DK1792927T3 - Ny blokcopolymer, micelletilberedning og anticancermiddel indeholdende samme som aktiv ingrediens - Google Patents
Ny blokcopolymer, micelletilberedning og anticancermiddel indeholdende samme som aktiv ingrediensInfo
- Publication number
- DK1792927T3 DK1792927T3 DK05783310.5T DK05783310T DK1792927T3 DK 1792927 T3 DK1792927 T3 DK 1792927T3 DK 05783310 T DK05783310 T DK 05783310T DK 1792927 T3 DK1792927 T3 DK 1792927T3
- Authority
- DK
- Denmark
- Prior art keywords
- active ingredient
- block copolymer
- same
- agent containing
- anticancer agent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
- C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
- C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polyamides (AREA)
- Epoxy Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004275625 | 2004-09-22 | ||
PCT/JP2005/017127 WO2006033296A1 (ja) | 2004-09-22 | 2005-09-16 | 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1792927T3 true DK1792927T3 (da) | 2013-06-10 |
Family
ID=36090056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05783310.5T DK1792927T3 (da) | 2004-09-22 | 2005-09-16 | Ny blokcopolymer, micelletilberedning og anticancermiddel indeholdende samme som aktiv ingrediens |
Country Status (15)
Country | Link |
---|---|
US (3) | US20080113028A1 (da) |
EP (1) | EP1792927B1 (da) |
JP (2) | JP4820758B2 (da) |
KR (1) | KR101203475B1 (da) |
CN (1) | CN101023119B (da) |
AU (1) | AU2005285953B2 (da) |
BR (1) | BRPI0515573A (da) |
CA (1) | CA2581125C (da) |
DK (1) | DK1792927T3 (da) |
ES (1) | ES2410591T3 (da) |
PL (1) | PL1792927T3 (da) |
PT (1) | PT1792927E (da) |
RU (1) | RU2375384C2 (da) |
TW (2) | TWI394774B (da) |
WO (1) | WO2006033296A1 (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2324701C2 (ru) * | 2003-03-20 | 2008-05-20 | Ниппон Каяку Кабусики Кайся | Мицеллярный препарат, содержащий малорастворимый в воде противораковый агент, содержащее его противораковое средство и новый блок-сополимер |
CA2581125C (en) | 2004-09-22 | 2013-04-23 | Nippon Kayaku Kabushiki Kaisha | Modified poly(ethylene oxide-amino acid) copolymer, micelle preparation, and anticancer agent containing the same |
CN101331173A (zh) * | 2005-10-05 | 2008-12-24 | 东京Cro株式会社 | 生物相容性嵌段共聚物、其用途和制造方法 |
JP5249016B2 (ja) * | 2006-03-28 | 2013-07-31 | 日本化薬株式会社 | タキサン類の高分子結合体 |
KR20090009241A (ko) | 2006-05-18 | 2009-01-22 | 니폰 가야꾸 가부시끼가이샤 | 포도필로톡신류의 고분자 결합체 |
US20090239782A1 (en) * | 2006-10-03 | 2009-09-24 | Masaharu Nakamura | High-molecular weight conjugate of resorcinol derivatives |
US8334364B2 (en) * | 2006-11-06 | 2012-12-18 | Nipon Kayaku Kabushiki Kaisha | High-molecular weight derivative of nucleic acid antimetabolite |
EP2090607B1 (en) * | 2006-11-08 | 2015-05-20 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
US8703878B2 (en) * | 2007-09-28 | 2014-04-22 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
