DK2186830T3 - Polyethylenglycol modificeret interferon alpha 2B og fremstillingsfremgangsmåde og applikationer deraf - Google Patents

Polyethylenglycol modificeret interferon alpha 2B og fremstillingsfremgangsmåde og applikationer deraf

Info

Publication number
DK2186830T3
DK2186830T3 DK07800861.2T DK07800861T DK2186830T3 DK 2186830 T3 DK2186830 T3 DK 2186830T3 DK 07800861 T DK07800861 T DK 07800861T DK 2186830 T3 DK2186830 T3 DK 2186830T3
Authority
DK
Denmark
Prior art keywords
polyethylene glycol
applications
manufacturing process
interferon alpha
glycol modified
Prior art date
Application number
DK07800861.2T
Other languages
English (en)
Inventor
Weidong Zhou
Qingjiang Xiao
Li Sun
Tiebing Wang
Fenghong Yin
Shihong Luo
Lu Zhuang
Min Liu
Tianle Xu
Yong Zhang
Original Assignee
Biosteed Gene Expression Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosteed Gene Expression Tech Co Ltd filed Critical Biosteed Gene Expression Tech Co Ltd
Application granted granted Critical
Publication of DK2186830T3 publication Critical patent/DK2186830T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/56IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DK07800861.2T 2007-09-04 2007-09-04 Polyethylenglycol modificeret interferon alpha 2B og fremstillingsfremgangsmåde og applikationer deraf DK2186830T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2007/002644 WO2009030066A1 (fr) 2007-09-04 2007-09-04 Interféron alpha 2b modifié par du polyethylèneglycol et procédé de préparation et applications associés

Publications (1)

Publication Number Publication Date
DK2186830T3 true DK2186830T3 (da) 2012-04-02

Family

ID=40428422

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07800861.2T DK2186830T3 (da) 2007-09-04 2007-09-04 Polyethylenglycol modificeret interferon alpha 2B og fremstillingsfremgangsmåde og applikationer deraf

Country Status (17)

