US10433952B2 - Prosthetic valve for avoiding obstruction of outflow - Google Patents

Prosthetic valve for avoiding obstruction of outflow Download PDF

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US10433952B2
US10433952B2 US15/418,511 US201715418511A US10433952B2 US 10433952 B2 US10433952 B2 US 10433952B2 US 201715418511 A US201715418511 A US 201715418511A US 10433952 B2 US10433952 B2 US 10433952B2
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anterior
valve
prosthetic
anchoring
commissure
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US20170216023A1 (en
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Randy Matthew Lane
Karen Tsoek-Ji Wong
Ian Fraser Kerr
Mark Segal
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Neovasc Tiara Inc
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Neovasc Tiara Inc
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Priority to US16/559,169 priority patent/US11357622B2/en
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Assigned to NEOVASC TIARA INC. reassignment NEOVASC TIARA INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: BIO IP VENTURES II LLC, AS COLLATERAL AGENT
Assigned to STRUL MEDICAL GROUP, LLC reassignment STRUL MEDICAL GROUP, LLC SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NEOVASC TIARA INC.
Assigned to NEOVASC TIARA INC. reassignment NEOVASC TIARA INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BANAI, SHMUEL
Assigned to STRUL MEDICAL GROUP, LLC reassignment STRUL MEDICAL GROUP, LLC CONFIRMATORY ASSIGNMENT OF SECURITY INTEREST Assignors: STRUL MEDICAL GROUP, LLC, AS COLLATERAL AGENT
Priority to US17/739,790 priority patent/US12193932B2/en
Assigned to NEOVASC MEDICAL INC., NEOVASC TIARA INC., NEOVASC INC. reassignment NEOVASC MEDICAL INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: STRUL MEDICAL GROUP, LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/243—Deployment by mechanical expansion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/2436—Deployment by retracting a sheath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0033—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0034—D-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/006—Y-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical

Definitions

  • Mitral regurgitation also known as mitral insufficiency or mitral incompetence
  • mitral insufficiency is a heart condition in which the mitral valve does not close properly. This results in abnormal leakage of blood retrograde from the left ventricle through the mitral valve back upstream into the atrium. Persistent mitral regurgitation can result in congestive heart failure.
  • Traditional surgical repair of the valve generally results in a good clinical outcome but requires open heart surgery and a lengthy and costly hospital stay with an extended recovery period.
  • minimally invasive procedures have been developed to deliver a prosthetic heart valve percutaneously over a catheter through the patient's vasculature to the heart.
  • a transapical procedure is used to introduce the prosthesis through the chest wall and through the apex of the heart.
  • An exemplary prosthesis includes that described in U.S. Pat. No. 8,579,964, the entire contents of which are incorporated herein by reference in their entirety for all purposes.
  • These prostheses and delivery procedures appear to be promising, but in certain circumstances they may obstruct blood flow, cause blood flow through the prosthesis to be turbulent, or disrupt the natural flow path, thereby potentially resulting in hemodynamic problems. Therefore, it would be desirable to provide improved devices, systems, and methods that avoid obstructing blood outflow and that maintain the natural flow path and natural hemodynamics. At least some of these objectives may be met by the exemplary embodiments described herein.
  • the present invention generally relates to medical systems, devices, and methods, and more particularly relates to prosthetic heart valves that may be used to repair a valve such as a mitral valve, a heart valve, or any other valve.
  • a prosthetic heart valve for implantation in a native mitral valve of a patient comprises a radially expandable anchor frame having an expanded configuration and a collapsed configuration.
  • the heart valve also comprises a prosthetic valve coupled to the anchor frame.
  • the prosthetic valve comprises a plurality of prosthetic valve leaflets each having a free end and a fixed end, with the fixed end coupled to the anchor frame, and the free ends of the plurality of prosthetic valve leaflets have an open configuration and a closed configuration. In the open configuration, the free ends are disposed away from one another to allow antegrade blood flow therethrough, and in the closed configuration the free ends are disposed adjacent one another to substantially prevent retrograde blood flow therethrough.
  • the prosthetic mitral valve is configured to direct blood flow passing through the prosthetic valve in a non-turbulent manner and circular direction along a posterior wall of the patient's left ventricle towards the apex of the heart and upward along a septal wall until it is ejected out the left ventricular outflow tract during systole.
  • the blood flow substantially maintains momentum and conserves energy as it flows through the prosthetic mitral valve and left ventricle and out the left ventricular outflow tract.
  • the blood flow is indirectly directed to the apex of the heart or the septal wall.
  • the plurality of prosthetic valve leaflets may comprise an anterior prosthetic leaflet that is sized to span the entire width of the native anterior leaflet. In systole, the anterior prosthetic leaflet may deflect away from the left ventricular outflow tract to provide a clear unobstructed outflow path for the blood flow.
  • a prosthetic heart valve for implantation in a native mitral valve of a patient comprises a radially expandable anchor frame having an expanded configuration and a collapsed configuration.
  • the prosthetic heart valve also comprises a prosthetic valve coupled to the anchor frame that comprises a plurality of prosthetic valve leaflets each having a free end and a fixed end.
  • the fixed end is coupled to the anchor frame, and the free ends of the plurality of prosthetic valve leaflets have an open configuration and a closed configuration. In the open configuration the free ends are disposed away from one another to allow antegrade blood flow therethrough, and in the closed configuration the free ends are disposed adjacent one another to substantially prevent retrograde blood flow therethrough.
  • the plurality of prosthetic valve leaflets comprise an anterior prosthetic leaflet sized to span the entire width of the native anterior leaflet. In systole, the anterior prosthetic leaflet deflects away from the left ventricular outflow tract to provide a clear unobstructed outflow path.
  • the prosthetic heart valve may be configured to direct blood flow through the prosthetic valve in a non-turbulent manner and blood flow is preferably directed in a circular direction along a posterior wall of the patient's left ventricle towards the apex of the heart and upward along a septal wall until it is ejected out the left ventricular outflow tract.
  • the blood flow preferably substantially maintains momentum and conserves energy as it flows through the prosthetic heart valve and left ventricle and out the left ventricular outflow tract.
  • the anchor frame may comprise an anterior anchoring tab configured to anchor on a fibrous trigone of the native mitral valve or on any tissue anterior of the anterior native leaflet and adjacent thereto.
  • the anchor frame may also comprise a second anterior anchoring tab that is configured to anchor on a second fibrous trigone of the native mitral valve or any tissue anterior of the anterior native leaflet and adjacent thereto.
  • the anchor frame may comprise a D-shaped cross-section having a substantially flat anterior portion and a cylindrically shaped posterior portion. The flat anterior portion prevents impingement of the prosthetic heart valve on the left ventricular outflow tract, and the cylindrically shaped portion engages the posterior portion of the native mitral valve.
  • the anchor frame may also comprise one or more commissure posts, and an anterior anchoring tab.
  • the one or more commissure posts may have a free end and an opposite end coupled to the anchor frame.
  • the plurality of commissure posts may be coupled to the plurality of prosthetic valve leaflets, and the anterior anchoring tab may be configured to anchor on a fibrous trigone of the native mitral valve or on any tissue anterior of the anterior native valve leaflet and adjacent thereto.
  • the anterior anchoring tab and the one or more commissure posts may be nested in one another when the anchor frame is in the collapsed configuration.
  • the anterior anchoring tab may originate from a circumferential position on the anchor frame, and the one or more commissure posts also may originate from the same circumferential position on the anchor frame as the anterior anchoring tab.
  • the anterior anchoring tab may originate from the one or more commissure posts, or the one or more commissure posts may originate from the anchoring tab.
  • a method of treating a native mitral valve in a patient's heart comprises providing a prosthetic mitral valve, anchoring the prosthetic mitral valve in the native mitral valve, and directing blood flow in a non-turbulent manner.
  • the blood flow is directed through the prosthetic mitral valve in a circular direction along a posterior wall of the patient's left ventricle towards the apex of the heart and upward along a septal wall until it is ejected out the left ventricular outflow tract.
  • the method may further comprise substantially maintaining momentum of the blood flow and conserving energy as the blood flows through the prosthetic mitral valve and left ventricle and out the left ventricular outflow tract.
  • Directing the blood flow may comprise indirectly directing the blood flow to the apex of the heart or the septal wall.
  • the prosthetic mitral valve may comprise an anterior prosthetic leaflet spanning the width of the native anterior valve leaflet, and the method may further comprise deflecting the anterior prosthetic leaflet away from the left ventricular outflow tract to provide a clear unobstructed outflow path during systole.
  • Anchoring the prosthesis may comprise anchoring an anterior anchoring tab disposed on an anterior portion of the prosthetic valve to a fibrous trigone of the native mitral valve or to tissue anterior of the native anterior valve leaflet and adjacent thereto.
  • a method of treating a native mitral valve in a patient's heart comprises providing a prosthetic mitral valve having an anterior prosthetic leaflet that spans the width of the native anterior valve leaflet, anchoring the prosthetic mitral valve in the native mitral valve, and deflecting the prosthetic anterior leaflet in systole away from the left ventricular outflow tract during systole thereby creating an unobstructed outflow path.
  • the method may further comprise directing blood flow in a non-turbulent manner through the prosthetic mitral valve and in a circular direction along a posterior wall of the patient's left ventricle towards the apex of the heart and upward along a septal wall until it is ejected out the left ventricular outflow tract.
  • Anchoring the prosthesis may comprise anchoring an anterior anchoring tab disposed on an anterior portion of the prosthetic valve to a fibrous trigone of the native mitral valve or to tissue anterior of the native anterior leaflet and adjacent thereto.
  • a prosthetic heart valve for implantation in a native mitral valve of a patient comprises a radially expandable anchor frame having an expanded configuration and a collapsed configuration; and a prosthetic valve coupled to the anchor frame.
  • the prosthetic valve comprises a plurality of prosthetic valve leaflets each having a free end and a fixed end.
  • the fixed end is coupled to the anchor frame and the free ends of the plurality of prosthetic valve leaflets have an open configuration and a closed configuration. In the open configuration the free ends are disposed away from one another to allow antegrade blood flow therethrough, and in the closed configuration the free ends are disposed adjacent one another to substantially prevent retrograde blood flow therethrough.
  • the plurality of prosthetic valve leaflets comprise an anterior prosthetic leaflet sized to span the entire width of the native anterior leaflet. In systole, the anterior prosthetic leaflet deflects away from the left ventricular outflow tract to provide a clear unobstructed outflow path.
  • the anchor frame may comprise an anterior anchoring tab configured to anchor on an anterior portion of the native mitral valve and the anterior portion of the native mitral valve may comprise a fibrous trigone.
  • the anchor frame may comprise a second anterior anchoring tab configured to anchor on a second anterior portion of the native mitral valve.
  • the anchor frame can comprise a D-shaped cross-section having a substantially flat anterior portion and a cylindrically shaped posterior portion, wherein the flat anterior portion prevents impingement of the prosthetic heart valve on the left ventricular outflow tract, and the cylindrically shaped posterior portion engages a posterior portion of the native mitral valve.
  • the anchor frame can comprise one or more commissure posts, and an anterior anchoring tab, the one or more commissure posts having a free end and an opposite end coupled to the anchor frame, the one or more commissure posts coupled to the plurality of prosthetic valve leaflets.
  • the anterior anchoring tab can be configured to anchor on an anterior portion of the native mitral valve.
  • the anterior anchoring tab and the one or more commissure posts can be nested in one another when the anchor frame is in the collapsed configuration.
  • the anterior anchoring tab originates from a circumferential position on a circumference of the anchor frame, and wherein the one or more commissure posts also originate from the same circumferential position on the circumference of the anchor frame as the anterior anchoring tab.
  • the anterior anchoring tab can originate from the one or more commissure posts, or the one or more commissure posts can originate from the anterior anchoring tab.
  • the anchor frame can further comprise a plurality of chordal bumper struts originating from the one or more commissure posts.
  • the plurality of chordal bumper struts can be configured to dispose native sub-valvular anatomy away from the LVOT.
  • the commissure posts can comprise an anchoring element adjacent a free end of the commissure post, the anchoring element configured to engage a delivery system.
  • the anchor frame can further comprise a plurality of wishbone shaped struts originating from the one or more commissure posts.
  • the plurality of wishbone shaped struts can be configured to arcuately span the distance between adjacent commissure posts.
  • Each wishbone shaped strut can be comprised of an anchoring element disposed at an apex of the wishbone shaped strut or adjacent a free end of the wishbone shaped strut.
  • the anchoring element can be configured to engage a delivery catheter.
  • the plurality of wishbone shaped struts can be deformable members and can allow radial compression of the anchor frame upon retraction into the delivery catheter.
  • the anchoring element can comprise a single threaded connector, a plurality of threaded connectors, a buckle connector, or a prong connector.
  • a prosthetic heart valve for implantation in a native mitral valve of a patient comprises a radially expandable anchor frame, an anterior anchoring tab coupled to the anchor frame, and a prosthetic valve coupled to the anchor frame.
  • the radially expandable anchor frame has an expanded configuration and a collapsed configuration and an upstream end and a downstream end.
  • the radially expandable anchor frame comprises one or more commissure posts having a free end and an opposite end coupled to the anchor frame adjacent the downstream end, and an anterior anchoring tab coupled to the anchor frame adjacent the downstream end.
  • the anterior anchoring tab is configured to anchor on an anterior portion of the native mitral valve.
  • the anterior anchoring tab and the one or more commissure posts are nested in one another when the anchor frame is in the collapsed configuration.
  • the prosthetic valve comprises one or more prosthetic valve leaflets each having a free end and a fixed end, wherein the fixed end is coupled to the anchor frame.
  • the one or more commissure posts are coupled to the one or more prosthetic valve leaflets.
  • the free ends of the one or more prosthetic valve leaflets can have an open configuration and a closed configuration. In the open configuration the free ends can be disposed away from one another to allow antegrade blood flow therethrough, and in the closed configuration the free ends can be disposed adjacent one another to substantially prevent retrograde blood flow therethrough.
  • the one or more prosthetic valve leaflets can comprise an anterior prosthetic leaflet sized to span a width of a native anterior valve leaflet between two native fibrous trigones. In systole, the anterior prosthetic leaflet can deflect away from the left ventricular outflow tract to provide a clear unobstructed outflow path.
  • the anterior portion of the native mitral valve can comprise a fibrous trigone.
  • the anchor frame can comprise a second anterior anchoring tab configured to anchor on a second anterior portion of the native mitral valve.
  • the anchor frame can comprise a D-shaped cross-section having a substantially flat anterior portion and a cylindrically shaped posterior portion. The flat anterior portion can prevent impingement of the prosthetic heart valve on the left ventricular outflow tract, and the cylindrically shaped portion can engage the posterior portion of the native mitral valve.
  • the anterior anchoring tab can originate from a circumferential position on a circumference of the anchor frame and the one or more commissure posts can also originate from the same circumferential position on the circumference of the anchor frame as the anterior anchoring tab. In some examples, the anterior anchoring tab can originate from the one or more commissure posts, or the one or more commissure posts can originate from the anterior anchoring tab.
  • a method of treating a native mitral valve in a patient's heart comprises: providing a prosthetic mitral valve having an anterior prosthetic leaflet that spans a width of a native anterior valve leaflet; anchoring the prosthetic mitral valve in the native mitral valve; and deflecting the prosthetic anterior leaflet in systole away from the left ventricular outflow tract during systole thereby creating an unobstructed outflow path.
  • Anchoring the prosthetic mitral valve in the native mitral valve can comprise anchoring an anterior anchoring tab disposed on an anterior portion of the prosthetic valve to an anterior portion of the native mitral valve.
  • the anterior portion of the native mitral valve can comprise a fibrous trigone.
  • the method can comprise radially expanding the prosthetic mitral valve from a collapsed configuration to an expanded configuration, wherein radially expanding the prosthetic mitral valve can comprise expanding one or more anterior anchoring tabs away from nested positions within one or more commissure posts.
  • the method can comprise radially expanding the prosthetic mitral valve from a collapsed configuration to an expanded configuration, wherein radially expanding can comprise expanding one or more posterior anchoring tabs away from nested positions within one or more commissure posts.
  • anchoring the prosthetic mitral valve can comprise actuating an actuator mechanism on a delivery system in a first direction, which can comprise moving a sheath catheter away from the prosthetic mitral valve to remove a constraint thereby allowing the prosthetic mitral valve to expand.
  • the method can further comprise actuating the actuator mechanism in a second direction opposite the first direction, which can comprise moving a sheath catheter toward the prosthetic mitral valve to provide a constraint thereby forcing the prosthetic mitral valve to be compressed.
  • actuating the actuator mechanism in the first direction can comprise moving a bell catheter away from an anchoring catheter to remove a constraint thereby allowing a commissure anchor to be released.
  • the commissure anchor can comprise an anchoring element that engages a frame of the prosthetic mitral valve to the delivery system.
  • Actuating the actuator mechanism in the second direction can comprise moving the bell catheter toward the anchoring catheter to provide a constraint that captures or restrains the commissure anchor.
  • Providing the constraint that captures or restrains the commissure anchor can comprise releasably sliding a retaining element over the commissure anchor.
  • actuating the actuator mechanism can comprise moving a sheath catheter over the anchoring catheter thereby applying a constraint, which can comprise allowing a commissure anchor to be compressed.
  • the commissure anchor can comprise a flexible anchoring element that can engage the frame of the prosthetic mitral valve to the delivery system.
  • a method of treating a native mitral valve in a patient's heart comprises: providing a prosthetic mitral valve coupled to a radially expandable anchor frame having an upstream end and a downstream end, expanding the radially expandable anchor frame from a collapsed configuration to an expanded configuration, anchoring the prosthetic mitral valve in the native mitral valve, wherein the anterior anchoring tab anchors on an anterior portion of the native mitral valve, and radially expanding the anterior anchoring tab away from a nested position within the one or more commissure posts.
  • the radially expandable anchor frame comprises one or more commissure posts having a free end and an opposite end coupled to the anchor frame adjacent the downstream end, and an anterior anchoring tab coupled to the anchor frame adjacent the downstream end.
  • the anterior portion of the native mitral valve can comprise a fibrous trigone.
  • radially expanding the anchor frame can comprise expanding the one or more commissure posts away from a nested position within the anterior anchoring tab.
  • the prosthetic mitral valve can comprise an anterior prosthetic leaflet and the method can comprise spanning a width of a native anterior valve leaflet between two native fibrous trigones, deflecting the anterior prosthetic leaflet away from a left ventricular outflow tract, and creating an unobstructed outflow path by the deflection of the anterior prosthetic leaflet.
  • a delivery system for delivering a prosthesis to a target treatment area comprises: an inner guidewire catheter having a proximal end, a distal end, and a lumen extending therebetween, the lumen sized to slidably receive a guidewire; a flexible dilating tip coupled to the guidewire catheter, the dilating tip having a tapered and flexible self-dilating edge, a sheath catheter slidably disposed over the inner guidewire catheter, the sheath catheter having a proximal end and a distal end; an actuator mechanism operably coupled to the proximal end of the sheath catheter.
  • Actuation of the actuator mechanism in a first direction moves the sheath catheter away from the dilator tip thereby removing a constraint from the prosthesis and allowing the prosthesis to expand.
  • actuation of the actuator mechanism in a second direction opposite the first direction moves the sheath catheter into engagement with the dilator tip thereby enclosing the prosthesis therein.
  • the system can comprise a stationary anchoring catheter fixedly disposed over the guidewire catheter, the anchoring catheter having an anchor element adjacent a distal end of the anchor catheter and configured to engage the prosthesis.
  • a bell catheter can be slidably disposed over the anchoring catheter.
  • the bell catheter can have a bell element disposed adjacent a distal end of the bell catheter and the bell element can constrain the prosthesis into engagement with the anchor catheter.
  • the anchoring catheter can have a flexible prong type anchor element adjacent the distal end of the anchor catheter, configured to engage the prosthesis.
  • the sheath catheter can be slidably disposed over the anchoring catheter. In particular, an advancement of the distal end of the sheath catheter can collapse the flexible prong type anchor elements into engagement with the prosthesis.
  • a stationary bell catheter can be fixedly disposed over the anchoring catheter.
  • the bell catheter can have a bell element disposed adjacent a distal end of the bell catheter, and the bell element can disengage the prosthesis from the anchor catheter.
  • the system can comprise a bell catheter rotatably disposed over the guidewire catheter.
  • the bell catheter can have an internally threaded bell element disposed adjacent a distal end of the bell catheter, and the threaded bell element can constrain the prosthesis into engagement.
  • a second actuator mechanism can be operably coupled to a proximal end of the bell catheter.
  • Actuation of the second actuator mechanism in a first direction can couple the prosthesis to the bell catheter, providing a constraint for the prosthesis, and actuation of the second actuator mechanism in a second direction opposite the first direction can de-couple the prosthesis from the bell catheter, removing the constraint from the prosthesis.
  • the system can comprise a rotating torque catheter rotatably disposed over the guidewire catheter.
  • the torque catheter can have a driving gear element adjacent a distal end of the torque catheter and configured to transmit torque.
  • a plurality of rotating thread-connector catheters can be rotatably disposed adjacent the torque catheter.
  • the thread-connector catheters can each have a driven gear element adjacent a distal end of each thread connector catheter, and a threaded socket adjacent to the distal end of each thread connector catheter.
  • the driven gear elements can be sized to enmesh with the driving gear element and receive torque, and the threaded sockets can be configured to constrain the prosthesis into engagement.
  • a second actuator mechanism can be operably coupled to a proximal end of the torque catheter. Actuation of the second actuator mechanism in a first direction can couple the prosthesis to the thread-connector catheters and actuation of the second actuator mechanism in a second direction opposite the first direction can de-couple the prosthesis from the thread-connector catheters.
  • the method may further comprise radially expanding the prosthetic mitral valve from a collapsed configuration to an expanded configuration.
  • Radially expanding the prosthesis may comprise expanding an anterior anchoring tab away from a nested configuration with a commissure post.
  • FIG. 1 depicts the anatomical heart in an anterior view.
  • FIG. 2 shows a cross-section of FIG. 1 , and the interior anatomy of the heart, including the left ventricular outflow tract (LVOT) and a prosthetic mitral valve.
  • LVOT left ventricular outflow tract
  • FIG. 3 depicts the anatomical heart in a posterior view.
  • FIG. 4 shows a cross-section of FIG. 3 , and the interior anatomy of the heart, particularly, the space inferior to the mitral and aortic valves.