EP2258397B1 (en) | 2008-03-18 | 2017-10-11 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of physiologically active substance |
WO2009136572A1 (ja) | 2008-05-08 | 2009-11-12 | 日本化薬株式会社 | 葉酸若しくは葉酸誘導体の高分子結合体 |
EP2431403B1 (en) | 2009-05-15 | 2016-09-28 | Nipponkayaku Kabushikikaisha | Polymer conjugate of bioactive substance having hydroxy group |
US20120231053A1 (en) * | 2009-10-21 | 2012-09-13 | Nippon Kayaku Kabushiki Kaisha | Block Copolymer For Intraperitoneal Administration Containing Anti-Cancer Agent, Micelle Preparation Thereof, And Cancer Therapeutic Agent Comprising The Micelle Preparation As Active Ingredient |
US9675521B2 (en) * | 2010-09-02 | 2017-06-13 | Nippon Kayaku Kabushiki Kaisha | Process for producing drug-block copolymer composite and pharmaceutical preparation containing same |
CN103221054A (zh) | 2010-11-17 | 2013-07-24 | 日本化药株式会社 | 新的胞苷类代谢拮抗剂的高分子衍生物 |
CN103874722B (zh) | 2011-09-11 | 2016-06-29 | 日本化药株式会社 | 嵌段共聚物的制造方法 |
CN102440961B (zh) * | 2011-12-08 | 2013-10-09 | 中山大学 | 一种具有酸敏亚表层的靶向聚合物胶束及其制备方法 |
CN102875789B (zh) * | 2012-09-26 | 2015-10-07 | 中国科学院长春应用化学研究所 | 一种聚醚嵌段共聚物及其制备方法 |
CN102875790B (zh) * | 2012-09-26 | 2016-03-23 | 中国科学院长春应用化学研究所 | 一种聚醚无规共聚物及其制备方法 |
WO2015002078A1 (ja) | 2013-07-03 | 2015-01-08 | 日本化薬株式会社 | ボロン酸化合物の新規製剤 |
EP2942348B1 (en) | 2014-05-07 | 2017-10-25 | Johannes Gutenberg-Universität Mainz | Thiol-protected amino acid derivatives and uses thereof |
CN104109255A (zh) * | 2014-07-13 | 2014-10-22 | 成都市绿科华通科技有限公司 | 新型医药用聚乙二醇功能材料 |
CN104086769A (zh) * | 2014-07-13 | 2014-10-08 | 成都市绿科华通科技有限公司 | 新型医用功能性聚乙二醇材料 |
CN104072758A (zh) * | 2014-07-13 | 2014-10-01 | 成都市绿科华通科技有限公司 | 一种医药用功能性聚乙二醇 |
US10226193B2 (en) | 2015-03-31 | 2019-03-12 | Medtronic Ps Medical, Inc. | Wireless pressure measurement and monitoring for shunts |
EP3378495B1 (en) | 2015-11-18 | 2020-08-05 | Nippon Kayaku Kabushiki Kaisha | Composition comprising novel glutamic acid derivative and block copolymer, and use thereof |
AU2016374759B2 (en) * | 2015-12-22 | 2021-04-01 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of sulfoxide derivative-coordinated platinum(II) complex |
US10869937B2 (en) | 2016-07-30 | 2020-12-22 | Nippon Kayaku Kabushiki Kaisha | Polymer derivatives, and novel polymer derivative imaging probe using same |
US10973762B2 (en) | 2016-08-02 | 2021-04-13 | Nippon Kayaku Kabushiki Kaisha | Active-targeting-type polymer derivative, composition containing said polymer derivative, and uses of said polymer derivative and said composition |
JP6848743B2 (ja) | 2017-07-24 | 2021-03-24 | 信越化学工業株式会社 | ポリアルキレングリコール誘導体の製造方法及び精製方法 |
CN111253345B (zh) * | 2020-03-02 | 2021-11-23 | 东北林业大学 | 一种红豆杉枝叶中紫杉醇的提取方法 |
EP4175966A1 (en) | 2020-07-06 | 2023-05-10 | Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen | Polymeric micelles comprising glucuronide-prodrugs |
CN112691081B (zh) * | 2021-01-18 | 2022-04-22 | 首都医科大学 | 一种基于(s)-2-癸酰氨基-3-(1-萘基)丙酰基-亮氨酰-缬氨酸的紫杉醇胶束 |
