DE60315145T2 - Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff - Google Patents
Hydrophiles polymerderivat mit y-verzweigung und herstellungsverfahren dafür; obige verbindung enthaltender medizinischer verbundwerkstoff Download PDFInfo
- Publication number
- DE60315145T2 DE60315145T2 DE60315145T DE60315145T DE60315145T2 DE 60315145 T2 DE60315145 T2 DE 60315145T2 DE 60315145 T DE60315145 T DE 60315145T DE 60315145 T DE60315145 T DE 60315145T DE 60315145 T2 DE60315145 T2 DE 60315145T2
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- Prior art keywords
- group
- peg
- branched
- derivative according
- polyethylene glycol
- Prior art date
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- Expired - Lifetime
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
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- 238000006243 chemical reaction Methods 0.000 claims description 15
- 125000000524 functional group Chemical group 0.000 claims description 15
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 57
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Classifications
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Medicinal Preparation (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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| PCT/CN2003/000179 WO2003076490A1 (en) | 2002-03-13 | 2003-03-12 | Hydrophilic polymer derivate with y type branch and preparation method of it medical composite comprising above compound |
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| AT (1) | ATE368066T1 (enExample) |
| AU (1) | AU2003221291A1 (enExample) |
| DE (1) | DE60315145T2 (enExample) |
| ES (1) | ES2291620T3 (enExample) |
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| DE10209822A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
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| WO2003076490A1 (en) | 2002-03-13 | 2003-09-18 | Beijing Jiankai Technology Co., Ltd. | Hydrophilic polymer derivate with y type branch and preparation method of it medical composite comprising above compound |
| MXPA05002594A (es) | 2002-09-11 | 2005-05-27 | Fresenius Kabi Gmbh | Derivados de polipeptidos con hidroxialquilalmidon, especialmente derivados de eritropoyetina con hidroxialquilalmidon. |
| DE10326303A1 (de) * | 2003-06-11 | 2004-12-30 | Celares Gmbh | Reagenzien zur Modifikation von Biopharmazeutika, deren Herstellung und Anwendung |
| WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
| GB0329825D0 (en) | 2003-12-23 | 2004-01-28 | Celltech R&D Ltd | Biological products |
| AR048035A1 (es) | 2004-03-11 | 2006-03-22 | Fresenius Kabi De Gmbh | Conjugados de almidon de hidroxialquilo y una proteina, preparados por aminacion reductora |
| US7858080B2 (en) | 2005-05-20 | 2010-12-28 | Agency For Science, Technology And Research | Aldehyde conjugated flavonoid preparations |
| AU2006248166B2 (en) * | 2005-05-20 | 2012-11-01 | Agency For Science, Technology And Research | Aldehyde conjugated flavonoid preparations |
| AU2006304856A1 (en) * | 2005-10-21 | 2007-04-26 | Synageva Biopharma Corp. | Glycolated and glycosylated poultry derived therapeutic proteins |
| US20080171696A1 (en) * | 2005-10-21 | 2008-07-17 | Avigenics, Inc. | Pharmacodynamically enhanced therapeutic proteins |
