CN100475269C - 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途 - Google Patents

亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途 Download PDF

Info

Publication number
CN100475269C
CN100475269C CNB021066914A CN02106691A CN100475269C CN 100475269 C CN100475269 C CN 100475269C CN B021066914 A CNB021066914 A CN B021066914A CN 02106691 A CN02106691 A CN 02106691A CN 100475269 C CN100475269 C CN 100475269C
Authority
CN
China
Prior art keywords
conjugate
group
hydrophilic polymer
glutamic acid
drug molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB021066914A
Other languages
English (en)
Chinese (zh)
Other versions
CN1442440A (zh
Inventor
嵇世山
朱德权
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Polytron Technologies Inc
Original Assignee
BEIJING JIANKAI SCIENCE AND TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CNB021066914A priority Critical patent/CN100475269C/zh
Application filed by BEIJING JIANKAI SCIENCE AND TECHNOLOGY Co Ltd filed Critical BEIJING JIANKAI SCIENCE AND TECHNOLOGY Co Ltd
Priority to DE60331135T priority patent/DE60331135D1/de
Priority to JP2003573050A priority patent/JP4365221B2/ja
Priority to AU2003221208A priority patent/AU2003221208A1/en
Priority to PCT/CN2003/000164 priority patent/WO2003074586A1/zh
Priority to ES03711787T priority patent/ES2340374T3/es
Priority to AT03711787T priority patent/ATE456379T1/de
Priority to EP03711787A priority patent/EP1489125B1/en
Priority to US10/506,524 priority patent/US7498035B2/en
Publication of CN1442440A publication Critical patent/CN1442440A/zh
Priority to CNB2003801109158A priority patent/CN100400657C/zh
Application granted granted Critical
Publication of CN100475269C publication Critical patent/CN100475269C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB021066914A 2002-03-05 2002-03-05 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途 Expired - Lifetime CN100475269C (zh)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CNB021066914A CN100475269C (zh) 2002-03-05 2002-03-05 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途
US10/506,524 US7498035B2 (en) 2002-03-05 2003-03-05 Compounds of hydrophilic polymer-polycarboxyl oligopeptide and medicines, medical composite comprising above compound and use of above compound in medicines
AU2003221208A AU2003221208A1 (en) 2002-03-05 2003-03-05 Compound of hydrophilic polymer-polycarboxyl oligopeptide and medicines, medical composite comprising above compound and use of above compound in medicimes
PCT/CN2003/000164 WO2003074586A1 (en) 2002-03-05 2003-03-05 Compound of hydrophilic polymer-polycarboxyl oligopeptide and medicines, medical composite comprising above compound and use of above compound in medicimes
ES03711787T ES2340374T3 (es) 2002-03-05 2003-03-05 Compuesto de oligopeptido policarboxilico polimerico hidrofilico y medicinas, composicion medica que comprende el compuesto mencionado y el uso del compuesto mencionado en medicinas.
AT03711787T ATE456379T1 (de) 2002-03-05 2003-03-05 Verbindung aus hydrophilem polymer und polycarboxyloligopeptid und arzneimittel, die obige verbindung enthaltender medizinischer verbund und verwendung der obigen verbindung in arzneimitteln
DE60331135T DE60331135D1 (de) 2002-03-05 2003-03-05 Verbindung aus hydrophilem polymer und polycarboxyloligopeptid und arzneimittel, die obige verbindung enthaltender medizinischer verbund und verwendung der obigen verbindung in arzneimitteln
JP2003573050A JP4365221B2 (ja) 2002-03-05 2003-03-05 親水性ポリマー−マルチカルボキシルオリゴペプチドと薬剤分子との結合生成物、医薬組成物およびその薬学上の使用
EP03711787A EP1489125B1 (en) 2002-03-05 2003-03-05 Compound of hydrophilic polymer-polycarboxyl oligopeptide and medicines, medical composite comprising above compound and use of above compound in medicines
CNB2003801109158A CN100400657C (zh) 2002-03-05 2003-12-31 磷酸激酶及其应用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB021066914A CN100475269C (zh) 2002-03-05 2002-03-05 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途

Publications (2)

Publication Number Publication Date
CN1442440A CN1442440A (zh) 2003-09-17
CN100475269C true CN100475269C (zh) 2009-04-08

Family

ID=27768504

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB021066914A Expired - Lifetime CN100475269C (zh) 2002-03-05 2002-03-05 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途
CNB2003801109158A Expired - Lifetime CN100400657C (zh) 2002-03-05 2003-12-31 磷酸激酶及其应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB2003801109158A Expired - Lifetime CN100400657C (zh) 2002-03-05 2003-12-31 磷酸激酶及其应用

