HUP0302053A3 - Stable salts of o-acetylsalicylic with basic amino acids amino acids - Google Patents

Stable salts of o-acetylsalicylic with basic amino acids amino acids

Info

Publication number
HUP0302053A3
HUP0302053A3 HU0302053A HUP0302053A HUP0302053A3 HU P0302053 A3 HUP0302053 A3 HU P0302053A3 HU 0302053 A HU0302053 A HU 0302053A HU P0302053 A HUP0302053 A HU P0302053A HU P0302053 A3 HUP0302053 A3 HU P0302053A3
Authority
HU
Hungary
Prior art keywords
amino acids
acetylsalicylic
stable salts
basic amino
basic
Prior art date
Application number
HU0302053A
Other languages
English (en)
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of HUP0302053A2 publication Critical patent/HUP0302053A2/hu
Publication of HUP0302053A3 publication Critical patent/HUP0302053A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
HU0302053A 2000-07-18 2001-07-05 Stable salts of o-acetylsalicylic with basic amino acids amino acids HUP0302053A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10034802A DE10034802A1 (de) 2000-07-18 2000-07-18 Stabile Salze von O-Acetylsalicylsäure mit basischen Aminosäuren
PCT/EP2001/007669 WO2002005782A2 (de) 2000-07-18 2001-07-05 Stabile salze von o-acetylsalicylsäure mit basischen aminosäuren

Publications (2)

Publication Number Publication Date
HUP0302053A2 HUP0302053A2 (hu) 2003-09-29
HUP0302053A3 true HUP0302053A3 (en) 2010-03-29

Family

ID=7649258

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302053A HUP0302053A3 (en) 2000-07-18 2001-07-05 Stable salts of o-acetylsalicylic with basic amino acids amino acids

Country Status (34)