Country Link
US (1) US8597635B2 (da)
EP (1) EP2186830B1 (da)
JP (1) JP5325884B2 (da)
KR (1) KR101502645B1 (da)
CN (1) CN101636414B (da)
AT (1) ATE548382T1 (da)
AU (1) AU2007358605B8 (da)
BR (1) BRPI0721984B8 (da)
CA (1) CA2698173C (da)
DK (1) DK2186830T3 (da)
ES (1) ES2382124T3 (da)
MX (1) MX2010002557A (da)
PL (1) PL2186830T3 (da)
PT (1) PT2186830E (da)
RU (1) RU2485134C2 (da)
WO (1) WO2009030066A1 (da)
ZA (1) ZA201001556B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008002399A1 (es) 2007-08-16 2009-01-02 Pharmaessentia Corp Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
US8597634B2 (en) 2007-09-04 2013-12-03 Biosteed Gene Expression Tech. Co., Ltd. Interferon alpha-2a modified by polyethylene glycol and methods of preparation thereof
PT2186830E (pt) 2007-09-04 2012-06-20 Biosteed Gene Expression Tech Co Ltd Interferão alfa 2b modificado com polietilenoglicol e método de preparação e aplicações do mesmo
UA109646C2 (uk) * 2009-12-10 2015-09-25 Терапевтичне застосування кон'югатів білка з полімером
KR101943821B1 (ko) * 2011-06-21 2019-01-31 한국전자통신연구원 무선 통신 시스템에서 제어채널 송수신 방법
EP2753348B1 (en) * 2011-09-05 2019-12-11 Hanmi Science Co., Ltd. Pharmaceutical compositions comprising an interferon alpha conjugate and gemcitabine for the treatment of cancer
EA022617B1 (ru) * 2013-03-28 2016-02-29 Илья Александрович МАРКОВ Монопегилированный интерферон-альфа разветвленной структуры и фармацевтическая композиция для приготовления лекарственного средства, обладающего активностью интерферона-альфа
EA021610B1 (ru) * 2013-03-28 2015-07-30 Илья Александрович МАРКОВ Жидкое противовирусное лекарственное средство
EA023323B1 (ru) * 2013-03-28 2016-05-31 Илья Александрович МАРКОВ Разветвленный ацилазидный пегилирующий агент, способ его получения и способ получения пегилированного интерферона
EA037151B1 (ru) * 2014-11-06 2021-02-11 Фармаэссентия Корпорейшн Способ лечения с использованием пегилированного интерферона
CN107532146A (zh) * 2015-03-17 2018-01-02 国立大学法人信州大学 通过使用ifn的非贴壁培养制备树突状细胞的方法
CN106146325B (zh) * 2015-04-24 2019-01-29 北京键凯科技股份有限公司 一种y型多缩乙二醇衍生物及其制备方法
EP3986555A4 (en) * 2019-06-19 2023-06-28 The Research Foundation for The State University of New York Methods for treating neointimal hyperplasia using f11r/jam-a inhibitors
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
US20230131808A1 (en) * 2020-04-22 2023-04-27 Southlake Pharmaceuticals, Inc. Pegylated interferon tau and compositions and methods thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US103411A (en) 1870-05-24 Improved liniment
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5951974A (en) * 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
JP2758154B2 (ja) * 1995-04-06 1998-05-28 エフ・ホフマン−ラ ロシユ アーゲー インターフェロンを含む液体製剤
TW517067B (en) 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
CN1243779A (zh) 1998-07-31 2000-02-09 东莞中镇鞋材有限公司 纤维板及其制造方法
US6610822B2 (en) * 2000-09-01 2003-08-26 Merck & Co., Inc. Purification process
US6887462B2 (en) * 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
AU2003221291A1 (en) 2002-03-13 2003-09-22 Beijing Jiankai Technology Co., Ltd. Hydrophilic polymer derivate with y type branch and preparation method of it medical composite comprising above compound
KR20050083677A (ko) * 2002-09-05 2005-08-26 더 제너럴 하스피탈 코포레이션 변형 아시알로 인터페론 및 그의 용도
WO2004039996A1 (en) * 2002-11-01 2004-05-13 Cadila Healthcare Limited Mthod for producing recombinant human interferon alpha 2b polypeptide in pichia pastoris
CA2503594C (en) * 2002-11-15 2011-05-10 Doris Brugger Positional isomers of peg ifn alpha 2a
CN1997666A (zh) * 2003-02-26 2007-07-11 印特缪恩股份有限公司 聚乙二醇修饰的干扰素组合物及其使用方法
CA2607651A1 (en) * 2005-05-18 2007-04-19 Maxygen, Inc. Evolved interferon-alpha polypeptides
ATE529442T1 (de) * 2005-06-03 2011-11-15 Ambrx Inc Verbesserte humane interferon-moleküle und ihre verwendungen
US8597634B2 (en) * 2007-09-04 2013-12-03 Biosteed Gene Expression Tech. Co., Ltd. Interferon alpha-2a modified by polyethylene glycol and methods of preparation thereof
PT2186830E (pt) 2007-09-04 2012-06-20 Biosteed Gene Expression Tech Co Ltd Interferão alfa 2b modificado com polietilenoglicol e método de preparação e aplicações do mesmo