Family Cites Families (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1467587A (en) * | 1974-07-11 | 1977-03-16 | Nestle Sa | Preparation of an asparagine or a glutamine |
GB8500209D0 (en) * | 1985-01-04 | 1985-02-13 | Ceskoslovenska Akademie Ved | Synthetic polymeric drugs |
JPS6296088A (ja) | 1985-10-22 | 1987-05-02 | Kanebo Ltd | 抗腫瘍性物質の製法 |
US4734512A (en) | 1985-12-05 | 1988-03-29 | Bristol-Myers Company | Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof |
CH667874A5 (fr) | 1985-12-19 | 1988-11-15 | Battelle Memorial Institute | Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments. |
JPS6310789A (ja) | 1986-07-01 | 1988-01-18 | Nippon Kayaku Co Ltd | 新規ポドフイロトキシン誘導体 |
JPS6323884A (ja) | 1986-07-17 | 1988-02-01 | Nippon Kayaku Co Ltd | 新規ポドフイロトキシン誘導体 |
JPS6461422A (en) | 1987-09-02 | 1989-03-08 | Nippon Kayaku Kk | Water-soluble polymeric carcinostatic agent |
JPS6461423A (en) | 1987-09-02 | 1989-03-08 | Nippon Kayaku Kk | Water-soluble polymeric carcinostatic agent |
US5182203A (en) * | 1989-03-29 | 1993-01-26 | E. I. Du Pont De Nemours And Company | Bifunctional compounds useful in catalyzed reporter deposition |
JP2517760B2 (ja) | 1989-05-11 | 1996-07-24 | 新技術事業団 | 水溶性高分子化医薬製剤 |
US5543390A (en) * | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
JP3310000B2 (ja) | 1990-11-07 | 2002-07-29 | 靖久 桜井 | 水溶性高分子抗癌剤及び薬物担持用担体 |
JPH05117385A (ja) | 1991-10-31 | 1993-05-14 | Res Dev Corp Of Japan | ブロツク共重合体の製造法、ブロツク共重合体及び水溶性高分子抗癌剤 |
WO1993024476A1 (en) | 1992-06-04 | 1993-12-09 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
KR940003548U (ko) | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
US5614549A (en) * | 1992-08-21 | 1997-03-25 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
JP3270592B2 (ja) * | 1992-10-26 | 2002-04-02 | 日本化薬株式会社 | ブロック共重合体−抗癌剤複合体医薬製剤 |
JP3268913B2 (ja) * | 1992-10-27 | 2002-03-25 | 日本化薬株式会社 | 高分子担体 |
JPH06206830A (ja) | 1992-10-27 | 1994-07-26 | Nippon Kayaku Co Ltd | ブロック共重合体−薬剤複合体及び高分子ブロック共重合体 |
FR2698543B1 (fr) * | 1992-12-02 | 1994-12-30 | Rhone Poulenc Rorer Sa | Nouvelles compositions à base de taxoides. |
US5985548A (en) * | 1993-02-04 | 1999-11-16 | E. I. Du Pont De Nemours And Company | Amplification of assay reporters by nucleic acid replication |
DE4307114A1 (de) * | 1993-03-06 | 1994-09-08 | Basf Ag | Verfahren zur Herstellung von Umsetzungsprodukten aus Polyasparaginsäureamid und Aminosäuren und ihre Verwendung |
JP2894923B2 (ja) | 1993-05-27 | 1999-05-24 | 日立造船株式会社 | ウォータージェット式双胴船のジェット水吸込口部構造 |
US5840900A (en) | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5571889A (en) * | 1994-05-30 | 1996-11-05 | Mitsui Toatsu Chemicals, Inc. | Polymer containing monomer units of chemically modified polyaspartic acids or their salts and process for preparing the same |
JPH0848766A (ja) | 1994-05-30 | 1996-02-20 | Mitsui Toatsu Chem Inc | 重合体及びその製造方法 |
