CY1111960T1 - Νεα φαρμακευτικα παρασκευασματα καθως επισης μεθοδος για την παρασκευη αυτων - Google Patents

Νεα φαρμακευτικα παρασκευασματα καθως επισης μεθοδος για την παρασκευη αυτων

Info

Publication number
CY1111960T1
CY1111960T1 CY20111100847T CY111100847T CY1111960T1 CY 1111960 T1 CY1111960 T1 CY 1111960T1 CY 20111100847 T CY20111100847 T CY 20111100847T CY 111100847 T CY111100847 T CY 111100847T CY 1111960 T1 CY1111960 T1 CY 1111960T1
Authority
CY
Cyprus
Prior art keywords
concentrated
pharmaceutical preparations
preparing
new pharmaceutical
supersaturated
Prior art date
Application number
CY20111100847T
Other languages
English (en)
Inventor
Berthold Roessler
Original Assignee
Baxter International Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc. filed Critical Baxter International Inc.
Publication of CY1111960T1 publication Critical patent/CY1111960T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση αφορά τη χρήση μερκαπτοαίθανο σουλφονικού-νατρίου (Mesna) για να αυξάνεται η διαλυτότητα του Ιφωσφαμιδίου σε σταθερά στην αποθήκευση, συμπυκνωμένα ή/και εντόνως συμπυκνωμένα (υπερκορεσμένα) υδατικά φαρμακευτικά παρασκευάσματα Ιφωσφαμιδίου για παρεντερική χορήγηση, καθώς επίσης μέθοδο παρασκευής αυτών.
CY20111100847T 2003-10-01 2011-09-05 Νεα φαρμακευτικα παρασκευασματα καθως επισης μεθοδος για την παρασκευη αυτων CY1111960T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50775003P 2003-10-01 2003-10-01
EP04789095A EP1667655B1 (en) 2003-10-01 2004-09-28 New use, pharmaceutical preparations as well as a process for their production

Publications (1)

Publication Number Publication Date
CY1111960T1 true CY1111960T1 (el) 2015-11-04

Family

ID=34421657

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100847T CY1111960T1 (el) 2003-10-01 2011-09-05 Νεα φαρμακευτικα παρασκευασματα καθως επισης μεθοδος για την παρασκευη αυτων

Country Status (13)

Country Link
US (1) US8093230B2 (el)
EP (1) EP1667655B1 (el)
JP (2) JP4886517B2 (el)
AT (1) ATE516014T1 (el)
CA (1) CA2540537A1 (el)
CY (1) CY1111960T1 (el)
DK (1) DK1667655T3 (el)
ES (1) ES2369776T3 (el)
HK (1) HK1091146A1 (el)
PL (1) PL1667655T3 (el)
PT (1) PT1667655E (el)
SI (1) SI1667655T1 (el)
WO (1) WO2005032515A1 (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1958618A1 (de) * 2007-02-15 2008-08-20 Octapharma AG Verfahren zur Gefriertrocknung mit optimierter Rekonstitution von Biopolymeren
WO2014180902A1 (en) * 2013-05-07 2014-11-13 Auxin Surgery Sa Device for chemically assisted dissection
PL3092009T3 (pl) 2014-01-06 2020-03-31 Auxin Surgery Sa Liofilozowane kompozycje mesny
PL3429555T3 (pl) * 2016-03-14 2020-08-24 Auxin Surgery Sa Preparat mesny i jego zastosowanie
BE1024110B1 (fr) * 2016-10-18 2017-11-16 Auxin Surgery Sa Dispositif, procédé et formulation pour dissection assistée de manière chimique

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732340A (en) * 1966-07-11 1973-05-08 Asta Werke Ag Chem Fab N',o-propylene phosphoric acid ester diamides
US4220660A (en) * 1977-12-14 1980-09-02 Asta-werke Aktiengesellschaft, Chemische Farik Process for the treatment of humans suffering from undesired urotoxic side effects caused by cytostatically active alkylating agents
US5204335A (en) * 1986-10-31 1993-04-20 Asta Pharma Aktiengesellschaft Ifosfamide lyophilisate and process for its preparation
DE3862595D1 (de) * 1987-03-06 1991-06-06 Asta Pharma Ag Verfahren zur herstellung von ifosfamid mit verbesserten eigenschaften.
ATE65402T1 (de) * 1988-03-19 1991-08-15 Asta Pharma Ag Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung.
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
DE19529057B4 (de) * 1995-08-08 2007-12-13 Baxter Healthcare S.A. Ifosfamid-Lyophilisat-Zubereitungen
DE19540132C2 (de) 1995-10-27 2003-04-03 Stada Arzneimittel Ag Ifosfamid-Lyophilisat
CA2470472A1 (en) 2001-12-13 2003-06-26 Sicor Inc. Aqueous ifosfamide composition
US6613927B1 (en) * 2002-02-08 2003-09-02 American Pharmaceutical Partners, Inc. Sterile lyophilized ifosfamide and associated methods
BR0314068A (pt) 2002-09-05 2005-07-05 Bharat Serums & Vaccines Ltd Processo para a preparação de uma composição estável com baixo nìvel de toxicidade; composição estável que contém oxazafosforina; uso de uma composição estável que contém oxazafosforina; e método de tratamento de uma doença maligna
US7199111B2 (en) * 2002-12-02 2007-04-03 Bharat Serums & Vaccines Ltd. Aqueous ifosfamide compositions for parenteral administration and a process for their preparations

Also Published As

Publication number Publication date
EP1667655A1 (en) 2006-06-14
US8093230B2 (en) 2012-01-10
PL1667655T3 (pl) 2012-05-31
CA2540537A1 (en) 2005-04-14
SI1667655T1 (sl) 2011-10-28
WO2005032515A1 (en) 2005-04-14
EP1667655B1 (en) 2011-07-13
PT1667655E (pt) 2011-08-18
ES2369776T3 (es) 2011-12-05
US20050124589A1 (en) 2005-06-09
HK1091146A1 (en) 2007-01-12
JP2007507506A (ja) 2007-03-29
JP2011137048A (ja) 2011-07-14
DK1667655T3 (da) 2011-10-24
JP4886517B2 (ja) 2012-02-29
ATE516014T1 (de) 2011-07-15

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