CN1155392C - 高分子嵌段共聚物-药物复合制剂 - Google Patents
高分子嵌段共聚物-药物复合制剂 Download PDFInfo
- Publication number
- CN1155392C CN1155392C CNB001219014A CN00121901A CN1155392C CN 1155392 C CN1155392 C CN 1155392C CN B001219014 A CNB001219014 A CN B001219014A CN 00121901 A CN00121901 A CN 00121901A CN 1155392 C CN1155392 C CN 1155392C
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- Prior art keywords
- block copolymer
- amycin
- dimer
- anthracycline
- compound
- Prior art date
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- Expired - Fee Related
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
样品 | 剂量(毫克/公斤) | 肿瘤消失的小鼠 |
阿霉素盐酸盐 | 510 | 0/52/5 |
实施例3的药剂 | 2.5510 | 1/45/53/5 |
实施例4的药剂 | 2.5510 | 0/51/54/5 |
实施例5的药剂 | 2.5510 | 0/52/53/5 |
样品 | LD50 | Min T/C42 1) | 化疗指标2) |
阿霉素盐酸盐 | 15 | 5.95 | 2.52 |
实施例3的药剂 | 15 | 2.59 | 5.78 |
实施例4的药剂 | 15 | 4.88 | 3.08 |
实施例5的药剂 | 15 | 6.02 | 2.49 |
样品 | 给药后的时间 | ||||
15分钟 | 1小时 | 4小时 | 24小时 | 48小时 | |
(A)(B)(C) | 0.4761.641.7 | 0.2953.729.2 | 0.3639.221.3 | 0.1015.98.2 | 0.074.72.2 |
样品 | 给药后的时间 | ||||
15分钟 | 1小时 | 4小时 | 24小时 | 48小时 | |
(A)(B)(C) | 2.32.32.3 | 2.43.82.7 | 1.74.94.9 | 1.39.67.0 | 1.09.14.0 |
样品 | 给药后的时间 | ||||
15分钟 | 1小时 | 4小时 | 24小时 | 48小时 | |
(A)(B)(C) | 10.54.96.5 | 7.04.25.4 | 4.63.33.8 | 1.11.61.4 | 0.51.00.7 |
样品 | 剂量(毫克/公斤) | 肿瘤消失的小鼠 |
阿霉素盐酸盐 | 510 | 0/52/5 |
实施例8的药剂 | 510* | 5/55/5 |
实施例12的药剂 | 1.252.5510 | 0/50/54/55/5 |
样品 | 给药后的时间 | ||||
15分钟 | 1小时 | 4小时 | 24小时 | 48小时 | |
(A)(1)(2) | 44.967.2 | 32.969.7 | 20.761.9 | 3.814.2 | 2.03.9 |
(B)(1)(2) | 27.723.0 | 12.322.5 | 5.319.4 | 1.911.1 | 0.57.0 |
样品 | 给药后的时间 | ||||
15分钟 | 1小时 | 4小时 | 24小时 | 48小时 | |
(A)(1)(2) | 4.01.1 | 3.11.0 | 6.86.4 | 19.014.1 | 20.412.2 |
(B)(1)(2) | 1.30.0 | 2.18.1 | 1.92.8 | 2.23.9 | 1.24.9 |
样品 | 给药后的时间 | |
1小时 | 24小时 | |
(A)(1)(2) | 36.783.5 | 6.817.9 |
(B)(1)(2) | 11.065.3 | 4.116.2 |
(C)(1)(2) | 40.6100.2 | 10.224.5 |
样品 | 给药后的时间 | |
1小时 | 24小时 | |
(A)(1)(2) | 3.41.8 | 21.016.1 |
(B)(1)(2) | 2.60.1 | 4.53.0 |
(C)(1)(2) | 5.02.1 | 9.16.3 |
Claims (13)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP253404/1995 | 1995-09-29 | ||
JP25340495 | 1995-09-29 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96191130A Division CN1069099C (zh) | 1995-09-29 | 1996-09-26 | 阿霉素的二聚物和三聚物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1288728A CN1288728A (zh) | 2001-03-28 |
CN1155392C true CN1155392C (zh) | 2004-06-30 |
Family
ID=17250915
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96191130A Expired - Fee Related CN1069099C (zh) | 1995-09-29 | 1996-09-26 | 阿霉素的二聚物和三聚物 |
CNB001219014A Expired - Fee Related CN1155392C (zh) | 1995-09-29 | 2000-07-11 | 高分子嵌段共聚物-药物复合制剂 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96191130A Expired - Fee Related CN1069099C (zh) | 1995-09-29 | 1996-09-26 | 阿霉素的二聚物和三聚物 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6080396A (zh) |
EP (1) | EP0795561B1 (zh) |
JP (1) | JP4039466B2 (zh) |
KR (1) | KR100413029B1 (zh) |
CN (2) | CN1069099C (zh) |
BR (1) | BR9606674B1 (zh) |
DE (1) | DE69625326T2 (zh) |
ES (1) | ES2185801T3 (zh) |
WO (1) | WO1997012895A1 (zh) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0971716A1 (en) * | 1996-03-22 | 2000-01-19 | Waldemar Priebe | Bis-anthracyclines with high activity against doxorubicin resistant tumors |