US5552517A (en) * | 1995-03-03 | 1996-09-03 | Monsanto Company | Production of polysuccinimide in an organic medium |
SG50747A1 (en) | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
JP2694923B2 (ja) | 1995-08-21 | 1997-12-24 | 科学技術振興事業団 | 水溶性高分子化医薬製剤 |
BR9710646A (pt) * | 1996-03-12 | 2000-01-11 | Pg Txl Co Lp | Pródrogas de paclitaxel solúveis em água. |
JP4420472B2 (ja) | 1996-04-15 | 2010-02-24 | 旭化成株式会社 | 薬物複合体 |
US5877205A (en) * | 1996-06-28 | 1999-03-02 | Board Of Regents, The University Of Texas System | Parenteral paclitaxel in a stable non-toxic formulation |
US6025385A (en) * | 1996-07-15 | 2000-02-15 | Kabushiki Kaisha Yakult Honsha | Taxane derivatives and drugs containing the same |
ES2208936T3 (es) | 1996-08-26 | 2004-06-16 | Transgene S.A. | Complejos de lipidos cationicos-acidos nucleicos. |
GB9625895D0 (en) * | 1996-12-13 | 1997-01-29 | Riley Patrick A | Novel compound useful as therapeutic agents and assay reagents |
DE59709788D1 (de) * | 1997-05-09 | 2003-05-15 | Deutsches Krebsforsch | Konjugat, umfassend einen Folsäureantagonisten und einen Träger |
JP4465109B2 (ja) | 1997-12-17 | 2010-05-19 | エンゾン ファーマシューティカルズ,インコーポレーテッド | アミノ及びヒドロキシル含有生物活性剤のポリマープロドラッグ |
US6824766B2 (en) * | 1998-04-17 | 2004-11-30 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
US6153655A (en) | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
JPH11335267A (ja) | 1998-05-27 | 1999-12-07 | Nano Career Kk | 水難溶性薬物を含有するポリマーミセル系 |
IN191203B (da) * | 1999-02-17 | 2003-10-04 | Amarnath Prof Maitra | |
US6207832B1 (en) * | 1999-04-09 | 2001-03-27 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
US20010041189A1 (en) * | 1999-04-13 | 2001-11-15 | Jingya Xu | Poly(dipeptide) as a drug carrier |
US6713454B1 (en) | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
US6380405B1 (en) | 1999-09-13 | 2002-04-30 | Nobex Corporation | Taxane prodrugs |
WO2001019361A2 (en) | 1999-09-14 | 2001-03-22 | Tepha, Inc. | Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate |
US6376470B1 (en) | 1999-09-23 | 2002-04-23 | Enzon, Inc. | Polymer conjugates of ara-C and ara-C derivatives |
US20030054977A1 (en) * | 1999-10-12 | 2003-03-20 | Cell Therapeutics, Inc. | Manufacture of polyglutamate-therapeutic agent conjugates |
NZ529789A (en) | 1999-10-12 | 2005-04-29 | Cell Therapeutics Inc | Manufacture of polyglutamate-20(S)-camptothecin conjugates |
JP3523821B2 (ja) * | 2000-02-09 | 2004-04-26 | ナノキャリア株式会社 | 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物 |
AU2001239275A1 (en) | 2000-02-29 | 2001-09-12 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives |
SI21172A (sl) | 2000-03-17 | 2003-10-31 | Cell Therapeutics, Inc. | Konjugati poliglutaminska kislina-kamptotecin in postopki za pripravo |
US20020161062A1 (en) * | 2001-11-06 | 2002-10-31 | Biermann Paul J. | Structure including a plurality of cells of cured resinous material, method of forming the structure and apparatus for forming the structure |
