JP2005519122A5 - - Google Patents
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- JP2005519122A5 JP2005519122A5 JP2003573050A JP2003573050A JP2005519122A5 JP 2005519122 A5 JP2005519122 A5 JP 2005519122A5 JP 2003573050 A JP2003573050 A JP 2003573050A JP 2003573050 A JP2003573050 A JP 2003573050A JP 2005519122 A5 JP2005519122 A5 JP 2005519122A5
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- JP
- Japan
- Prior art keywords
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- binding
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003814 drug Substances 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 7
- 230000008878 coupling Effects 0.000 claims 6
- 238000010168 coupling process Methods 0.000 claims 6
- 238000005859 coupling reaction Methods 0.000 claims 6
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims 4
- RODXRVNMMDRFIK-UHFFFAOYSA-N scopoletin Chemical compound C1=CC(=O)OC2=C1C=C(OC)C(O)=C2 RODXRVNMMDRFIK-UHFFFAOYSA-N 0.000 claims 4
- 229920003169 water-soluble polymer Polymers 0.000 claims 4
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 229940127093 camptothecin Drugs 0.000 claims 3
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 3
- 229920001477 hydrophilic polymer Polymers 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- -1 polyacrylmorpholine Polymers 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims 2
- XEHFSYYAGCUKEN-UHFFFAOYSA-N Dihydroscopoletin Natural products C1CC(=O)OC2=C1C=C(OC)C(O)=C2 XEHFSYYAGCUKEN-UHFFFAOYSA-N 0.000 claims 2
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims 2
- 102000015636 Oligopeptides Human genes 0.000 claims 2
- 108010038807 Oligopeptides Proteins 0.000 claims 2
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 2
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 2
- 229960003720 enoxolone Drugs 0.000 claims 2
- 229930182478 glucoside Natural products 0.000 claims 2
- 150000008131 glucosides Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- FWYIBGHGBOVPNL-UHFFFAOYSA-N scopoletin Natural products COC=1C=C2C=CC(OC2=C(C1)O)=O FWYIBGHGBOVPNL-UHFFFAOYSA-N 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 1
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 229930013930 alkaloid Natural products 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- 229930003935 flavonoid Natural products 0.000 claims 1
- 150000002215 flavonoids Chemical class 0.000 claims 1
- 235000017173 flavonoids Nutrition 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229930015704 phenylpropanoid Natural products 0.000 claims 1
- 150000002995 phenylpropanoid derivatives Chemical class 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 150000003505 terpenes Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021066914A CN100475269C (zh) | 2002-03-05 | 2002-03-05 | 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途 |
| PCT/CN2003/000164 WO2003074586A1 (en) | 2002-03-05 | 2003-03-05 | Compound of hydrophilic polymer-polycarboxyl oligopeptide and medicines, medical composite comprising above compound and use of above compound in medicimes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005519122A JP2005519122A (ja) | 2005-06-30 |
| JP2005519122A5 true JP2005519122A5 (enExample) | 2005-12-22 |
| JP4365221B2 JP4365221B2 (ja) | 2009-11-18 |
Family
ID=27768504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003573050A Expired - Lifetime JP4365221B2 (ja) | 2002-03-05 | 2003-03-05 | 親水性ポリマー−マルチカルボキシルオリゴペプチドと薬剤分子との結合生成物、医薬組成物およびその薬学上の使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7498035B2 (enExample) |
| EP (1) | EP1489125B1 (enExample) |
| JP (1) | JP4365221B2 (enExample) |
| CN (2) | CN100475269C (enExample) |
| AT (1) | ATE456379T1 (enExample) |
| AU (1) | AU2003221208A1 (enExample) |
| DE (1) | DE60331135D1 (enExample) |
| ES (1) | ES2340374T3 (enExample) |
| WO (1) | WO2003074586A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1496076B1 (en) * | 2002-03-13 | 2007-07-25 | Beijing Jiankai Technology Co., Ltd. | Hydrophilic polymer derivate with y type branch and preparation method of it medical composite comprising above compound |
| CN1613868A (zh) * | 2003-11-07 | 2005-05-11 | 北京键凯科技有限公司 | 亲水性聚合物－黄杨木提取物的结合物及其药物组合物 |
| CN100374443C (zh) * | 2004-03-29 | 2008-03-12 | 北京键凯科技有限公司 | 亲水性聚合物-雷公藤提取物的结合物及其药物组合物 |
| CN100475837C (zh) * | 2004-06-11 | 2009-04-08 | 北京键凯科技有限公司 | 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物 |
| RU2375384C2 (ru) * | 2004-09-22 | 2009-12-10 | Ниппон Каяку Кабусики Кайся | Новый блок-сополимер, мицеллярный препарат и противораковое средство, включающее мицеллярный препарат в качестве активного ингредиента |