WO2001013953A2 (en) | 1999-08-21 | 2001-03-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Synergistic combination of pde inhibitors and beta 2 adrenoceptor agonist |
EP1002810A4 (en) * | 1998-06-04 | 2002-07-17 | Kao Corp | POLYMER EMULSION AND METHOD FOR THE PRODUCTION THEREOF |
US6338859B1 (en) * | 2000-06-29 | 2002-01-15 | Labopharm Inc. | Polymeric micelle compositions |
US6939564B2 (en) | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
WO2003000771A1 (fr) | 2001-06-20 | 2003-01-03 | Nippon Kayaku Kabushiki Kaisha | Copolymere bloc a taux d'impuretes reduit, support polymere, preparations pharmaceutiques sous forme polymere et procede de preparation associe |
JP4063510B2 (ja) * | 2001-07-13 | 2008-03-19 | ナノキャリア株式会社 | 薬物含有高分子ミセルの凍結乾燥用組成物およびその凍結乾燥製剤 |
JP2004018494A (ja) * | 2002-06-19 | 2004-01-22 | Japan Science & Technology Corp | ブロック共重合体−薬剤複合体の製造法 |
US20050004038A1 (en) * | 2003-06-27 | 2005-01-06 | Lyon Robert P. | Bivalent inhibitors of Glutathione-S-Transferases |
US7311901B2 (en) * | 2003-10-10 | 2007-12-25 | Samyang Corporation | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery |
US20050226932A1 (en) * | 2004-04-09 | 2005-10-13 | Samyang Corporation | Pharmaceutical formulations for itraconazole |
JP4758346B2 (ja) * | 2004-07-05 | 2011-08-24 | 財団法人神奈川科学技術アカデミー | 高分子ミセル型mri造影剤 |
DE602007014087D1 (de) * | 2006-10-19 | 2011-06-01 | Nanocarrier Co Ltd | Blockcopolymer für wirkstoffkonjugate und deren pharmazeutische zusammensetzungen |
EP2214503A1 (en) * | 2007-10-15 | 2010-08-11 | Revolymer Limited | Solvent-free synthesis of amphiphilic polymeric material |
WO2010114770A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
WO2010114768A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-epothilone conjugates, particles, compositions, and related methods of use |
AU2010234916A1 (en) * | 2009-03-30 | 2011-10-13 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
US20100292432A1 (en) * | 2009-04-30 | 2010-11-18 | Intezyne Technologies, Incorporated | Polymers for polynucleotide encapsulation |
US8524784B2 (en) | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
EP2424359A4 (en) | 2009-04-30 | 2014-01-15 | Intezyne Technologies Inc | POLYMIC MICELLES WITH ANTHRACYCLINES FOR THE TREATMENT OF CANCER |
WO2013124867A1 (en) | 2012-02-21 | 2013-08-29 | Amrita Vishwa Vidyapeetham University | Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules |
WO2014141289A1 (en) | 2013-03-12 | 2014-09-18 | Amrita Vishwa Vidyapeetham University | Photo - chemo composition on the basis of microcapsules with a core -shell structure |
CN106947107B (zh) * | 2017-03-24 | 2019-08-09 | 西北工业大学 | 孔壁上接枝有阿霉素的超支化聚苯乙烯多孔膜的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4263428A (en) * | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
FR2522269A1 (fr) * | 1982-02-26 | 1983-09-02 | Pasteur Institut | Agents antitumoraux, tels que la daunorubicine, a efficacite amelioree, leur obtention et procede pour augmenter l'efficacite des agents antitumoraux |
JP2517760B2 (ja) * | 1989-05-11 | 1996-07-24 | 新技術事業団 | 水溶性高分子化医薬製剤 |
US4965348A (en) * | 1989-05-19 | 1990-10-23 | Bristol-Myers Company | Dimeric epipodophyllotoxin glucoside derivatives |
JP2626654B2 (ja) * | 1990-03-31 | 1997-07-02 | 科学技術振興事業団 | 標的指向性高分子医薬化合物及びその中間体 |
JP3310000B2 (ja) * | 1990-11-07 | 2002-07-29 | 靖久 桜井 | 水溶性高分子抗癌剤及び薬物担持用担体 |
JP3111099B2 (ja) * | 1991-10-31 | 2000-11-20 | 科学技術振興事業団 | 水溶性高分子化薬剤の製造法 |
