YU2003A - Stabilne soli o-acetilsalicilne kiseline sa baznim amino-kiselinama - Google Patents

Stabilne soli o-acetilsalicilne kiseline sa baznim amino-kiselinama

Info

Publication number
YU2003A
YU2003A YU2003A YUP2003A YU2003A YU 2003 A YU2003 A YU 2003A YU 2003 A YU2003 A YU 2003A YU P2003 A YUP2003 A YU P2003A YU 2003 A YU2003 A YU 2003A
Authority
YU
Yugoslavia
Prior art keywords
amino acids
basic amino
stable salts
acetylsalicyclic acid
acetylsalicyclic
Prior art date
Application number
YU2003A
Other languages
English (en)
Inventor
Gerhard Franckowiak
Hubert Appolt
Gregor Leifker
Hans-Peter Wirges
Wolfram Ledwoch
Original Assignee
Bayer Health Care Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Health Care Ag. filed Critical Bayer Health Care Ag.
Publication of YU2003A publication Critical patent/YU2003A/sh
Publication of RS50329B publication Critical patent/RS50329B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

Abstract

Pronalazak se odnosi na stabilne soli o-acetilsalicilne kiseline sa baznim amino kiselinama, na postupak za njihovo pripremanje kao i na njihovu primenu kao leka.[The invention relates to stable salts of o-acetylsalicyclic acid with basic amino acids, to a method for producing them and to their use as medicaments.
YUP-20/03A 2000-07-18 2001-07-05 Stabilne soli o-acetilsalicilne kiseline sa baznim amino-kiselinama RS50329B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10034802A DE10034802A1 (de) 2000-07-18 2000-07-18 Stabile Salze von O-Acetylsalicylsäure mit basischen Aminosäuren

Publications (2)

Publication Number Publication Date
YU2003A true YU2003A (sh) 2006-08-17
RS50329B RS50329B (sr) 2009-09-08

Family

ID=7649258

Country Status (34)

Country Link
US (2) US6773724B2 (sh)
EP (1) EP1365737B1 (sh)
JP (2) JP2004507463A (sh)
KR (1) KR100773658B1 (sh)
CN (1) CN1205176C (sh)
AR (1) AR030305A1 (sh)
AT (1) ATE293589T1 (sh)
AU (2) AU2001278471B2 (sh)
BR (1) BR0112538A (sh)
CA (1) CA2416288C (sh)
CR (1) CR6888A (sh)
CZ (1) CZ300337B6 (sh)
DE (2) DE10034802A1 (sh)
DK (1) DK1365737T3 (sh)
EC (1) ECSP034437A (sh)
ES (1) ES2241849T3 (sh)
GT (1) GT200100134A (sh)
HK (1) HK1061811A1 (sh)
HR (1) HRP20030108B1 (sh)
HU (1) HUP0302053A3 (sh)
IL (2) IL153873A0 (sh)
MX (1) MXPA03000510A (sh)
MY (1) MY134521A (sh)
NO (1) NO20030222D0 (sh)
PE (1) PE20020267A1 (sh)
PL (1) PL204593B1 (sh)
PT (1) PT1365737E (sh)
RS (1) RS50329B (sh)
SK (1) SK286162B6 (sh)
SV (1) SV2002000557A (sh)
TW (1) TWI299729B (sh)
UY (1) UY26841A1 (sh)
WO (1) WO2002005782A2 (sh)
ZA (1) ZA200300469B (sh)