  • FIG. 5 illustrates an embodiment of a prosthetic mitral valve configured to avoid LVOT obstruction.
  • FIG. 6 depicts an inflow view of a tri-leaflet prosthetic mitral valve configured to avoid LVOT obstruction.
  • FIG. 7 depicts an outflow view of a tri-leaflet prosthetic mitral valve configured to avoid LVOT obstruction.
  • FIG. 8A shows an outflow view of a mono-leaflet prosthetic mitral valve, in the style of a duck-bill valve.
  • FIG. 8B shows an outflow view of a bi-leaflet prosthetic mitral valve.
  • FIG. 8C depicts an outflow view of an anterior mono-leaflet prosthetic mitral valve, in the open position.
  • FIG. 8D shows an outflow view of an anterior mono-leaflet prosthetic mitral valve, in the closed position.
  • FIG. 8E shows an outflow view of a tri-leaflet prosthetic mitral valve, with a large anterior leaflet.
  • FIG. 8F shows an outflow view of a tetra-leaflet prosthetic mitral valve.
  • FIG. 9 shows a frame flat-pattern of a prosthetic mitral valve frame.
  • FIG. 10 shows a frame flat-pattern of a prosthetic mitral valve frame, with chordal bumper struts.
  • FIG. 11 shows a frame flat-pattern of a prosthetic mitral valve frame, with chordal bumper struts and wishbone shaped struts.
  • FIG. 12 shows a frame flat-pattern of a prosthetic mitral valve frame, with wishbone shaped struts.
  • FIG. 13 illustrates an embodiment of a prosthetic mitral valve with wishbone shaped struts, and fashioned to avoid LVOT obstruction.
  • FIG. 14 illustrates an embodiment of a prosthetic mitral valve with wishbone shaped struts, anchored to a delivery system.
  • FIG. 15A shows an embodiment of a delivery system and wishbone shaped strut anchoring variation, with a plurality of threaded connectors, connected.
  • FIG. 15B shows an embodiment of a delivery system and wishbone shaped strut anchoring variation, with a plurality of threaded connectors, disconnected.
  • FIG. 16A shows an embodiment of a delivery system and wishbone shaped strut anchoring variation, with a split-threaded connector, connected.
  • FIG. 16B shows an embodiment of a delivery system and wishbone shaped strut anchoring variation, with a split-threaded connector, disconnected.
  • FIG. 17A shows an embodiment of a delivery system and wishbone shaped strut anchoring method, with a flexing pin connector, connected.
  • FIG. 17B shows an embodiment of a delivery system and wishbone shaped strut anchoring method, with a flexing pin connector, disconnected.
  • FIG. 18A shows an embodiment of a delivery system and wishbone shaped strut anchoring method, with a flexible buckle connector, connected.
  • FIG. 18B shows an embodiment of a delivery system and wishbone shaped strut anchoring method, with an internal view of a flexible buckle connector, connected.
  • FIG. 18C shows an embodiment of a delivery system and wishbone shaped strut anchoring method, with an internal view of a flexible buckle connector, disconnected.
  • FIG. 19A shows an embodiment of a delivery system and wishbone shaped strut anchoring method, with an internal view of an anchor shaped connector, connected.
  • FIG. 19B shows an embodiment of a delivery system and wishbone shaped strut anchoring method, with an anchor shaped connector, unconstrained to allow disconnection.
  • FIG. 20A depicts an embodiment of a delivery system in a closed configuration, with a prosthetic mitral valve loaded internally.
  • FIG. 20B depicts an embodiment of a delivery system in a partially opened configuration, with a prosthetic mitral valve loaded internally and being deployed.
  • FIG. 20C depicts an embodiment of a delivery system in a substantially opened configuration, with a prosthetic mitral valve loaded internally and in mid deployment.
  • FIG. 20D depicts an embodiment of a delivery system in a substantially opened configuration, with a prosthetic mitral valve loaded and nearly released.
  • FIG. 20E depicts an embodiment of a delivery system in a fully opened configuration, with a prosthetic mitral valve loaded internally, just prior to final deployment.
  • FIG. 20F depicts an embodiment of a prosthetic mitral valve, post release.
  • FIGS. 21A-C show an embodiment of a delivery system having a slotted anchor mechanism that may accommodate anchored wishbone shaped struts.
  • FIG. 22 shows an enlarged view of an embodiment of a delivery system having a slotted anchor mechanism that may accommodate anchored wishbone shaped struts.
  • FIG. 23 shows an exploded view of a delivery system having a slotted anchor mechanism that may accommodate anchored wishbone shaped struts.
  • FIGS. 24A-C show an embodiment of a delivery system having a flexible connector anchor mechanism that may accommodate pinned wishbone shaped struts.
  • FIG. 25 depicts an exploded view of an embodiment of a delivery system having a flexible connector anchor mechanism that may accommodate pinned wishbone shaped struts.
  • FIG. 26A depicts an exploded view of an embodiment of a delivery system having a sliding connector anchor mechanism that may accommodate flexible buckle wishbone shaped struts.
  • FIG. 26B depicts an enlarged view of an embodiment of a delivery system having a sliding connector anchor mechanism that may accommodate flexible buckle wishbone shaped struts.
  • FIG. 27 depicts an exploded view of an embodiment of a delivery system with a singular screw connector anchor mechanism that may accommodate split-threaded wishbone shaped struts.
  • FIG. 28 shows an enlarged view of an embodiment of a delivery system with a singular screw connector anchor mechanism that may accommodate split-threaded wishbone shaped struts.
  • FIG. 29 shows an exploded view of an embodiment of a delivery system with a plurality of screw connector anchor mechanisms that may accommodate threaded wishbone shaped struts.
  • FIG. 30 shows an exploded view of the concentric catheters of an embodiment of a delivery system with a plurality of screw connector anchor mechanisms that may accommodate threaded wishbone shaped struts.
  • FIG. 31 shows an enlarged view of the sun-gear and plurality of screw connector anchor mechanisms at the end of an embodiment of a delivery system that may accommodate threaded wishbone shaped struts.
  • FIG. 32 shows turbulent blood flow in a heart.
  • FIG. 33 shows non-turbulent blood flow in a heart.
  • FIG. 34 illustrates a prosthetic mitral valve directing blood in the heart in a non-turbulent manner.
  • FIG. 35 illustrates a perspective view of a prosthetic valve.
  • FIG. 36A illustrates the atrial skirt of a prosthetic valve.
  • FIG. 36B illustrates a top view of a prosthetic valve.
  • FIG. 37 illustrates a flat pattern of a prosthetic valve.
  • FIG. 38 illustrates a perspective view of a prosthetic valve.
  • FIG. 39A illustrates an anterior view of a prosthetic valve.
  • FIG. 39B illustrates a top view of a prosthetic valve.
  • FIG. 40 illustrates deployment of a prosthetic valve.
  • FIG. 41 illustrates a side view of a prosthetic valve.
  • FIG. 42 illustrates a combined commissure post and anchor tab.
  • FIGS. 43A-43B illustrate an unexpanded and expanded anchor tab.
  • FIG. 43C illustrates a flat pattern for an expanded anchor tab.
  • FIG. 44 shows a D-shaped prosthesis.
  • FIG. 45 shows a side view of a prosthetic valve.
  • FIG. 46 shows a top view of a prosthetic valve with four leaflets and four anchors.
  • FIG. 47 shows a top view of a prosthetic valve with three leaflets and three anchors.
  • FIG. 48 shows a flat pattern of a prosthetic valve.
  • FIG. 49 shows native valve leaflets superimposed over anchor tabs.
  • FIG. 50 shows an inversion of the anchor tab with the commissure post nested within.
  • FIG. 51 shows an embodiment with two anchors located adjacent the native anterior leaflet and an expansion region void of similar anchors in the posterior portion.
  • FIG. 52 shows a flat pattern of a prosthetic valve.
  • FIG. 53 shows another flat pattern of a prosthetic valve.
  • FIG. 54 shows a perspective view of a prosthetic valve.
  • FIG. 55 shows a mitral valve adjacent the aortic valve.
  • FIG. 56 shows still another anchor tab nested in a commissure post in the expanded configuration.
  • FIG. 57 shows an anchor tab nested in a commissure post in the expanded configuration.
  • FIG. 58 shows an anchor tab nested in a commissure post in the collapsed configuration.
  • FIG. 59 shows variable strut thickness
  • FIG. 1 provides an illustration of the anatomical heart, herein represented by an anterior aspect 10 of the heart. Anterior views of various structures of the anatomical heart are also presented. The superior vena cava 50 , right atrium 40 , and right ventricle 20 are shown on the (viewer's) left side of said anterior aspect 10 , with superior and inferior structures being separated by the right coronary artery 120 . A cross-section line A-A divides the cardiac anatomy into side sections and is further discussed in FIG. 2 . Moving to the (viewer's) right side of the heart, an anterior view of the aorta 60 can be seen in a superior position to the pulmonary trunk 90 .
  • Beneath the pulmonary trunk 90 are the left atrium 70 and left atrial appendage 80 . Beneath and flanking to the (viewer's) left and right of the left atrial appendage 80 are the left anterior descending coronary artery 100 and the intermediate coronary artery 110 , respectively. Finally, inferior to all previously mentioned elements is the left ventricle 30 .
  • FIG. 2 shows the internal structures of the heart after sectioning the anterior aspect 10 (as shown in FIG. 1 ) of the heart along cross-section A-A.
  • the cross-section A-A is bounded by a hatched zone 130 that represents the plane of sectioning.
  • the aorta 140 is depicted in a posterior aspect.
  • Below and behind the aorta 140 is the right atrium 180 .
  • An interior view of the left atrium 150 is shown, revealing where a prosthetic mitral valve 210 may be located after implantation.
  • the inflow region 220 of the prosthetic mitral valve 210 and the outflow region 230 of the prosthetic mitral valve can also be seen.
  • An anterior aspect 170 of the prosthetic mitral valve 210 may be adjacent to a zone 190 of the left ventricular outflow tract 200 (LVOT).
  • An anterior anchoring tab 240 may be located in a position that avoids blockage of the LVOT 200 .
  • the prosthetic mitral valve may comprise one or more tabs.
  • the prosthetic mitral valve may comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 tabs.
  • a posterior anchoring tab 250 may be located opposite the anterior anchoring tab 240 of the prosthetic mitral valve 210 .
  • the posterior anchoring tab 250 may abut the native anatomy and rest against a posterior ventricular shelf region 160 , which is formed within the ventricle at the junction of the ventricle and posterior mitral annulus (see FIG. 4 for a clearer depiction).
  • a third anchoring tab is hidden is the depiction of FIG. 2 .
  • a valve leaflet 260 typically constructed from chemically-preserved pericardial tissue harvested from various species such as bovine, porcine, or ovine species, may be located between the anterior anchoring tab 240 and the posterior anchoring tab 250 . Further details relating to the prosthetic mitral valve 210 are provided beginning with FIG. 5 .
  • FIG. 3 provides an illustration of the anatomical heart, herein represented by a posterior aspect 265 of the heart. Posterior views of various structures of the anatomical heart are also presented. Beginning with the most superior elements, a posterior aspect of the superior vena cava 380 is adjacent to a posterior aspect of the aorta 370 and above a posterior aspect of the pulmonary trunk 390 . Further depicted posteriorly are the right atrium 270 , the left atrial appendage 280 (appearing to the viewer's left), the left atrium 340 , the right pulmonary veins 350 , and the left pulmonary veins 360 (appearing to the viewer's right).
  • a cross-section line B-B divides the presented cardiac anatomy into superior and inferior sections and is further discussed in FIG. 4 .
  • the coronary arteries and relevant branches include the left marginal branch 290 , the circumflex branch 300 , the posterior left ventricular branch 310 of the left coronary artery, and the posterior interventricular branch 320 of the right coronary artery. Finally, in the most inferior position of the elements is the apex of the heart 330 .
  • FIG. 4 shows the internal structures of the heart after sectioning the posterior aspect 265 (as shown in FIG. 3 ) of the heart along cross-section B-B.
  • the cross-section B-B is bounded by a hatched zone 400 that represents the plane of sectioning.
  • the posterior ventricular shelf 470 is adjacent to and connected by tissue with the fixed end of the posterior mitral leaflet 450 .
  • This shelf may provide a location for a posterior anchoring tab of a prosthetic mitral valve, as described herein.
  • An arcade of posterior chordae tendinae 455 are located adjacent to and connected by tissue with the posterior mitral leaflet 450 , finding their insertion points along the free edge of the leaflet.
  • the fixed ends of the chordae 455 find insertion points in both the antero-lateral papillary muscles 430 and postero-medial papillary muscles 440 .
  • the papillary muscles 430 and 440 act as muscular support bases for the tethering effect provided by said chordae, spanning the distance between leaflet free edge insertion and papillary muscle insertion while under dynamic tension.
  • Directly opposing the posterior mitral leaflet 450 is an anterior mitral leaflet 460 .
  • the posterior mitral leaflet 450 and the anterior mitral leaflet 460 are brought into communication as their free edges shut against each other, in order to prevent retrograde blood flow into the left atrium.
  • the free edge of the anterior leaflet 460 is also adjacent to and connected by tissue with an arcade of anterior chordae tendinae 465 , which also find fixed end insertion points in both the antero-lateral 430 and postero-medial 440 papillary muscles, mirroring the chordal structure of the posterior leaflet.
  • the fixed end of the anterior leaflet 460 is directly adjacent and connected by tissue with the inflow of the aortic valve 500 .
  • This adjacency is commonly known as the aorto-mitral continuity. It is in this region that a risk for outflow tract obstruction presents itself, necessitating the present invention, which aims to minimize LVOT obstruction.
  • Flanking the fixed end of the anterior leaflet 460 are regions of dense cartilaginous tissue known as the fibrous trigones, which act as skeletal-like structures for the heart-at-large.
  • the antero-septal fibrous trigone 480 and the antero-lateral fibrous trigone 490 are represented by triangles, which demarcate landing zones on which the anterior anchoring tabs of the prosthetic mitral valve (not shown) may abut during valve deployment.
  • the tricuspid valve 410 and the aorta 420 are shown at the bottom of the figure.
  • FIG. 5 illustrates the present invention in perspective, showing a prosthetic mitral valve 510 ( 210 , as shown in FIG. 2 ) with a large anterior leaflet.
  • the prosthesis may comprise an atrial region, an annular region, a valvular region, and an anchoring region.
  • a frame 525 may provide the structural means on which the entirety of the prosthetic valve may be erected, and is shown by dashed lines in FIG. 5 .
  • the frame may be a nitinol frame.
  • the frame 525 may be layered within various biocompatible fabrics that provide excellent sealing properties.
  • the biocompatible fabrics may comprise polyester, nylon, or any other biocompatible fabric as is known to one having skill in the art. Medical grade suture may used to sew the various fabrics onto the frame 525 to construct the prosthesis.
  • the atrial region of the prosthesis may comprise an atrial skirt 520 which acts as a flange and allows the inflow region of the valve ( 220 , as shown in FIG. 2 ) to register and seal against the native mitral annulus, upon the floor of the left atrium.
  • the atrial skirt 520 may traverse the entire circumference of the inflow region ( 220 , as shown in FIG. 2 ) of the prosthetic valve, and may be in communication with and connected to an annular region 530 that also traverses the circumference of the prosthetic valve.
  • the anterior surface of the prosthetic valve is shown facing away and to the right, from the viewer.
  • an anterior leaflet 580 is shown facing away and to the right.
  • One or more valve leaflets may form the valvular region of the prosthesis.
  • the leaflets may comprise the anterior leaflet 580 , a postero-septal leaflet 570 , and a postero-lateral leaflet 590 .
  • the anterior leaflet 580 may comprise an anterior leaflet inflow surface, as described herein.
  • the postero-septal leaflet 570 may comprise a postero-septal leaflet inflow surface, as described herein.
  • the postero-lateral leaflet 590 may comprise a postero-lateral leaflet inflow surface, as described herein.
  • One or more of the plurality of leaflets may comprise chemically-preserved pericardial tissue.
  • the chemically-preserved pericardial tissue may be treated with chemical preservatives that promote polymer cross-linking, render the tissue inert and biocompatible to humans, and/or prepare the tissue for further sterilization treatments.
  • the leaflet tissue may be derived from bovine, porcine, or ovine sources, but shall not be limited to the aforementioned species.
  • the free ends of each of the anterior leaflet 580 , postero-septal leaflet 570 , and postero-lateral leaflet 590 may meet at a triple-point of leaflet coaptation 600 .
  • each leaflet may be sutured to both the annular region of the valve, and to the next adjacent leaflet at a specific location that provides increased structural resilience, as described herein.
  • FIG. 5 shows three leaflets
  • the prosthetic mitral valve may comprise any number of leaflets.
  • the prosthetic mitral valve may comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 leaflets.
  • each leaflet may be successively joined to the next adjacent leaflet at a commissure attachment point, through a commissure suture pad.
  • the prosthetic mitral valve may comprise one or more commissure attachment points and one or more commissure suture pads.
  • the postero-septal 570 and anterior 580 leaflets may be joined together and attached to an antero-septal commissure attachment point 550 through an antero-septal commissure suture pad 560
  • the anterior 580 and postero-lateral 590 leaflets may be joined together and attached to an antero-lateral commissure attachment point 625 through an antero-lateral commissure suture pad 615
  • the postero-lateral 590 and postero-septal 570 leaflets may be joined together and attached to a posterior commissure attachment point 645 through a posterior commissure suture pad 640 .
  • FIG. 5 shows three commissure attachment points and three commissure suture pads
  • the prosthetic mitral valve may comprise any number of commissure attachment points.
  • the prosthetic mitral valve may comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 commissure attachment points and 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 commissure suture pads.
  • One or more commissure anchors may extend away from the valve and into free space from each of the commissure attachment points.
  • an antero-septal commissure anchor 555 may extend from the antero-septal commissure attachment point 560
  • an antero-lateral commissure anchor 620 may extend from the antero-lateral commissure attachment point 625
  • a posterior commissure anchor 650 may extend from the posterior commissure attachment point 645 .
  • Each of the commissure anchors may comprise the means through which the prosthesis may be anchored and connected to an appropriate delivery system, as described herein.
  • each of the plurality of commissure anchors may generally resemble the shape of an anchor or half-moon, but those skilled in the art will recognize that any shapes that allow the plurality of commissure anchors to be anchored effectively to a potential delivery system may be implied by this element.
  • FIG. 5 shows three commissure anchors
  • the prosthetic mitral valve may comprise any number of commissure anchors.
  • the prosthetic mitral valve may comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 commissure anchors.
  • Each anchoring tab may comprise a fixed end which is in communication with a commissure attachment point, and a free end which extends towards the atrial skirt and provides an anchoring means through which the prosthetic may attach itself to the native anatomy.
  • Anterior anchoring tabs may generally rest against the native fibrous trigones of the mitral valve, while posterior anchoring tabs may generally rest against the posterior ventricular shelf of the mitral valve.
  • An antero-septal trigonal anchoring tab 540 ( 240 , as shown in FIG.
  • An antero-lateral trigonal anchoring tab 610 ( 260 , as shown in FIG. 2 ) may be connected at a fixed end to the antero-lateral commissure anchor point 625 , and may have a free end (not shown in this view) that is brought to rest against the antero-lateral fibrous trigone ( 490 , as shown in FIG. 4 ).
  • a posterior anchoring tab 630 ( 250 , as shown in FIG.
  • the prosthetic mitral valve may comprise any number of anchoring tabs.
  • the prosthetic mitral valve may comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 anchoring tabs.
  • FIG. 6 illustrates an inflow view 660 of a prosthetic mitral valve ( 510 , as shown in FIG. 5 ).
  • the approximate “D” shape of the prosthetic mitral valve may be fully appreciated by tracing a path from the anterior aspect 690 of the valve inflow (flat side of the D shape) in a clockwise direction until the posterior aspect 700 of the valve inflow(curved portion of the D shape) is reached, and then back again to the anterior aspect 690 of the valve inflow.
  • Adjacent the anterior aspect 690 of the valve inflow is the anterior portion 670 of the atrial skirt ( 520 , as shown in FIG. 5 ).
  • Adjacent the posterior aspect 700 of the valve inflow is the posterior portion 680 of the atrial skirt.
  • a plurality of frame struts 740 may encircle the valve inflow circumferentially.
  • the frame struts 740 may provide structural support and attachment means for both the anterior 670 and posterior 680 portions of the atrial skirt to the annular region of the prosthetic mitral valve ( 530 , as shown in FIG. 5 ).
  • the postero-lateral leaflet inflow surface 710 (corresponding to the postero-lateral leaflet 590 , as shown in FIG. 5 ), anterior leaflet inflow surface 720 (corresponding to the anterior leaflet 580 , as shown in FIG. 5 ), and postero-septal leaflet inflow surface 730 (corresponding to the postero-septal leaflet 570 , as shown in FIG. 5 ) are also depicted.
  • the posterior anchoring tab free end 635 antero-lateral trigonal anchoring tab free end 610
  • antero-septal trigonal anchoring tab free end 545 are also depicted.
  • FIG. 7 illustrates an outflow view 750 of a prosthetic mitral valve ( 510 , as shown in FIG. 5 ).
  • the triple-point of leaflet coaptation ( 600 , as shown in FIG. 5 ) as previously mentioned, may be formed during systole, when a coaptation surface 775 of a postero-septal leaflet 770 ( 570 , as shown in FIG. 5 ), a coaptation surface 765 of a postero-lateral leaflet 760 ( 590 , as shown in FIG. 5 ), and a coaptation surface 785 of an anterior leaflet 780 ( 580 , as shown in FIG. 5 ) are brought into contact with one another through valve closure.
  • commissures and anchoring tabs are also depicted in this outflow view 750 , and are identified by a posterior anchoring tab 800 ( 630 , as shown in FIG. 5 ) and associated posterior commissure anchor 805 ( 650 , as shown in FIG. 5 ), an antero-septal trigonal anchoring tab 810 ( 540 , as shown in FIG. 5 ) and associated antero-septal commissure anchor 815 ( 555 , as shown in FIG. 5 ), and an antero-lateral trigonal anchoring tab 790 ( 610 , as shown in FIG. 5 ) and associated antero-lateral commissure anchor 795 ( 620 , as shown in FIG. 5 ).
  • FIG. 8A illustrates an embodiment of a prosthetic mitral valve ( 510 , as shown in FIG. 5 ) having a single mono-leaflet 830 that is in the style of a duckbill valve, and is presented in an outflow view 820 .