| US8323669B2 (en) | 2006-03-28 | 2012-12-04 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of taxane |
| WO2007135910A1 (ja) | 2006-05-18 | 2007-11-29 | Nippon Kayaku Kabushiki Kaisha | ポドフィロトキシン類の高分子結合体 |
| RU2009114154A (ru) * | 2006-09-15 | 2010-10-20 | Энзон Фармасьютикалз, Инк. (Us) | Полимерные пролекарства с направленной доставкой, содержащие полифункциональные линкеры |
| US20090239782A1 (en) * | 2006-10-03 | 2009-09-24 | Masaharu Nakamura | High-molecular weight conjugate of resorcinol derivatives |
| CN101168594B (zh) * | 2006-10-24 | 2011-07-27 | 北京键凯科技有限公司 | 寡肽为骨架的聚乙二醇活性衍生物、其制备方法及与药物分子的结合物 |
| EP2080779B1 (en) * | 2006-11-06 | 2016-05-18 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
| JP5548365B2 (ja) * | 2006-11-08 | 2014-07-16 | 日本化薬株式会社 | 核酸系代謝拮抗剤の高分子誘導体 |
| USRE46190E1 (en) | 2007-09-28 | 2016-11-01 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
| EP2258397B1 (en) | 2008-03-18 | 2017-10-11 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of physiologically active substance |
| US9149540B2 (en) | 2008-05-08 | 2015-10-06 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
| JP2011162569A (ja) * | 2008-05-23 | 2011-08-25 | Nano Career Kk | カンプトテシン高分子誘導体及びその用途 |
| ITRM20080551A1 (it) * | 2008-10-15 | 2010-04-16 | Univ Catania | Derivati anfifilici del poliossietilenglicole (peg), procedimento di preparazione e loro usi nella preparazione di sistemi farmaceutici. |
| WO2010131675A1 (ja) | 2009-05-15 | 2010-11-18 | 日本化薬株式会社 | 水酸基を有する生理活性物質の高分子結合体 |
| JP2013234207A (ja) * | 2010-08-31 | 2013-11-21 | Jsr Corp | 新規重合体及び新規ｎ−カルボキシアミノ酸無水物、ならびにそれらの製造方法 |
| WO2012067138A1 (ja) | 2010-11-17 | 2012-05-24 | 日本化薬株式会社 | 新規なシチジン系代謝拮抗剤の高分子誘導体 |
| ES2635117T3 (es) | 2011-09-11 | 2017-10-02 | Nippon Kayaku Kabushiki Kaisha | Método para la fabricación de un copolímero de bloques |
| CN103083680B (zh) * | 2011-11-07 | 2014-12-24 | 北京键凯科技有限公司 | 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物 |
| WO2014093343A2 (en) * | 2012-12-10 | 2014-06-19 | Massachusetts Institute Of Technology | Multistage nanoparticle drug delivery system for the treatment of solid tumors |
| WO2014114262A1 (zh) * | 2013-01-28 | 2014-07-31 | 天津键凯科技有限公司 | 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途 |
| US9700633B2 (en) | 2013-01-28 | 2017-07-11 | Jenkem Technology Co., Ltd., Tianjin Branch | Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof |
| CN104448295B (zh) * | 2013-12-02 | 2018-01-23 | 北京键凯科技股份有限公司 | 聚乙二醇‑多爪寡肽键合的雷帕霉素衍生物 |
| CN107033305B (zh) * | 2017-05-20 | 2019-03-01 | 西南大学 | 一种还原性响应的两亲性蠕虫状单分子前药的制备方法 |
| CN114948850B (zh) * | 2022-05-26 | 2024-02-27 | 中国药科大学 | 可载药寡肽及其可溶性分层微针的制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6096605A (ja) * | 1983-10-31 | 1985-05-30 | Mitsubishi Chem Ind Ltd | 低分子量の水溶性物質の分離方法 |
| DE3730797A1 (de) * | 1987-09-14 | 1989-03-23 | Siegel Rolf | Materialien mit nicht-thrombogener oberflaeche |
| US5879923A (en) * | 1995-06-26 | 1999-03-09 | Daiichi Pure Chemicals Co., Ltd. | Stable plasmin solution |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| SI0932399T1 (sl) * | 1996-03-12 | 2006-10-31 | Pg Txl Co Lp | Vodotopna paklitakselna predzdravila |
| CN1110681C (zh) * | 1996-04-10 | 2003-06-04 | 丰田自动车株式会社 | 有色金属熔化保持炉与有色金属熔液保持炉 |
| US6824766B2 (en) * | 1998-04-17 | 2004-11-30 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| US7060708B2 (en) * | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6733755B2 (en) * | 2000-02-04 | 2004-05-11 | Supratek Pharma, Inc. | Ligand for vascular endothelial growth factor receptor |
| CN1376785A (zh) * | 2001-03-22 | 2002-10-30 | 上海博德基因开发有限公司 | 一种多肽——硫氨焦磷酸激酶－26.73和编码这种多肽的多核苷酸 |
| US6489153B1 (en) * | 2001-10-31 | 2002-12-03 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| CN1309763C (zh) * | 2002-10-31 | 2007-04-11 | 日本化药株式会社 | 喜树碱的高分子衍生物 |
-
2002
- 2002-03-05 CN CNB021066914A patent/CN100475269C/zh not_active Expired - Lifetime
-
2003
- 2003-03-05 AU AU2003221208A patent/AU2003221208A1/en not_active Abandoned
- 2003-03-05 JP JP2003573050A patent/JP4365221B2/ja not_active Expired - Lifetime
- 2003-03-05 DE DE60331135T patent/DE60331135D1/de not_active Expired - Lifetime
- 2003-03-05 ES ES03711787T patent/ES2340374T3/es not_active Expired - Lifetime
- 2003-03-05 US US10/506,524 patent/US7498035B2/en not_active Expired - Lifetime
- 2003-03-05 EP EP03711787A patent/EP1489125B1/en not_active Expired - Lifetime
- 2003-03-05 WO PCT/CN2003/000164 patent/WO2003074586A1/zh not_active Ceased
- 2003-03-05 AT AT03711787T patent/ATE456379T1/de not_active IP Right Cessation
- 2003-12-31 CN CNB2003801109158A patent/CN100400657C/zh not_active Expired - Lifetime
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