AR030305A1 - Composicion que comprende sales de acido o-acetilsalicilico con aminoacidos basicos, un procedimiento para su preparacion, uso de dicha composicion para la manufactura de un medicamento - Google Patents
Composicion que comprende sales de acido o-acetilsalicilico con aminoacidos basicos, un procedimiento para su preparacion, uso de dicha composicion para la manufactura de un medicamentoInfo
- Publication number
- AR030305A1 AR030305A1 ARP010103378A ARP010103378A AR030305A1 AR 030305 A1 AR030305 A1 AR 030305A1 AR P010103378 A ARP010103378 A AR P010103378A AR P010103378 A ARP010103378 A AR P010103378A AR 030305 A1 AR030305 A1 AR 030305A1
- Authority
- AR
- Argentina
- Prior art keywords
- composition
- procedure
- manufacture
- preparation
- basic amino
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
Abstract
Composicion que comprende una sal de ácido o-acetilsalicílico con un aminoácido básico, caracterizada porque la sal presenta en una distribucion de tamanos de grano medida en condiciones estándar con un aparato Malvern 2600D un tamano medio de grano superior a un tamano de grano de 160 mm y una proporcion de más de 60% de las partículas con un tamano de grano en un intervalo de 100 a 200 mm, a un procedimiento para su preparacion así como a un medicamento y el uso de dicha composicion para la manufactura de un medicamento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10034802A DE10034802A1 (de) | 2000-07-18 | 2000-07-18 | Stabile Salze von O-Acetylsalicylsäure mit basischen Aminosäuren |
Publications (1)
Publication Number | Publication Date |
---|---|
AR030305A1 true AR030305A1 (es) | 2003-08-20 |
Family
ID=7649258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103378A AR030305A1 (es) | 2000-07-18 | 2001-07-16 | Composicion que comprende sales de acido o-acetilsalicilico con aminoacidos basicos, un procedimiento para su preparacion, uso de dicha composicion para la manufactura de un medicamento |
Country Status (34)
Country | Link |
---|---|
US (2) | US6773724B2 (es) |
EP (1) | EP1365737B1 (es) |
JP (2) | JP2004507463A (es) |
KR (1) | KR100773658B1 (es) |
CN (1) | CN1205176C (es) |
AR (1) | AR030305A1 (es) |
AT (1) | ATE293589T1 (es) |
AU (2) | AU2001278471B2 (es) |
BR (1) | BR0112538A (es) |
CA (1) | CA2416288C (es) |
CR (1) | CR6888A (es) |
CZ (1) | CZ300337B6 (es) |
DE (2) | DE10034802A1 (es) |
DK (1) | DK1365737T3 (es) |
EC (1) | ECSP034437A (es) |
ES (1) | ES2241849T3 (es) |
GT (1) | GT200100134A (es) |
HK (1) | HK1061811A1 (es) |
HR (1) | HRP20030108B1 (es) |
HU (1) | HUP0302053A3 (es) |
IL (2) | IL153873A0 (es) |
MX (1) | MXPA03000510A (es) |
MY (1) | MY134521A (es) |
NO (1) | NO20030222D0 (es) |
PE (1) | PE20020267A1 (es) |
PL (1) | PL204593B1 (es) |
PT (1) | PT1365737E (es) |
RS (1) | RS50329B (es) |
SK (1) | SK286162B6 (es) |
SV (1) | SV2002000557A (es) |
TW (1) | TWI299729B (es) |
UY (1) | UY26841A1 (es) |
WO (1) | WO2002005782A2 (es) |
ZA (1) | ZA200300469B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
DE10202019A1 (de) * | 2002-01-18 | 2003-07-24 | Bayer Ag | Stabile Salze von o-Acetylsalicylsäure mit basischen Aminosäuren II |
US8142810B2 (en) | 2002-05-30 | 2012-03-27 | The Procter & Gamble Company | Dietary method for modulating glucose metabolism and associated conditions and increasing longevity |
DE60329167D1 (de) * | 2003-05-16 | 2009-10-22 | Cephalon France | Verfahren zur Herstellung von Modafinil |
EP1778652A2 (en) * | 2004-08-20 | 2007-05-02 | EntreMed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
US20060166901A1 (en) * | 2005-01-03 | 2006-07-27 | Yu Ruey J | Compositions comprising O-acetylsalicyl derivatives of aminocarbohydrates and amino acids |
DE102005025283A1 (de) | 2005-06-02 | 2006-12-07 | Bayer Healthcare Ag | Stabiler Wirkstoffkomplex von Salzen der o-Acetylsalicylsäure mit basischen Aminosäuren und Glycin |
DE102005049293A1 (de) * | 2005-10-15 | 2007-04-26 | Bayer Healthcare Ag | Kombinationspräparate von Salzen oder o-Acetylsalicylsäure |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
JP5759672B2 (ja) | 2006-07-09 | 2015-08-05 | テックフィールズ バイオケム カンパニー リミテッド | アスピリンの正荷電水溶性プロドラッグ |
AU2007354632B2 (en) * | 2007-06-04 | 2014-06-26 | Techfields Inc | Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses |
DE102008004386A1 (de) | 2008-01-14 | 2009-07-23 | Activaero Gmbh | Verwendung eines Acetylsalicylsäuresalzes zur Behandlung viraler Infektionen |
CN101314029B (zh) * | 2008-06-18 | 2010-12-08 | 四川省农业科学院实验场 | 乙酰水杨酸肽及其制备方法 |
US20100120727A1 (en) * | 2008-11-12 | 2010-05-13 | Kyphia Pharmaceuticals, Inc. | Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof |
MX362949B (es) | 2008-12-04 | 2019-02-27 | Yu Chongxi | Composiciones de alta penetracion y sus aplicaciones. |
EA021588B1 (ru) * | 2009-06-25 | 2015-07-30 | Тетра Сиа | Бетаиновые соли ацетилсалициловой кислоты |
CN101633624B (zh) * | 2009-08-04 | 2013-05-01 | 蚌埠丰原医药科技发展有限公司 | 改进的赖氨匹林的制备方法 |
FR2965261B1 (fr) * | 2009-09-30 | 2012-10-26 | Holis Technologies | Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue par ce procede |
FR2950625B1 (fr) * | 2009-09-30 | 2016-12-02 | Holis Tech | Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue |
FR2973370B1 (fr) * | 2011-03-29 | 2013-05-03 | Holis Technologies | Procede a faible cout pour la preparation d'un acide o-acetylsalicyclique et d'un acide amine basique |
CN102503845A (zh) * | 2011-09-28 | 2012-06-20 | 广州普星药业有限公司 | 一种dl-赖氨酸阿司匹林盐的制备方法及其应用 |
CA3189252A1 (en) | 2012-05-16 | 2013-11-21 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions |
CN102976962B (zh) * | 2012-11-20 | 2015-02-04 | 南京工业大学 | L-鸟氨酸阿司匹林复盐及其制备方法和应用 |
FR3021654B1 (fr) * | 2014-05-28 | 2016-06-24 | Unither Pharmaceuticals | Procede de preparation d'un sel d'acide acetylsalicylique et d'un acide amine basique |
JP7012725B2 (ja) * | 2016-12-23 | 2022-01-28 | アスピエアー ゲーエムベーハー | アセチルサリチル酸リジン・グリシン粒子の改良された合成 |
CA3064012A1 (en) | 2017-05-30 | 2018-12-06 | Rhoshan Pharmaceuticals, Inc. | In-vial deposition of a stable, sterile and crystalline o-acetyl salicylic acid (aspirin) |
WO2019026992A1 (ja) * | 2017-08-03 | 2019-02-07 | 参天製薬株式会社 | クロルヘキシジンを含有する医薬組成物 |
CN113105326A (zh) * | 2021-03-24 | 2021-07-13 | 海南卓华制药有限公司 | 赖氨匹林的制备方法及应用 |
CN114478287A (zh) * | 2021-12-31 | 2022-05-13 | 蚌埠丰原医药科技发展有限公司 | 一种赖氨匹林晶型及制备方法和应用 |
WO2023131645A1 (en) | 2022-01-05 | 2023-07-13 | Aspiair Gmbh | Improved synthesis of lysine acetylsalicylate · glycine particles |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2115060A1 (en) * | 1970-11-26 | 1972-07-07 | Metabio | Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin |
ES388158A1 (es) * | 1971-02-11 | 1974-03-16 | Liade Sa Lab | Procedimiento de obtencion de sales solubles del acido ace-til salicilico. |
JPS4856815A (es) * | 1971-11-13 | 1973-08-09 | ||
JPS55127345A (en) * | 1979-03-23 | 1980-10-02 | Kyowa Hakko Kogyo Co Ltd | Preparation of acetylsalicylic acid salt |
JPS5610110A (en) * | 1979-07-06 | 1981-02-02 | Green Cross Corp:The | Acetyl salicylate salt preparation for injection |
JPS56113741A (en) * | 1980-02-13 | 1981-09-07 | Mitsui Toatsu Chem Inc | Preparation of crystal of acetylsalicylic acid salt |
JPS5721345A (en) * | 1980-07-15 | 1982-02-04 | Mitsui Toatsu Chem Inc | Purification of acetylsalicylate salt |
CS247688B1 (cs) * | 1984-12-22 | 1987-01-15 | Evzen Kasafirek | Způsob výroby soli lysinu s kyselinou acetylsalicylovou |
JPS632929A (ja) * | 1986-06-20 | 1988-01-07 | Kao Corp | アセチルサリチル酸製剤 |
EP0499142A3 (en) * | 1991-02-09 | 1993-05-05 | Hoechst Aktiengesellschaft | Potentiation of the antireactive-antiasthmatic effect of inhaled loop diuretics by inhaled non steroidal anti-flammatory drugs |
DE4332093C2 (de) * | 1993-09-22 | 1995-07-13 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Acetylsalicylsäure und Verfahren zu seiner Herstellung |
-
2000
- 2000-07-18 DE DE10034802A patent/DE10034802A1/de not_active Withdrawn
-
2001
- 2001-07-05 CN CNB018158811A patent/CN1205176C/zh not_active Expired - Fee Related
- 2001-07-05 DE DE50105985T patent/DE50105985D1/de not_active Expired - Lifetime
- 2001-07-05 AU AU2001278471A patent/AU2001278471B2/en not_active Ceased
- 2001-07-05 SK SK67-2003A patent/SK286162B6/sk not_active IP Right Cessation
- 2001-07-05 IL IL15387301A patent/IL153873A0/xx unknown
- 2001-07-05 RS YUP-20/03A patent/RS50329B/sr unknown
- 2001-07-05 EP EP01956511A patent/EP1365737B1/de not_active Expired - Lifetime
- 2001-07-05 WO PCT/EP2001/007669 patent/WO2002005782A2/de active IP Right Grant
- 2001-07-05 JP JP2002511715A patent/JP2004507463A/ja active Pending
- 2001-07-05 DK DK01956511T patent/DK1365737T3/da active
- 2001-07-05 PL PL365648A patent/PL204593B1/pl not_active IP Right Cessation
- 2001-07-05 AU AU7847101A patent/AU7847101A/xx active Pending
- 2001-07-05 ES ES01956511T patent/ES2241849T3/es not_active Expired - Lifetime
- 2001-07-05 AT AT01956511T patent/ATE293589T1/de not_active IP Right Cessation
- 2001-07-05 KR KR1020037000713A patent/KR100773658B1/ko not_active IP Right Cessation
- 2001-07-05 CZ CZ20030164A patent/CZ300337B6/cs not_active IP Right Cessation
- 2001-07-05 BR BR0112538-9A patent/BR0112538A/pt not_active IP Right Cessation
- 2001-07-05 MX MXPA03000510A patent/MXPA03000510A/es active IP Right Grant
- 2001-07-05 CA CA002416288A patent/CA2416288C/en not_active Expired - Fee Related
- 2001-07-05 PT PT01956511T patent/PT1365737E/pt unknown
- 2001-07-05 HU HU0302053A patent/HUP0302053A3/hu unknown
- 2001-07-11 GT GT200100134A patent/GT200100134A/es unknown
- 2001-07-16 MY MYPI20013365A patent/MY134521A/en unknown
- 2001-07-16 AR ARP010103378A patent/AR030305A1/es unknown
- 2001-07-16 TW TW090117276A patent/TWI299729B/zh active
- 2001-07-16 UY UY26841A patent/UY26841A1/es not_active Application Discontinuation
- 2001-07-16 US US09/906,497 patent/US6773724B2/en not_active Expired - Lifetime
- 2001-07-17 PE PE2001000717A patent/PE20020267A1/es not_active Application Discontinuation
- 2001-07-17 SV SV2001000557A patent/SV2002000557A/es unknown
-
2003
- 2003-01-09 IL IL153873A patent/IL153873A/en not_active IP Right Cessation
- 2003-01-16 NO NO20030222A patent/NO20030222D0/no not_active Application Discontinuation
- 2003-01-17 EC EC2003004437A patent/ECSP034437A/es unknown
- 2003-01-17 ZA ZA200300469A patent/ZA200300469B/en unknown
- 2003-01-17 CR CR6888A patent/CR6888A/es unknown
- 2003-02-17 HR HR20030108A patent/HRP20030108B1/xx not_active IP Right Cessation
-
2004
- 2004-07-07 HK HK04104934A patent/HK1061811A1/xx not_active IP Right Cessation
- 2004-08-09 US US10/915,652 patent/US7449198B2/en not_active Expired - Fee Related
-
2012
- 2012-03-28 JP JP2012072662A patent/JP2012131824A/ja active Pending
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Legal Events
Date | Code | Title | Description |
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FB | Suspension of granting procedure |