  • the duckbill style valve may be created by making an incision 840 at approximately the center of the single mono-leaflet 830 , which may create a leaflet coaptation edge on which the resultant valve may function.
  • the prosthetic mitral valve may further comprise one or more of the anterior aspect 690 of the valve inflow, posterior aspect 700 of the valve inflow, the antero-lateral trigonal anchoring tab 790 and associated antero-lateral commissure anchor 795 , the posterior anchoring tab 800 and associated posterior commissure anchor 805 , or the antero-septal trigonal anchoring tab 810 and associated antero-septal commissure anchor 815 .
  • FIG. 8B illustrates an embodiment of a prosthetic mitral valve ( 510 , as shown in FIG. 5 ) comprising a dual or bi-leaflet configuration, again shown in an outflow view 850 .
  • the bi-leaflet configuration may be realized by way of a pair of leaflets, comprising an anterior leaflet 870 and a posterior leaflet 860 , which may be brought together during systole at a leaflet coaptation edge 880 .
  • the prosthetic mitral valve may further comprise one or more of the anterior aspect 690 of the valve inflow, posterior aspect 700 of the valve inflow, the antero-lateral trigonal anchoring tab 790 and associated antero-lateral commissure anchor 795 , the posterior anchoring tab 800 and associated posterior commissure anchor 805 , and/or the antero-septal trigonal anchoring tab 810 and associated antero-septal commissure anchor 815 .
  • FIGS. 8C and 8D show an embodiment of a mono-leaflet prosthetic mitral valve ( 510 , as shown in FIG. 5 ) seen from the outflow view 890 comprising one large anterior leaflet 900 that may be able to span the entire valve orifice during systole, and seal against the posterior aspect of 700 of the valve inflow.
  • a posterior outflow region 910 may allow antegrade blood flow through the valve and into the left ventricle, from the left atrium.
  • the prosthetic mitral valve may further comprise one or more of the anterior aspect 690 of the valve inflow, posterior aspect 700 of the valve inflow, the antero-lateral trigonal anchoring tab 790 and associated antero-lateral commissure anchor 795 , the posterior anchoring tab 800 and associated posterior commissure anchor 805 , or the antero-septal trigonal anchoring tab 810 and associated antero-septal commissure anchor 815 .
  • FIG. 8D shows that in the closed configuration 920 , the large anterior leaflet 900 has closed and that a posterior covering region 925 of said anterior leaflet 900 has sealed against a leaflet coaptation edge 930 that appears on the posterior aspect 700 of the valve inflow.
  • the prosthetic mitral valve may further comprise one or more of the anterior aspect 690 of the valve inflow, posterior aspect 700 of the valve inflow, the antero-lateral trigonal anchoring tab 790 and associated antero-lateral commissure anchor 795 , the posterior anchoring tab 800 and associated posterior commissure anchor 805 , or the antero-septal trigonal anchoring tab 810 and associated antero-septal commissure anchor 815 .
  • FIG. 8E illustrates an embodiment of a prosthetic mitral valve ( 510 , as shown in FIG. 5 ) comprising a tri-leaflet configuration 940 , and formed from the plurality of leaflets that are herein described as the large anterior leaflet 960 , the small postero-lateral leaflet 970 , and the small postero-septal leaflet 950 .
  • said leaflets are forced to close and contact each other along a leaflet coaptation edge 980 .
  • the prosthetic mitral valve may further comprise one or more of the anterior aspect 690 of the valve inflow, posterior aspect 700 of the valve inflow, the antero-lateral trigonal anchoring tab 790 and associated antero-lateral commissure anchor 795 , the posterior anchoring tab 800 and associated posterior commissure anchor 805 , or the antero-septal trigonal anchoring tab 810 and associated antero-septal commissure anchor 815 .
  • FIG. 8F depicts an embodiment of a prosthetic mitral valve ( 510 , as shown in FIG. 5 ), seen from the outflow view and comprising a tetra-leaflet configuration 990 .
  • the valve may be formed from the plurality of leaflets that are herein described as a posterior leaflet 1000 , a septal leaflet 1010 , an anterior leaflet 1020 , and a lateral leaflet 1030 . During systole, the leaflets may be forced to close and contact each other along a leaflet coaptation edge 1040 . of the prosthetic mitral valve may comprise one or more anchoring tabs and commissure anchors.
  • a postero-septal 1060 and a postero-lateral 1050 anchoring tab may be present, as well as the corresponding postero-septal 1065 and postero-lateral 1055 commissure anchors.
  • the prosthetic mitral valve may further comprise one or more of the anterior aspect 690 of the valve inflow, posterior aspect 700 of the valve inflow, the antero-lateral trigonal anchoring tab 790 and associated antero-lateral commissure anchor 795 , the posterior anchoring tab 800 and associated posterior commissure anchor 805 , or the antero-septal trigonal anchoring tab 810 and associated antero-septal commissure anchor 815 .
  • FIG. 9 depicts a frame flat pattern 1070 , which is a representation of a toolpath that a machine-tool (such as a focused laser, router, end mill, or any other machine-tool as is known to one having skill in the art) may follow during the fashioning of a prosthetic valve ( 510 , as shown in FIG. 5 ).
  • the frame may be cut from a tubular stock of material.
  • the frame may be cut from a tubular stock of nitinol.
  • the device may include several features discussed previously (introduced in FIG. 5 ), such as an antero-lateral commissure anchor 795 (element 620 of FIG. 5 ), an antero-septal commissure anchor 815 (element 555 of FIG.
  • strut format refers to the elements illustrated in a frame flat pattern, whereupon the elements of the frame may be undeformed (i.e., shapeset through metallurgical heat-treatments that are known to those skilled in the art) and generally resemble rectangular members or “struts.” Additional details regarding the commissure structures and their spatial relationships with the anchoring tabs are depicted in FIG. 9 .
  • This flat pattern represents an embodiment of the prosthetic mitral valve depicted in FIG. 5 .
  • the prosthetic mitral valve may comprise one or more attachment rails, one or more commissures, one or more commissure attachment holes, one or more commissure slots, and one or more commissure junctions.
  • the prosthetic mitral valve may comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 attachment rails, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 commissures, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 commissure attachment holes, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 commissure slots, and 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 commissure junctions.
  • the antero-lateral commissure anchor 795 may protrude directly from the antero-lateral commissure 1085 .
  • the antero-lateral commissure may be the origin and insertion of the antero-lateral anchoring tab 1110 ( 610 , as shown in FIG. 5 ) via an antero-lateral commissural junction 1100 .
  • One or more rows of antero-lateral commissure attachment holes 1090 may be located adjacent to an antero-lateral commissure attachment slot 1095 within the structure of the antero-lateral commissure 1085 .
  • the attachment holes 1090 may provide a location for suture that may be used to sew the antero-lateral commissure suture pads ( 615 , as shown in FIG. 5 ) into place.
  • the antero-lateral commissure suture pads may work in conjunction with the antero-lateral commissure attachment holes to help fasten the valve leaflets of the prosthetic mitral valve to the frame.
  • a free end 1111 of the antero-lateral anchoring tab 1110 is also shown, as are a free end 1116 of the antero-septal anchoring tab 1115 and a free end 1121 of the posterior anchoring tab 1120 .
  • a plurality of struts or attachment rails may be used to locate and fasten leaflets onto the frame. Each strut may space a space between successive adjacent commissures. Each strut may have a “u” or arc-shaped form.
  • an anterior leaflet attachment rail 1080 may span the space between the antero-lateral commissure 1085 and the antero-septal commissure 1086 .
  • the anterior leaflet attachment-rail 1080 may be used to attach the anterior leaflet (not shown) to the frame.
  • a postero-septal leaflet attachment rail 1130 may span the space between the antero-septal commissure 1086 and the posterior commissure 1087 .
  • the postero-septal leaflet attachment rail 1130 may be used to attach the postero-septal leaflet (not shown) to the frame.
  • the postero-lateral leaflet attachment rail 1125 may span the space between the posterior commissure 1087 and the antero-lateral commissure 1085 .
  • a postero-lateral leaflet attachment rail 1125 may be used to attach the postero-lateral leaflet (not shown).
  • the posterior commissure anchor 805 , posterior commissure 1087 , posterior anchoring tab 1120 , and the free end 1121 of the posterior anchoring tab 1120 are shown on both sides of FIG. 9 to emphasize how the prosthetic mitral valve may be laid out in a frame flat configuration.
  • Additional structures may support radial compression against the native mitral annulus and/or help to seal the valve inflow against the left atrial floor.
  • a plurality of rows of annular rhomboids 1150 may be located at the annular region 1140 of the frame, traversing the circumference of the frame.
  • a plurality of atrial skirt support struts 1170 may emanate from the annular region 1140 and may act as support beams for a plurality of atrial skirt circumferential struts 1165 .
  • the atrial skirt support struts may be substantially parallel to one another and may extend longitudinally.
  • the atrial skirt circumferential struts may be substantially parallel to one another and may be substantially “v-shaped”.
  • Each atrial skirt support struts may be connected at top and bottom to atrial skirt circumferential struts.
  • the combination of atrial skirt support struts 1170 and atrial skirt circumferential struts 1165 may form the atrial region 1160 of the valve frame and may provide a location for the atrial skirt to be sutured onto the valve frame.
  • FIG. 10 illustrates an embodiment of a frame flat pattern 1180 .
  • the frame flat configuration 1180 may comprise any or all of the elements of FIG. 9 , with further modifications.
  • the frame flat configuration 1180 may additionally comprise one or more strut features.
  • the configuration may comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 strut features.
  • one or more strut features may be added, each adjacent to two of the leaflet attachment rails.
  • a postero-lateral chordal bumper strut 1190 may run approximately parallel to the postero-lateral leaflet attachment rail 1125 .
  • the postero-lateral chordal bumper strut 1190 may aid in valvular operation by pushing the native chordae away from the prosthetic valve. This may further prevent obstruction in the sub-valvular space and LVOT.
  • the configuration may comprise one or more bumper strut attachment points.
  • the configuration may comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 bumper strut attachment points.
  • One or more postero-lateral chordal bumper strut attachment points 1195 may be located at each end of the postero-lateral chordal bumper strut 1190 .
  • Each postero-lateral chordal bumper strut attachment point 1195 may effectively connect an end of the postero-lateral chordal bumper strut 1190 to the adjacent commissure.
  • a postero-septal chordal bumper strut 1210 may run approximately parallel to the postero-septal leaflet attachment rail 1130 .
  • One or more postero-septal chordal bumper strut attachment points 1200 may be located at each end of the postero-septal chordal bumper strut 1210 . Each postero-septal chordal bumper strut attachment point 1200 may effectively connect and end of the postero-septal chordal bumper strut 1210 to the adjacent commissure.
  • the postero-septal chordal bumper strut 1210 may be functionally equivalent to the postero-lateral chordal bumper strut 1190 .
  • the postero-septal choral bumper strut attachment points 1200 may be functionally equivalent to the postero-lateral choral bumper strut attachment points 1195 .
  • FIG. 11 shows an embodiment of a frame flat pattern 1220 .
  • the frame flat configuration 1220 may comprise any or all of the elements of FIG. 10 , with further modifications.
  • the frame flat configuration 1220 may further comprise one or more wishbone-shaped members and an absence of the previously described commissure anchors. These alterations may provide an alternative method of anchoring the valve frame to a delivery system, as described herein.
  • the configuration may comprise one or more wishbone struts, one or more wishbone anchors, and one or more wishbone attachment points.
  • the configuration may comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 wishbone struts, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 wishbone anchors, and 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 wishbone attachment points.
  • a postero-lateral wishbone shaped strut 1230 may emanate from a first strut attachment point 1240 on the antero-lateral commissure 1085 .
  • the postero-lateral wishbone shaped strut 1230 may arc upwardly and across the postero-lateral leaflet space until it meets a second strut attachment point 1240 located on the posterior commissure 1087 .
  • At the apex of the postero-lateral wishbone shaped strut 1230 may be a postero-lateral wishbone anchor 1235 which may replace the previously depicted antero-lateral and posterior commissure anchors ( 795 and 805 of FIG. 10 , respectively).
  • the postero-lateral wishbone anchor 1235 may be functionally and structurally equivalent to the antero-lateral and posterior commissure anchors.
  • a postero-septal wishbone shaped strut 1250 may emanate from a first strut attachment point 1260 on the antero-septal commissure 1086 .
  • the postero-septal wishbone shaped strut may arc upwardly and across the postero-septal leaflet space until it meets a second strut attachment point 1260 located on the posterior commissure 1087 .
  • At the apex of the postero-septal wishbone shaped strut 1250 may be a postero-septal wishbone anchor 1255 which may replace the previously depicted antero-septal and posterior commissure anchors ( 815 and 805 of FIG. 10 , respectively).
  • the postero-septal wishbone anchor may be functionally and structurally equivalent to the antero-septal and posterior commissure anchors.
  • the wishbone shaped struts may allow the prosthetic mitral valve to be forced into an easily compressible configuration for delivery with a catheter, as described herein. This may result in a more easily retractable and/or repositionable prosthesis. wishbone shaped strut
  • FIG. 12 shows yet an embodiment of a frame flat pattern 1270 .
  • the frame flat configuration 1220 may comprise any or all of the elements of FIG. 11 , with further modification.
  • the frame flat configuration 1270 may lack certain elements of FIG. 11 .
  • the postero-lateral chordal bumper struts ( 1190 , as shown in FIG. 11 ) and/or postero-septal chordal bumper struts ( 1210 , as shown in FIG. 11 ) may be excluded from the frame flat configuration 1270 .
  • the frame flat configuration 1270 may be functionally equivalent to the frame flat configuration 1220 of FIG. 11 .
  • a perspective view of the prosthetic mitral valve of FIG. 12 can be seen in FIG. 13 .
  • FIG. 13 shows a perspective view of the prosthetic mitral valve shown as the frame flat configuration 1270 in FIG. 12 .
  • Any or all of the features and elements previously described in FIG. 5 may be present in the embodiment of FIG. 13 .
  • the embodiment of FIG. 13 may be functionally and structurally equivalent to the embodiment of FIG. 5 , save for the addition of one or more wishbone shaped struts and one or more wishbone attachment regions.
  • the embodiment of FIG. 13 may comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 wishbone shaped struts and 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more than 10 wishbone attachment regions. 1330 .
  • a postero-septal wishbone shaped strut 1320 may find a first insertion with the frame at an antero-septal tab wishbone attachment region 1300 , which may be located adjacent to the antero-septal commissure.
  • the postero-septal wishbone shaped strut 1320 may find a second insertion with the frame at a posterior tab wishbone attachment region 1290 , which may be located adjacent to the posterior commissure.
  • a postero-septal wishbone anchor 1255 may be located at the apex of the wishbone, allowing for attachment to a delivery system, as described herein.
  • a postero-lateral wishbone shaped strut 1330 may find a first insertion with the frame at an antero-lateral tab wishbone attachment region 1310 , which may be located adjacent to the antero-lateral commissure.
  • the postero-lateral wishbone shaped strut 1330 may find a second insertion with the frame at a posterior tab wishbone attachment region 1290 , which may be located adjacent to the posterior commissure.
  • a postero-lateral wishbone anchor 1235 may be located at the apex of the wishbone, allowing for attachment to a delivery system, as described herein.
  • Prior minimally invasive procedures have been developed to deliver a prosthetic heart valve percutaneously over a delivery catheter through the patient's vasculature to the heart, or through the use of a transapical procedure to introduce the prosthesis through the chest wall and through the apex of the heart ( 330 as shown in FIG. 3 ).
  • An exemplary prosthesis includes that described in U.S. Pat. No. 8,579,964, the entire contents of which are incorporated herein by reference in their entirety for all purposes. Further embodiments of exemplary delivery catheters and delivery systems are described and illustrated in the following figures.
  • FIG. 14 shows the prosthetic mitral valve with wishbone attachment of FIG. 13 .
  • the prosthetic mitral valve 1280 may comprise any or all of the elements of FIG. 13 .
  • the prosthetic mitral valve 1280 may be connected to a delivery system 1340 .
  • the delivery system 1340 may comprise a completely withdrawn delivery catheter 1350 .
  • the delivery system 1340 is shown in FIG. 14 as connected to a non-specific anchoring mechanism. Embodiments of the anchoring mechanism are described in FIGS. 15-19 , as communicated by enlarged detail element 1345 .
  • FIGS. 15A-B show an embodiment of an anchoring method used to anchor commissure anchors to a delivery system utilizing a plurality of threaded connectors.
  • FIG. 15A shows a plurality of threaded connectors 1370 in a connected configuration.
  • a first male threaded connector 1390 and a second male threaded connector 1395 may be in threaded connection with a first female threaded connector 1375 and a second female threaded connector 1380 , respectively.
  • the first and second male threaded connectors ( 1390 and 1395 , respectively) may each comprise a segment of male threads 1400 appearing at a free end of a wishbone shaped strut 1410 .
  • the wishbone shaped strut may replace the plurality of commissure anchors ( 1255 and 1235 , as shown in FIG. 13 ).
  • the male threads may be sized to fasten and mate to similarly threaded first and second segments of female thread 1405 .
  • Arrows 1385 indicate rotation of each of the first and second female threaded connectors ( 1375 and 1380 , respectively). Upon rotation in the direction of the arrows 1385 , the connectors may be in the state depicted in FIG. 15B .
  • FIG. 15B shows a plurality of threaded connectors ( 1390 and 1395 ) in a disconnected configuration 1420 . It should be apparent that in the state depicted in FIG. 15B , the male threaded connectors may be completely disconnected from the female threaded connectors. Upon disconnection, a prosthetic valve that was initially attached to a catheter delivery system through the wishbone connectors may be fully released from its delivery system. A further discussion of the internal mechanisms responsible for the operation of this embodiment of a delivery system begins with the description of FIG. 29 .
  • FIGS. 16A-B show an embodiment of an anchoring method used to anchor commissure anchors to a delivery system using a single split-threaded connector.
  • FIG. 16A shows a split-threaded connector 1430 in a connected configuration.
  • One or more male split-threaded connectors 1450 may be in threaded connection with one or more female split-threaded connectors 1440 .
  • Each male split-threaded connector 1450 may comprise a segment of male thread 1455 appearing at a free end of a wishbone shaped strut 1460 .
  • the wishbone shaped strut may replace the plurality of commissure anchors ( 1255 and 1235 , as shown in FIG. 13 ).
  • the male threads may be sized to fasten and mate to similar threaded segments of female thread 1445 within the female threaded connector 1440 .
  • Arrows 1435 indicate rotation of the individual female threaded connector 1440 . Upon rotation, the connectors may be in the state depicted in FIG. 16B .
  • FIG. 16B shows the split-threaded connector 1455 in a disconnected configuration 1470 . It should be apparent that in the state depicted in FIG. 16B , the male split-threaded connector may be completely disconnected from the female threaded connector. Upon disconnection, a prosthetic valve that was initially attached to a catheter delivery system through the wishbone connectors may be fully released from its delivery system. A further discussion of the internal mechanisms responsible for the operation of this embodiment of a delivery system begins with the description of FIG. 27 .
  • FIGS. 17A-B show an embodiment of an anchoring method used to anchor commissure anchors to a delivery using a flexing pin-connector type anchoring mechanism.
  • FIG. 17A shows a flexing pin-connector type anchoring mechanism 1480 in a connected configuration.
  • One or more flexible sleeves 1490 may be closed about a plurality of pinhole connectors 1530 .
  • the flexible sleeves 1490 may comprise a plurality of flexible sleeve portions 1495 that may be able to snap open and shut when a translating sleeve 1500 is drawn over or off of them. This movement of the translating sleeve may effective encapsulating the flexible sleeve portions 1495 .
  • the flexible sleeve 1490 may comprise a shape-settable and/or super-elastic nitinol material, as is known to those having skill in the art.
  • Each flexible sleeve portion 1495 may comprise a terminal point 1510 , appearing at the free end of the flexible sleeve 1490 .
  • the terminal points may allow connection of the flexing pin-connector type anchoring mechanism 1480 to wishbone shaped struts 1520 .
  • FIG. 17B shows the flexing pin-connector type anchoring mechanism 1480 in a disconnected configuration 1540 .
  • the internal surface of each of the terminal points 1510 may comprise a connector pin 1555 which may fit into a complimentary hole for pin connection 1560 .
  • Each of the wishbone shaped struts 1520 of the prosthetic mitral valve may terminate in a pinhole connector 1530 .
  • the pinhole connectors may replace the plurality of commissure anchors ( 1255 and 1235 , as shown in FIG. 13 ).
  • Arrows 1550 indicate rotation of each of the individual flexible sleeve portions 1495 . Upon rotation, the connector may be in the state depicted in FIG. 17B .
  • Arrow 1545 indicates translation of the translating sleeve 1500 over the flexible sleeve portions 1495 . It should be apparent that in the state depicted in FIG. 17B , the connector pins 1555 may be completely disconnected from the holes for pin connection 1560 . Upon disconnection, a prosthetic valve that was initially attached to a catheter delivery system through the wishbone connectors may be fully released from its delivery system. A further discussion of the internal mechanisms responsible for the operation of this embodiment of a delivery system begins with the description of FIG. 24A .
  • FIGS. 18A-C show an embodiment of an anchoring method used to anchor commissure anchors to a delivery system using a plurality of flexible buckle type anchoring mechanisms is employed.
  • FIG. 18A shows a plurality of flexible buckle type connectors 1570 in a connected configuration.
  • a plurality of flexible buckles 1580 may be in captured connection with, restrained by, or disposed within an aperture 1575 that is sized to accept and retain the flexible buckles 1580 utilizing opposing tensile forces.
  • the aperture may be fashioned in the side of a translating sleeve 1500 .
  • Each of the flexible buckles may be located adjacent to and protruding from the end of a wishbone shaped strut 1520 , which may replace the plurality of commissure anchors ( 1255 and 1235 , as shown in FIG. 13 ).
  • a sheath catheter 1350 may be concentrically positioned over the top of the translating sleeve 1500 . When the translating sleeve 1500 is drawn against the sheath catheter 1350 , the mechanism of action may be achieved.
  • FIG. 18B depicts the hidden structure of the flexible buckles 1580 , as the translating sleeve 1500 blocks said structure from view in FIG. 18A .
  • FIG. 18C shows the flexible buckle type anchoring mechanisms in a disconnected configuration.