ES2386258T3 (es) | 2000-06-02 | 2012-08-14 | Eidgenössische Technische Hochschule Zürich | Relaciones de adición conjugadas para la entrega controlada de compuestos farmacéuticamente activos |
JP2002069184A (ja) | 2000-06-12 | 2002-03-08 | Mitsui Chemicals Inc | 重合体及びその製造方法 |
WO2002006279A1 (en) | 2000-07-17 | 2002-01-24 | Oxigene Inc | Efficient method of synthesizing combretastatin a-4 prodrugs |
US20020099013A1 (en) * | 2000-11-14 | 2002-07-25 | Thomas Piccariello | Active agent delivery systems and methods for protecting and administering active agents |
DE60233137D1 (de) | 2001-02-16 | 2009-09-10 | Univ R | Transporter mit beabstandeten arginin-teilchen |
DE60223499T2 (de) | 2001-02-20 | 2008-10-16 | Enzon, Inc. | Terminal verzweigte, polymere linker und diese enthaltende polymere konjugate |
EP1361895B1 (en) | 2001-02-20 | 2007-11-14 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
WO2003000771A1 (fr) | 2001-06-20 | 2003-01-03 | Nippon Kayaku Kabushiki Kaisha | Copolymere bloc a taux d'impuretes reduit, support polymere, preparations pharmaceutiques sous forme polymere et procede de preparation associe |
EP1438281A4 (en) | 2001-10-26 | 2006-04-26 | Oxigene Inc | FUNCTIONALIZED STYLENE DERIVATIVES AS IMPROVED MEDIUM-TERM MEDICAL DEVICES |
AU2002356301A1 (en) | 2001-12-21 | 2003-07-15 | Cancer Research Technology Ltd. | 3,4-diarylpyrazoles and their use in the therapy of cancer |
NZ534719A (en) * | 2002-03-01 | 2008-02-29 | Univ Tulane | Conjugates of therapeutic or cytotoxic agents and biologically active peptides |
CN100475269C (zh) | 2002-03-05 | 2009-04-08 | 北京键凯科技有限公司 | 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途 |
KR20040097237A (ko) * | 2002-03-26 | 2004-11-17 | 반유 세이야꾸 가부시끼가이샤 | 항종양성 인돌로피롤로카바졸 유도체와 기타 항암제의 병용 |
US6596757B1 (en) | 2002-05-14 | 2003-07-22 | Immunogen Inc. | Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use |
JP2003342168A (ja) | 2002-05-24 | 2003-12-03 | Nano Career Kk | 注射用薬物含有ポリマーミセル製剤の製造方法 |
JP2003342167A (ja) | 2002-05-24 | 2003-12-03 | Nano Career Kk | カンプトテシン誘導体の製剤およびその調製方法 |
JP4270485B2 (ja) | 2002-05-28 | 2009-06-03 | 第一三共株式会社 | タキサン類の還元方法 |
JP2004010479A (ja) * | 2002-06-03 | 2004-01-15 | Japan Science & Technology Corp | ブロック共重合体とアンスラサイクリン系抗癌剤を含む新規固型製剤及びその製造法 |
KR101057102B1 (ko) | 2002-10-31 | 2011-08-16 | 니폰 가야꾸 가부시끼가이샤 | 캄프토테신의 고분자량 유도체 |
GB0228417D0 (en) | 2002-12-05 | 2003-01-08 | Cancer Rec Tech Ltd | Pyrazole compounds |
GB0229618D0 (en) | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
US7169892B2 (en) * | 2003-01-10 | 2007-01-30 | Astellas Pharma Inc. | Lipid-peptide-polymer conjugates for long blood circulation and tumor specific drug delivery systems |
NZ541479A (en) | 2003-02-11 | 2008-11-28 | Vernalis Cambridge Liimited | Isoxazole compounds as inhibitors of heat shock proteins |