Country Status (9)

Country Link
US (1) US7498035B2 (enExample)
EP (1) EP1489125B1 (enExample)
JP (1) JP4365221B2 (enExample)
CN (2) CN100475269C (enExample)
AT (1) ATE456379T1 (enExample)
AU (1) AU2003221208A1 (enExample)
DE (1) DE60331135D1 (enExample)
ES (1) ES2340374T3 (enExample)
WO (1) WO2003074586A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003076490A1 (en) * 2002-03-13 2003-09-18 Beijing Jiankai Technology Co., Ltd. Hydrophilic polymer derivate with y type branch and preparation method of it medical composite comprising above compound
CN1613868A (zh) * 2003-11-07 2005-05-11 北京键凯科技有限公司 亲水性聚合物－黄杨木提取物的结合物及其药物组合物
CN100374443C (zh) * 2004-03-29 2008-03-12 北京键凯科技有限公司 亲水性聚合物-雷公藤提取物的结合物及其药物组合物
CN100475837C (zh) * 2004-06-11 2009-04-08 北京键凯科技有限公司 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物
JP4820758B2 (ja) * 2004-09-22 2011-11-24 日本化薬株式会社 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
KR20080106254A (ko) 2006-03-28 2008-12-04 니폰 가야꾸 가부시끼가이샤 탁산류의 고분자 결합체
RU2447095C2 (ru) 2006-05-18 2012-04-10 Ниппон Каяку Кабусики Кайся Высокомолекулярный конъюгат подофиллотоксинов
WO2008034124A2 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Targeted polymeric prodrugs containing multifunctional linkers
US20090239782A1 (en) * 2006-10-03 2009-09-24 Masaharu Nakamura High-molecular weight conjugate of resorcinol derivatives
CN101168594B (zh) * 2006-10-24 2011-07-27 北京键凯科技有限公司 寡肽为骨架的聚乙二醇活性衍生物、其制备方法及与药物分子的结合物
US8334364B2 (en) 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
US8188222B2 (en) 2006-11-08 2012-05-29 Nippon Kayaku Kabushiki Kaisha High molecular weight derivative of nucleic acid antimetabolite
WO2009041570A1 (ja) * 2007-09-28 2009-04-02 Nippon Kayaku Kabushiki Kaisha ステロイド類の高分子結合体
CN101977631A (zh) 2008-03-18 2011-02-16 日本化药株式会社 生理活性物质的高分子量偶联物
JP5366940B2 (ja) 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
JP2011162569A (ja) * 2008-05-23 2011-08-25 Nano Career Kk カンプトテシン高分子誘導体及びその用途
ITRM20080551A1 (it) * 2008-10-15 2010-04-16 Univ Catania Derivati anfifilici del poliossietilenglicole (peg), procedimento di preparazione e loro usi nella preparazione di sistemi farmaceutici.
WO2010131675A1 (ja) * 2009-05-15 2010-11-18 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
JP2013234207A (ja) * 2010-08-31 2013-11-21 Jsr Corp 新規重合体及び新規ｎ−カルボキシアミノ酸無水物、ならびにそれらの製造方法
US9018323B2 (en) 2010-11-17 2015-04-28 Nippon Kayaku Kabushiki Kaisha Polymer derivative of cytidine metabolic antagonist
RU2623426C2 (ru) 2011-09-11 2017-06-26 Ниппон Каяку Кабусики Кайся Способ получения блок-сополимера
CN103083680B (zh) * 2011-11-07 2014-12-24 北京键凯科技有限公司 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物
US9919059B2 (en) * 2012-12-10 2018-03-20 Massachusetts Institute Of Technology Multistage nanoparticle drug delivery system for the treatment of solid tumors
WO2014114262A1 (zh) * 2013-01-28 2014-07-31 天津键凯科技有限公司 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途
US9700633B2 (en) 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
WO2015081821A1 (zh) * 2013-12-02 2015-06-11 北京键凯科技有限公司 聚乙二醇-多爪寡肽键合的雷帕霉素衍生物
CN107033305B (zh) * 2017-05-20 2019-03-01 西南大学 一种还原性响应的两亲性蠕虫状单分子前药的制备方法
CN114948850B (zh) * 2022-05-26 2024-02-27 中国药科大学 可载药寡肽及其可溶性分层微针的制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
CN1110681C (zh) * 1996-04-10 2003-06-04 丰田自动车株式会社 有色金属熔化保持炉与有色金属熔液保持炉