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US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
DE10202019A1 (de) * 2002-01-18 2003-07-24 Bayer Ag Stabile Salze von o-Acetylsalicylsäure mit basischen Aminosäuren II
US8142810B2 (en) 2002-05-30 2012-03-27 The Procter & Gamble Company Dietary method for modulating glucose metabolism and associated conditions and increasing longevity
ATE442352T1 (de) * 2003-05-16 2009-09-15 Cephalon France Verfahren zur herstellung von modafinil
US20060063930A1 (en) * 2004-08-20 2006-03-23 Agoston Gregory E Compositions and methods comprising proteinase activated receptor antagonists
US20060166901A1 (en) * 2005-01-03 2006-07-27 Yu Ruey J Compositions comprising O-acetylsalicyl derivatives of aminocarbohydrates and amino acids
DE102005025283A1 (de) * 2005-06-02 2006-12-07 Bayer Healthcare Ag Stabiler Wirkstoffkomplex von Salzen der o-Acetylsalicylsäure mit basischen Aminosäuren und Glycin
DE102005049293A1 (de) * 2005-10-15 2007-04-26 Bayer Healthcare Ag Kombinationspräparate von Salzen oder o-Acetylsalicylsäure
US20090238763A1 (en) * 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
AU2006346195B2 (en) 2006-07-09 2013-03-07 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aspirin
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
RU2509076C2 (ru) 2007-06-04 2014-03-10 Текфилдз Инк Пролекарства нестероидных противовоспалительных средств (nsaia) c очень высокой скоростью проникновения через кожу и мембраны и новые медицинские применения указанных пролекарств
DE102008004386A1 (de) * 2008-01-14 2009-07-23 Activaero Gmbh Verwendung eines Acetylsalicylsäuresalzes zur Behandlung viraler Infektionen
CN101314029B (zh) * 2008-06-18 2010-12-08 四川省农业科学院实验场 乙酰水杨酸肽及其制备方法
WO2010056919A2 (en) * 2008-11-12 2010-05-20 Kyphia Pharmaceuticals, Inc. Eflornithine prodrugs, conjugates and salts, and methods of use thereof
RU2765463C2 (ru) 2008-12-04 2022-01-31 Чунси ЮЙ Композиции интенсивного проникновения и их применение
WO2010151095A1 (en) * 2009-06-25 2010-12-29 Tetra, Sia Novel acetylsalicylic acid salts
CN101633624B (zh) * 2009-08-04 2013-05-01 蚌埠丰原医药科技发展有限公司 改进的赖氨匹林的制备方法
FR2965261B1 (fr) * 2009-09-30 2012-10-26 Holis Technologies Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue par ce procede
FR2950625B1 (fr) * 2009-09-30 2016-12-02 Holis Tech Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue
FR2973370B1 (fr) * 2011-03-29 2013-05-03 Holis Technologies Procede a faible cout pour la preparation d'un acide o-acetylsalicyclique et d'un acide amine basique
CN102503845A (zh) * 2011-09-28 2012-06-20 广州普星药业有限公司 一种dl-赖氨酸阿司匹林盐的制备方法及其应用
AU2013262320B2 (en) 2012-05-16 2018-02-22 Techfields Pharma Co., Ltd. High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions
CN102976962B (zh) * 2012-11-20 2015-02-04 南京工业大学 L-鸟氨酸阿司匹林复盐及其制备方法和应用
FR3021654B1 (fr) * 2014-05-28 2016-06-24 Unither Pharmaceuticals Procede de preparation d'un sel d'acide acetylsalicylique et d'un acide amine basique
WO2018115434A1 (en) * 2016-12-23 2018-06-28 Ventaleon Gmbh Improved synthesis of lysine acetylsalicylate · glycine particles
EP3630120A4 (en) 2017-05-30 2021-01-13 Rhoshan Pharmaceuticals, Inc. STABLE, STERILE AND CRYSTALLINE O-ACETYLSALICYLIC ACID (ASPIRIN) BOTTLE DEPOSIT
JPWO2019026992A1 (ja) * 2017-08-03 2020-06-18 参天製薬株式会社 クロルヘキシジンを含有する医薬組成物
CN113105326A (zh) * 2021-03-24 2021-07-13 海南卓华制药有限公司 赖氨匹林的制备方法及应用
CN114478287A (zh) * 2021-12-31 2022-05-13 蚌埠丰原医药科技发展有限公司 一种赖氨匹林晶型及制备方法和应用
WO2023131645A1 (en) 2022-01-05 2023-07-13 Aspiair Gmbh Improved synthesis of lysine acetylsalicylate · glycine particles

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FR2115060A1 (en) * 1970-11-26 1972-07-07 Metabio Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin
ES388158A1 (es) * 1971-02-11 1974-03-16 Liade Sa Lab Procedimiento de obtencion de sales solubles del acido ace-til salicilico.
JPS4856815A (sh) * 1971-11-13 1973-08-09
JPS55127345A (en) * 1979-03-23 1980-10-02 Kyowa Hakko Kogyo Co Ltd Preparation of acetylsalicylic acid salt
JPS5610110A (en) * 1979-07-06 1981-02-02 Green Cross Corp:The Acetyl salicylate salt preparation for injection
JPS56113741A (en) * 1980-02-13 1981-09-07 Mitsui Toatsu Chem Inc Preparation of crystal of acetylsalicylic acid salt
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Also Published As

Publication number Publication date
NO20030222L (no) 2003-01-16
US7449198B2 (en) 2008-11-11
NO20030222D0 (no) 2003-01-16
TWI299729B (en) 2008-08-11
CA2416288C (en) 2009-12-22
ATE293589T1 (de) 2005-05-15
MY134521A (en) 2007-12-31
US20020091108A1 (en) 2002-07-11
SK672003A3 (en) 2003-06-03
CZ2003164A3 (cs) 2003-04-16
US6773724B2 (en) 2004-08-10
RS50329B (sr) 2009-09-08
WO2002005782A3 (de) 2003-10-02
DK1365737T3 (da) 2005-07-11
EP1365737B1 (de) 2005-04-20
CA2416288A1 (en) 2003-01-15
AU7847101A (en) 2002-01-30
DE10034802A1 (de) 2002-01-31
CZ300337B6 (cs) 2009-04-22
JP2012131824A (ja) 2012-07-12
KR20030019586A (ko) 2003-03-06
SK286162B6 (sk) 2008-04-07
HUP0302053A2 (hu) 2003-09-29
HRP20030108B1 (en) 2006-12-31
PL204593B1 (pl) 2010-01-29
ECSP034437A (es) 2003-03-31
PE20020267A1 (es) 2002-06-08
AU2001278471B2 (en) 2004-07-22
PT1365737E (pt) 2005-08-31
IL153873A0 (en) 2003-07-31
PL365648A1 (en) 2005-01-10
CN1468209A (zh) 2004-01-14
ZA200300469B (en) 2004-06-21
SV2002000557A (es) 2002-10-24
IL153873A (en) 2009-05-04
JP2004507463A (ja) 2004-03-11
ES2241849T3 (es) 2005-11-01
MXPA03000510A (es) 2004-04-20
KR100773658B1 (ko) 2007-11-05
GT200100134A (es) 2002-03-22
DE50105985D1 (de) 2005-05-25
AR030305A1 (es) 2003-08-20
HUP0302053A3 (en) 2010-03-29
UY26841A1 (es) 2002-02-28
HK1061811A1 (en) 2004-10-08
US20050009791A1 (en) 2005-01-13
CN1205176C (zh) 2005-06-08
EP1365737A2 (de) 2003-12-03
WO2002005782A2 (de) 2002-01-24
HRP20030108A2 (en) 2005-02-28
BR0112538A (pt) 2003-09-09
CR6888A (es) 2004-10-28

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