RU2324701C2 (ru) * | 2003-03-20 | 2008-05-20 | Ниппон Каяку Кабусики Кайся | Мицеллярный препарат, содержащий малорастворимый в воде противораковый агент, содержащее его противораковое средство и новый блок-сополимер |
KR20050115315A (ko) * | 2003-03-26 | 2005-12-07 | 가부시키가이샤 엘티티 바이오파마 | 약물 전달 및 서방성 약물 방출을 표적으로 하는 정맥 내 나노입자 |
GB0309637D0 (en) | 2003-04-28 | 2003-06-04 | Cancer Rec Tech Ltd | Pyrazole compounds |
WO2005018674A1 (ja) * | 2003-08-22 | 2005-03-03 | Kyowa Hakko Kogyo Co., Ltd. | イムノグロブリン遺伝子の転座を伴う疾患の治療薬 |
EP1680073B1 (en) * | 2003-10-21 | 2013-01-02 | IGF Oncology, LLC | Compounds and method for treating cancer |
FR2862536B1 (fr) | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques |
US7176185B2 (en) * | 2003-11-25 | 2007-02-13 | Tsrl, Inc. | Short peptide carrier system for cellular delivery of agent |
EP2497785B1 (en) * | 2004-01-07 | 2018-09-12 | Seikagaku Corporation | Hyaluronic acid derivative and drug containing the same |
CA2581125C (en) * | 2004-09-22 | 2013-04-23 | Nippon Kayaku Kabushiki Kaisha | Modified poly(ethylene oxide-amino acid) copolymer, micelle preparation, and anticancer agent containing the same |
US8399464B2 (en) * | 2005-03-09 | 2013-03-19 | Nippon Kayaku Kabushiki Kaisha | HSP90 inhibitor |
CA2598899A1 (en) | 2005-03-09 | 2006-09-14 | Nippon Kayaku Kabushiki Kaisha | Novel hsp90 inhibitor |
WO2006095668A1 (ja) | 2005-03-09 | 2006-09-14 | Toray Industries, Inc. | 微粒子および医薬品組成物 |
JP2008137894A (ja) | 2005-03-22 | 2008-06-19 | Nippon Kayaku Co Ltd | 新規なアセチレン誘導体 |
JPWO2006115293A1 (ja) | 2005-04-22 | 2008-12-18 | 国立大学法人 東京大学 | pH応答性高分子ミセルの調製に用いる新規ブロック共重合体及びその製造法 |
CA2606939C (en) * | 2005-05-11 | 2013-09-03 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of cytidine metabolic antagonist |
US20090275732A1 (en) * | 2005-05-12 | 2009-11-05 | Ichiro Hirotsu | Agent for improving circulatory disorder |
EP2382995A3 (en) | 2005-08-19 | 2013-09-25 | Endocyte, Inc. | Ligand conjugates of Vinca alkaloids, analogs and derivatives |
CN1800238A (zh) | 2005-12-05 | 2006-07-12 | 中国科学院长春应用化学研究所 | 有生物功能的脂肪族聚酯—聚氨基酸共聚物及合成方法 |
JP2007182407A (ja) | 2006-01-10 | 2007-07-19 | Medgel Corp | 徐放性ハイドロゲル製剤 |
JP2007191643A (ja) | 2006-01-20 | 2007-08-02 | Mitsui Chemicals Inc | 生体への定着性が付与されたポリアミノ酸誘導体 |
JP5249016B2 (ja) | 2006-03-28 | 2013-07-31 | 日本化薬株式会社 | タキサン類の高分子結合体 |
KR20090009241A (ko) * | 2006-05-18 | 2009-01-22 | 니폰 가야꾸 가부시끼가이샤 | 포도필로톡신류의 고분자 결합체 |
AU2007274402A1 (en) | 2006-07-19 | 2008-01-24 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of combretastatin |
US20090239782A1 (en) * | 2006-10-03 | 2009-09-24 | Masaharu Nakamura | High-molecular weight conjugate of resorcinol derivatives |
US8334364B2 (en) * | 2006-11-06 | 2012-12-18 | Nipon Kayaku Kabushiki Kaisha | High-molecular weight derivative of nucleic acid antimetabolite |
EP2090607B1 (en) | 2006-11-08 | 2015-05-20 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
US8703878B2 (en) * | 2007-09-28 | 2014-04-22 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
