 영진약품 주식회사 | C18:1, c18:1(oh) 또는 c18:2의 장쇄 지방산이 포함된 오일류를 포함한 방출억제제를 적용한 서방출성 마이크로스피어 및 이의 제조방법 |
KR20190110567A (ko) * | 2017-01-31 | 2019-09-30 | 베루 인코퍼레이티드 | 성선 자극 호르몬-방출 호르몬(GnRH) 길항제의 장기간 방출을 위한 조성물 및 방법 |
KR102142026B1 (ko) * | 2017-05-31 | 2020-08-06 | 주식회사 대웅제약 | 방출제어가 용이한 서방성 약물 미립자의 제조방법 |
KR102047983B1 (ko) | 2017-11-30 | 2019-11-22 | 주식회사 지투지바이오 | 안전성 및 저장 안정성이 향상된 생분해성 미립구의 제조방법 |
KR20190121699A (ko) * | 2018-04-18 | 2019-10-28 | (주)인벤티지랩 | 데옥시콜린산을 포함하는 피하 주사용 조성물 및 이의 제조 방법 |
WO2019203543A1 (ko) * | 2018-04-18 | 2019-10-24 | (주)인벤티지랩 | 데옥시콜린산을 포함하는 피하 주사용 조성물 및 이의 제조 방법 |
US20220023217A1 (en) * | 2018-12-17 | 2022-01-27 | G2Gbio, Inc. | Sustained-release injection comprising deslorelin, and preparation method therefor |
WO2023090899A1 (ko) * | 2021-11-18 | 2023-05-25 | (주)인벤티지랩 | 난용성 약물을 포함하는 마이크로 입자의 제조 방법 |
CN114668729B (zh) * | 2022-02-25 | 2023-09-29 | 浙江圣兆药物科技股份有限公司 | 一种曲普瑞林缓释制剂的连续化生产方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5366734A (en) | 1981-02-16 | 1994-11-22 | Zeneca Limited | Continuous release pharmaceutical compositions |
TW448055B (en) | 1995-09-04 | 2001-08-01 | Takeda Chemical Industries Ltd | Method of production of sustained-release preparation |
DE69738124T2 (de) * | 1997-05-08 | 2008-06-12 | Amarnath Maitra | Verfahren zur Herstellung von hochmonodisperser, Polymeren, hydrophiler Nanopartikel |
KR100754352B1 (ko) * | 1999-05-24 | 2007-08-31 | 소너스파머슈티칼즈인코포레이티드 | 난용성 약물용 에멀젼 부형제의 제조방법 |
JP3523821B2 (ja) * | 2000-02-09 | 2004-04-26 | ナノキャリア株式会社 | 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物 |
KR100433061B1 (ko) | 2001-09-12 | 2004-05-28 | 김시환 | 휴대용 멀티 표시장치 |
CN101444476B (zh) * | 2001-12-26 | 2011-11-30 | 武田药品工业株式会社 | 新微球和其生产方法 |
KR100709015B1 (ko) * | 2002-11-13 | 2007-04-18 | (주)아모레퍼시픽 | 지속적 약물방출이 가능한 고분자 미립구 및 그 제조방법 |
JP2007514529A (ja) * | 2003-12-19 | 2007-06-07 | エスセーエフ テクノロジーズ アクティーゼルスカブ | 微粒子およびその他の物質を調製するためのシステム |
TW200529890A (en) * | 2004-02-10 | 2005-09-16 | Takeda Pharmaceutical | Sustained-release preparations |
KR100816065B1 (ko) * | 2006-11-27 | 2008-03-24 | 동국제약 주식회사 | 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐 |
-
2008
- 2008-08-29 KR KR1020080085368A patent/KR101113044B1/ko active IP Right Grant
-
2009
- 2009-08-28 MX MX2011002210A patent/MX2011002210A/es not_active Application Discontinuation
- 2009-08-28 US US13/061,389 patent/US20110200679A1/en not_active Abandoned
- 2009-08-28 EP EP09810220A patent/EP2327397A2/en not_active Withdrawn
- 2009-08-28 RU RU2011111714/15A patent/RU2011111714A/ru unknown
- 2009-08-28 WO PCT/KR2009/004820 patent/WO2010024615A2/ko active Application Filing
- 2009-08-28 BR BRPI0917714A patent/BRPI0917714A2/pt not_active IP Right Cessation
- 2009-08-28 CN CN2009801340116A patent/CN102137657A/zh active Pending
- 2009-08-28 JP JP2011524904A patent/JP2012501321A/ja not_active Withdrawn
-
2011
- 2011-02-23 CL CL2011000393A patent/CL2011000393A1/es unknown
- 2011-02-28 CO CO11023782A patent/CO6341545A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2010024615A2 (ko) | 2010-03-04 |