Country Link
US (2) US6773724B2 (hu)
EP (1) EP1365737B1 (hu)
JP (2) JP2004507463A (hu)
KR (1) KR100773658B1 (hu)
CN (1) CN1205176C (hu)
AR (1) AR030305A1 (hu)
AT (1) ATE293589T1 (hu)
AU (2) AU2001278471B2 (hu)
BR (1) BR0112538A (hu)
CA (1) CA2416288C (hu)
CR (1) CR6888A (hu)
CZ (1) CZ300337B6 (hu)
DE (2) DE10034802A1 (hu)
DK (1) DK1365737T3 (hu)
EC (1) ECSP034437A (hu)
ES (1) ES2241849T3 (hu)
GT (1) GT200100134A (hu)
HK (1) HK1061811A1 (hu)
HR (1) HRP20030108B1 (hu)
HU (1) HUP0302053A3 (hu)
IL (2) IL153873A0 (hu)
MX (1) MXPA03000510A (hu)
MY (1) MY134521A (hu)
NO (1) NO20030222D0 (hu)
PE (1) PE20020267A1 (hu)
PL (1) PL204593B1 (hu)
PT (1) PT1365737E (hu)
RS (1) RS50329B (hu)
SK (1) SK286162B6 (hu)
SV (1) SV2002000557A (hu)
TW (1) TWI299729B (hu)
UY (1) UY26841A1 (hu)
WO (1) WO2002005782A2 (hu)
ZA (1) ZA200300469B (hu)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
DE10202019A1 (de) * 2002-01-18 2003-07-24 Bayer Ag Stabile Salze von o-Acetylsalicylsäure mit basischen Aminosäuren II
US8142810B2 (en) 2002-05-30 2012-03-27 The Procter & Gamble Company Dietary method for modulating glucose metabolism and associated conditions and increasing longevity
ATE442352T1 (de) * 2003-05-16 2009-09-15 Cephalon France Verfahren zur herstellung von modafinil
AU2005277203A1 (en) * 2004-08-20 2006-03-02 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
US20060166901A1 (en) * 2005-01-03 2006-07-27 Yu Ruey J Compositions comprising O-acetylsalicyl derivatives of aminocarbohydrates and amino acids
DE102005025283A1 (de) * 2005-06-02 2006-12-07 Bayer Healthcare Ag Stabiler Wirkstoffkomplex von Salzen der o-Acetylsalicylsäure mit basischen Aminosäuren und Glycin
DE102005049293A1 (de) * 2005-10-15 2007-04-26 Bayer Healthcare Ag Kombinationspräparate von Salzen oder o-Acetylsalicylsäure
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
AU2006346195B2 (en) 2006-07-09 2013-03-07 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aspirin
KR101853971B1 (ko) 2007-06-04 2018-05-02 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도
DE102008004386A1 (de) * 2008-01-14 2009-07-23 Activaero Gmbh Verwendung eines Acetylsalicylsäuresalzes zur Behandlung viraler Infektionen
CN101314029B (zh) * 2008-06-18 2010-12-08 四川省农业科学院实验场 乙酰水杨酸肽及其制备方法
US20100120727A1 (en) * 2008-11-12 2010-05-13 Kyphia Pharmaceuticals, Inc. Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof
CA2745206C (en) 2008-12-04 2018-09-18 Chongxi Yu High penetration compositions and their applications
CN102803199B (zh) * 2009-06-25 2015-04-15 泰特拉有限公司 乙酰水杨酸盐
CN101633624B (zh) * 2009-08-04 2013-05-01 蚌埠丰原医药科技发展有限公司 改进的赖氨匹林的制备方法
FR2950625B1 (fr) * 2009-09-30 2016-12-02 Holis Tech Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue
FR2965261B1 (fr) * 2009-09-30 2012-10-26 Holis Technologies Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue par ce procede
FR2973370B1 (fr) * 2011-03-29 2013-05-03 Holis Technologies Procede a faible cout pour la preparation d'un acide o-acetylsalicyclique et d'un acide amine basique
CN102503845A (zh) * 2011-09-28 2012-06-20 广州普星药业有限公司 一种dl-赖氨酸阿司匹林盐的制备方法及其应用
IN2014KN02583A (hu) 2012-05-16 2015-05-08 Techfields Pharma Co Ltd
CN102976962B (zh) * 2012-11-20 2015-02-04 南京工业大学 L-鸟氨酸阿司匹林复盐及其制备方法和应用
FR3021654B1 (fr) * 2014-05-28 2016-06-24 Unither Pharmaceuticals Procede de preparation d'un sel d'acide acetylsalicylique et d'un acide amine basique
JP7012725B2 (ja) * 2016-12-23 2022-01-28 アスピエアー ゲーエムベーハー アセチルサリチル酸リジン・グリシン粒子の改良された合成
CA3064012A1 (en) 2017-05-30 2018-12-06 Rhoshan Pharmaceuticals, Inc. In-vial deposition of a stable, sterile and crystalline o-acetyl salicylic acid (aspirin)
KR20200035047A (ko) * 2017-08-03 2020-04-01 산텐 세이야꾸 가부시키가이샤 클로르헥시딘을 함유하는 의약 조성물
CN113105326A (zh) * 2021-03-24 2021-07-13 海南卓华制药有限公司 赖氨匹林的制备方法及应用
CN114478287A (zh) * 2021-12-31 2022-05-13 蚌埠丰原医药科技发展有限公司 一种赖氨匹林晶型及制备方法和应用
CA3239851A1 (en) 2022-01-05 2023-07-13 Karlheinz Nocker Improved synthesis of lysine acetylsalicylate · glycine particles

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2115060A1 (en) * 1970-11-26 1972-07-07 Metabio Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin
ES388158A1 (es) * 1971-02-11 1974-03-16 Liade Sa Lab Procedimiento de obtencion de sales solubles del acido ace-til salicilico.
JPS4856815A (hu) * 1971-11-13 1973-08-09
JPS55127345A (en) * 1979-03-23 1980-10-02 Kyowa Hakko Kogyo Co Ltd Preparation of acetylsalicylic acid salt
JPS5610110A (en) * 1979-07-06 1981-02-02 Green Cross Corp:The Acetyl salicylate salt preparation for injection
JPS56113741A (en) * 1980-02-13 1981-09-07 Mitsui Toatsu Chem Inc Preparation of crystal of acetylsalicylic acid salt
JPS5721345A (en) * 1980-07-15 1982-02-04 Mitsui Toatsu Chem Inc Purification of acetylsalicylate salt
CS247688B1 (cs) * 1984-12-22 1987-01-15 Evzen Kasafirek Způsob výroby soli lysinu s kyselinou acetylsalicylovou
JPS632929A (ja) * 1986-06-20 1988-01-07 Kao Corp アセチルサリチル酸製剤
EP0499142A3 (en) * 1991-02-09 1993-05-05 Hoechst Aktiengesellschaft Potentiation of the antireactive-antiasthmatic effect of inhaled loop diuretics by inhaled non steroidal anti-flammatory drugs
DE4332093C2 (de) * 1993-09-22 1995-07-13 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Acetylsalicylsäure und Verfahren zu seiner Herstellung