JPH05117385A (ja) * | 1991-10-31 | 1993-05-14 | Res Dev Corp Of Japan | ブロツク共重合体の製造法、ブロツク共重合体及び水溶性高分子抗癌剤 |
KR940003548U (ko) * | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
JP3270592B2 (ja) * | 1992-10-26 | 2002-04-02 | 日本化薬株式会社 | ブロック共重合体−抗癌剤複合体医薬製剤 |
JPH06206830A (ja) * | 1992-10-27 | 1994-07-26 | Nippon Kayaku Co Ltd | ブロック共重合体−薬剤複合体及び高分子ブロック共重合体 |
JP3682475B2 (ja) * | 1993-08-31 | 2005-08-10 | 靖久 桜井 | 水溶性抗癌剤 |
JP2690276B2 (ja) * | 1995-01-10 | 1997-12-10 | 科学技術振興事業団 | 静電結合型高分子ミセル薬物担体とその薬剤 |
-
1996
- 1996-09-26 US US08/836,965 patent/US6080396A/en not_active Expired - Fee Related
- 1996-09-26 CN CN96191130A patent/CN1069099C/zh not_active Expired - Fee Related
- 1996-09-26 BR BRPI9606674-1A patent/BR9606674B1/pt not_active IP Right Cessation
- 1996-09-26 ES ES96932005T patent/ES2185801T3/es not_active Expired - Lifetime
- 1996-09-26 KR KR1019970703611A patent/KR100413029B1/ko not_active IP Right Cessation
- 1996-09-26 EP EP96932005A patent/EP0795561B1/en not_active Expired - Lifetime
- 1996-09-26 DE DE69625326T patent/DE69625326T2/de not_active Expired - Lifetime
- 1996-09-26 JP JP51067097A patent/JP4039466B2/ja not_active Expired - Lifetime
- 1996-09-26 WO PCT/JP1996/002789 patent/WO1997012895A1/ja active IP Right Grant
-
2000
- 2000-07-11 CN CNB001219014A patent/CN1155392C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6080396A (en) | 2000-06-27 |
KR100413029B1 (ko) | 2004-04-30 |
CN1288728A (zh) | 2001-03-28 |
DE69625326T2 (de) | 2003-09-18 |
BR9606674B1 (pt) | 2010-08-10 |
EP0795561A4 (en) | 1998-11-11 |
ES2185801T3 (es) | 2003-05-01 |
EP0795561A1 (en) | 1997-09-17 |
CN1069099C (zh) | 2001-08-01 |
DE69625326D1 (de) | 2003-01-23 |
CN1165518A (zh) | 1997-11-19 |
EP0795561B1 (en) | 2002-12-11 |
BR9606674A (pt) | 1997-10-21 |
KR987000322A (ko) | 1998-03-30 |
WO1997012895A1 (fr) | 1997-04-10 |
JP4039466B2 (ja) | 2008-01-30 |
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SAKURAI JINGJIU; NIPPON KAYAKU K. K. Free format text: FORMER OWNER: JAPAN SCIENCE + TECH AGENCY; SAKURAI JINGJIU; NIPPON KAYAKU K. K. Effective date: 20060630 |
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C41 | Transfer of patent application or patent right or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: JAPAN SCIENCE & TECH AGENCY; SAKURAI JINGJIU; NIPP Free format text: FORMER NAME OR ADDRESS: JAPAN SCIENCE + TECH CORPORATION; SAKURAI JINGJIU; NIPPON KAYAKU K. K. |
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CP03 | Change of name, title or address |
Address after: Saitama, Japan Co-patentee after: Sakurai, Yasuhisa Patentee after: JAPAN SCIENCE AND TECHNOLOGY AGENCY Co-patentee after: NIPPON KAYAKU Kabushiki Kaisha Address before: Saitama, Japan Co-patentee before: Sakurai, Yasuhisa Patentee before: Japan Science and Technology Corp. Co-patentee before: NIPPON KAYAKU Kabushiki Kaisha |
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TR01 | Transfer of patent right |
Effective date of registration: 20060630 Co-patentee after: NIPPON KAYAKU Kabushiki Kaisha Patentee after: Sakurai, Yasuhisa Address before: Saitama, Japan Co-patentee before: Sakurai, Yasuhisa Patentee before: JAPAN SCIENCE AND TECHNOLOGY AGENCY Co-patentee before: NIPPON KAYAKU Kabushiki Kaisha |
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C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040630 Termination date: 20120926 |