  • the flexible buckles 1585 may be forced closed by the inner surface of the sheath catheter 1500 , and released from constraint. It should be apparent that in the state depicted in FIG. 18C , the flexible buckle type connectors may be completely disconnected from their aperture 1575 and associated translating sleeve 1500 . Upon disconnection, a prosthetic valve that was initially attached to a catheter delivery system through wishbone connections may be fully released from its delivery system.
  • FIG. 26A shows the description of FIG. 26A .
  • FIGS. 19A-B show an embodiment of an anchoring method used to anchor commissure anchors to a delivery system using a plurality of anchor shaped commissure anchors.
  • FIG. 19A shows a plurality of anchor shaped commissure anchors 1630 , adjacent to and connected with the ends of a plurality of wishbone shaped struts 1410 , in a connected configuration.
  • the plurality of commissure anchors 1630 may rest within a complimentary plurality of slots 1615 .
  • the slots may act to retain the anchors and resist tensile forces that may be developed during operation of the delivery system.
  • the slots 1615 may be fashioned on the anchoring end 1610 of an anchoring catheter 1600 .
  • the plurality of commissure anchors 1630 depicted in FIG. 19A-B may be identical to the plurality of commissure anchors ( 1255 and 1235 , as shown in FIG. 13 ) in design, construction, and function.
  • FIG. 19B shows the commissure anchors 1640 in an unconstrained configuration that may allow disconnection.
  • Arrow 1620 indicates translation of an anchoring sleeve member 1360 .
  • the state depicted in FIG. 19B may be realized.
  • the commissure anchors 1640 may be unconstrained and capable of being disconnected from the slots 1615 of the anchoring catheter 1600 .
  • a prosthetic valve that was initially attached to a catheter delivery system may be released from its delivery system.
  • FIGS. 20A-20F depict the successive stages of unsheathing an embodiment of a delivery system and implanting a mitral valve prosthesis.
  • the resultant effects of the operation of said delivery system (such as the release of a constrained prosthetic mitral valve) are discussed with reference to the relevant elements necessary for illustration, the mechanical relationships of the various internal components necessary for the physical realization of the delivery system embodiments are not illustrated or discussed until further below, in FIGS. 21-31 .
  • the deployment process as depicted in FIGS. 20A-20F proceeds as follows.
  • a sheath catheter which may constrain a compressed prosthetic valve comprised of tissues, fabrics, sutures and a nitinol frame may be retracted from the valve while in place within the implantation zone.
  • the physiological temperature of the blood in a patient's heart may cause the nitinol material to expand and conform to the space in which it has been implanted.
  • elements of the invention that are responsible for anchoring to the native anatomy may also expand, allowing the prosthesis to remain in place in order to function as a one-way valve and support proper circulation of blood. It shall be recognized that the relevant anatomy has been previously illustrated in FIGS. 1-4 , but is not repeated in the following figures, leaving room to focus on the prosthesis and delivery system.
  • FIG. 20A depicts an embodiment of a fully loaded (sheathed and closed) delivery system 1700 .
  • the delivery system may comprise a prosthetic mitral valve (shown in FIGS. 20B-20F ) that has been compressed and inserted into a sheath catheter 1350 prior to implantation.
  • a long, tapered and flexible self-dilating dilator tip 1710 may aid the insertion of the delivery system within a small incision that is prepared in the prospective patient (not shown). The incision may be made in the thorax and may lead directly into and through the apex of the heart.
  • FIG. 20B depicts an embodiment 1730 of a loaded delivery system with the atrial skirt revealed, showing the sheath catheter 1350 previously described in FIG. 20A translated a slight distance away from the dilator tip 1710 .
  • the leading edge 1725 of the sheath catheter 1350 may be moved away from the edge 1720 of the dilator tip 1710 , and may thereby reveal a partially constrained atrial skirt 1750 .
  • FIG. 20C depicts an embodiment 1760 of a loaded delivery system with the anterior trigonal anchoring tabs revealed, showing the sheath catheter 1350 previously described in FIG. 20B translated away from the dilator tip 1710 to an even greater extent. Specifically, the leading edge 1725 of the sheath catheter 1350 may be moved further away from the edge 1720 of the dilator tip 1710 , and may thereby reveal most of the structure of the encapsulated prosthetic mitral valve. An atrial skirt 1770 may now be approximately released, yet a still partially constrained annular region 1775 may remain constricted by the sheath catheter 1350 . The configuration of FIG. 20C may remove a constraint that may allow the self-expansion of a portion of the prosthetic mitral valve.
  • Adjacent to and directly beneath the constrained annular region 1775 may be a constrained anterior leaflet 1780 , which may remain substantially compressed.
  • Protruding from beneath the leading edge 1725 of the sheath catheter 1350 may be a plurality of trigonal anchoring tabs, such as an antero-lateral trigonal anchoring tab 790 (with an associated free end 1790 ), and an antero-septal trigonal anchoring tab 540 (with an associated free end 545 ).
  • FIG. 20D depicts an embodiment 1800 of a loaded delivery system with the anterior trigonal anchoring tabs fully open, showing the sheath catheter 1350 previously described in FIG. 20C translated away from the dilator tip 1710 to an advanced extent. Specifically, the leading edge 1725 of the sheath catheter 1350 may be moved further away from the edge 1720 of the dilator tip 1710 , and may thereby reveal all of the structure of the encapsulated prosthetic mitral valve, except for the commissure attachment (not shown).
  • the atrial skirt 1770 may now be completely unconstrained, as may an annular region 1810 . Adjacent to and directly beneath annular region 1810 may be a partially constrained anterior leaflet 1825 , which may be almost completely released.
  • the anterior leaflet 1825 may be operational and able to coapt against any other leaflets present in this embodiment (not shown).
  • the plurality of trigonal anchoring tabs (antero-lateral trigonal anchoring tab 790 and associated free end 1790 , and antero-septal trigonal anchoring tab 540 and associated free end 545 ) may be splayed open due to the interaction between the leading edge 1725 of the sheath catheter 1350 and the still-constrained wishbone shaped struts 1820 to which the trigonal anchoring tabs may be directly connected. This opening effect may allow the trigonal anchoring tabs to reach around the native anterior mitral leaflet ( 460 , as shown in FIG.
  • Emanating from and concentrically nested within the sheath catheter 1350 may be a guidewire catheter 1830 , which may be directly connected to and provide support for the dilator tip 1710 .
  • FIG. 20E shows an embodiment 1840 of a loaded delivery system, just prior to final release, showing the sheath catheter 1350 previously described in FIG. 20D translated away from the dilator tip 1710 to an advanced extent.
  • the leading edge 1725 of the sheath catheter 1350 may be moved further away from the edge 1720 of the dilator tip 1710 , and may thereby reveal all of the structure of the encapsulated prosthetic mitral valve, such as the fully deployed wishbone shaped struts 1880 , which may be about to be released from the delivery system.
  • the antero-septal 1860 and antero-lateral 1870 trigonal anchoring tabs may be released from their constraint, and may now be in their final position.
  • the anterior leaflet 1850 may be completely freed, and may be in an operable state spanning the native anterior leaflet.
  • FIG. 20E depicts final deployment 1890 with the delivery system removed.
  • the wishbone shaped struts 1900 and associated commissure anchors 1910 may be entirely released and free from constraint by the delivery system.
  • the prosthesis of the present invention may be fully functional, and free to operate within the native anatomy.
  • FIGS. 21A-23 depict an embodiment of a delivery system that corresponds to the description relating to FIGS. 19A-19B and that may be compatible with the prosthetic mitral valve embodiment described in FIG. 13 .
  • FIG. 21A shows an embodiment of a fully open, extended-length delivery system 1920 .
  • the delivery system may comprise a delivery system handle 1940 .
  • the delivery system handle may comprise a slender, graspable member 1960 that may allow for the housing of various mechanical components, and may provide a location for a family of concentrically nested catheters.
  • the delivery system handle 1940 may also provide an actuation mechanism, such as in the form of a rotatable (see arrow 1950 indicating rotation) thumbwheel 1955 .
  • the thumbwheel may be substantially cylindrical and may have internal threads (not shown) that transform rotational torque applied by a user into linear force. The linear force may be used to translate certain catheters from the family of concentrically nested catheters.
  • the anchoring catheter 1930 may itself be cylindrical and concentrically nested within the anchoring sleeve member 1360 . Further detail regarding the anchoring catheter 1930 is provided in FIG. 22 .
  • the innermost concentrically nested catheter is the guidewire catheter 1830 , which may be connected to the dilator tip 1710 .
  • An arrow 1925 depicting translation shows how the sheath catheter 1350 may be brought toward the dilator tip 1710 as the thumbwheel 1955 is rotated.
  • FIG. 21B shows the device introduced in FIG. 21A in a configuration 1970 , with the sole differences being the position of the sheath catheter 1350 and the position of the anchoring sleeve member 1360 .
  • the sheath catheter may be translated even further toward the dilator tip 1710 (as depicted by arrow 1975 indicating translation).
  • the anchoring sleeve member 1360 may also be translated. By translating toward the dilator tip 1710 , the anchoring sleeve member 1360 may effectively cover up the anchoring catheter 1930 , FIG. 21A . This is the same mechanical relationship depicted in FIGS. 19A and 19B , although in the reverse order.
  • FIG. 21C shows a closed delivery system 1980 , wherein the thumbwheel 1955 may be rotated to its full extent, and the sheath catheter 1350 may be brought to close against the dilator tip 1710 .
  • FIG. 22 shows the embodiment and configuration of the device as illustrated in FIG. 21A with additional detail in the form of an enlarged view 1985 .
  • a stabilizer member 1990 may be located between the inner surface of the sheath catheter 1350 and the outer surface of the anchoring sleeve member 1360 .
  • the stabilizer member may take the form of a star shaped cylindrical prism.
  • the stabilizer member may force concentricity between said catheters while still allowing blood and/or saline to flow past.
  • the slotted end of the anchoring catheter 1930 is also portrayed. It may be seen that the anchoring sleeve member 1360 may be positioned concentrically around and in slidable communication with the anchoring catheter 1930 .
  • the guidewire catheter 1830 is again shown exiting the anchoring catheter 1930 .
  • FIG. 23 illustrates an exploded view of the exemplary device of FIGS. 21A-22B .
  • the device may comprise a delivery system handle A-side 2140 that may be in mated connection with a delivery system handle B-side 2145 .
  • the device may effectively provide a housing and location for the family of concentrically nested catheters seen to the left side of the handle elements (and described in FIGS. 22-22 ), and the various elements seen to the right side of the handle elements.
  • the device may comprise a needle hub 2130 , which may be in mated connection with the proximal end 2000 of the guidewire catheter 1830 .
  • the mated connection may be formed using adhesives.
  • the needle hub 2130 may act as a connecting port, through which a syringe (not shown) may be attached to the device and used to flush sterile saline through the innermost lumen to remove air prior to insertion into a patient.
  • a cylindrical anchoring nut 2120 may be in threaded connection with threads on the proximal end 2035 of the anchoring catheter 2010 .
  • the cylindrical anchoring nut may be located within the plurality of handle halves 2140 and 2145 so as to fasten the anchoring catheter 2010 to the delivery system.
  • An inner lumen may run the entirety of the length of the anchoring catheter 2010 and may allow for the concentric nesting of the guidewire catheter 1830 within.
  • a spring 2110 may be mated to and press against a bell slider cap 2100 , which may itself mated to a bell slider 2090 .
  • the spring 2110 may provide a bias force with which the bell slider 2090 may be moved when a leadscrew 2080 is brought out of contact with it.
  • the leadscrew 2080 may be translated linearly and may be brought into contact with the distal portion of the bell slider 2090 , which may in turn be biased against the spring 2110 .
  • the bell slider 2090 may act as a carriage for the proximal end 2060 of the bell catheter 2040 (previously referred to as an anchoring sleeve member 1360 ) and may allow the distal end 2050 of said bell catheter 2040 to be brought away from the distal end 2020 of the anchoring catheter 2010 , which may be the mechanism responsible for final valve commissure release.
  • the leadscrew 2080 may also be translated in an opposite direction by turning the thumbwheel 1955 , in order to close the delivery system and seal the valve inside. This may be achieved by way of the leadscrew's 2080 connection to a leadscrew cap 2070 , which may itself be mated to the proximal end 2065 of the sheath catheter 1350 .
  • rotating the thumbwheel 1955 in a first direction may move the leadscrew 2080 towards the dilator tip 1710 , and by extension may also move the sheath catheter 1350 towards said dilator tip 1710 in order to close the device.
  • Rotating the thumbwheel 1955 in a second opposite direction may move the leadscrew 2080 towards the bell slider 2090 and by extension may move both the sheath catheter 1350 and the bell catheter 2040 away from the dilator tip 1710 to open the device and release the prosthetic valve contained within. It should be understood that while both the sheath catheter 1350 and bell catheter 2040 may move synchronously by way of thumbwheel 1955 rotation, there may be a delay in contact provided by the dimensions of the relevant catheters and leadscrew 2080 .
  • the delay may allow some portions of the prosthesis to be uncovered before other portions as the deployment progresses.
  • the prosthetic valve may ultimately be recaptured or obtained for repositioning or removal by simply closing the sheath catheter 1350 until the leading edge 1725 of said sheath catheter 1350 again contacts the edge 1720 of the dilator tip 1710 .
  • a distal end 1995 of the guidewire catheter 1830 may be in mated connection with and anchored to the dilator tip 1710 .
  • FIGS. 24A-25 depict an embodiment of a delivery system corresponding to the description relating to FIGS. 17A-17B .
  • a fully open delivery system 2150 may be designed for a flexible connection type of attachment to a prosthetic valve (not shown).
  • An arrow 2190 indicating rotation shows that as the thumbwheel 1955 is rotated, the sheath catheter 1350 may again translate (see arrow 2180 indicating translation) toward the dilator tip 1710 .
  • a plurality of flexible connector prongs 2160 may be subjected to a camming action due to their inherent arcuate profile and the gradually increasing level of contact between said flexible connector prongs 2160 and the leading edge 1725 of the sheath catheter 1350 . This may bring the flexible connector prongs 2160 into close contact with one another.
  • a connecting element 2170 At the distal tip of each flexible connector prong 2160 may be a connecting element 2170 , which may be a substantially cylindrical boss that may mate with a substantially cylindrical hole or cavity within the commissure element of an associated prosthetic valve (elements 1530 , 1555 , and 1560 show in FIG. 17B ).
  • FIGS. 24B and 24C show the logical continuation of the sheathing process ( 2200 partially open, FIG. 24B, and 2210 fully closed, FIG. 24C ) whereby the leading edge 1725 of the sheath catheter 1350 may be eventually brought into contact with the edge 1720 of the dilator tip 1710 .
  • FIGS. 26A-26B depict an embodiment of a delivery system corresponding to the description relating to FIGS. 18A-18C .
  • FIG. 26A shows an exploded view of an embodiment of a delivery system that may be suitable for connecting with a prosthetic valve frame having flexible buckle type anchors. The components set forth in this depiction may differ only slightly from the components set forth in FIG. 23 .
  • the proximal end 2035 of the anchoring catheter 2010 may be in mated connection with the bell slider 2090 instead of an anchoring nut and may be able to freely translate along with the bell slider 2090 when contacted by the leadscrew 2080 .
  • the bell slider 2090 may further comprise a plurality of pins 2226 that may transmit the force from the leadscrew 2080 to the bell slider 2090 while also providing clearance for a stationary bell catheter nut 2224 that may anchor and retain the stationary bell catheter 2040 to the delivery system.
  • a stationary bell catheter nut 2224 that may anchor and retain the stationary bell catheter 2040 to the delivery system.
  • an enlarged view 2228 is provided, which shows in detail the elements that may be present at the distal most end of the translating anchoring catheter 2010 and stationary bell catheter 2040 .
  • an aperture 2229 that may be formed within the distal end 2227 of the anchoring catheter 2010 may also brought into said bell catheter distal end 2050 . This action effectively may provide the mechanism behind the embodiment illustrated in FIGS. 18A-18C .
  • FIGS. 27 and 28 depict an embodiment of a delivery system corresponding to the description relating to FIGS. 16A-16B .
  • FIG. 27 shows an exploded view 2230 of an embodiment of a delivery system that may suitable for connecting with a prosthetic valve frame having a single threaded connector anchor.
  • the components set forth in this depiction may differ only slightly from the components set forth in FIG. 23 .
  • the embodiment may comprise a plurality of stabilizers 1990 .
  • the stabilizers may improve concentricity of the concentrically nested catheters.
  • a plurality of handle halves A-side 2250 , and B-side 2260 ) may provide a location for the various internal components.
  • the delivery system may also comprise a plurality of thumbwheels, such as a first thumbwheel 1955 for actuating the sheath catheter 1350 and a second thumbwheel 2270 for rotating the threaded bell catheter 2040 .
  • the first and second thumbwheels may allow the catheter to connect and disconnect from the related prosthetic valve.
  • the second thumbwheel 2270 may contain a hole 2275 through which the proximal end 2060 of the rotating bell catheter 2040 may be fastened to said second thumbwheel 2270 .
  • An exploded view 2240 of the family of concentrically nested catheters is provided, and further detail regarding the threaded mechanism at the distal end of the family of catheters is provided in FIG. 28 .
  • FIG. 28 shows an exploded view 2280 focusing on the distal end of the family of nested catheters.
  • Arrow 2300 indicates rotation, which corresponds to the rotation of the threaded and distal end of the bell catheter 2310 in order to connect or disconnect from threaded fasteners that may be present in a valve prosthesis.
  • FIGS. 29-31 depict an embodiment of a delivery system corresponding to the description relating to FIGS. 15A-15B .
  • FIG. 29 shows an exploded view of an embodiment of a delivery system that may be suitable for connecting with a prosthetic valve frame having a plurality of threaded type connector anchors ( 1400 , as shown in FIG. 15A ).
  • the components set forth in this depiction may be substantially similar to the components set forth in FIG. 23 .
  • FIG. 29 shows an exploded view of the delivery handle portion of the delivery system 2320 and an exploded view of the concentrically nested catheters 2330 .
  • a slot 2390 may be formed at the proximal end of both delivery system handle A-side 2370 , and B-side 2380 .
  • the slots may allow for rotational displacement of a level 2420 that may be orthogonal to and originates from a cylindrical torque transmitting member 2410 .
  • the torque transmitting member 2410 may be in mated connection with the proximal or driving end 2355 of a torque catheter 2350 , and may travel concentrically through a catheter mount 2400 , a leadscrew 2080 , a plurality of stabilizers 2360 , and a sheath catheter 1350 before terminating in a distal or driven end 2352 that may further transmit torque through a geared relationship and that is further described in FIG. 31 .
  • the catheter mount 2400 may provide a lateral location and fixation for fixed ends 2345 of a plurality of twisting thread-connector catheters 2340 .
  • the thread-connector catheters 2340 may be long, thin, flexible members which may be structurally rigid in compression.
  • the thread-connector catheters may be able to be twisted about their axes when an appropriate torque is applied.
  • a plurality of stabilizers 2360 may act as journal bearings to both internally retain the placement of the torque catheter 2350 and to externally retain the placement of the plurality of thread-connector catheters 2340 .
  • the plurality of thread-connector catheters may be concentrically nested within the sheath catheter 1350 .
  • the leadscrew 2080 and by extension sheath catheter 1350 may be made to translate, which in turn may cause the leading edge 1725 of the sheath catheter 1350 to advance towards or retreat from the dilator tip 1710 .
  • FIG. 30 shows the exploded view 2330 of FIG. 29 in greater detail and shows the nesting configuration of the family of catheters.
  • FIG. 31 shows an enlarged view 2430 , which illustrates in detail the mechanical interaction at the distal end of the delivery system of FIG. 29 .
  • actuating the lever ( 2400 , as shown in FIG. 29 ) may cause the torque catheter to rotate, and may further cause a driving gear 2490 to rotate and transmit torque to a plurality of driven gears 2470 that are adjacent to the distal ends 2342 of the plurality of thread-connector catheters 2340 and by extension also adjacent to the threaded socket 2480 of each thread-connector catheter 2340 .
  • each thread-connector catheter 2340 may be a threaded socket ( 2480 , as shown in FIG. 31 ) which may be used to connectedly mate to a threaded fastener that may be anchored to an embodiment of the prosthetic valve ( 1390 and 1395 , as shown in FIG. 15A ).
  • FIG. 32 illustrates a prosthetic valve implanted in a mitral valve of a patient's heart.
  • the natural blood flow path may be disrupted and blood flow may become turbulent.
  • the blood may flow toward the apex of the heart and towards the septal wall creating turbulence.
  • FIG. 33 illustrates the desired blood flow path through the mitral valve and out the ventricle.
  • the native mitral valve directs the blood to flow along the posterior wall of the ventricle towards the apex of the heart where the blood then continues to flow in a non-turbulent manner up the septal wall and then during heart systole the blood is ejected out of the left ventricular outflow tract (LVOT) and through the aorta to the rest of the body.
  • LVOT left ventricular outflow tract
  • FIG. 34 illustrates a prosthetic valve implanted in a native mitral valve.
  • the prosthetic mitral valve has features which preferably avoid obstructing the left ventricular outflow tract and also may help maintain the natural blood flow path so as to conserve momentum of the blood flow and avoid turbulence.
  • the prosthetic valve preferably has a large anterior prosthetic valve leaflet 3410 that spans the width of the native anterior valve leaflet. This will help mimic the size and motion of the native valve leaflet thereby avoiding obstruction of the LVOT.
  • the prosthesis has a low profile so that it does not extend too far in to the ventricle, and an atrial flange or skirt helps anchor the prosthesis to the atrial floor.
  • the atrial skirt 3420 also preferably has a low profile.
  • the prosthesis may also include one or preferably two anterior anchoring tabs 3430 that extend behind (anterior of the native leaflet) the native valve leaflets and anchor the prosthesis to the fibrous trigones on the anterior portion of the valve, or anchor on tissue adjacent and anterior of the anterior leaflet.
  • the body 3440 of the valve may direct blood flow to the posterior. Additional details of the anchoring tabs may be found in U.S. Pat. No. 8,579,964, the entire contents of which have been previously been incorporated herein by reference.
  • the body of the prosthesis may be designed to avoid LVOT obstruction and this may help direct blood flow downward along the posterior wall of the heart in a circular manner toward the apex, and then upward along the septum toward the LVOT, thereby maintaining a substantially normal blood flow path that avoids turbulance and maintains momentum of the blood flow. Additional details about these and other features of the prosthesis are discussed in greater detail in this specification.