| US20090285780A1 (en) * | 2006-05-24 | 2009-11-19 | Chyi Lee | Peg linker compounds and biologically active conjugates thereof |
| CN101168594B (zh) * | 2006-10-24 | 2011-07-27 | 北京键凯科技有限公司 | 寡肽为骨架的聚乙二醇活性衍生物、其制备方法及与药物分子的结合物 |
| CN102827284B (zh) * | 2006-11-14 | 2015-07-29 | 上海仁会生物制药股份有限公司 | 带有聚乙二醇基团的Exendin或其类似物及其制剂和用途 |
| CN101835482A (zh) * | 2007-08-20 | 2010-09-15 | 安佐制药股份有限公司 | 含吡啶基二硫化物部分的聚合连接基 |
| CA2698173C (en) * | 2007-09-04 | 2015-02-03 | Biosteed Gene Expression Tech. Co., Ltd. | Interferon alpha 2b modified by polyethylene glycol, the preparation and use thereof |
| CN101636411B (zh) * | 2007-09-04 | 2013-01-09 | 厦门伯赛基因转录技术有限公司 | 聚乙二醇修饰的干扰素α2a及其制备方法和应用 |
| EP2070950A1 (en) | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Hydroxyalkyl starch derivatives and process for their preparation |
| US8530417B2 (en) | 2007-12-29 | 2013-09-10 | Biosteed Gene Expression Tech Co. Ltd. | Y-shaped polyethylene glycol modified G-CSF, the preparation and use thereof |
| JP5458416B2 (ja) * | 2008-04-03 | 2014-04-02 | バイオスティード ジーン エクスプレッション テック． カンパニー リミテッド | 二本鎖ポリエチレングリコール化成長ホルモン、その製造方法およびその使用 |
| CN101701068B (zh) * | 2009-10-30 | 2011-09-21 | 北京化工大学 | 一种pH响应性的Y型药物输送材料及其制备方法 |
| JP2011105792A (ja) * | 2009-11-12 | 2011-06-02 | Japan Science & Technology Agency | ブロックコポリマー、ブロックコポリマー−金属錯体複合体、及びそれを用いた中空構造体キャリア |
| FR2953720B1 (fr) | 2009-12-11 | 2012-05-11 | Oreal | Utilisation de derives de benzyloxy-ethylamines comme conservateur, |
| US20140073778A9 (en) | 2010-07-09 | 2014-03-13 | Fresenius Kabi Deutschland Gmbh | Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation |
| EP2590677A1 (en) | 2010-07-09 | 2013-05-15 | Fresenius Kabi Deutschland GmbH | Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation |
| EP2590678A1 (en) | 2010-07-09 | 2013-05-15 | Fresenius Kabi Deutschland GmbH | Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation |
| EP2590680A1 (en) | 2010-07-09 | 2013-05-15 | Fresenius Kabi Deutschland GmbH | Conjugates comprising hydroxyalkyl starch and a cytotoxic agent and process for their preparation |
| JP2014503187A (ja) | 2010-10-29 | 2014-02-13 | ノクソン ファーマ エージー | 身体からヘプシジンを除去するためのヘプシジン結合核酸の使用 |
| CN103083680B (zh) * | 2011-11-07 | 2014-12-24 | 北京键凯科技有限公司 | 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物 |
| JP5999659B2 (ja) * | 2011-12-14 | 2016-09-28 | 国立大学法人 筑波大学 | 新規分岐ポリエチレングリコール及びその用途 |
| WO2014114262A1 (zh) * | 2013-01-28 | 2014-07-31 | 天津键凯科技有限公司 | 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途 |
| US9700633B2 (en) | 2013-01-28 | 2017-07-11 | Jenkem Technology Co., Ltd., Tianjin Branch | Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof |
| CN103965458B (zh) * | 2013-01-28 | 2017-02-15 | 天津键凯科技有限公司 | 聚乙二醇‑氨基酸寡肽‑达沙替尼结合物及其药物组合物 |
| CN104109235B (zh) * | 2014-05-30 | 2017-07-18 | 厦门赛诺邦格生物科技股份有限公司 | 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质 |
| CN106146325B (zh) * | 2015-04-24 | 2019-01-29 | 北京键凯科技股份有限公司 | 一种y型多缩乙二醇衍生物及其制备方法 |
| CN107446908A (zh) * | 2016-06-01 | 2017-12-08 | 湖南华腾制药有限公司 | 分支型聚乙二醇修饰的l‑门冬酰胺酶及其制备方法 |
| CN106750250B (zh) * | 2016-12-21 | 2019-04-23 | 沈阳化工大学 | 以氨基酸作为连接臂的聚乙二醇齐墩果酸衍生物及其制备方法和应用 |
| CN108530637B (zh) * | 2017-03-05 | 2021-03-30 | 厦门赛诺邦格生物科技股份有限公司 | 一种单一功能化支化聚乙二醇的制备方法 |