Also Published As

Publication number Publication date
KR20030019586A (ko) 2003-03-06
EP1365737B1 (de) 2005-04-20
YU2003A (sh) 2006-08-17
NO20030222L (no) 2003-01-16
US20050009791A1 (en) 2005-01-13
PT1365737E (pt) 2005-08-31
PL365648A1 (en) 2005-01-10
PE20020267A1 (es) 2002-06-08
HUP0302053A2 (hu) 2003-09-29
SK672003A3 (en) 2003-06-03
ECSP034437A (es) 2003-03-31
HRP20030108B1 (en) 2006-12-31
AR030305A1 (es) 2003-08-20
GT200100134A (es) 2002-03-22
BR0112538A (pt) 2003-09-09
US20020091108A1 (en) 2002-07-11
AU2001278471B2 (en) 2004-07-22
CR6888A (es) 2004-10-28
WO2002005782A3 (de) 2003-10-02
MXPA03000510A (es) 2004-04-20
IL153873A0 (en) 2003-07-31
EP1365737A2 (de) 2003-12-03
WO2002005782A2 (de) 2002-01-24
JP2012131824A (ja) 2012-07-12
ZA200300469B (en) 2004-06-21
CA2416288A1 (en) 2003-01-15
CN1205176C (zh) 2005-06-08
ATE293589T1 (de) 2005-05-15
CA2416288C (en) 2009-12-22
HK1061811A1 (en) 2004-10-08
KR100773658B1 (ko) 2007-11-05
US6773724B2 (en) 2004-08-10
HRP20030108A2 (en) 2005-02-28
IL153873A (en) 2009-05-04
NO20030222D0 (no) 2003-01-16
DE50105985D1 (de) 2005-05-25
US7449198B2 (en) 2008-11-11
MY134521A (en) 2007-12-31
UY26841A1 (es) 2002-02-28
DK1365737T3 (da) 2005-07-11
SV2002000557A (es) 2002-10-24
TWI299729B (en) 2008-08-11
CZ2003164A3 (cs) 2003-04-16
ES2241849T3 (es) 2005-11-01
SK286162B6 (sk) 2008-04-07
RS50329B (sr) 2009-09-08
CZ300337B6 (cs) 2009-04-22
PL204593B1 (pl) 2010-01-29
JP2004507463A (ja) 2004-03-11
CN1468209A (zh) 2004-01-14
AU7847101A (en) 2002-01-30
DE10034802A1 (de) 2002-01-31

Similar Documents

Publication Publication Date Title
IL153873A0 (en) Stable salts of o-acetylsalicylic with basic amino acids
AU2001278471A1 (en) Stable salts of o-acetylsalicyclic with basic amino acids
HUP0300299A3 (en) Composition comprising free amino acids
GB0018828D0 (en) Alkyl Amino Acid Derivatives useful as pharmaceutical agents
HK1080371A1 (en) Stable salts of o-acetylsalicylic acid containing basic amino acids ii
GB9806815D0 (en) Amino acid derivatives
HUP0001560A3 (en) Stable crystal salts of 5-methyl-tetrahydrofolic acid
HRP20020963A2 (en) Beta-amino acid nitrile derivatives
AU6699201A (en) Stable gabapentin having ph within a controlled range
AU1497802A (en) Ss-thio-amino acids
GB0024693D0 (en) Beta-amino acid cyclic carboxylic acids
AU3569801A (en) Amino acid derivatives and use thereof as nep, ace and ece inhibitors
PL357011A1 (en) Novel alpha-sulfin- and alpha-sulfonamino acid amide derivatives
AU2001258543A1 (en) Branched amino acids
GB0025386D0 (en) Branched amino acids
PL357715A1 (en) Alpha-sulfin- and alpha-sulfonamino acid amide derivatives
PL357012A1 (en) Novel alpha-sulfin- and alpha-sulfonamino acid amides
SI1317426T1 (sl) Beta-tio-aminokisline
GB0017435D0 (en) 3-arylsulfonyl-2-hydroxy-2-methylpropanoic acid derivatives
GB0027198D0 (en) Diastereomerically enriched amino acids
AUPQ896500A0 (en) Amino acid derivatives
GB0027024D0 (en) Substituted Phenyl-Cycloalkyl-Alkanoic acids compounds
SI1178958T1 (en) N-cyanomethyl amides as protease inhibitors
UA3783S (uk) Етикетка "азмол старт 2т"
HUP0204378A3 (en) A process for the preparation of salts of l-carnitine and alkanoyl l-carnitine with mucic acid

Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, DE

Free format text: FORMER OWNER(S): BAYER AG., DE; BAYER HEALTHCARE AG., DE

FD9A Lapse of provisional protection due to non-payment of fees