  • FIG. 35 illustrates a ventricular view of the prosthesis which preferably has a large anterior prosthetic leaflet, and two posterior leaflets.
  • three commissure posts are used to support the prosthetic valve leaflets and form a tricuspid prosthetic valve.
  • the prosthesis may comprise an atrial skirt 3520 .
  • the prosthesis preferably includes two anterior anchor tabs 3510 and optionally one or more posterior anchor tabs 3530 .
  • the anterior anchor tabs may anchor to the fibrous trigones of the valve or they may anchor to tissue that is anterior of the anterior leaflet and adjacent thereto, and in order to avoid interfering with movement of the anterior prosthetic leaflet, the anterior anchor tabs are also preferably at the same circumferential position as the commissure posts.
  • the anterior anchor tabs are located approximately at the 10 o'clock and 2 o'clock positions along with two of the commissure posts.
  • the prosthesis is preferably D-shaped in order to conform to the native valve anatomy. Therefore, the anterior portion of the valve is preferably flat and linear so that it does not impinge on the LVOT, and the posterior of the prosthesis is preferably cylindrical so that it conforms to the native valve. In some embodiments, instead of a flat and linear anterior portion, the anterior portion may be concave or slightly convex.
  • FIG. 36A illustrates more clearly the two anterior anchor tabs which extend upward toward the atrium and away from the commissure posts which extend toward the ventricle, and similarly the posterior anchor also extends upward toward the atrium while the adjacent commissure post extends downward toward the ventricle. Note that in this view, only one of the anterior anchor tabs is visible.
  • the prosthesis may comprise an atrial skirt 3610 .
  • FIG. 36B illustrates an outflow view of the prosthesis of FIG. 36A , whereby both anterior trigonal anchoring tabs are present, as well as the posterior anchoring tab, and the commissures associated with each of said tabs. It should be apparent that the commissure posts and anchoring tabs are adjacent each other.
  • the prosthesis may comprise an anterior anchor 3620 , an anterior leaflet 3630 , an anterior commissure 3640 , a posterior anchor 3650 , and a posterior commissure 3660 .
  • FIG. 37 illustrates two embodiments of structure on the prosthesis for coupling it to a delivery catheter.
  • the figure shows a pattern of the anchor frame after it has been flattened and unrolled. It is formed from numerous interconnected struts which form open or closed cells that can self-expand or that may be balloon expandable.
  • a first exemplary embodiment shows a single arcuate strut that forms a closed single cell on the atrial portion of the device. This strut may be folded radially outward to form a flanged region or atrial skirt which can anchor to the atrial floor.
  • a commissure post with a D-shaped or mushroom head shaped, or anchor shaped portion on the opposite end of the prosthesis may be used to couple and uncouple the device from a delivery catheter as described previously in this specification and in U.S. Pat. No. 8,579,964 previously incorporated by reference, and is generally on a ventricular portion of the device.
  • a triangular anchor tab is nested in the single cell between the commissure post and the atrial flange. Thus, the anchor tab is superior to the commissure post.
  • the anchor tab may be formed to flare radially outward during deployment so that the anchor tab may be disposed behind a native leaflet (anterior to the anterior native leaflet, or posterior to a native posterior leaflet) and engage the anterior or posterior native anatomy as described in this specification.
  • the commissure may have suture holes disposed therein in order to allow sutures to attach tissue or other material to the commissure posts. Nesting of the anchor tab adjacent the commissure post helps reduce overall device profile.
  • FIG. 37 illustrates another exemplary embodiment of an anchor structure that allows the prosthesis to be coupled to the delivery catheter.
  • multiple closed cells form the atrial region of the device which may be formed to flare radially outward and create a flanged region that may be secured to the atrial floor of the atrium.
  • Two commissure posts include a slotted region for receiving sutures so that tissue or other material may be coupled to the device.
  • the commissure posts are connected together with a wishbone shaped strut having a central tab that may be coupled to the delivery catheter.
  • the wishbone may extend between two commissures or three commissures, or more commissures.
  • the struts of the frame may be EDM machined or laser cut from tubing (e.g. hypo tube), laser cutting or photo etching a flat sheet and welding the ends together, or by other techniques known in the art.
  • FIG. 38 illustrates a perspective view of the prosthetic mitral valve.
  • An upper portion includes an atrial skirt or atrial flange that generally takes the same form as the atrial skirt or flange described in U.S. Pat. No. 8,579,964, previously incorporated herein by reference.
  • the prosthetic valve leaflets are also shown, and preferably include one large anterior leaflet that spans the width of the native anterior mitral valve leaflet, and may include two, or three, or more posterior prosthetic leaflets. Thus, the prosthetic valve may only have two prosthetic leaflets, or three or more prosthetic leaflets in total.
  • Two anterior anchoring tabs also preferably share the same position as the commissure posts. This keeps the anterior commissure posts and the anterior anchor tabs out of the flow path thereby helping to avoid LVOT obstruction, and also helps keep overall profile of the device to a minimum in the collapsed configuration which is desirable during delivery.
  • FIG. 39A shows an anterior view of the prosthetic valve in the expanded configuration with the anchoring tabs flared outward and in the expanded configuration.
  • FIG. 39B shows a top view of the prosthetic valve with four prosthetic leaflets including one large anterior leaflet that spans the width of the native anterior leaflet and three posterior leaflets, all coupled together with four commissure posts that may optionally be combined with four anchor tabs.
  • Two of these anchor tabs are preferably anterior anchoring tabs for anchoring the prosthetic valve to the fibrous trigones or any other anatomic location described herein including a region anterior of the anterior leaflet and adjacent thereto, and the two posterior tabs may anchor the prosthetic valve to the posterior shelf of the posterior annulus and posterior to the native posterior leaflet.
  • FIG. 40 shows deployment of the prosthesis by either a transseptal or by a transapical delivery system.
  • an outer sheath catheter constrains the device from self-expanding and when the outer sheath catheter is retracted the device self-expands.
  • the sheath catheter is partially retracted and the anterior 4010 and posterior 4020 anchor tabs are partially deployed.
  • FIG. 41 shows a partial perspective view of the prosthetic valve with an upper saddle shaped atrial skirt for atrial anchoring along with the combined large anterior leaflet and two or three posterior leaflets and combined anchor tabs/commissure posts.
  • FIG. 42 shows a flat pattern of the combined anterior or posterior anchor tab that is nested in the commissure post.
  • the anchors in alternative embodiments may be cut above the commissure posts and bent backward during heat treating and shape setting so they can anchor to the native heart valve anatomy as described in this specification. This may require the anchors to be deployed first, before other portions of the prosthesis, as seen in FIG. 40 . This may also involve anchoring of the prosthesis to the delivery catheter on both the inflow end and the outflow ends of the prosthesis for successful delivery.
  • FIG. 43A shows the unexpanded anchor tabs which may be triangular in the collapsed configuration and have a horizontal paddle shape in the expanded configuration in order to increase the contact area and thereby minimize tissue trauma, tissue piercing during anchoring, as illustrated in FIG. 43B .
  • the anchors may have pointed tips which pierce or embed in tissue to help anchor the device.
  • FIG. 43C shows an exemplary cut pattern of the prosthesis that provides the results seen in FIGS. 43A-43B .
  • FIG. 44 illustrates a top view of the prosthetic valve with a large anterior leaflet that spans the width of the native anterior leaflet, and two posterior prosthetic leaflets.
  • the prosthetic leaflets are coupled together with three commissure posts.
  • FIG. 45 shows portions of the prosthesis including the upper atrial skirt, an annular region and the anchor tabs which may be combined with commissure posts.
  • the anchor tabs are preferably 10 mm-50 mm long, more preferably 20 mm-30 mm long to allow adequate length to go under and behind the native valve leaflets to reach the fibrous trigones and/or posterior annulus or to anchor on other anatomic locations described herein including regions that are anterior of the native leaflet and adjacent thereto.
  • the prosthetic valve may not include a posterior anchoring tab.
  • the annular section which is preferably D-shaped may be radially expanded into engagement with the native valve annulus and thus the radial force may be adequate to prevent the posterior portion of the prosthesis from tilting or otherwise pivoting upward into the atrium. Or teeth may be used to engage and/or penetrate the posterior annulus.
  • the prosthesis may be recaptured and resheathed if needed in order to either abort the delivery procedure or to reposition the device.
  • Preferred embodiments are formed from nitinol or any other biocompatible material that is self-expanding.
  • Preferred target sizes and profiles may be dependent on patient anatomy, but are estimated to be approximately 30 mm-50 mm ⁇ 40 mm-50 mm D-shaped prosthesis that may be delivered in a delivery system that is less than 45 French in size. More preferably, the prosthesis is 35 mm-45 mm ⁇ 40 mm-50 mm D-shaped and delivered with a delivery system less than 40 French in size. Smaller sizes are preferred, and nominally, the prosthesis is 40 mm ⁇ 45 mm D-shaped and delivered with a delivery system less than 40 French.
  • tethers may be used to help couple the prosthesis to the delivery system for controlling delivery.
  • FIG. 46 shows a top view of a prosthetic valve with four prosthetic leaflets and four commissure posts.
  • four anchoring tabs may also be co-located with the four commissure posts.
  • FIG. 47 shows a top view of prosthetic valve with three prosthetic leaflets and three commissure posts.
  • three anchoring tabs may also be co-located with the three commissure posts.
  • FIG. 48 shows the prosthesis unrolled and flattened out and having three commissure posts with three prosthetic leaflets and three anchoring tabs.
  • the atrial skirt is also illustrated below the commissure posts and anchor tabs.
  • FIG. 49 shows the native anterior and posterior leaflet unrolled and flattened and superimposed over the three anchoring tabs.
  • FIG. 50 shows an embodiment where the anchor tabs (triangular shaped cells) are connected to the commissure posts configured for deployment as depicted in FIG. 40 , where the anchor tabs are deployed first as an outer sheath when the delivery system is retracted.
  • Alternative catheter attachment methods are depicted for this embodiment. Either the use of mushroom shaped anchor tabs at the atrial aspect of the device or a central wishbone style attachment can be used to secure the device to the catheter.
  • FIG. 51 shows a large anterior leaflet superimposed over two anterior anchor tabs and a posterior section of diamond shaped cells which may engage or pierce the posterior annulus in an exemplary embodiment that does not use a posterior anchor tab.
  • FIG. 52 illustrates another exemplary embodiment showing two anterior anchoring tabs formed and nested within the anterior commissure posts and a series of expandable diamond shaped cells which may anchor against the posterior annulus or may pierce into the posterior annulus thereby avoiding the need for a posterior anchoring tab.
  • This embodiment includes four commissure posts.
  • FIG. 53 illustrates another exemplary flat pattern of a prosthetic valve having two anterior anchor tabs nested in two anterior commissure posts and two posterior commissure posts. The atrial flange is shown below the commissure posts.
  • FIG. 54 shows a perspective view of a prosthetic valve with four commissure posts and a large anterior prosthetic leaflet coupled to two anterior commissure posts.
  • FIG. 55 shows a native mitral valve adjacent the aortic valve and preferably the anterior leaflet moves well away from the LVOT during systole.
  • a prosthetic anterior leaflet would have similar motion to maintain natural flow dynamics such as maintaining blood flow momentum and reducing or eliminating turbulance.
  • FIG. 56 shows another exemplary embodiment of a section of prosthetic valve having an anchoring tab nested within the commissure post and the adjacent closed cells of the frame are also shown.
  • FIG. 57 illustrates still another exemplary embodiment of a prosthetic valve having a commissure post and an anchoring tab nested with the commissure post.
  • FIG. 58 shows yet another variation of a prosthetic valve having an anchoring tab nested within the commissure post.
  • FIG. 59 shows how variable strut thickness (e.g. thicker 5910 and thinner 5920 regions) may be used to control the material properties of the prosthesis to create stiffer regions and less stiff regions.
  • variable strut thickness e.g. thicker 5910 and thinner 5920 regions

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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10856984B2 (en) * 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11253363B2 (en) 2018-01-07 2022-02-22 Jc Medical Inc. Heart valve prosthesis
US11259923B2 (en) 2013-03-14 2022-03-01 Jc Medical, Inc. Methods and devices for delivery of a prosthetic valve
US11331184B2 (en) 2018-01-07 2022-05-17 Jc Medical, Inc. Methods and devices for delivery of a prosthetic valve
US11406497B2 (en) 2013-03-14 2022-08-09 Jc Medical, Inc. Heart valve prosthesis
US11446144B2 (en) 2009-03-30 2022-09-20 Jc Medical, Inc. Devices and methods for delivery of valve prostheses
US11491006B2 (en) 2019-04-10 2022-11-08 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
US11510769B2 (en) 2013-03-14 2022-11-29 Jc Medical, Inc. Embolic protection devices and methods of use
US12193932B2 (en) 2016-01-29 2025-01-14 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2580053C (en) 2004-09-14 2014-07-08 Edwards Lifesciences Ag. Device and method for treatment of heart valve regurgitation
EP2491891A3 (en) 2004-10-02 2013-03-20 Endoheart AG Devices for embolic protection and mitral valve repair
US7803168B2 (en) 2004-12-09 2010-09-28 The Foundry, Llc Aortic valve repair
CA2629534C (en) 2005-11-10 2015-02-24 Arshad Quadri Balloon-expandable, self-expanding, vascular prosthesis connecting stent
WO2008013915A2 (en) 2006-07-28 2008-01-31 Arshad Quadri Percutaneous valve prosthesis and system and method for implanting same
US20090276040A1 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
AU2009295960A1 (en) 2008-09-29 2010-04-01 Cardiaq Valve Technologies, Inc. Heart valve
EP2358297B1 (en) 2008-11-21 2019-09-11 Percutaneous Cardiovascular Solutions Pty Limited Heart valve prosthesis
CA2961053C (en) 2009-04-15 2019-04-30 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
NZ596179A (en) 2009-04-29 2014-05-30 Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
EP2582326B2 (en) 2010-06-21 2024-07-03 Edwards Lifesciences CardiAQ LLC Replacement heart valve
WO2012040655A2 (en) 2010-09-23 2012-03-29 Cardiaq Valve Technologies, Inc. Replacement heart valves, delivery devices and methods
CA3035048C (en) 2010-12-23 2021-05-04 Mark Deem System for mitral valve repair and replacement
US12502276B2 (en) 2011-05-16 2025-12-23 Edwards Lifesciences Corporation Inversion delivery device and method for a prosthesis
AU2012272855C1 (en) 2011-06-21 2018-04-05 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US11202704B2 (en) 2011-10-19 2021-12-21 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
CA2849030C (en) 2011-10-19 2020-10-27 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9039757B2 (en) 2011-10-19 2015-05-26 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
AU2012325809B2 (en) 2011-10-19 2016-01-21 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US20140277427A1 (en) 2013-03-14 2014-09-18 Cardiaq Valve Technologies, Inc. Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
WO2014189974A1 (en) 2013-05-20 2014-11-27 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
EP3107497B1 (en) 2014-02-21 2020-07-22 Edwards Lifesciences CardiAQ LLC Delivery device for controlled deployment of a replacement valve
CA3161000A1 (en) 2014-05-19 2015-11-26 Edwards Lifesciences Cardiaq Llc Replacement mitral valve with annular flap
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
RU2017114607A (ru) 2014-09-28 2018-10-29 Кардиокинетикс, Инк. Устройства для терапии нарушений функции сердца
CN106999281B (zh) 2014-11-26 2020-05-05 爱德华兹生命科学公司 经导管人工心脏瓣膜和递送系统
WO2016153918A1 (en) 2015-03-20 2016-09-29 Cardiokinetix, Inc. Systems and methods for delivering an implantable device
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
CA2990872C (en) 2015-06-22 2022-03-22 Edwards Lifescience Cardiaq Llc Actively controllable heart valve implant and methods of controlling same
US10092400B2 (en) 2015-06-23 2018-10-09 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
JP7111610B2 (ja) 2015-08-21 2022-08-02 トゥエルヴ， インコーポレイテッド 埋込可能な心臓弁デバイス、僧帽弁修復デバイス、ならびに関連するシステム及び方法
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10117744B2 (en) 2015-08-26 2018-11-06 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
JP6643498B2 (ja) 2015-11-06 2020-02-12 マイコー・リミテッド 僧帽弁プロテーゼ
EP3448316B1 (en) 2016-04-29 2023-03-29 Medtronic Vascular Inc. Prosthetic heart valve devices with tethered anchors
US10299921B2 (en) * 2016-05-12 2019-05-28 St. Jude Medical, Cardiology Division, Inc. Mitral heart valve replacement
US10350062B2 (en) 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
CN109843219B (zh) 2016-08-26 2022-04-05 爱德华兹生命科学公司 多部分置换心脏瓣膜假体
WO2018160790A1 (en) * 2017-03-03 2018-09-07 St. Jude Medical, Cardiology Division, Inc. Transcatheter mitral valve design
US10575950B2 (en) 2017-04-18 2020-03-03 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US10433961B2 (en) 2017-04-18 2019-10-08 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US10792151B2 (en) 2017-05-11 2020-10-06 Twelve, Inc. Delivery systems for delivering prosthetic heart valve devices and associated methods
US10646338B2 (en) 2017-06-02 2020-05-12 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US10709591B2 (en) 2017-06-06 2020-07-14 Twelve, Inc. Crimping device and method for loading stents and prosthetic heart valves
CA3067150A1 (en) 2017-07-06 2019-01-10 Edwards Lifesciences Corporation Steerable rail delivery system
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10729541B2 (en) 2017-07-06 2020-08-04 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10806573B2 (en) * 2017-08-22 2020-10-20 Edwards Lifesciences Corporation Gear drive mechanism for heart valve delivery apparatus
CA3078699C (en) 2017-10-13 2023-10-10 W.L. Gore & Associates, Inc. Telescoping prosthetic valve and delivery system
US10722349B2 (en) 2017-12-07 2020-07-28 Medtronic Vascular, Inc. Adjustable prosthetic heart valve
CN111818877B (zh) 2018-01-25 2023-12-22 爱德华兹生命科学公司 在部署后用于辅助置换瓣膜重新捕获和重新定位的递送系统
US11051934B2 (en) 2018-02-28 2021-07-06 Edwards Lifesciences Corporation Prosthetic mitral valve with improved anchors and seal
WO2019195860A2 (en) 2018-04-04 2019-10-10 Vdyne, Llc Devices and methods for anchoring transcatheter heart valve
WO2020006026A1 (en) * 2018-06-26 2020-01-02 The Regents Of The University Of California Flexible heart valve prosthesis
US12186187B2 (en) 2018-09-20 2025-01-07 Vdyne, Inc. Transcatheter deliverable prosthetic heart valves and methods of delivery
US11278437B2 (en) 2018-12-08 2022-03-22 Vdyne, Inc. Compression capable annular frames for side delivery of transcatheter heart valve replacement
US11071627B2 (en) 2018-10-18 2021-07-27 Vdyne, Inc. Orthogonally delivered transcatheter heart valve frame for valve in valve prosthesis
US12310850B2 (en) 2018-09-20 2025-05-27 Vdyne, Inc. Transcatheter deliverable prosthetic heart valves and methods of delivery
US11344413B2 (en) 2018-09-20 2022-05-31 Vdyne, Inc. Transcatheter deliverable prosthetic heart valves and methods of delivery
US10321995B1 (en) 2018-09-20 2019-06-18 Vdyne, Llc Orthogonally delivered transcatheter heart valve replacement
US11109969B2 (en) 2018-10-22 2021-09-07 Vdyne, Inc. Guidewire delivery of transcatheter heart valve
CN109350308B (zh) 2018-12-03 2020-10-20 宁波健世生物科技有限公司 一种分步夹持式瓣膜假体及其输送系统
CN109350309B (zh) * 2018-12-03 2021-07-20 宁波健世科技股份有限公司 一种支架瓣膜假体及其输送系统
US11253359B2 (en) 2018-12-20 2022-02-22 Vdyne, Inc. Proximal tab for side-delivered transcatheter heart valves and methods of delivery
WO2020146842A1 (en) 2019-01-10 2020-07-16 Vdyne, Llc Anchor hook for side-delivery transcatheter heart valve prosthesis
US11273032B2 (en) 2019-01-26 2022-03-15 Vdyne, Inc. Collapsible inner flow control component for side-deliverable transcatheter heart valve prosthesis
US11185409B2 (en) 2019-01-26 2021-11-30 Vdyne, Inc. Collapsible inner flow control component for side-delivered transcatheter heart valve prosthesis
US20220142778A1 (en) * 2019-01-28 2022-05-12 Vesalius Cardiovascular Inc. Apparatus for use in repairing mitral valves and method of use thereof