EP2258397B1 (en) | 2008-03-18 | 2017-10-11 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of physiologically active substance |
WO2009136572A1 (ja) * | 2008-05-08 | 2009-11-12 | 日本化薬株式会社 | 葉酸若しくは葉酸誘導体の高分子結合体 |
EP2287230B1 (en) | 2008-05-23 | 2012-09-26 | NanoCarrier Co., Ltd. | Docetaxel polymer derivative, method for producing same and use of same |
EP2431403B1 (en) * | 2009-05-15 | 2016-09-28 | Nipponkayaku Kabushikikaisha | Polymer conjugate of bioactive substance having hydroxy group |
CN103221054A (zh) * | 2010-11-17 | 2013-07-24 | 日本化药株式会社 | 新的胞苷类代谢拮抗剂的高分子衍生物 |
CN103874722B (zh) * | 2011-09-11 | 2016-06-29 | 日本化药株式会社 | 嵌段共聚物的制造方法 |
-
2005
- 2005-09-16 CA CA2581125A patent/CA2581125C/en not_active Expired - Fee Related
- 2005-09-16 US US11/662,834 patent/US20080113028A1/en not_active Abandoned
- 2005-09-16 RU RU2007115075/02A patent/RU2375384C2/ru active
- 2005-09-16 AU AU2005285953A patent/AU2005285953B2/en not_active Ceased
- 2005-09-16 KR KR1020077006614A patent/KR101203475B1/ko active IP Right Grant
- 2005-09-16 PL PL05783310T patent/PL1792927T3/pl unknown
- 2005-09-16 ES ES05783310T patent/ES2410591T3/es active Active
- 2005-09-16 DK DK05783310.5T patent/DK1792927T3/da active
- 2005-09-16 PT PT57833105T patent/PT1792927E/pt unknown
- 2005-09-16 JP JP2006536368A patent/JP4820758B2/ja not_active Expired - Fee Related
- 2005-09-16 EP EP05783310A patent/EP1792927B1/en active Active
- 2005-09-16 WO PCT/JP2005/017127 patent/WO2006033296A1/ja active Application Filing
- 2005-09-16 BR BRPI0515573-8A patent/BRPI0515573A/pt not_active IP Right Cessation
- 2005-09-16 CN CN2005800315373A patent/CN101023119B/zh not_active Expired - Fee Related
- 2005-09-21 TW TW101133848A patent/TWI394774B/zh not_active IP Right Cessation
- 2005-09-21 TW TW094132581A patent/TWI394773B/zh not_active IP Right Cessation
-
2011
- 2011-04-25 JP JP2011096822A patent/JP5369137B2/ja not_active Expired - Fee Related
-
2013
- 2013-08-20 US US13/971,036 patent/US9434822B2/en active Active
-
2015
- 2015-06-02 US US14/727,912 patent/US20150259479A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101023119B (zh) | 2010-05-05 |
CN101023119A (zh) | 2007-08-22 |
RU2375384C2 (ru) | 2009-12-10 |
US20080113028A1 (en) | 2008-05-15 |
RU2007115075A (ru) | 2008-10-27 |
CA2581125A1 (en) | 2006-03-30 |
AU2005285953B2 (en) | 2011-01-20 |
US20150259479A1 (en) | 2015-09-17 |
JP5369137B2 (ja) | 2013-12-18 |
EP1792927B1 (en) | 2013-03-06 |
ES2410591T3 (es) | 2013-07-02 |
EP1792927A1 (en) | 2007-06-06 |
JP4820758B2 (ja) | 2011-11-24 |
KR20070056113A (ko) | 2007-05-31 |
TWI394773B (zh) | 2013-05-01 |
EP1792927A4 (en) | 2011-11-30 |
JPWO2006033296A1 (ja) | 2008-05-15 |
TW200616663A (en) | 2006-06-01 |
PL1792927T3 (pl) | 2013-09-30 |
TWI394774B (zh) | 2013-05-01 |
WO2006033296A1 (ja) | 2006-03-30 |
JP2011173908A (ja) | 2011-09-08 |
US9434822B2 (en) | 2016-09-06 |
BRPI0515573A (pt) | 2008-07-29 |
KR101203475B1 (ko) | 2012-11-21 |
TW201302850A (zh) | 2013-01-16 |
CA2581125C (en) | 2013-04-23 |
US20140024703A1 (en) | 2014-01-23 |
AU2005285953A1 (en) | 2006-03-30 |
PT1792927E (pt) | 2013-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1792927T3 (da) | Ny blokcopolymer, micelletilberedning og anticancermiddel indeholdende samme som aktiv ingrediens | |
NO20035298D0 (no) | CDK-inhiberende pyrimider, deres fremstilling og deres anvendelse som legemidler | |
NO20052493D0 (no) | Selekterte CGRP antagonister, fremgangsmater for fremstilling derav og deres anvendelse som farmasoytiske sammensetninger. | |
DK1592457T3 (da) | Folat-vinblastin-konjugat som lægemiddel | |
NO20052496D0 (no) | Selekterte CGRP antagonister, fremgangsmater for fremstilling derav og anvendelse derav som medikamenter. | |
NO20043702L (no) | 8-azaprostaglandinderivatforbindelser og legemidler inneholdende forbindelsene som den aktive bestanddel | |
IL177533A (en) | Benzimidazole derivatives, their preparation and pharmaceutical compositions comprising them | |
IL181301A0 (en) | Cyclopamine analogues, pharmaceutical compositions comprising them and uses thereof | |
DK1445252T3 (da) | Sulfonamid-derivater, deres fremstilling og anvendelse som medikamenter | |
ZA200701482B (en) | Sulphonamide derivatives, their preparation and their therapeutic application | |
DK1498411T3 (da) | Diketohydrazinderivatforbindelser og medikamenter indeholdende forbindelserne som den aktive bestanddel | |
ZA200705750B (en) | Compositions and methods for stabilizing active pharmaceutical ingredients | |
WO2006132647A3 (en) | Antimicrobial copolymers and uses thereof | |
IS8422A (is) | Bensímídasólafleiður, efnablöndur sem innihalda þær, framleiðsla þeirra og notkun þeirra | |
IS8219A (is) | Bensímídasólafleiður, efnablöndur sem innihalda þær, framleiðsla þeirra og notkun | |
ZA200706254B (en) | 18-methyl-19-nor-17-pregn-4-en-21,17-carbolactones and pharmaceutical preparations comprising the same | |
DK1095025T3 (da) | Benzimidazoler, deres fremstilling og deres anvendelse som lægemidler | |
DK1557415T3 (da) | Heterocykliske forbindelser og antitumorlægemidler indeholdende samme som den aktive ingrediens | |
NO20073026L (no) | 2-alkoksy-3,4,5-trihydroksy-alkylamider, fremstilling og sammensetninger derav samt anvendelse derav | |
ITMI20031570A1 (it) | Composizione per uso dietetico, farmaceutico o cosmetico | |
EP1731609A4 (en) | INHIBITOR OF THE EXPRESSION OF RAD51, MEDICAMENT CONTAINING THE INHIBITOR AS ACTIVE INGREDIENT AND USE THEREOF | |
WO2003063851A8 (en) | Composition for pharmaceutical or dietetic use for combating hair loss | |
NO20054214D0 (no) | Iminoeterderivatforbindelser og legemidler inneholdende forbindelsene som den aktive bestanddel | |
HK1104823A1 (en) | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof i | |
EP1608395A4 (en) | ANTICROPE WITH LK8 PROTEIN AS AN ACTIVE SUBSTANCE |