JPS56113741A - Preparation of crystal of acetylsalicylic acid salt - Google Patents
Preparation of crystal of acetylsalicylic acid saltInfo
- Publication number
- JPS56113741A JPS56113741A JP1545080A JP1545080A JPS56113741A JP S56113741 A JPS56113741 A JP S56113741A JP 1545080 A JP1545080 A JP 1545080A JP 1545080 A JP1545080 A JP 1545080A JP S56113741 A JPS56113741 A JP S56113741A
- Authority
- JP
- Japan
- Prior art keywords
- crystal
- amino acid
- acetylsalicylic acid
- acid salt
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled crystal useful as an antipyretic, analgesic and antirheumatic agent, in high quality and processability, by reacting acetylsalicylic acid with an amino acid in a solvent system containing a specific solvent, and crystallizing the reaction product.
CONSTITUTION: Acetylsalicylic acid is made to react with an amino acid (e.g. dl- lysine) using an alcohol or its aqueous mixture, or acetone or its aquesous mixture as the reaction and crystallization solvent to obtain crystal of acetylsalicylic acid amino acid salt. When an aromatic hydrocarbon (e.g. benzene) is added to the reaction system, the size of the crystallized aspirin amino acid salt crystal is increased, and consequently, the filtration and washing of the crystal are facilitated, the hydrolysis of the product is prevented, and the drying is also facilitated.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1545080A JPS56113741A (en) | 1980-02-13 | 1980-02-13 | Preparation of crystal of acetylsalicylic acid salt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1545080A JPS56113741A (en) | 1980-02-13 | 1980-02-13 | Preparation of crystal of acetylsalicylic acid salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56113741A true JPS56113741A (en) | 1981-09-07 |
| JPS6323985B2 JPS6323985B2 (en) | 1988-05-18 |
Family
ID=11889130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1545080A Granted JPS56113741A (en) | 1980-02-13 | 1980-02-13 | Preparation of crystal of acetylsalicylic acid salt |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56113741A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004507463A (en) * | 2000-07-18 | 2004-03-11 | バイエル アクチェンゲゼルシャフト | Stable salt of o-acetylsalicylic acid and basic amino acid |
-
1980
- 1980-02-13 JP JP1545080A patent/JPS56113741A/en active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004507463A (en) * | 2000-07-18 | 2004-03-11 | バイエル アクチェンゲゼルシャフト | Stable salt of o-acetylsalicylic acid and basic amino acid |
| US6773724B2 (en) * | 2000-07-18 | 2004-08-10 | Bayer Ag | Stable salts of O-acetylsalicylic acid with basic amino acids |
| US7449198B2 (en) | 2000-07-18 | 2008-11-11 | Bayer Healthcare Ag | Stable salts of O-acetylsalicylic acid with basic amino acids |
| JP2012131824A (en) * | 2000-07-18 | 2012-07-12 | Bayer Pharma AG | Stable salt of o-acetylsalicylic acid with basic amino acid |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6323985B2 (en) | 1988-05-18 |
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