| WO2018177055A1 (zh) * | 2017-03-30 | 2018-10-04 | 北京键凯科技股份有限公司 | 一种y型分支的亲水性聚合物羧酸衍生物的制备方法 |
| CN108659227B (zh) * | 2017-03-30 | 2020-11-06 | 北京键凯科技股份有限公司 | 一种y型分支的亲水性聚合物羧酸衍生物的制备方法 |
| CN108530642B (zh) * | 2017-11-24 | 2021-01-15 | 四川大学 | 可生物降解的三嵌段杂臂星形双亲性高分子材料及其制备方法 |
| CN109400868B (zh) * | 2018-11-30 | 2021-01-15 | 吉林化工学院 | 一种聚乙二醇单苯甲醚化合物的合成方法 |
| JP2023541816A (ja) | 2020-08-27 | 2023-10-04 | イノージ・セラピューティクス・コーポレイション | 自己免疫性疾患および癌を治療するための方法および組成物 |
| CN112898561A (zh) * | 2021-01-27 | 2021-06-04 | 大连理工大学 | 马来酰亚胺封端聚苯醚及其制备方法 |
| EP4509544A4 (en) | 2022-04-12 | 2025-07-02 | Xiamen Sinopeg Biotech Co Ltd | NONLINEAR PEGYLATED LIPID CONTAINING TERTIARY AMINE AND ITS APPLICATION |
| CN117510828A (zh) | 2022-07-28 | 2024-02-06 | 厦门赛诺邦格生物科技股份有限公司 | 一种含氨基酸残基的三臂聚乙二醇衍生物 |
| JP2026505416A (ja) | 2023-02-09 | 2026-02-13 | シェ、ヤンホイ | ポリエチレングリコール修飾インターロイキン２、グルココルチコイドおよびヒアルロン酸によるアトピー性皮膚炎の治療 |
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| US7060708B2 (en) | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| WO2001057067A1 (en) | 2000-02-04 | 2001-08-09 | Supratek Pharma Inc. | Ligand for vascular endothelial growth factor receptor |
| CN1125097C (zh) | 2000-07-05 | 2003-10-22 | 天津大学 | 聚乙二醇支载的紫杉醇或多烯紫杉醇的前药 |
| CN100475269C (zh) * | 2002-03-05 | 2009-04-08 | 北京键凯科技有限公司 | 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途 |
| WO2003076490A1 (en) | 2002-03-13 | 2003-09-18 | Beijing Jiankai Technology Co., Ltd. | Hydrophilic polymer derivate with y type branch and preparation method of it medical composite comprising above compound |
| DK1580216T3 (da) | 2002-10-31 | 2014-08-18 | Nippon Kayaku Kk | Derivater med høj molekylvægt af camptotheciner |
-
2003
- 2003-03-12 WO PCT/CN2003/000179 patent/WO2003076490A1/zh not_active Ceased
- 2003-03-12 AT AT03709581T patent/ATE368066T1/de active
- 2003-03-12 ES ES03709581T patent/ES2291620T3/es not_active Expired - Lifetime
- 2003-03-12 JP JP2003574704A patent/JP4272537B2/ja not_active Expired - Fee Related
- 2003-03-12 AU AU2003221291A patent/AU2003221291A1/en not_active Abandoned
- 2003-03-12 CN CNB038011050A patent/CN1243779C/zh not_active Expired - Lifetime
- 2003-03-12 US US10/507,452 patent/US8003089B2/en active Active
- 2003-03-12 EP EP03709581A patent/EP1496076B1/en not_active Expired - Lifetime
- 2003-03-12 DE DE60315145T patent/DE60315145T2/de not_active Expired - Lifetime
-
2010
- 2010-05-17 US US12/781,173 patent/US20100221213A1/en not_active Abandoned
-
2011
- 2011-06-17 US US13/163,080 patent/US20110243892A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005520006A (ja) | 2005-07-07 |
| EP1496076A4 (en) | 2006-06-21 |
| WO2003076490A1 (en) | 2003-09-18 |
| US20050180946A1 (en) | 2005-08-18 |
| US20100221213A1 (en) | 2010-09-02 |
| DE60315145D1 (de) | 2007-09-06 |
| WO2003076490A8 (en) | 2004-10-28 |
| CN1556828A (zh) | 2004-12-22 |
| ATE368066T1 (de) | 2007-08-15 |
| CN1243779C (zh) | 2006-03-01 |
| EP1496076A1 (en) | 2005-01-12 |
| EP1496076B1 (en) | 2007-07-25 |
| JP4272537B2 (ja) | 2009-06-03 |
| US8003089B2 (en) | 2011-08-23 |
| ES2291620T3 (es) | 2008-03-01 |
| US20110243892A1 (en) | 2011-10-06 |
| AU2003221291A1 (en) | 2003-09-22 |
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