CN101314029B - 乙酰水杨酸肽及其制备方法 - Google Patents
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Abstract
本发明提供了一种用于禽、畜类的乙酰水杨酸肽，由如下组分组成：乙酰水杨酸1mg，多肽1～2mg，氨基酸类0.2～2mg，注射用水5～10ml，多肽采用肌肽、聚合氨基酸、玉米肽、大豆肽、鱼精蛋白肽中的1～3种，氨基酸类采用甘氨酸、亮氨酸、缬氨酸、精氯酸、赖氨酸中的1～3种。退热、镇痛效果佳。本发明还提供了乙酰水杨酸肽的制备方法。
Description
技术领域：
本发明与用于禽、畜类的退热、镇痛的乙酰水杨酸肽及其制备方法有关。
背景技术：
目前用于退热、镇痛药物，有阿期匹林。但由于是单一氨基酸复合物，容易引起粘膜出血及阿期匹林副反应等。
发明内容：
本发明的目的是为了克服以上不足，提供一种退热、镇痛效果佳，无副反应的用于禽、畜类的乙酰水杨酸肽。本发明的另一个目的是为了提供乙酰水杨酸肽的制备方法。
本发明的目的是这样来实现的：
本发明乙酰水杨酸肽，由如下组分组成：
乙酰水杨酸 1mg
多肽 1～2mg
氨基酸类 0.2～2mg
注射用水 5～10ml。
上述的多肽采用肌肽、聚合氨基酸、玉米肽、大豆肽、鱼精蛋白肽等中的1～3种，上述的氨基酸类采用甘氨酸、亮氨酸、缬氨酸、精氨酸、赖氨酸中的1～3种。
本发明乙酰水杨酸肽的制备方法，该方法是按比例配料，将多肽溶于注射用水中加温到40～60℃后加入乙酰水杨酸，使之全部溶解，pH为7～8，再加入氨基酸类，搅拌即成。
本发明乙酰水杨酸肽抗炎作用强，是普遍水杨酸的3倍以上，镇痛作用强，使炎症引起的高热、疼痛迅速减轻。
本发明乙酰水杨酸肽退热、镇痛效果佳、无副作用。本发明乙酰水杨酸肽制备方法简单。
本发明申请人作了大量试验。部分试验结果如下：
实施例：
1、猪无名高热
使用本药物0.2-2g肌肉注射，使39-41℃高热的猪在15-90分钟内退热，平均热度下降2-5℃。猪炎症、疼痛减轻，持续时间3-10小时，有效率80-100％。
2、牛、羊感冒发烧
注射本发明药物0.5-6g，使牛羊感冒症状减退，有效率20-90％。
3、鱼虾夏季高温产生应激反应
按本发明药物0.1-1g/m2泼洒，使鱼虾高热烦躁拒食降低，并能正常摄食，有效率60-80％
具实施方式：
本发明乙酰水杨酸肽实施例见表1。
表1：
上述各实施例乙酰水杨酸肽的制备方法，是按比例配料，将多肽溶于注射用水中加温到40～60℃后加入乙酰水杨酸，使之全部溶解，pH为7～8，再加入氨基酸类，搅拌即成。
上述各实施例是对本发明的上述内容作进一步的说明，但不应将此理解为本发明上述主题的范围仅限于上述实施例。凡基于上述内容所实现的技术均属于本发明的范围。
Claims (2)
1.乙酰水杨酸肽的制备方法，其特征在于所述的乙酰水杨酸肽由如下组分组成：
乙酰水杨酸 1mg
多肽 1～2mg
氨基酸类 0.2～2mg
注射用水 5～10ml，
该方法是按比例配料，将多肽溶于注射用水中加温到40～60℃后加入乙酰水杨酸，使之全部溶解，pH为7～8，再加入氨基酸类，搅拌即成。
2.如权利要求1所述的乙酸水杨酸肽的制备方法，其特征在于多肽采用肌肽、聚合氨基酸、玉米肽、大豆肽、鱼精蛋白肽中的1～3种，氨基酸类采用甘氨酸、亮氨酸、缬氨酸、精氨酸、赖氨酸中的1～3种。
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| CN2008100447236A CN101314029B (zh) | 2008-06-18 | 2008-06-18 | 乙酰水杨酸肽及其制备方法 |
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| CN2008100447236A CN101314029B (zh) | 2008-06-18 | 2008-06-18 | 乙酰水杨酸肽及其制备方法 |
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| CN101314029A CN101314029A (zh) | 2008-12-03 |
| CN101314029B true CN101314029B (zh) | 2010-12-08 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1468209A (zh) * | 2000-07-18 | 2004-01-14 | 0-乙酰水杨酸与碱性氨基酸的稳定盐 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1468209A (zh) * | 2000-07-18 | 2004-01-14 | 0-乙酰水杨酸与碱性氨基酸的稳定盐 |
Non-Patent Citations (2)
| Title |
|---|
| 唐承薇等.奥曲肽联合阿司匹林抑制胃癌生长和转移.中华消化杂志.2002,22(3),135-137. * |
| 罗发强等.脑苷肌肽治疗2型糖尿病并稳定型心绞痛的临床观察.中国医刊.2006,41(3),43-44. * |
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Address after: Chengdu City, Sichuan province Jinjiang District 610066 east mountain lion Patentee after: Agro-Food Science & Technology Research Institute Address before: 610100, No. 588, east route, Longquan Development Zone, Chengdu, Sichuan Patentee before: Agro-Food Science & Technology Research Institute |
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