EP3921012A1 (en) 2019-02-04 2021-12-15 Edwards Lifesciences Corporation Guide wire apparatuses and methods
CA3132162A1 (en) 2019-03-05 2020-09-10 Vdyne, Inc. Tricuspid regurgitation control devices for orthogonal transcatheter heart valve prosthesis
CN113747860B (zh) * 2019-03-14 2025-09-09 维迪内股份有限公司 可侧向输送的经导管假体瓣膜以及用于输送和锚定其的方法
US11076956B2 (en) 2019-03-14 2021-08-03 Vdyne, Inc. Proximal, distal, and anterior anchoring tabs for side-delivered transcatheter mitral valve prosthesis
US11173027B2 (en) 2019-03-14 2021-11-16 Vdyne, Inc. Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same
JP7381601B2 (ja) 2019-04-12 2023-11-15 エドワーズ ライフサイエンシーズ コーポレイション マルチパートフレーム及び関連するレジリエントブリッジ特徴部を備えた弁
CN113924066B (zh) 2019-04-23 2026-04-14 爱德华兹生命科学公司 电动植入物递送系统
CN114072106B (zh) 2019-05-04 2025-09-19 维迪内股份有限公司 用于在自体瓣环中部署侧面递送的假体心脏瓣膜的束紧装置和方法
EP4480458B1 (en) 2019-08-20 2026-08-12 VDyne, Inc. Delivery devices for side-deliverable transcatheter prosthetic valves
CN114630665B (zh) 2019-08-26 2025-06-17 维迪内股份有限公司 可侧面输送的经导管假体瓣膜及其输送和锚定方法
WO2021146515A1 (en) * 2020-01-17 2021-07-22 Vdyne, Inc. Ventricular stability elements for side-deliverable prosthetic heart valves and methods of delivery
IL319705B2 (en) 2020-02-06 2026-03-01 Laplace Interventional Inc Transcatheter heart valve prosthesis assembled inside heart chambers or blood vessels
WO2022132569A1 (en) 2020-12-18 2022-06-23 Edwards Lifesciences Corporation Storage jar assembly for aprosthetic heart valve
CA3217344A1 (en) 2021-05-05 2022-11-10 Innovalve Bio Medical Ltd. Delivery device
WO2023012680A1 (en) * 2021-08-04 2023-02-09 Laguna Tech Usa, Inc. Prosthetic heart valve device, frame, delivery system, interventional system and related methods
US12226313B2 (en) 2021-10-12 2025-02-18 Laguna Tech Usa, Inc. Prosthetic heart valve device, delivery system, interventional system and related method
CN118302132A (zh) 2021-10-27 2024-07-05 爱德华兹生命科学公司 用于卷曲和装载假体心脏瓣膜的系统和方法
EP4469002A1 (en) * 2022-01-25 2024-12-04 Innovheart S.r.l. Prosthesis for heart valve and method for constructing a component thereof
US11510777B1 (en) 2022-02-10 2022-11-29 Laplace Interventional Inc. Prosthetic heart valves
CN115177408B (zh) * 2022-07-08 2025-10-31 金仕生物科技（常熟）有限公司 一种介入瓣膜输送系统的使用方法
US11712336B1 (en) 2022-07-20 2023-08-01 Laplace Interventional Inc. Prosthetic heart valves
AU2023358759A1 (en) 2022-10-14 2025-05-15 Vdyne, Inc. Devices and methods for delivering a prosthetic heart valve using supra-annular support
CN115607339B (zh) * 2022-11-07 2023-02-28 广东捍宇医疗科技有限公司 瓣膜装置及瓣膜装置植入系统
WO2024163313A1 (en) * 2023-01-30 2024-08-08 Edwards Lifesciences Corporation Prosthetic medical device delivery apparatus
CN118680725B (zh) * 2023-03-24 2026-07-10 上海臻亿医疗科技有限公司 人工心脏瓣膜
WO2025193739A1 (en) * 2024-03-11 2025-09-18 Acclarent, Inc. Dilation instrument with lead screw drive for catheter
US12702543B2 (en) 2024-05-29 2026-08-11 Vesalius Cardiovascular Inc. Tissue anchors
US12440336B1 (en) 2025-02-11 2025-10-14 Laplace Interventional Inc. Prosthetic heart valves

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040117009A1 (en) 2002-09-23 2004-06-17 Cali Douglas S. Prosthetic mitral valve
US20060259136A1 (en) * 2005-05-13 2006-11-16 Corevalve Sa Heart valve prosthesis and methods of manufacture and use
US20060293745A1 (en) * 2004-01-23 2006-12-28 Carpentier Alain F Anatomically approximate prosthetic mitral heart valve
WO2011069048A2 (en) 2009-12-04 2011-06-09 Edward Lifesciences Corporation Prosthetic valve for replacing mitral valve
US20120239143A1 (en) 2010-09-30 2012-09-20 BioStable Science & Engineering, Inc. Non-Axisymmetric Aortic Valve Devices
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US20140257467A1 (en) 2013-03-11 2014-09-11 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
WO2017127939A1 (en) 2016-01-29 2017-08-03 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow

Family Cites Families (1687)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB243370A (en) 1924-11-20 1926-08-26 Charles Choffel Improvements in or relating to carburettors for internal combustion engines
FR1171437A (fr) 1958-01-27 1959-01-26 Eastman Kodak Co Procédé de fabrication de polyoléfines, produits obtenus et catalyseurs pour la mise en oeuvre de ce procédé
DE3517131C1 (de) 1985-05-11 1986-11-13 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Verfahren zur Messung der Potentialdifferenz zwischen einer Probenfluessigkeit und einem Referenzelektrolyten sowie Vorrichtung zur Messung der Ionenkonzentration in der Probenfluessigkeit
US6203542B1 (en) 1995-06-07 2001-03-20 Arthrocare Corporation Method for electrosurgical treatment of submucosal tissue
US6231608B1 (en) 1995-06-07 2001-05-15 Crosscart, Inc. Aldehyde and glycosidase-treated soft and bone tissue xenografts
US6837887B2 (en) 1995-06-07 2005-01-04 Arthrocare Corporation Articulated electrosurgical probe and methods
US6149620A (en) 1995-11-22 2000-11-21 Arthrocare Corporation System and methods for electrosurgical tissue treatment in the presence of electrically conductive fluid
SE510577C2 (sv) 1996-05-08 1999-06-07 Carag Ag Anordning vid implantat
US6315791B1 (en) 1996-12-03 2001-11-13 Atrium Medical Corporation Self-expanding prothesis
US6183411B1 (en) 1998-09-21 2001-02-06 Myocor, Inc. External stress reduction device and method
US6045497A (en) 1997-01-02 2000-04-04 Myocor, Inc. Heart wall tension reduction apparatus and method
US5957949A (en) * 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US6395024B1 (en) 1997-05-20 2002-05-28 Triflo Medical, Inc. Mechanical heart valve
US6613278B1 (en) 1998-11-13 2003-09-02 Regeneration Technologies, Inc. Tissue pooling process
US6530952B2 (en) 1997-12-29 2003-03-11 The Cleveland Clinic Foundation Bioprosthetic cardiovascular valve system
US7208011B2 (en) 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US7658727B1 (en) 1998-04-20 2010-02-09 Medtronic, Inc Implantable medical device with enhanced biocompatibility and biostability
US6221104B1 (en) 1998-05-01 2001-04-24 Cor Restore, Inc. Anterior and interior segment cardiac restoration apparatus and method
US6250308B1 (en) 1998-06-16 2001-06-26 Cardiac Concepts, Inc. Mitral valve annuloplasty ring and method of implanting
CA2337164A1 (en) 1998-07-13 2000-01-20 Acorn Cardiovascular, Inc. Cardiac disease treatment device and method
US7569062B1 (en) 1998-07-15 2009-08-04 St. Jude Medical, Inc. Mitral and tricuspid valve repair
EP2111800B1 (en) 1998-07-29 2016-06-15 Edwards Lifesciences AG Transventricular implant tools and devices
US6260552B1 (en) 1998-07-29 2001-07-17 Myocor, Inc. Transventricular implant tools and devices
US6406488B1 (en) 1998-08-27 2002-06-18 Heartstent Corporation Healing transmyocardial implant
US7118600B2 (en) 1998-08-31 2006-10-10 Wilson-Cook Medical, Inc. Prosthesis having a sleeve valve
JP2003524444A (ja) 1998-09-10 2003-08-19 パーカーディア，インコーポレイティド Ｔｍｒシャント
US6641610B2 (en) 1998-09-10 2003-11-04 Percardia, Inc. Valve designs for left ventricular conduits
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US6200341B1 (en) 1998-09-25 2001-03-13 Sulzer Carbomedics Inc. Mechanical heart valve assembly with super-elastic lock wire
US6248112B1 (en) 1998-09-30 2001-06-19 C. R. Bard, Inc. Implant delivery system
US6458092B1 (en) 1998-09-30 2002-10-01 C. R. Bard, Inc. Vascular inducing implants
CA2345799C (en) 1998-09-30 2010-01-05 Medtronic, Inc. Process for reducing mineralization of tissue used in transplantation
US6432126B1 (en) 1998-09-30 2002-08-13 C.R. Bard, Inc. Flexible vascular inducing implants
US6475239B1 (en) 1998-10-13 2002-11-05 Sulzer Carbomedics Inc. Method for making polymer heart valves with leaflets having uncut free edges
US6102945A (en) 1998-10-16 2000-08-15 Sulzer Carbomedics, Inc. Separable annuloplasty ring
EP1124592B1 (en) 1998-10-28 2006-06-07 Cellon S.A. Textured and porous silicone rubber
BE1012536A3 (fr) 1998-11-04 2000-12-05 Baxter Int Element muni d'une couche de fibrine sa preparation et son utilisation.
US6001056A (en) 1998-11-13 1999-12-14 Baxter International Inc. Smooth ventricular assist device conduit
US6540780B1 (en) 1998-11-23 2003-04-01 Medtronic, Inc. Porous synthetic vascular grafts with oriented ingrowth channels
US6692520B1 (en) 1998-12-15 2004-02-17 C. R. Bard, Inc. Systems and methods for imbedded intramuscular implants
AU2583200A (en) 1998-12-28 2000-07-31 Andrei Vasilievich Agafonov Heart valve prosthesis
EP1146835B1 (en) 1999-01-26 2008-11-19 Edwards Lifesciences Corporation Anatomical orifice sizers
EP1143882B1 (en) 1999-01-26 2007-12-05 Edwards Lifesciences Corporation Flexible heart valve
ATE465693T1 (de) 1999-01-27 2010-05-15 Medtronic Inc Vorrichtung für herzklappeneingriffe
DE19904975A1 (de) 1999-02-06 2000-09-14 Impella Cardiotech Ag Vorrichtung zur intravasalen Herzklappenoperation
US6425916B1 (en) * 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
US20030068815A1 (en) 1999-02-11 2003-04-10 Stone Kevin R. Sterilized xenograft tissue
NO308575B1 (no) 1999-02-17 2000-10-02 Sumit Roy Flerbruksventil
DE19910233A1 (de) 1999-03-09 2000-09-21 Jostra Medizintechnik Ag Anuloplastieprothese
US7666204B2 (en) 1999-04-09 2010-02-23 Evalve, Inc. Multi-catheter steerable guiding system and methods of use
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US8216256B2 (en) 1999-04-09 2012-07-10 Evalve, Inc. Detachment mechanism for implantable fixation devices
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US7604646B2 (en) 1999-04-09 2009-10-20 Evalve, Inc. Locking mechanisms for fixation devices and methods of engaging tissue
CA2369641C (en) 1999-04-09 2009-02-10 Evalve, Inc. Methods and apparatus for cardiac valve repair
US6231602B1 (en) 1999-04-16 2001-05-15 Edwards Lifesciences Corporation Aortic annuloplasty ring
AU4242800A (en) 1999-04-23 2000-11-10 St. Jude Medical Cardiovascular Group, Inc. Artificial heart valve attachment apparatus
US6620170B1 (en) 1999-04-26 2003-09-16 C. R. Bard, Inc. Devices and methods for treating ischemia by creating a fibrin plug
ATE366557T1 (de) 1999-04-28 2007-08-15 St Jude Medical Aortenherzklappenprothesenmess- und - markierungsvorrichtung
DE19919625C2 (de) 1999-04-29 2002-10-31 Symetis Ag Zuerich In-vitro-Verfahren zum Herstellen einer homologen Herzklappe und durch dieses Verfahren herstellbare Klappe
EP1098673B1 (en) 1999-05-14 2006-07-19 C.R. Bard, Inc. Agent delivery systems
US6790229B1 (en) 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
JP4576521B2 (ja) 1999-06-25 2010-11-10 ハンセン メディカル， インコーポレイテッド 組織を処置するための装置および方法
SE514718C2 (sv) 1999-06-29 2001-04-09 Jan Otto Solem Anordning för behandling av bristande tillslutningsförmåga hos mitralisklaffapparaten
US7192442B2 (en) 1999-06-30 2007-03-20 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US6610071B1 (en) 1999-07-26 2003-08-26 Beth Israel Deaconess Medical Center Suture system
US7022088B2 (en) 1999-08-05 2006-04-04 Broncus Technologies, Inc. Devices for applying energy to tissue
AU6530800A (en) 1999-08-05 2001-03-05 Broncus Technologies, Inc. Methods and devices for creating collateral channels in the lungs
US6293951B1 (en) 1999-08-24 2001-09-25 Spiration, Inc. Lung reduction device, system, and method
US6350281B1 (en) 1999-09-14 2002-02-26 Edwards Lifesciences Corp. Methods and apparatus for measuring valve annuluses during heart valve-replacement surgery
EP1225948B1 (en) 1999-09-20 2007-08-08 ev3 Endovascular, Inc. Apparatus for closing a body lumen
EP1214106B1 (en) 1999-09-22 2003-11-19 Baxter International Inc. Cardiac valve and method for preparing a biological tissue
US6358278B1 (en) 1999-09-24 2002-03-19 St. Jude Medical, Inc. Heart valve prosthesis with rotatable cuff
IT1307268B1 (it) 1999-09-30 2001-10-30 Sorin Biomedica Cardio Spa Dispositivo per interventi di riparazione o sostituzione valvolarecardiaca.
US6371983B1 (en) 1999-10-04 2002-04-16 Ernest Lane Bioprosthetic heart valve
US6416547B1 (en) 1999-10-06 2002-07-09 Edwards Lifesciences Corporation Heart valve carrier and rinse cage
FR2799364B1 (fr) 1999-10-12 2001-11-23 Jacques Seguin Dispositif d'annuloplastie utilisable par voie mini-invasive
CA2286929A1 (en) 1999-10-18 2001-04-18 Anthony Paolitto Valve surgery apparatus
US6440164B1 (en) 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
JP2001120582A (ja) 1999-10-22 2001-05-08 Gunze Ltd 人工心臓弁およびその作製方法
FR2815844B1 (fr) 2000-10-31 2003-01-17 Jacques Seguin Support tubulaire de mise en place, par voie percutanee, d'une valve cardiaque de remplacement
US20070043435A1 (en) 1999-11-17 2007-02-22 Jacques Seguin Non-cylindrical prosthetic valve system for transluminal delivery
FR2800984B1 (fr) 1999-11-17 2001-12-14 Jacques Seguin Dispositif de remplacement d'une valve cardiaque par voie percutanee
US7195641B2 (en) 1999-11-19 2007-03-27 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
GB9928905D0 (en) 1999-12-08 2000-02-02 Aortech Europ Ltd Prosthesis
GB0114345D0 (en) 2001-06-13 2001-08-08 Aortech Europ Ltd Heart valve prosthesis and method of manufacture
US7632309B1 (en) 1999-12-13 2009-12-15 St. Jude Medical, Inc. Pyrolytic carbon and metal/metalloid carbide composites
SE9904569L (sv) 1999-12-14 2001-05-14 Jcl Technic Ab Kärlventil, såsom hjärtklaff,samt förfarande för dess framställning
EP1239795B1 (en) 1999-12-23 2006-12-06 Edwards Lifesciences Corporation Enhanced visualization of medical implants
NL1014095C2 (nl) 2000-01-17 2001-07-18 Cornelis Hendrikus Anna Witten Implantaatklep voor implantatie in een bloedvat.
WO2001054745A2 (en) 2000-01-25 2001-08-02 Edwards Lifesciences Corporation Bioactive coatings to prevent tissue overgrowth on artificial heart valves
US6682559B2 (en) 2000-01-27 2004-01-27 3F Therapeutics, Inc. Prosthetic heart valve
US7296577B2 (en) 2000-01-31 2007-11-20 Edwards Lifescience Ag Transluminal mitral annuloplasty with active anchoring
EP1900343B1 (en) 2000-01-31 2015-10-21 Cook Biotech Incorporated Stent valves
US6402781B1 (en) 2000-01-31 2002-06-11 Mitralife Percutaneous mitral annuloplasty and cardiac reinforcement
KR100880550B1 (ko) 2000-01-31 2009-01-30 쿠크 바이오텍, 인코포레이티드 판막 기구 및 심장 판막 기구
US6540782B1 (en) 2000-02-02 2003-04-01 Robert V. Snyders Artificial heart valve
AU3803801A (en) 2000-02-03 2001-08-14 Cook Inc Implantable vascular device
FR2804718B1 (fr) 2000-02-09 2002-05-03 Peugeot Citroen Automobiles Sa Systeme d'aide a la regeneration d'un filtre a particules integre dans une ligne d'echappement d'un moteur diessel de vehicule automobile
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
US6378221B1 (en) 2000-02-29 2002-04-30 Edwards Lifesciences Corporation Systems and methods for mapping and marking the thickness of bioprosthetic sheet
ES2236204T3 (es) 2000-03-03 2005-07-16 Cook Incorporated Valvula bulbiforme y stent para el tratamiento del reflujo vascular.
US6679264B1 (en) 2000-03-04 2004-01-20 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
WO2001067985A1 (en) 2000-03-10 2001-09-20 Paracor Surgical, Inc. Expandable cardiac harness for treating congestive heart failure
WO2001068158A1 (en) 2000-03-15 2001-09-20 Orbus Medical Technologies Inc. Coating that promotes endothelial cell adherence
US6537198B1 (en) 2000-03-21 2003-03-25 Myocor, Inc. Splint assembly for improving cardiac function in hearts, and method for implanting the splint assembly
US6953476B1 (en) 2000-03-27 2005-10-11 Neovasc Medical Ltd. Device and method for treating ischemic heart disease
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
ITPC20000013A1 (it) 2000-04-13 2000-07-13 Paolo Ferrazzi Dispositivo endoventricolare e metodo relativo per il trattamento e la correzione di miocardiopatie.
DE50115407D1 (de) 2000-04-27 2010-05-06 Corlife Gbr Individuelle venenklappenprothese
US8632583B2 (en) 2011-05-09 2014-01-21 Palmaz Scientific, Inc. Implantable medical device having enhanced endothelial migration features and methods of making the same
US8252044B1 (en) 2000-11-17 2012-08-28 Advanced Bio Prosthestic Surfaces, Ltd. Device for in vivo delivery of bioactive agents and method of manufacture thereof
US6419695B1 (en) 2000-05-22 2002-07-16 Shlomo Gabbay Cardiac prosthesis for helping improve operation of a heart valve
EP1284688B1 (fr) 2000-05-25 2005-10-26 Bioring SA Dispositif pour retrecir et/ou renforcer les orifices valvulaires du coeur
US6902522B1 (en) 2000-06-12 2005-06-07 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
EP1330189B1 (en) 2000-06-23 2007-12-19 Viacor Incorporated Automated annular plication for mitral valve repair
US6695878B2 (en) 2000-06-26 2004-02-24 Rex Medical, L.P. Vascular device for valve leaflet apposition
EP1512383B1 (en) 2000-06-26 2013-02-20 Rex Medical, L.P. A vascular system for valve leaflet apposition
WO2002001999A2 (en) 2000-06-30 2002-01-10 Viacor, Incorporated Method and apparatus for performing a procedure on a cardiac valve
US7077861B2 (en) 2000-07-06 2006-07-18 Medtentia Ab Annuloplasty instrument
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
EP1307246B1 (en) 2000-07-11 2005-09-21 Alessandro Verona Biomaterial including animal corneal tissue
DE10033858B4 (de) 2000-07-12 2006-01-26 Max Hauser Süddeutsche Chirurgiemechanik GmbH Vorrichtung zum Spreizen von Gewebe, Gewebeteilen, Organen, Knochen oder anderen Körperteilen bei chirurgischen Eingriffen in menschlichen oder tierischen Körpern
AU2001276878B2 (en) 2000-07-12 2005-05-05 Edwards Lifesciences Corporation Method and apparatus for forming a heart valve wireform
US6409758B2 (en) 2000-07-27 2002-06-25 Edwards Lifesciences Corporation Heart valve holder for constricting the valve commissures and methods of use
US7862500B2 (en) 2002-08-01 2011-01-04 Cardiokinetix, Inc. Multiple partitioning devices for heart treatment
US7399271B2 (en) 2004-01-09 2008-07-15 Cardiokinetix, Inc. Ventricular partitioning device
EP1179353A1 (de) 2000-08-11 2002-02-13 B. Braun Melsungen Ag Antithrombogene Implantate mit Beschichtung aus Polyphosphazenen und einem pharmakologisch aktiven Wirkstoff
US7056533B2 (en) 2000-08-15 2006-06-06 Surmodics, Inc. Medicament incorporation matrix
US6572652B2 (en) 2000-08-29 2003-06-03 Venpro Corporation Method and devices for decreasing elevated pulmonary venous pressure
US6458155B1 (en) 2000-09-01 2002-10-01 Edwards Lifesciences Corporation Fresh donor heart valve sizer and method of use
DE10046550A1 (de) 2000-09-19 2002-03-28 Adiam Life Science Ag Prothetische Mitral-Herzklappe
US8956407B2 (en) 2000-09-20 2015-02-17 Mvrx, Inc. Methods for reshaping a heart valve annulus using a tensioning implant
US8784482B2 (en) 2000-09-20 2014-07-22 Mvrx, Inc. Method of reshaping a heart valve annulus using an intravascular device
AU2001291074A1 (en) 2000-09-21 2002-04-02 St. Jude Medical Inc. Valved prostheses with reinforced polymer leaflets
US6461382B1 (en) 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures
US6602288B1 (en) 2000-10-05 2003-08-05 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery template, system and method of use
US6616684B1 (en) 2000-10-06 2003-09-09 Myocor, Inc. Endovascular splinting devices and methods
US6602286B1 (en) 2000-10-26 2003-08-05 Ernst Peter Strecker Implantable valve system
CA2426819A1 (en) 2000-10-30 2002-05-10 Children's Medical Center Corporation Tissue-engineered vascular structures
EP1337188B1 (en) 2000-11-16 2012-03-07 Donald J. Hill Automatic suture fixation apparatus and method
JP4328093B2 (ja) 2000-11-21 2009-09-09 レックス メディカル リミテッド パートナーシップ 経皮的な大動脈弁
US6953332B1 (en) 2000-11-28 2005-10-11 St. Jude Medical, Inc. Mandrel for use in forming valved prostheses having polymer leaflets by dip coating
DE10060660A1 (de) 2000-12-06 2002-06-20 Frey Rainer Verfahren zur Konservierung von biologischen Prothesen, konservierte biologische Prothese und Konservierungslösung
WO2002047575A2 (en) 2000-12-15 2002-06-20 Angiomed Gmbh & Co. Medizintechnik Kg Stent with valve
DE10064948C1 (de) 2000-12-20 2002-07-11 Auto Tissue Gmbh Verfahren zur Dezellularisierung von Fremdmaterial zur Herstellung von Bioprothesen und Vorrichtung zur Durchführung des Verfahrens
US6964682B2 (en) 2000-12-21 2005-11-15 Edwards Lifesciences Corporation Heart valve holder that resist suture looping
US7591826B2 (en) 2000-12-28 2009-09-22 Cardiac Dimensions, Inc. Device implantable in the coronary sinus to provide mitral valve therapy
DE10065824B4 (de) 2000-12-28 2018-10-31 Jotec Gmbh Endovaskulärer Stent zur Implantation in den aufsteigenden Ast der Aorta
WO2002060352A1 (en) 2001-01-30 2002-08-08 Ev3 Santa Rosa, Inc. Medical system and method for remodeling an extravascular tissue structure
US6955689B2 (en) 2001-03-15 2005-10-18 Medtronic, Inc. Annuloplasty band and method
US6503272B2 (en) 2001-03-21 2003-01-07 Cordis Corporation Stent-based venous valves
DK1245202T3 (da) 2001-03-27 2004-08-30 Cook William Europ Aortagrafindretning
ATE397426T1 (de) 2001-03-29 2008-06-15 Viacor Inc Gerät zur verbesserung der mitralklappenfunktion
CA2821193C (en) 2001-04-27 2015-09-08 Satterfield, Richard C. Prevention of myocardial infarction induced ventricular expansion and remodeling
ATE437637T1 (de) 2001-05-02 2009-08-15 Nitromed Inc Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
US6800090B2 (en) 2001-05-14 2004-10-05 Cardiac Dimensions, Inc. Mitral valve therapy device, system and method
US6676702B2 (en) 2001-05-14 2004-01-13 Cardiac Dimensions, Inc. Mitral valve therapy assembly and method
US6858039B2 (en) 2002-07-08 2005-02-22 Edwards Lifesciences Corporation Mitral valve annuloplasty ring having a posterior bow
ITMI20011012A1 (it) 2001-05-17 2002-11-17 Ottavio Alfieri Protesi anulare per valvola mitrale
CA2447998A1 (en) 2001-05-24 2002-11-28 Chase Medical, L.P. Apparatus, kit, and method for use during ventricular restoration
GB0113121D0 (en) 2001-05-30 2001-07-18 Univ Leeds Biologically active photosensitisers
JP4078298B2 (ja) 2001-06-08 2008-04-23 レックス メディカル リミテッド パートナーシップ 血管壁に近接する弁を備えた血管器具
ATE278367T1 (de) 2001-06-11 2004-10-15 Sorin Biomedica Cardio Spa Annuloplastieprothese und herstellungsverfahren dafür
NL1018302C1 (nl) 2001-06-15 2002-07-17 Eric Berreklouw Applicator voor een prothese, samenstel omvattende een dergelijke applicator alsmede spanstelsel voor het laden van een dergelijke applicator.
