DE60331135D1 - Verbindung aus hydrophilem polymer und polycarboxyloligopeptid und arzneimittel, die obige verbindung enthaltender medizinischer verbund und verwendung der obigen verbindung in arzneimitteln - Google Patents

Verbindung aus hydrophilem polymer und polycarboxyloligopeptid und arzneimittel, die obige verbindung enthaltender medizinischer verbund und verwendung der obigen verbindung in arzneimitteln

Info

Publication number
DE60331135D1
DE60331135D1 DE60331135T DE60331135T DE60331135D1 DE 60331135 D1 DE60331135 D1 DE 60331135D1 DE 60331135 T DE60331135 T DE 60331135T DE 60331135 T DE60331135 T DE 60331135T DE 60331135 D1 DE60331135 D1 DE 60331135D1
Authority
DE
Germany
Prior art keywords
compound
medicaments
hydrophilic polymer
polycarboxyloligopeptide
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60331135T
Other languages
English (en)
Inventor
Shishan Ji
Dequan Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Jiankai Technology Co Ltd
Original Assignee
Beijing Jiankai Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Jiankai Technology Co Ltd filed Critical Beijing Jiankai Technology Co Ltd
Application granted granted Critical
Publication of DE60331135D1 publication Critical patent/DE60331135D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
DE60331135T 2002-03-05 2003-03-05 Verbindung aus hydrophilem polymer und polycarboxyloligopeptid und arzneimittel, die obige verbindung enthaltender medizinischer verbund und verwendung der obigen verbindung in arzneimitteln Expired - Lifetime DE60331135D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB021066914A CN100475269C (zh) 2002-03-05 2002-03-05 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途
PCT/CN2003/000164 WO2003074586A1 (fr) 2002-03-05 2003-03-05 Compose d'oligopeptide de polycarboxyle/de polymere hydrophile et medicaments, composition medicale renfermant le compose susmentionne et utilisation dudit compose dans des medicaments

Publications (1)

Publication Number Publication Date
DE60331135D1 true DE60331135D1 (de) 2010-03-18

Family

ID=27768504

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60331135T Expired - Lifetime DE60331135D1 (de) 2002-03-05 2003-03-05 Verbindung aus hydrophilem polymer und polycarboxyloligopeptid und arzneimittel, die obige verbindung enthaltender medizinischer verbund und verwendung der obigen verbindung in arzneimitteln

Country Status (9)

Country Link
US (1) US7498035B2 (de)
EP (1) EP1489125B1 (de)
JP (1) JP4365221B2 (de)
CN (2) CN100475269C (de)
AT (1) ATE456379T1 (de)
AU (1) AU2003221208A1 (de)
DE (1) DE60331135D1 (de)
ES (1) ES2340374T3 (de)
WO (1) WO2003074586A1 (de)