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6096605A (ja) * 1983-10-31 1985-05-30 Mitsubishi Chem Ind Ltd 低分子量の水溶性物質の分離方法
DE3730797A1 (de) * 1987-09-14 1989-03-23 Siegel Rolf Materialien mit nicht-thrombogener oberflaeche
EP0835931A4 (en) * 1995-06-26 2000-11-15 Daiichi Pure Chemicals Co Ltd STABLE PLASMINE SOLUTION
CZ297979B6 (cs) * 1996-03-12 2007-05-16 Pg-Txl Company, L. P. Kompozice obsahující protinádorové lécivo konjugované s ve vode rozpustným polymerem, její pouzití pro výrobu léciva a implantovatelná lékarská pomucka
US6824766B2 (en) * 1998-04-17 2004-11-30 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
US7060708B2 (en) * 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
JP2003528824A (ja) * 2000-02-04 2003-09-30 スプラテック ファーマ インコーポレイティド 血管内皮成長因子受容体のためのリガンド
CN1376785A (zh) * 2001-03-22 2002-10-30 上海博德基因开发有限公司 一种多肽——硫氨焦磷酸激酶－26.73和编码这种多肽的多核苷酸
US6489153B1 (en) * 2001-10-31 2002-12-03 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
AU2003280592B2 (en) * 2002-10-31 2008-12-18 Nippon Kayaku Kabushiki Kaisha High-molecular weight derivatives of camptothecins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
CN1110681C (zh) * 1996-04-10 2003-06-04 丰田自动车株式会社 有色金属熔化保持炉与有色金属熔液保持炉

Also Published As

Publication number Publication date
US7498035B2 (en) 2009-03-03
AU2003221208A1 (en) 2003-09-16
US20050147617A1 (en) 2005-07-07
EP1489125B1 (en) 2010-01-27
DE60331135D1 (de) 2010-03-18
CN1886500A (zh) 2006-12-27
CN100400657C (zh) 2008-07-09
EP1489125A4 (en) 2006-09-13
EP1489125A1 (en) 2004-12-22
WO2003074586A1 (en) 2003-09-12
ES2340374T3 (es) 2010-06-02
ATE456379T1 (de) 2010-02-15
JP4365221B2 (ja) 2009-11-18
CN1442440A (zh) 2003-09-17
JP2005519122A (ja) 2005-06-30

Similar Documents

Publication Publication Date Title
CN100475269C (zh) 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途
AU772074B2 (en) Enzymatically activated polymeric drug conjugates
CN100475837C (zh) 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物
KR920006912B1 (ko) 수용성 고분자 중합화 약제
US8003089B2 (en) Y shape branched hydrophilic polymer derivatives, their preparation methods, conjugates of the derivatives and drug molecules, and pharmaceutical compositions comprising the conjugates
DE69925830T2 (de) Peg-lhrh analog konjugate
EP0854731B1 (en) Copolymeric micelle drug composition and method for the preparation thereof
CN101724144A (zh) 新型的多臂聚乙二醇及其制备方法和应用
CN101420962A (zh) 经修饰的大分子
CN100374443C (zh) 亲水性聚合物-雷公藤提取物的结合物及其药物组合物
KR20050070103A (ko) 캄프토테신의 고분자량 유도체
WO2004110358A2 (en) Polymeric conjugates for tissue activated drug delivery
CN101489592A (zh) 考布他汀的高分子量偶联物
WO2013067767A1 (zh) 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物
KR20070122519A (ko) Ｐｅｇ－폴리아세탈 이블록 및 삼블록 공중합체 및 약학조성물
CN1867578B (zh) 亲水性聚合物-黄杨木提取物的结合物及其药物组合物
CN100415801C (zh) 聚乙二醇氨基酸n-内环羰酐活性衍生物及其药物键合物和凝胶
CN111346234B (zh) 去铁胺-八臂星型聚乙二醇结合物及其应用
CN1448420A (zh) 亲水性聚合物与丹参酮类药物的结合物以及包含该结合物的药物组合物
JPH06256220A (ja) 薬物担体用高分子
CN1206257C (zh) 亲水性聚合物－水飞蓟提取物的结合物以及包含该结合物的药物组合物
EP1357928B1 (en) A novel pharmaceutical compound and methods of making and using same
EP1401374B1 (en) A novel pharmaceutical compound containing atenolol and methods of making and using same
KR0169195B1 (ko) PVMA-Ara-C 결합체
CA2428971A1 (en) Conjugates of a therapeutic agent and a peptide carrier

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee
CP03 Change of name, title or address

Address after: 100085 Beijing Haidian District information on Road No. 2 (Beijing is a high-tech development company, 2-1, 2-2, 2-1) 4 storey building C West

Patentee after: Beijing Polytron Technologies Inc

Address before: 100084 Beijing science and Technology Research Institute

Patentee before: Beijing Jiankai Science and Technology Co., Ltd.

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20090408