FR2826863B1 (fr) 2001-07-04 2003-09-26 Jacques Seguin Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
ES2321590T3 (es) 2001-07-26 2009-06-09 3F Therapeutics, Inc Metodo de corte de material para utilizar en un dispositivo medico implantable.
FR2828091B1 (fr) 2001-07-31 2003-11-21 Seguin Jacques Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
FR2828263B1 (fr) 2001-08-03 2007-05-11 Philipp Bonhoeffer Dispositif d'implantation d'un implant et procede d'implantation du dispositif
US20040249443A1 (en) 2001-08-20 2004-12-09 Shanley John F. Expandable medical device for treating cardiac arrhythmias
US6726716B2 (en) 2001-08-24 2004-04-27 Edwards Lifesciences Corporation Self-molding annuloplasty ring
US6845776B2 (en) 2001-08-27 2005-01-25 Richard S. Stack Satiation devices and methods
US6675809B2 (en) 2001-08-27 2004-01-13 Richard S. Stack Satiation devices and methods
US6908482B2 (en) 2001-08-28 2005-06-21 Edwards Lifesciences Corporation Three-dimensional annuloplasty ring and template
ES2310609T3 (es) 2001-09-07 2009-01-16 Mardil, Inc. Metodo y aparato para la estabilizacion externa del corazon.
US6562069B2 (en) 2001-09-19 2003-05-13 St. Jude Medical, Inc. Polymer leaflet designs for medical devices
US7060023B2 (en) 2001-09-25 2006-06-13 The Foundry Inc. Pericardium reinforcing devices and methods of using them
US6695769B2 (en) 2001-09-25 2004-02-24 The Foundry, Inc. Passive ventricular support devices and methods of using them
CA2461531C (en) 2001-09-26 2010-11-16 Edwards Lifesciences Corporation Low-profile heart valve sewing ring
US6790237B2 (en) 2001-10-09 2004-09-14 Scimed Life Systems, Inc. Medical stent with a valve and related methods of manufacturing
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
CA2458595C (en) 2001-10-11 2007-12-04 Peter M. Wilson Bronchial flow control devices and methods of use
US6893431B2 (en) 2001-10-15 2005-05-17 Scimed Life Systems, Inc. Medical device for delivering patches
US6923936B2 (en) 2001-10-23 2005-08-02 Medtronic Minimed, Inc. Sterile device and method for producing same
WO2003039549A2 (en) 2001-11-07 2003-05-15 4Sc Ag Selective antibacterial agents
US6805710B2 (en) 2001-11-13 2004-10-19 Edwards Lifesciences Corporation Mitral valve annuloplasty ring for molding left ventricle geometry
US20050177180A1 (en) 2001-11-28 2005-08-11 Aptus Endosystems, Inc. Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
EP1465546B1 (en) 2001-11-29 2007-07-18 Cook Incorporated Medical device delivery system
US6908478B2 (en) 2001-12-05 2005-06-21 Cardiac Dimensions, Inc. Anchor and pull mitral valve device and method
US6976995B2 (en) 2002-01-30 2005-12-20 Cardiac Dimensions, Inc. Fixed length anchor and pull mitral valve device and method
EP1465555B1 (en) 2001-12-21 2015-05-06 QuickRing Medical Technologies Ltd. Implantation system for annuloplasty rings
EP2181668A1 (en) 2001-12-28 2010-05-05 Edwards Lifesciences AG Device for treating mitral annulus dilatation comprising a balloon catheter and a stent
US7189258B2 (en) 2002-01-02 2007-03-13 Medtronic, Inc. Heart valve system
US6756449B2 (en) 2002-02-27 2004-06-29 Medtronic, Inc. AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods
US7048754B2 (en) 2002-03-01 2006-05-23 Evalve, Inc. Suture fasteners and methods of use
US6797001B2 (en) 2002-03-11 2004-09-28 Cardiac Dimensions, Inc. Device, assembly and method for mitral valve repair
ITPD20020064A1 (it) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
US6719786B2 (en) 2002-03-18 2004-04-13 Medtronic, Inc. Flexible annuloplasty prosthesis and holder
DE60234675D1 (de) 2002-03-27 2010-01-21 Sorin Biomedica Emodialisi S R Anuloplastieprothese mit einem durchbohrten Bestandteil
NL1020288C1 (nl) 2002-04-02 2003-05-07 Eric Berreklouw Samenstel omvattende een stabilisator en een in of rondom een door lichaamsweefsel, omgeven doorgang te positioneren instrument.
US6752828B2 (en) 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
DK1492579T3 (da) 2002-04-09 2009-01-19 Numat As Medicinske proteseindretninger med forbedret bioforligelighed
US7108685B2 (en) 2002-04-15 2006-09-19 Boston Scientific Scimed, Inc. Patch stabilization of rods for treatment of cardiac muscle
US7160320B2 (en) 2002-04-16 2007-01-09 The International Heart Institute Of Montana Foundation Reed valve for implantation into mammalian blood vessels and heart with optional temporary or permanent support
FR2838631B1 (fr) 2002-04-23 2004-12-24 Engeneering And Technological Procede de realisation d'une prothese de valve cardiaque aortique ou mitrale et prothese de valve cardiaque aortique ou mitrale ainsi obtenue
US6761735B2 (en) 2002-04-25 2004-07-13 Medtronic, Inc. Heart valve fixation process and apparatus
WO2003094801A1 (en) 2002-05-08 2003-11-20 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US7485141B2 (en) 2002-05-10 2009-02-03 Cordis Corporation Method of placing a tubular membrane on a structural frame
US7351256B2 (en) 2002-05-10 2008-04-01 Cordis Corporation Frame based unidirectional flow prosthetic implant
JP2005525169A (ja) 2002-05-10 2005-08-25 コーディス・コーポレイション 一定の構造フレームの上に一定の薄い壁部の管状の膜を有する医療装置を作成する方法
DE10221076A1 (de) 2002-05-11 2003-11-27 Ruesch Willy Gmbh Stent
CN101134119A (zh) 2002-05-24 2008-03-05 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
AU2003245507A1 (en) 2002-06-13 2003-12-31 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US7753924B2 (en) 2003-09-04 2010-07-13 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US20060122633A1 (en) 2002-06-13 2006-06-08 John To Methods and devices for termination
US7172625B2 (en) 2002-07-16 2007-02-06 Medtronic, Inc. Suturing rings for implantable heart valve prostheses
US7578843B2 (en) 2002-07-16 2009-08-25 Medtronic, Inc. Heart valve prosthesis
CA2487405A1 (en) 2002-07-26 2004-02-05 Emphasys Medical, Inc. Bronchial flow control devices with membrane seal
US8292884B2 (en) 2002-08-01 2012-10-23 Levine Robert A Cardiac devices and methods for minimally invasive repair of ischemic mitral regurgitation
DE10235237A1 (de) 2002-08-01 2004-02-12 Symetis Ag In-vitro-Verfahren zum Herstellen einer homologen "gestenteten" Tissue eingineerten Herzklappe
DE10362367B3 (de) 2002-08-13 2022-02-24 Jenavalve Technology Inc. Vorrichtung zur Verankerung und Ausrichtung von Herzklappenprothesen
DE10301026B4 (de) 2002-08-13 2014-10-30 Jenavalve Technology Inc. Vorrichtung zur Verankerung und Ausrichtung von Herzklappenprothesen
EP1534185B1 (en) 2002-08-15 2015-09-16 Cook Medical Technologies LLC Stent and method of forming a stent with integral barbs
EP2601910B1 (en) 2002-08-15 2018-09-19 Cook Medical Technologies LLC Implantable vascular device
US20040092858A1 (en) 2002-08-28 2004-05-13 Heart Leaflet Technologies, Inc. Leaflet valve
CA2497042A1 (en) 2002-08-29 2004-03-11 Md3 Technologies Llc Implantable devices for controlling the internal circumference of an anatomic orifice or lumen
KR100442330B1 (ko) 2002-09-03 2004-07-30 주식회사 엠아이텍 스텐트 및 이 스텐트의 제조방법
DE10242154A1 (de) 2002-09-05 2004-03-18 Sievers, Hans-Heinrich, Prof.Dr. Gefäßprothese, insbesondere zum Ersatz der Aorta ascendens
US7137184B2 (en) 2002-09-20 2006-11-21 Edwards Lifesciences Corporation Continuous heart valve support frame and method of manufacture
CA2498030A1 (en) 2002-10-01 2004-04-15 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus
WO2004032724A2 (en) 2002-10-10 2004-04-22 The Cleveland Clinic Foundation Method and apparatus for replacing a mitral valve with a stentless bioprosthetic valve having chordae
EP1560526B1 (en) 2002-11-12 2007-06-06 Myocor, Inc. Devices for heart valve treatment
JP4568116B2 (ja) 2002-11-13 2010-10-27 ビアカー・インコーポレーテッド 心臓弁処置方法及び装置
ES2329891T3 (es) 2002-11-27 2009-12-02 Carag Ag Un implante para ocluir un conducto.
FR2847800B1 (fr) 2002-11-28 2005-10-14 Perouse Laboratoires Valve prothetique interchangeable
GB0229274D0 (en) 2002-12-16 2003-01-22 Anson Medical Ltd Instrument for testing pulsatile endurance of vascular implants
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US6945957B2 (en) 2002-12-30 2005-09-20 Scimed Life Systems, Inc. Valve treatment catheter and methods
WO2004066805A2 (en) 2003-01-27 2004-08-12 Corassist Cardiovascular Ltd. In vivo device for improving diastolic ventricular function
US7767219B2 (en) 2003-01-31 2010-08-03 Boston Scientific Scimed, Inc. Localized drug delivery using drug-loaded nanocapsules
GB2398245B (en) 2003-02-06 2007-03-28 Great Ormond Street Hospital F Valve prosthesis
ATE343403T1 (de) 2003-02-10 2006-11-15 Heraeus Gmbh W C Verbesserte metalllegierung für medizinische geräte und implantate
US7077801B2 (en) 2003-02-19 2006-07-18 Corlife Gbr Methods and devices for improving cardiac output
US20040254600A1 (en) 2003-02-26 2004-12-16 David Zarbatany Methods and devices for endovascular mitral valve correction from the left coronary sinus
NZ542645A (en) 2003-02-28 2008-01-31 Edward G Shifrin Extravenous corrector for repair of incompetent venous valves
US20040220655A1 (en) 2003-03-03 2004-11-04 Sinus Rhythm Technologies, Inc. Electrical conduction block implant device
EP1603492B1 (en) 2003-03-12 2009-12-23 Cook Incorporated Prosthetic valve that permits retrograde flow
US7381210B2 (en) 2003-03-14 2008-06-03 Edwards Lifesciences Corporation Mitral valve repair system and method for use
US7399315B2 (en) 2003-03-18 2008-07-15 Edwards Lifescience Corporation Minimally-invasive heart valve with cusp positioners
JP4473861B2 (ja) 2003-03-20 2010-06-02 エイオアテック、インターナショナル、ピーエルシー 弁
CH696185A5 (fr) 2003-03-21 2007-02-15 Afksendiyos Kalangos Dispositif de renfort intraparietal pour prothèse biologique et prothèse biologique renforcée.
KR100466839B1 (ko) 2003-03-28 2005-01-17 주식회사 사이언씨티 대동맥판막 성형기구 세트 및 이를 이용한 치료방법
WO2004089253A1 (en) 2003-04-01 2004-10-21 Cook Incorporated Percutaneously deployed vascular valves
EP1615593B1 (en) 2003-04-08 2010-01-06 Cook Incorporated Intraluminal support device with graft
US7530995B2 (en) 2003-04-17 2009-05-12 3F Therapeutics, Inc. Device for reduction of pressure effects of cardiac tricuspid valve regurgitation
US7159593B2 (en) 2003-04-17 2007-01-09 3F Therapeutics, Inc. Methods for reduction of pressure effects of cardiac tricuspid valve regurgitation
WO2004096100A1 (en) 2003-04-24 2004-11-11 Cook Incorporated Artificial valve prosthesis with improved flow dynamics
WO2004096095A2 (en) 2003-04-28 2004-11-11 Medtronic, Inc. Compliant venous graft
GB0309616D0 (en) 2003-04-28 2003-06-04 Angiomed Gmbh & Co Loading and delivery of self-expanding stents
EP1472995B1 (en) 2003-04-30 2008-12-03 Medtronic Vascular, Inc. Perivascular leak repair system
EP1472996B1 (en) 2003-04-30 2009-09-30 Medtronic Vascular, Inc. Percutaneously delivered temporary valve
US8043854B2 (en) 2003-05-15 2011-10-25 Waseda University Method of decellularizing tissues
DE10322024A1 (de) 2003-05-16 2004-12-02 Symetis Ag Bioreaktor zum Herstellen einer Gewebeprothese, insbesondere Herzklappe
EP1648340B1 (en) 2003-05-19 2010-03-03 SeptRx, Inc. Tissue distention device and related methods for therapeutic intervention
WO2004103222A1 (en) 2003-05-19 2004-12-02 Cook Incorporated Implantable medical device with constrained expansion
WO2004103223A1 (en) 2003-05-20 2004-12-02 The Cleveland Clinic Foundation Apparatus and methods for repair of a cardiac valve
US7520947B2 (en) 2003-05-23 2009-04-21 Ati Properties, Inc. Cobalt alloys, methods of making cobalt alloys, and implants and articles of manufacture made therefrom
US7041127B2 (en) 2003-05-28 2006-05-09 Ledergerber Walter J Textured and drug eluting coronary artery stent
US7628804B2 (en) 2003-05-28 2009-12-08 Cook Incorporated Prosthetic valve with vessel engaging member
US7445593B2 (en) 2003-06-18 2008-11-04 The Texas A&M University System Device for proactive modulation of cardiac strain patterns
US6974862B2 (en) 2003-06-20 2005-12-13 Kensey Nash Corporation High density fibrous polymers suitable for implant
EP1648339B2 (en) 2003-07-08 2020-06-17 Ventor Technologies Ltd. Implantable prosthetic devices particularly for transarterial delivery in the treatment of aortic stenosis, and methods of implanting such devices
US7201772B2 (en) 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
NZ527025A (en) 2003-07-16 2007-01-26 David Peter Shaw Prosthetic valves for medical application
IES20030531A2 (en) 2003-07-17 2005-09-21 Medtronic Vascular Connaught Methods and devices for placing a fistula device in fluid communication with a target vessel
EP1646332B1 (en) 2003-07-18 2015-06-17 Edwards Lifesciences AG Remotely activated mitral annuloplasty system
AU2004258942B2 (en) 2003-07-21 2009-12-03 The Trustees Of The University Of Pennsylvania Percutaneous heart valve
US9498366B2 (en) 2003-07-28 2016-11-22 Baronova, Inc. Devices and methods for pyloric anchoring
DE10334868B4 (de) 2003-07-29 2013-10-17 Pfm Medical Ag Implantierbare Einrichtung als Organklappenersatz, dessen Herstellungsverfahren sowie Grundkörper und Membranelement dafür
EP1659992B1 (en) 2003-07-31 2013-03-27 Cook Medical Technologies LLC Prosthetic valve devices and methods of making such devices
FR2858543B1 (fr) 2003-08-08 2006-02-03 Assist Publ Hopitaux De Paris Anneau aortique et ancillaire pour sa pose
CA2536961A1 (en) 2003-08-14 2005-02-24 Blue Medical Devices B.V. Endoluminal prosthesis comprising a therapeutic agent
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
DE10340265A1 (de) 2003-08-29 2005-04-07 Sievers, Hans-Hinrich, Prof. Dr.med. Prothese zum Ersatz der Aorten- und/oder Mitralklappe des Herzens
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US20050075725A1 (en) 2003-10-02 2005-04-07 Rowe Stanton J. Implantable prosthetic valve with non-laminar flow
EP1684670B1 (en) 2003-10-03 2016-12-07 Edwards Lifesciences Corporation Annulopasty rings for repair of abnormal mitral valves.
WO2005046528A1 (en) 2003-10-06 2005-05-26 3F Therapeutics, Inc. Minimally invasive valve replacement system
US20060259137A1 (en) 2003-10-06 2006-11-16 Jason Artof Minimally invasive valve replacement system
US10219899B2 (en) 2004-04-23 2019-03-05 Medtronic 3F Therapeutics, Inc. Cardiac valve replacement systems
US7604650B2 (en) 2003-10-06 2009-10-20 3F Therapeutics, Inc. Method and assembly for distal embolic protection
US7842084B2 (en) 2005-06-21 2010-11-30 3F Therapeutics, Inc. Method and systems for sizing, folding, holding, and delivering a heart valve prosthesis
US9579194B2 (en) 2003-10-06 2017-02-28 Medtronic ATS Medical, Inc. Anchoring structure with concave landing zone
US20050075713A1 (en) 2003-10-06 2005-04-07 Brian Biancucci Minimally invasive valve replacement system
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
WO2005039428A2 (en) 2003-10-17 2005-05-06 Edwards Lifesciences Ag Heart valve leaflet locator
ITBO20030631A1 (it) 2003-10-23 2005-04-24 Roberto Erminio Parravicini Apparecchiatura protesica valvolare, in particolare per applicazioni cardiache.
US7070616B2 (en) 2003-10-31 2006-07-04 Cordis Corporation Implantable valvular prosthesis
US7347869B2 (en) 2003-10-31 2008-03-25 Cordis Corporation Implantable valvular prosthesis
SE526861C2 (sv) 2003-11-17 2005-11-15 Syntach Ag Vävnadslesionsskapande anordning samt en uppsättning av anordningar för behandling av störningar i hjärtrytmregleringssystemet
JP4913602B2 (ja) 2003-12-03 2012-04-11 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 医用デバイスに生細胞を磁気的にコーティングするためのキット、装置、および方法
EP1768604B1 (en) 2003-12-04 2018-01-24 Boston Scientific Scimed, Inc. System for delivering a left atrial appendage containment device
EP3332744B1 (en) 2003-12-19 2020-05-13 Cardiac Dimensions Pty. Ltd. Device for modifying the shape of a body organ
WO2005058210A1 (en) 2003-12-19 2005-06-30 Patrick Leahy An anti-reflux system
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US8328868B2 (en) 2004-11-05 2012-12-11 Sadra Medical, Inc. Medical devices and delivery systems for delivering medical devices
JP4842144B2 (ja) 2003-12-23 2011-12-21 サドラ・メディカル・インコーポレーテッド 再配備可能な心臓弁
CN101947146B (zh) 2003-12-23 2014-08-06 萨德拉医学公司 可再定位的心脏瓣膜
US8052749B2 (en) 2003-12-23 2011-11-08 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
ES2547692T3 (es) 2003-12-23 2015-10-08 Boston Scientific Scimed, Inc. Válvula cardiaca sustituible
WO2005070343A1 (fr) 2003-12-23 2005-08-04 Laboratoires Perouse Necessaire destine a etre implante dans un conduit
US20050137696A1 (en) 2003-12-23 2005-06-23 Sadra Medical Apparatus and methods for protecting against embolization during endovascular heart valve replacement
EP1557138B1 (de) 2004-01-21 2012-12-05 Admedes Schuessler GmbH Expandierbarer Stent mit Koppeleinrichtung
US7597711B2 (en) 2004-01-26 2009-10-06 Arbor Surgical Technologies, Inc. Heart valve assembly with slidable coupling connections
EP1771132B1 (en) 2004-02-03 2019-03-27 V-Wave Ltd. Device and method for controlling in-vivo pressure
DE602004023812D1 (de) 2004-02-06 2009-12-10 Sangomed S R L Externes Abstützelement zur Wiederherstellung der Funktionsfähigkeit von Venenklappen durch Zug an ihren Kommissurenwänden
WO2005082289A1 (en) 2004-02-20 2005-09-09 Cook Incorporated Prosthetic valve with spacing member
US8206439B2 (en) 2004-02-23 2012-06-26 International Heart Institute Of Montana Foundation Internal prosthesis for reconstruction of cardiac geometry
ITTO20040135A1 (it) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa Protesi valvolare cardiaca
EP2368525B1 (en) 2004-03-08 2019-09-18 Pulmonx, Inc Implanted bronchial isolation devices
EP3308744B2 (en) 2004-03-11 2023-08-02 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous heart valve prosthesis
US8777974B2 (en) 2004-03-19 2014-07-15 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects
NL1025830C2 (nl) 2004-03-26 2005-02-22 Eric Berreklouw Samenstel omvattende een ring voor bevestiging in een door lichaamsweefsel omgeven doorgang alsmede een applicator voor het in de doorgang plaatsen van de ring.