Also Published As

Publication number Publication date
RU2010106430A (ru) 2011-10-10
CN101636414A (zh) 2010-01-27
BRPI0721984A2 (pt) 2014-03-18
EP2186830B1 (en) 2012-03-07
BRPI0721984B1 (pt) 2020-11-17
AU2007358605B2 (en) 2011-09-08
CN101636414B (zh) 2012-02-15
WO2009030066A1 (fr) 2009-03-12
PT2186830E (pt) 2012-06-20
CA2698173C (en) 2015-02-03
US20110158943A1 (en) 2011-06-30
BRPI0721984B8 (pt) 2021-05-25
RU2485134C2 (ru) 2013-06-20
CA2698173A1 (en) 2009-03-12
ZA201001556B (en) 2010-12-29
AU2007358605A1 (en) 2009-03-12
KR20100082774A (ko) 2010-07-19
US8597635B2 (en) 2013-12-03
PL2186830T3 (pl) 2012-09-28
ATE548382T1 (de) 2012-03-15
EP2186830A1 (en) 2010-05-19
ES2382124T3 (es) 2012-06-05
MX2010002557A (es) 2011-12-16
KR101502645B1 (ko) 2015-03-13
JP2010538022A (ja) 2010-12-09
EP2186830A4 (en) 2010-10-20
JP5325884B2 (ja) 2013-10-23
AU2007358605B8 (en) 2012-02-02

Similar Documents

Publication Publication Date Title
DK2186830T3 (da) Polyethylenglycol modificeret interferon alpha 2B og fremstillingsfremgangsmåde og applikationer deraf
CY1114356T1 (el) Αναστολεις του ιου της ηπατιτιδας c
BR112012011100A2 (pt) compostos inibidores do vírus da hepatite, composição e uso dos mesmos
MX2010001650A (es) Entidades quimicas biciclicas que contienen nitrogeno para el tratamiento de infecciones virales.
NO20090453L (no) Hepatitt C Virusinhibitorer
BR112012014677A2 (pt) inibidores do vírus da hepatite c
BR112013003101A2 (pt) inibidores do vírus da hepatite c
EA200900298A1 (ru) Ингибиторы вируса гепатита с
BR112013002729A2 (pt) inibidores de vírus de hepatite c
SG10201900695PA (en) Functionalized benzamide derivatives as antiviral agents against hbv infection
CL2008001005A1 (es) Compuestos derivados de azufre, inhibidores de la serina proteasa ns3 del virus de la hepatitis c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de trastornos asociados a la proteasa de hcv.
CL2009000305A1 (es) Compuestos derivados de 2-aril-sustituido-1-benzofurano-3-carboxamida, inhibidores de la polimerasa ns5b; composicion farmaceutica; y su uso en el tratamiento de una enfermedad causada por el virus de la hepatitis c (hcv).
ATE551337T1 (de) Inhibitoren des hepatitis-c-virus
CL2011000145A1 (es) Compuesto macrociclico derivado de quinoxalina y sus sales; inhibidor de la proteasa ns3 del virus de la hepatitis c(hcv); composicion farmaceutica que lo comprende; y uso en la prevencion o el tratamiento de una infeccion por hcv.
CL2008003819A1 (es) Compuestos derivados del acido 2-cetoamino benzoico sustituido, inhibidores del virus de la hepatitis c; composicion farmaceutica; y su uso en el tratamiento de una infeccion por vhc.
TN2009000398A1 (en) 5,6-dihydro-1h-pyridin-2-one compounds
EA200971106A1 (ru) Соединения с семичленным кольцом и их фармацевтические применения для предупреждения и лечения диабета и метаболического синдрома
BR112014013972A2 (pt) inibidores de hcv nssa
CL2021002390A1 (es) Derivados de pirimidona de anillo fusionado para su uso en el tratamiento de la infección por vhb (virus hepatitis b) o de enfermedades inducidas por el vhb.
BR112014015582A2 (pt) compostos antivirais
SV2005001919A (es) Compuestos nucleosidos para el tratamiento de infecciones virales
UY31888A (es) Compuestos de 1,1-dióxido de [1,2,4,]tiadiazina
CY1115326T1 (el) Φυτικη συνθεση για τη θεραπεια ή την προληψη ιογενων νοσων του αιματος, που προκαλουνται απο τον ιο της ανθρωπινης ανοσοανεπαρκειας (hiv) ή την ηπατιτιδα c
ATE497978T1 (de) Pharmazeutische zusammensetzungen von antikörpern von viruserkrankungen
ATE538108T1 (de) Thiazolhydrazide und deren verwendung zur behandlung von neurodegenerativen krankheiten