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ES2291620T3 (es) * 2002-03-13 2008-03-01 Beijing Jiankai Technology Co., Ltd. Derivado de polimeros hidrfilicos con rama tipo y y metodo de preparacion de compuesto metodo que comprende el compuesto anterior.
CN1613868A (zh) * 2003-11-07 2005-05-11 北京键凯科技有限公司 亲水性聚合物－黄杨木提取物的结合物及其药物组合物
CN100374443C (zh) * 2004-03-29 2008-03-12 北京键凯科技有限公司 亲水性聚合物-雷公藤提取物的结合物及其药物组合物
CN100475837C (zh) * 2004-06-11 2009-04-08 北京键凯科技有限公司 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物
PL1792927T3 (pl) * 2004-09-22 2013-09-30 Nippon Kayaku Kk Nowy kopolimer blokowy, preparat micelarny i lek przeciwnowotworowy zawierający ten preparat micelarny jako składnik czynny
WO2007111211A1 (ja) 2006-03-28 2007-10-04 Nippon Kayaku Kabushiki Kaisha タキサン類の高分子結合体
CA2652656A1 (en) 2006-05-18 2007-11-29 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of podophyllotoxins
CA2662981A1 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Targeted polymeric prodrugs containing multifunctional linkers
JP5548364B2 (ja) * 2006-10-03 2014-07-16 日本化薬株式会社 レゾルシノール誘導体の高分子結合体
CN101168594B (zh) * 2006-10-24 2011-07-27 北京键凯科技有限公司 寡肽为骨架的聚乙二醇活性衍生物、其制备方法及与药物分子的结合物
JP5503872B2 (ja) * 2006-11-06 2014-05-28 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
EP2090607B1 (de) * 2006-11-08 2015-05-20 Nippon Kayaku Kabushiki Kaisha Polymerderivat eines nukleinsäuremetabolismus-antagonisten
USRE46190E1 (en) * 2007-09-28 2016-11-01 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
CN101977631A (zh) * 2008-03-18 2011-02-16 日本化药株式会社 生理活性物质的高分子量偶联物
JP5366940B2 (ja) 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
JP2011162569A (ja) * 2008-05-23 2011-08-25 Nano Career Kk カンプトテシン高分子誘導体及びその用途
ITRM20080551A1 (it) * 2008-10-15 2010-04-16 Univ Catania Derivati anfifilici del poliossietilenglicole (peg), procedimento di preparazione e loro usi nella preparazione di sistemi farmaceutici.
JP5544357B2 (ja) * 2009-05-15 2014-07-09 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
JP2013234207A (ja) * 2010-08-31 2013-11-21 Jsr Corp 新規重合体及び新規ｎ−カルボキシアミノ酸無水物、ならびにそれらの製造方法
CN103221054A (zh) 2010-11-17 2013-07-24 日本化药株式会社 新的胞苷类代谢拮抗剂的高分子衍生物
RU2623426C2 (ru) 2011-09-11 2017-06-26 Ниппон Каяку Кабусики Кайся Способ получения блок-сополимера
CN103083680B (zh) * 2011-11-07 2014-12-24 北京键凯科技有限公司 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物
US9919059B2 (en) * 2012-12-10 2018-03-20 Massachusetts Institute Of Technology Multistage nanoparticle drug delivery system for the treatment of solid tumors
US9700633B2 (en) 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
WO2014114262A1 (zh) * 2013-01-28 2014-07-31 天津键凯科技有限公司 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途
WO2015081821A1 (zh) * 2013-12-02 2015-06-11 北京键凯科技有限公司 聚乙二醇-多爪寡肽键合的雷帕霉素衍生物
CN107033305B (zh) * 2017-05-20 2019-03-01 西南大学 一种还原性响应的两亲性蠕虫状单分子前药的制备方法
CN114948850B (zh) * 2022-05-26 2024-02-27 中国药科大学 可载药寡肽及其可溶性分层微针的制备方法和应用

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DE3730797A1 (de) * 1987-09-14 1989-03-23 Siegel Rolf Materialien mit nicht-thrombogener oberflaeche
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WO1997033552A1 (en) * 1996-03-12 1997-09-18 Pg-Txl Company, L.P. Water soluble paclitaxel prodrugs
CN1110681C (zh) * 1996-04-10 2003-06-04 丰田自动车株式会社 有色金属熔化保持炉与有色金属熔液保持炉
US6824766B2 (en) * 1998-04-17 2004-11-30 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
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WO2001057067A1 (en) * 2000-02-04 2001-08-09 Supratek Pharma Inc. Ligand for vascular endothelial growth factor receptor
CN1376785A (zh) * 2001-03-22 2002-10-30 上海博德基因开发有限公司 一种多肽——硫氨焦磷酸激酶－26.73和编码这种多肽的多核苷酸
US6489153B1 (en) * 2001-10-31 2002-12-03 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
JP4745664B2 (ja) * 2002-10-31 2011-08-10 日本化薬株式会社 カンプトテシン類の高分子誘導体

Also Published As

Publication number Publication date
EP1489125A4 (de) 2006-09-13
JP2005519122A (ja) 2005-06-30
AU2003221208A1 (en) 2003-09-16
CN1886500A (zh) 2006-12-27
JP4365221B2 (ja) 2009-11-18
CN100400657C (zh) 2008-07-09
ES2340374T3 (es) 2010-06-02
EP1489125A1 (de) 2004-12-22
US7498035B2 (en) 2009-03-03
EP1489125B1 (de) 2010-01-27
CN1442440A (zh) 2003-09-17
CN100475269C (zh) 2009-04-08
WO2003074586A1 (fr) 2003-09-12
ATE456379T1 (de) 2010-02-15
US20050147617A1 (en) 2005-07-07

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