JP2012501321A (ja) | 2012-01-19 |
CN102137657A (zh) | 2011-07-27 |
WO2010024615A3 (ko) | 2010-06-17 |
BRPI0917714A2 (pt) | 2016-02-16 |
KR101113044B1 (ko) | 2012-02-27 |
RU2011111714A (ru) | 2012-10-10 |
EP2327397A2 (en) | 2011-06-01 |
KR20100026384A (ko) | 2010-03-10 |
CL2011000393A1 (es) | 2011-08-19 |
US20110200679A1 (en) | 2011-08-18 |
MX2011002210A (es) | 2011-06-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6341545A2 (es) | Metodo para elaborar una microesfera de liberacion sostenida mediante un metodo de la evaporacion de solvente | |
TR201902233T4 (tr) | Hızlı çözünen katı dozaj formu. | |
BR112015019546A2 (pt) | implante de distribuição de drogas prolongado | |
AR077325A1 (es) | Diferenciacion de celulas madre embrionarias humanas | |
CY1117964T1 (el) | Αντιψυχωτικη ενεσιμη συνθεση μακρας διαρκειας δρασης τεχνικος τομεας | |
MX2011004994A (es) | Metodo para preparar microesferas y microesferas producidas por el mismo. | |
PE20071139A1 (es) | Formulacion de liberacion sostenida que comprende octreotida y dos o mas polimeros de polilactido-co-glicolido | |
EA201190300A1 (ru) | Микроэлектрод и множественные микроэлектроды, содержащие устройства для высвобождения лекарственных средств в ткани | |
AR063446A1 (es) | Sistema de administracion para el tratamiento remoto de un animal | |
BR112012021256A2 (pt) | composições para liberação alvejada de sirna. | |
AR075913A1 (es) | Metodo para preparar un conjugado polipeptidico fisiologicamente activo de sitio especifico | |
EA201590583A1 (ru) | Способ получения терапевтических наночастиц | |
BRPI0809326B8 (pt) | métodos de preparação de microesfera de liberação controlada contendo exendina com camada de revestimento, composição e microesfera | |
AR027520A1 (es) | Implantes farmaceuticos para liberar de manera controlable una droga y metodos para fabricar y administrar el implante | |
UY31816A (es) | Agente para el tratamiento y/o prevención de una enfemedad autoinmune y para la formación de células t reguladoras | |
MX2009011275A (es) | Una composicion de microesferas biodegradables adecuadas para la liberacion controlada de peptido de control de la glucosa y formulacion de la misma. | |
IN2012DN00570A (es) | ||
UY31975A (es) | Sistema y administración transdérmica de estrógeno | |
EP3494959A3 (en) | Sustained release latanoprost implant | |
CL2012001725A1 (es) | Procesos para la preparacion de 2-(6-fluoro-1h-indol-3-il)etanamina, a partir de (6-fluoro-1h-indol-3-il)acetonitrilo y un catalizador de metal de transicion en un solvente alcoholico, posteriormente hidrogenar la mezcla con h2. | |
ATE539676T1 (de) | Vorrichtung zur verabreichung eines implantierbaren monitors | |
BRPI0910037A2 (pt) | método para fabricar polilactídeo estável | |
CR20150299A (es) | Dispersión sólida de un modulador selectivo de los receptores de progesterona | |
PE20110876A1 (es) | Formulacion de deposito de octreotida con niveles de exposicion constantemente altos | |
CO6260054A2 (es) | Extruidos con enmascaramiento del sabor mejorado |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |