CN101636414B - 聚乙二醇修饰的干扰素α2b及其制备方法和应用 - Google Patents
聚乙二醇修饰的干扰素α2b及其制备方法和应用 Download PDFInfo
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- CN101636414B CN101636414B CN2007800505428A CN200780050542A CN101636414B CN 101636414 B CN101636414 B CN 101636414B CN 2007800505428 A CN2007800505428 A CN 2007800505428A CN 200780050542 A CN200780050542 A CN 200780050542A CN 101636414 B CN101636414 B CN 101636414B
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A61P25/00—Drugs for disorders of the nervous system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
Description
反应组分 | 体积 |
50mM NH4HCO3,pH8.0 | 7.08ml |
PEG-IFN-α2b SP2(3.82mg/ml) | 1.32ml |
胰蛋白酶(0.5μg/μl) | 0.2ml |
反应总体积 | 8.6ml |
时间(分钟) | A% | B% | ACN% | |
1 | 0 | 100 | 0 | 0 |
2 | 8 | 100 | 0 | 0 |
3 | 68 | 40 | 60 | 54 |
4 | 72 | 40 | 60 | 54 |
5 | 75 | 100 | 0 | 0 |
6 | 80 | 100 | 0 | 0 |
样品 | 检出N端肽段序列 | 对应PEG修饰位点 |
YPEG-IFN-α2b S100-1 | XYSPXAW | Lys134 |
Claims (31)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2007/002644 WO2009030066A1 (fr) | 2007-09-04 | 2007-09-04 | Interféron alpha 2b modifié par du polyethylèneglycol et procédé de préparation et applications associés |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101636414A CN101636414A (zh) | 2010-01-27 |
CN101636414B true CN101636414B (zh) | 2012-02-15 |
Family
ID=40428422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007800505428A Active CN101636414B (zh) | 2007-09-04 | 2007-09-04 | 聚乙二醇修饰的干扰素α2b及其制备方法和应用 |
Country Status (17)
Country | Link |
---|---|
US (1) | US8597635B2 (zh) |
EP (1) | EP2186830B1 (zh) |
JP (1) | JP5325884B2 (zh) |
KR (1) | KR101502645B1 (zh) |
CN (1) | CN101636414B (zh) |
AT (1) | ATE548382T1 (zh) |
AU (1) | AU2007358605B8 (zh) |
BR (1) | BRPI0721984B8 (zh) |
CA (1) | CA2698173C (zh) |
DK (1) | DK2186830T3 (zh) |
ES (1) | ES2382124T3 (zh) |
MX (1) | MX2010002557A (zh) |
PL (1) | PL2186830T3 (zh) |
PT (1) | PT2186830E (zh) |
RU (1) | RU2485134C2 (zh) |
WO (1) | WO2009030066A1 (zh) |
ZA (1) | ZA201001556B (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2008002399A1 (es) | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c. |
EP2196475B1 (en) | 2007-09-04 | 2012-06-06 | Biosteed Gene Expression Tech. CO., LTD. | INTERFERON ALPHA 2a MODIFIED BY POLYETHYLENE GLYCOL, ITS SYNTHESIS PROCESS AND APPLICATION |
US8597635B2 (en) | 2007-09-04 | 2013-12-03 | Biosteed Gene Expression Tech. Co., Ltd. | Interferon alpha-2B modified by polyethylene glycol and methods of preparation thereof |
UA109646C2 (uk) * | 2009-12-10 | 2015-09-25 | Терапевтичне застосування кон'югатів білка з полімером | |
KR101943821B1 (ko) | 2011-06-21 | 2019-01-31 | 한국전자통신연구원 | 무선 통신 시스템에서 제어채널 송수신 방법 |
CA2847837A1 (en) * | 2011-09-05 | 2013-03-14 | Hanmi Science Co., Ltd. | A pharmaceutical composition for treating cancer, comprising interferon alpha conjugate |
EA021610B1 (ru) * | 2013-03-28 | 2015-07-30 | Илья Александрович МАРКОВ | Жидкое противовирусное лекарственное средство |
EA023323B1 (ru) * | 2013-03-28 | 2016-05-31 | Илья Александрович МАРКОВ | Разветвленный ацилазидный пегилирующий агент, способ его получения и способ получения пегилированного интерферона |
EA022617B1 (ru) * | 2013-03-28 | 2016-02-29 | Илья Александрович МАРКОВ | Монопегилированный интерферон-альфа разветвленной структуры и фармацевтическая композиция для приготовления лекарственного средства, обладающего активностью интерферона-альфа |
HUE064909T2 (hu) * | 2014-11-06 | 2024-04-28 | Pharmaessentia Corp | Adagolási rendszer pegilált interferonhoz |
EP3272857B1 (en) * | 2015-03-17 | 2020-08-12 | Shigetaka Shimodaira | Method for preparing dendritic cell by non-adhesive culture using ifn |
CN106146325B (zh) * | 2015-04-24 | 2019-01-29 | 北京键凯科技股份有限公司 | 一种y型多缩乙二醇衍生物及其制备方法 |
US20220339248A1 (en) * | 2019-06-19 | 2022-10-27 | The Research Foundation For The State University Of New York | Methods for treating neointimal hyperlasia using f11r/jam-a inhibitors |
WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
CN115968291A (zh) * | 2020-04-22 | 2023-04-14 | 南湖制药公司 | 聚乙二醇化干扰素tau及其组合物和方法 |
Citations (1)
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CN1556828A (zh) * | 2002-03-13 | 2004-12-22 | ƽ | 具有y形分支的亲水性聚合物衍生物、其制备方法、与药物分子的结合物以及包含该结合物的药物组合物 |
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US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
TW426523B (en) * | 1995-04-06 | 2001-03-21 | Hoffmann La Roche | Interferon solution |
TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
CN1243779A (zh) | 1998-07-31 | 2000-02-09 | 东莞中镇鞋材有限公司 | 纤维板及其制造方法 |
US6610822B2 (en) * | 2000-09-01 | 2003-08-26 | Merck & Co., Inc. | Purification process |
US6887462B2 (en) * | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
CA2497777A1 (en) * | 2002-09-05 | 2004-03-18 | The General Hospital Corporation | Modified asialo-interferons and uses thereof |
EP1556498A1 (en) * | 2002-11-01 | 2005-07-27 | Cadila Healthcare Ltd. | Method for producing recombinant human interferon alpha 2b polypeptide in pichia pastoris |
PL376883A1 (pl) * | 2002-11-15 | 2006-01-09 | F. Hoffmann-La Roche Ag | Izomery podstawienia PEG IFN alfa 2a |
JP2006519235A (ja) * | 2003-02-26 | 2006-08-24 | インターミューン インコーポレイティッド | ポリエチレングリコール修飾インターフェロン組成物およびその使用方法 |
MX2007014524A (es) * | 2005-05-18 | 2008-02-07 | Maxygen Inc | Polipeptidos desarrollados de interferon-alfa. |
EP1893229B1 (en) * | 2005-06-03 | 2011-10-19 | Ambrx, Inc. | Improved human interferon molecules and their uses |
EP2196475B1 (en) | 2007-09-04 | 2012-06-06 | Biosteed Gene Expression Tech. CO., LTD. | INTERFERON ALPHA 2a MODIFIED BY POLYETHYLENE GLYCOL, ITS SYNTHESIS PROCESS AND APPLICATION |
US8597635B2 (en) | 2007-09-04 | 2013-12-03 | Biosteed Gene Expression Tech. Co., Ltd. | Interferon alpha-2B modified by polyethylene glycol and methods of preparation thereof |
-
2007
- 2007-09-04 US US12/676,525 patent/US8597635B2/en active Active
- 2007-09-04 PT PT07800861T patent/PT2186830E/pt unknown
- 2007-09-04 DK DK07800861.2T patent/DK2186830T3/da active
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- 2007-09-04 PL PL07800861T patent/PL2186830T3/pl unknown
- 2007-09-04 BR BRPI0721984A patent/BRPI0721984B8/pt active IP Right Grant
- 2007-09-04 ES ES07800861T patent/ES2382124T3/es active Active
- 2007-09-04 AU AU2007358605A patent/AU2007358605B8/en active Active
- 2007-09-04 WO PCT/CN2007/002644 patent/WO2009030066A1/zh active Application Filing
- 2007-09-04 AT AT07800861T patent/ATE548382T1/de active
- 2007-09-04 EP EP07800861A patent/EP2186830B1/en active Active
- 2007-09-04 RU RU2010106430/10A patent/RU2485134C2/ru active
- 2007-09-04 MX MX2010002557A patent/MX2010002557A/es active IP Right Grant
- 2007-09-04 CN CN2007800505428A patent/CN101636414B/zh active Active
- 2007-09-04 CA CA2698173A patent/CA2698173C/en active Active
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Patent Citations (1)
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CN1556828A (zh) * | 2002-03-13 | 2004-12-22 | ƽ | 具有y形分支的亲水性聚合物衍生物、其制备方法、与药物分子的结合物以及包含该结合物的药物组合物 |
Non-Patent Citations (2)
Title |
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Yu-Sen Wang ET AL..Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications.《ADVANCED DRUG DELIVERY REVIEWS》.2002,第54卷547 - 570. |
Yu-Sen Wang ET AL..Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications.《ADVANCED DRUG DELIVERY REVIEWS》.2002,第54卷547- 570. * |
Also Published As
Publication number | Publication date |
---|---|
US20110158943A1 (en) | 2011-06-30 |
MX2010002557A (es) | 2011-12-16 |
CN101636414A (zh) | 2010-01-27 |
CA2698173C (en) | 2015-02-03 |
US8597635B2 (en) | 2013-12-03 |
BRPI0721984A2 (pt) | 2014-03-18 |
AU2007358605A1 (en) | 2009-03-12 |
WO2009030066A1 (fr) | 2009-03-12 |
RU2010106430A (ru) | 2011-10-10 |
JP2010538022A (ja) | 2010-12-09 |
ES2382124T3 (es) | 2012-06-05 |
KR101502645B1 (ko) | 2015-03-13 |
EP2186830A4 (en) | 2010-10-20 |
KR20100082774A (ko) | 2010-07-19 |
ZA201001556B (en) | 2010-12-29 |
CA2698173A1 (en) | 2009-03-12 |
PL2186830T3 (pl) | 2012-09-28 |
BRPI0721984B1 (pt) | 2020-11-17 |
DK2186830T3 (da) | 2012-04-02 |
AU2007358605B8 (en) | 2012-02-02 |
BRPI0721984B8 (pt) | 2021-05-25 |
JP5325884B2 (ja) | 2013-10-23 |
RU2485134C2 (ru) | 2013-06-20 |
ATE548382T1 (de) | 2012-03-15 |
EP2186830B1 (en) | 2012-03-07 |
PT2186830E (pt) | 2012-06-20 |
AU2007358605B2 (en) | 2011-09-08 |
EP2186830A1 (en) | 2010-05-19 |
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Inventor after: Zhou Weidong Inventor after: Zhang Yong Inventor after: Xiao Qingjiang Inventor after: Sun Li Inventor after: Wang Tiebing Inventor after: Yin Fenghong Inventor after: Luo Shihong Inventor after: Zhuang Lu Inventor after: Liu Min Inventor after: Xu Tianle Inventor before: Zhou Weidong Inventor before: Zhang Yong Inventor before: Xiao Qingjiang Inventor before: Sun Li Inventor before: Wang Tiebing Inventor before: Yin Fenghong Inventor before: Luo Shihong Inventor before: Zhuang Lu Inventor before: Liu Min Inventor before: Xu Tianle |