US20050228494A1 (en) 2004-03-29 2005-10-13 Salvador Marquez Controlled separation heart valve frame
EP1754684B1 (en) 2004-03-30 2016-02-03 Toyo Advanced Technologies Co., Ltd. Method for treating surface of base, surface-treated base, material for medical use and instrument for medical use
AU2005231356A1 (en) 2004-03-31 2005-10-20 Med Institute, Inc. Endoluminal graft with a prosthetic valve
US7993397B2 (en) 2004-04-05 2011-08-09 Edwards Lifesciences Ag Remotely adjustable coronary sinus implant
US7294148B2 (en) 2004-04-29 2007-11-13 Edwards Lifesciences Corporation Annuloplasty ring for mitral valve prolapse
NL1026076C2 (nl) 2004-04-29 2005-11-01 Univ Eindhoven Tech Vormdeel vervaardigd door middel van elektro-spinnen en een werkwijze voor de vervaardiging daarvan evenals de toepassing van een dergelijk vormdeel.
EP1740265B1 (en) 2004-04-30 2019-10-16 St. Jude Medical, Cardiology Division, Inc. Devices for modulation of heart valve function
CA2563426C (en) 2004-05-05 2013-12-24 Direct Flow Medical, Inc. Unstented heart valve with formed in place support structure
ES2436399T3 (es) 2004-05-14 2013-12-30 St. Jude Medical, Inc. Aparato para sostener y soportar un anillo de anuloplastia
US7803182B2 (en) 2004-05-28 2010-09-28 Cordis Corporation Biodegradable vascular device with buffering agent
US7785615B2 (en) 2004-05-28 2010-08-31 Cordis Corporation Biodegradable medical implant with encapsulated buffering agent
EP1768630B1 (en) 2004-06-16 2015-01-07 Machine Solutions, Inc. Stent crimping device
ATE383833T1 (de) 2004-06-29 2008-02-15 Sievers Hans Hinrich Prof Dr M Ringprothese für anuloplastie
US7462191B2 (en) 2004-06-30 2008-12-09 Edwards Lifesciences Pvt, Inc. Device and method for assisting in the implantation of a prosthetic valve
US7276078B2 (en) 2004-06-30 2007-10-02 Edwards Lifesciences Pvt Paravalvular leak detection, sealing, and prevention
JP2008506458A (ja) 2004-07-15 2008-03-06 ミカルディア・コーポレーション 心臓の解剖学的構造を再成形するための磁気装置および方法
EP1778127B1 (en) 2004-07-19 2015-09-02 St. Jude Medical, Inc. Heart valve support and lid liner system and methods
US7585369B2 (en) 2004-08-04 2009-09-08 Larson Marian L Apparatus for coating medical devices
CA2578259A1 (en) 2004-08-27 2006-03-09 Cook Incorporated Placement of multiple intraluminal medical devices within a body vessel
CA2578706A1 (en) 2004-09-01 2006-03-16 Cook Incorporated Delivery system which facilitates hydration of an intraluminal medical device
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
FR2874813B1 (fr) 2004-09-07 2007-06-22 Perouse Soc Par Actions Simpli Prothese valvulaire
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
FR2874812B1 (fr) 2004-09-07 2007-06-15 Perouse Soc Par Actions Simpli Valve protheique interchangeable
US20060135962A1 (en) 2004-09-09 2006-06-22 Kick George F Expandable trans-septal sheath
CA2580053C (en) 2004-09-14 2014-07-08 Edwards Lifesciences Ag. Device and method for treatment of heart valve regurgitation
JP5124274B2 (ja) 2004-09-27 2013-01-23 エヴァルヴ インコーポレイテッド 組織の把持および評価のための方法および装置
EP2491891A3 (en) 2004-10-02 2013-03-20 Endoheart AG Devices for embolic protection and mitral valve repair
EP1827577B1 (en) 2004-10-13 2008-09-24 Medtronic, Inc. Self-fixating implantable scaffolds for the administration of biological or pharmaceutical substances
US20060079736A1 (en) 2004-10-13 2006-04-13 Sing-Fatt Chin Method and device for percutaneous left ventricular reconstruction
EP1833425B1 (en) 2004-12-01 2011-02-23 Cook Incorporated Sensing delivery system for intraluminal medical devices
US7803168B2 (en) 2004-12-09 2010-09-28 The Foundry, Llc Aortic valve repair
US7758640B2 (en) 2004-12-16 2010-07-20 Valvexchange Inc. Cardiovascular valve assembly
US7674238B2 (en) 2004-12-23 2010-03-09 Boston Scientific Scimed, Inc. Methods and apparatus for emboli removal
CN101128225B (zh) 2004-12-24 2011-06-15 塞尔克斯塞尔有限公司 可植入生物材料和制造它的方法
US8287583B2 (en) 2005-01-10 2012-10-16 Taheri Laduca Llc Apparatus and method for deploying an implantable device within the body
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20060173490A1 (en) 2005-02-01 2006-08-03 Boston Scientific Scimed, Inc. Filter system and method
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
EP2410948B1 (en) 2005-02-07 2016-07-20 Abbott Vascular Devices for cardiac valve repair
US20060229708A1 (en) 2005-02-07 2006-10-12 Powell Ferolyn T Methods, systems and devices for cardiac valve repair
ITTO20050074A1 (it) 2005-02-10 2006-08-11 Sorin Biomedica Cardio Srl Protesi valvola cardiaca
EP1693025A1 (en) 2005-02-17 2006-08-23 Universität Zürich Method of manufacturing a tissue-engineered prosthesis
WO2006089236A1 (en) 2005-02-18 2006-08-24 The Cleveland Clinic Foundation Apparatus and methods for replacing a cardiac valve
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7955385B2 (en) 2005-02-28 2011-06-07 Medtronic Vascular, Inc. Device, system, and method for aiding valve annuloplasty
US9180006B2 (en) 2005-02-28 2015-11-10 Medtentia Ab Devices and a kit for improving the function of a heart valve
US20060195186A1 (en) 2005-02-28 2006-08-31 Drews Michael J Connectors for two piece heart valves and methods for implanting such heart valves
CA2602050C (en) 2005-03-11 2013-12-03 Wake Forest University Health Sciences Production of tissue engineered heart valves
FR2882916B1 (fr) 2005-03-14 2007-06-15 Assist Publ Hopitaux De Paris Dispositif de mesure du diametre d'un panneau aortique
WO2006102063A2 (en) 2005-03-19 2006-09-28 Cook Biotech Incorporated Prosthetic implants including ecm composite material
KR100691503B1 (ko) 2005-03-21 2007-03-09 (주) 태웅메디칼 식도용 스텐트
US7575595B2 (en) 2005-03-23 2009-08-18 Edwards Lifesciences Corporation Annuloplasty ring and holder combination
US7842085B2 (en) 2005-03-23 2010-11-30 Vaso Adzich Annuloplasty ring and holder combination
US7736385B2 (en) 2005-03-24 2010-06-15 Cook Incorporated Exchangeable delivery system with distal protection
US9492276B2 (en) 2005-03-25 2016-11-15 St. Jude Medical, Cardiology Division, Inc. Methods and apparatus for controlling the internal circumference of an anatomic orifice or lumen
FR2883721B1 (fr) 2005-04-05 2007-06-22 Perouse Soc Par Actions Simpli Necessaire destine a etre implante dans un conduit de circulation du sang, et endoprothese tubulaire associee
US8062359B2 (en) 2005-04-06 2011-11-22 Edwards Lifesciences Corporation Highly flexible heart valve connecting band
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
SE531468C2 (sv) 2005-04-21 2009-04-14 Edwards Lifesciences Ag En anordning för styrning av blodflöde
EP1874954B1 (en) 2005-04-27 2017-12-27 Stout Medical Group, L.P. Expandable support device
ATE534346T1 (de) 2005-05-06 2011-12-15 Sorin Biomedica Cardio Srl Annuloplastieprothese
AU2006247571A1 (en) 2005-05-13 2006-11-23 Cook Incorporated Medical device delivery systems that facilitate medical device placement in the presence of ultrasonic waves
WO2006125055A2 (en) 2005-05-17 2006-11-23 Cook Incorporated Prosthetic valve devices and methods of making and using such devices
WO2006122573A1 (en) 2005-05-17 2006-11-23 Syntach Ag A device a kit for treatment of disorders in the heart rhythm regulation system
JP4912395B2 (ja) 2005-05-24 2012-04-11 エドワーズ ライフサイエンシーズ コーポレイション 迅速配置式補綴用心臓弁
US8974523B2 (en) 2005-05-27 2015-03-10 Hlt, Inc. Stentless support structure
US8663312B2 (en) 2005-05-27 2014-03-04 Hlt, Inc. Intravascular cuff
US8211169B2 (en) 2005-05-27 2012-07-03 Medtronic, Inc. Gasket with collar for prosthetic heart valves and methods for using them
US7739971B2 (en) 2005-06-07 2010-06-22 Edwards Lifesciences Corporation Systems and methods for assembling components of a fabric-covered prosthetic heart valve
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US7780723B2 (en) 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
US8685083B2 (en) 2005-06-27 2014-04-01 Edwards Lifesciences Corporation Apparatus, system, and method for treatment of posterior leaflet prolapse
US8663277B2 (en) 2005-06-29 2014-03-04 Ethicon, Inc. Braided barbed suture
EP1913899B1 (en) 2005-07-08 2010-10-06 Beijing Balance Medical Co. Ltd. A valved patch and a valved tube for repairing a cardiac outflow vessel
US7776084B2 (en) 2005-07-13 2010-08-17 Edwards Lifesciences Corporation Prosthetic mitral heart valve having a contoured sewing ring
EP1919397B1 (en) 2005-07-13 2013-01-02 Medtronic, Inc. Two-piece percutaneous prosthetic heart valves
DE102005032974B4 (de) 2005-07-14 2013-11-07 Siemens Aktiengesellschaft Verfahren zur 3D-Visualisierung vaskulärer Einsatzstücke im menschlichen Körper mit dem C-Bogen
CA2615467A1 (en) 2005-07-15 2007-01-25 The Cleveland Clinic Foundation Apparatus and method for remodeling a cardiac valve annulus
US8790396B2 (en) 2005-07-27 2014-07-29 Medtronic 3F Therapeutics, Inc. Methods and systems for cardiac valve delivery
WO2007016165A1 (en) 2005-07-29 2007-02-08 Cook Incorporated Elliptical implantable device
WO2007016260A2 (en) 2005-07-29 2007-02-08 Cvdevices, Llc. Devices and methods for controlling blood perfusion pressure using a retrograde cannula
WO2007022519A2 (en) 2005-08-19 2007-02-22 Chf Technologies, Inc. Steerable heart implants for congestive heart failure
US7455689B2 (en) 2005-08-25 2008-11-25 Edwards Lifesciences Corporation Four-leaflet stented mitral heart valve
US9492277B2 (en) 2005-08-30 2016-11-15 Mayo Foundation For Medical Education And Research Soft body tissue remodeling methods and apparatus
WO2007028052A2 (en) 2005-09-01 2007-03-08 Cook Incorporated Attachment of material to an implantable frame by cross-linking
JP4958907B2 (ja) 2005-09-07 2012-06-20 メドテンチア インターナショナル エルティーディ オーワイ 心臓弁の機能を改善するための機器および方法
US7530253B2 (en) 2005-09-09 2009-05-12 Edwards Lifesciences Corporation Prosthetic valve crimping device
US7712606B2 (en) 2005-09-13 2010-05-11 Sadra Medical, Inc. Two-part package for medical implant
DE102005044009A1 (de) 2005-09-14 2007-03-22 Biophan Europe Gmbh Biologische oder künstliche Klappenprothese zur Verwendung im menschlichen und/oder tierischen Körper zum Einsatz einer Organklappe oder Gefäßklappe
US7972359B2 (en) 2005-09-16 2011-07-05 Atritech, Inc. Intracardiac cage and method of delivering same
US7569071B2 (en) 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
WO2007038089A2 (en) 2005-09-21 2007-04-05 Medtronic, Inc. Composite heart valve apparatus manufactured using techniques involving laser machining of tissue
EP1945142B1 (en) 2005-09-26 2013-12-25 Medtronic, Inc. Prosthetic cardiac and venous valves
US20070073391A1 (en) 2005-09-28 2007-03-29 Henry Bourang System and method for delivering a mitral valve repair device
FR2891134B1 (fr) 2005-09-29 2008-08-22 Jean Noel Fabiani Prothese annulaire pour plastie valvulaire aortique, procede pour plastie valvulaire aortique et combinaison de la prothese annulaire et d'une prothese pour segment aortique
US8007530B2 (en) 2005-09-30 2011-08-30 Medtronic, Inc. Tool and method for implanting an annuloplasty prosthesis
US9265605B2 (en) 2005-10-14 2016-02-23 Boston Scientific Scimed, Inc. Bronchoscopic lung volume reduction valve
US8167932B2 (en) 2005-10-18 2012-05-01 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
US7503928B2 (en) 2005-10-21 2009-03-17 Cook Biotech Incorporated Artificial valve with center leaflet attachment
US20070100441A1 (en) 2005-10-26 2007-05-03 St. Jude Medical, Inc. Saddle-shaped mitral valve annuloplasty prostheses with asymmetry, and related methods
US8092525B2 (en) 2005-10-26 2012-01-10 Cardiosolutions, Inc. Heart valve implant
US8449606B2 (en) 2005-10-26 2013-05-28 Cardiosolutions, Inc. Balloon mitral spacer
DE102005051849B4 (de) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen
ES2882051T3 (es) 2005-11-02 2021-12-01 Medicaltree Patents Ltd Válvula artificial para implante
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
FR2892939B1 (fr) 2005-11-10 2010-01-22 Groupement Coeur Artificiel Total Carpentier Matra Carmat Materiau hemocompatible composite et son procede d'obtention
CA2629534C (en) 2005-11-10 2015-02-24 Arshad Quadri Balloon-expandable, self-expanding, vascular prosthesis connecting stent
ATE429194T1 (de) 2005-11-16 2009-05-15 Micardia Corp Magnetische befestigung eines katheters an ein implantat
US8764820B2 (en) 2005-11-16 2014-07-01 Edwards Lifesciences Corporation Transapical heart valve delivery system and method
CN100362971C (zh) 2005-11-16 2008-01-23 程英升 贲门支架
GB0524087D0 (en) 2005-11-25 2006-01-04 Symetis Ag Biodegradable scaffold
FR2894131B1 (fr) 2005-12-02 2008-12-05 Perouse Soc Par Actions Simpli Dispositif de traitement d'un vaisseau sanguin, et necessaire de traitement associe.
CA2631662C (en) 2005-12-07 2014-08-05 Arbor Surgical Technologies, Inc. Connection systems for two piece prosthetic heart valve assemblies
EP1959865B1 (en) 2005-12-15 2014-12-10 The Cleveland Clinic Foundation Apparatus for treating a regurgitant valve
CA2669188C (en) 2005-12-15 2014-08-05 Georgia Tech Research Corporation Papillary muscle position control devices, systems, & methods
AU2006328896B2 (en) 2005-12-22 2013-08-29 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US9308077B2 (en) 2005-12-23 2016-04-12 Vysera Biomedical Limited Medical device suitable for treating reflux from a stomach to an oesophagus
DE602005015238D1 (de) 2005-12-28 2009-08-13 Sorin Biomedica Cardio Srl Prothese für Annuloplastie mit auxetischer Struktur
DK1968482T3 (da) 2006-01-04 2009-10-26 Nanosin Sarl Kunstigt kontraktilt væv
US9717468B2 (en) 2006-01-10 2017-08-01 Mediguide Ltd. System and method for positioning an artificial heart valve at the position of a malfunctioning valve of a heart through a percutaneous route
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
EP1991168B1 (en) 2006-02-16 2016-01-27 Transcatheter Technologies GmbH Minimally invasive heart valve replacement
US8219229B2 (en) 2006-03-02 2012-07-10 Edwards Lifesciences Corporation Virtual heart valve
US7431692B2 (en) 2006-03-09 2008-10-07 Edwards Lifesciences Corporation Apparatus, system, and method for applying and adjusting a tensioning element to a hollow body organ
DE102006013113B4 (de) 2006-03-22 2008-12-11 Vielberg, Heinrich, Dr. med. Ventilgetriebe
WO2007123658A1 (en) 2006-03-28 2007-11-01 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
RU2325874C2 (ru) 2006-04-04 2008-06-10 Александр Васильевич Самков Протез клапана сердца
FR2899096B1 (fr) 2006-04-04 2008-12-05 Perouse Soc Par Actions Simpli Dispositif de traitement d'un conduit de circulation du sang et procede de preparation de ce dispositif
US8454683B2 (en) 2006-04-12 2013-06-04 Medtronic Vascular, Inc. Annuloplasty device having a helical anchor and methods for its use
US7806926B2 (en) 2006-04-14 2010-10-05 Edwards Lifesciences Corporation Holders for prosthetic aortic heart valves
WO2007124053A1 (en) 2006-04-19 2007-11-01 William A. Cook Australia Pty. Ltd. Twin bifurcated stent graft
CN101442958B (zh) 2006-04-28 2012-09-05 麦德托尼克公司 心脏瓣膜替换设备
JP5016667B2 (ja) 2006-04-29 2012-09-05 メドトロニック，インコーポレイテッド 複数部材の人工心臓弁アセンブリ並びにそれを用いた装置及びその使用方法
CA2651281A1 (en) 2006-05-05 2007-11-15 Children's Medical Center Corporation Transcatheter heart valve prostheses
ATE499074T1 (de) 2006-05-15 2011-03-15 Edwards Lifesciences Ag System zur veränderung der geometrie des herzens
WO2007131553A1 (en) 2006-05-17 2007-11-22 Syntach Ag A controllable device, a kit and a method for treatment of disorders in the heart rhythm regulation system
US8932348B2 (en) 2006-05-18 2015-01-13 Edwards Lifesciences Corporation Device and method for improving heart valve function
JP5208926B2 (ja) 2006-05-19 2013-06-12 ミトラル・ソリューションズ・インコーポレイテッド 解剖学的な構造又は内腔のサイズ及び形状を制御するための移植可能な装置
AU2007268123A1 (en) 2006-05-25 2007-12-06 Deep Vein Medical, Inc. Device for regulating blood flow
CA2653913C (en) 2006-05-30 2012-04-17 Cook Incorporated Artificial valve prosthesis
EP2032080B1 (en) 2006-06-01 2017-05-03 Edwards Lifesciences Corporation Prosthetic insert for improving heart valve function
US8197538B2 (en) 2006-06-02 2012-06-12 Medtronic, Inc. Annuloplasty prosthesis with in vivo shape identification and related methods of use
US9283073B2 (en) 2006-06-02 2016-03-15 Medtronic, Inc. Annuloplasty ring and method
ITTO20060413A1 (it) 2006-06-07 2007-12-08 Arrigo Lessana Dispositivo sostitutivo delle corde tendinee di una valvola atrioventricolare
EP1864687B1 (en) 2006-06-09 2013-07-31 Eidgenössische Technische Hochschule Zürich Scaffolds for artificial heart valves and vascular structures
US20080004696A1 (en) 2006-06-29 2008-01-03 Valvexchange Inc. Cardiovascular valve assembly with resizable docking station
JP4981374B2 (ja) 2006-07-10 2012-07-18 パーパス株式会社 細胞又は組織の培養装置及び培養方法
US20080021546A1 (en) 2006-07-18 2008-01-24 Tim Patz System for deploying balloon-expandable heart valves
RU2325873C2 (ru) 2006-07-20 2008-06-10 Александр Васильевич Самков Створка искусственного клапана сердца и способ ее изготовления
US8020503B2 (en) 2006-07-31 2011-09-20 Edwards Lifesciences Corporation Automated surgical implant sewing system and method
US7363821B2 (en) 2006-08-28 2008-04-29 Cordis Corporation Systems and methods for fatigue testing stents
WO2008025855A2 (en) 2006-09-01 2008-03-06 Zotz Rainer J Devices, system, kit and method for epicardial access
US20080058924A1 (en) 2006-09-01 2008-03-06 Aaron Ingle Saddle-shaped annuloplasty ring
ATE470410T1 (de) 2006-09-08 2010-06-15 Edwards Lifesciences Corp Integriertes system zum einsatz eines herzventils
US8052750B2 (en) 2006-09-19 2011-11-08 Medtronic Ventor Technologies Ltd Valve prosthesis fixation techniques using sandwiching
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
US9211115B2 (en) 2006-09-28 2015-12-15 Bioventrix, Inc. Location, time, and/or pressure determining devices, systems, and methods for deployment of lesion-excluding heart implants for treatment of cardiac heart failure and other disease states
FR2906454B1 (fr) 2006-09-28 2009-04-10 Perouse Soc Par Actions Simpli Implant destine a etre place dans un conduit de circulation du sang.
US7534261B2 (en) 2006-10-02 2009-05-19 Edwards Lifesciences Corporation Sutureless heart valve attachment
US7575592B2 (en) 2006-10-03 2009-08-18 St. Jude Medical, Inc. Synthetic blood vessel grafts
US8029556B2 (en) 2006-10-04 2011-10-04 Edwards Lifesciences Corporation Method and apparatus for reshaping a ventricle
US8163011B2 (en) 2006-10-06 2012-04-24 BioStable Science & Engineering, Inc. Intra-annular mounting frame for aortic valve repair
FR2906998B1 (fr) 2006-10-16 2009-04-10 Perouse Soc Par Actions Simpli Implant destine a etre place dans un conduit de circulation du sang.
US8388680B2 (en) 2006-10-18 2013-03-05 Guided Delivery Systems, Inc. Methods and devices for catheter advancement and delivery of substances therethrough
US8007992B2 (en) 2006-10-27 2011-08-30 Edwards Lifesciences Corporation Method of treating glutaraldehyde-fixed pericardial tissue with a non-aqueous mixture of glycerol and a C1-C3 alcohol
US7771467B2 (en) 2006-11-03 2010-08-10 The Cleveland Clinic Foundation Apparatus for repairing the function of a native aortic valve
DE102006052564B3 (de) 2006-11-06 2007-12-13 Georg Lutter Mitralklappenstent
EP2081515B1 (en) 2006-11-07 2015-10-21 Cook Medical Technologies LLC Fenestrations for stent graft arrangements and stent graft including the same
EP1920789A1 (en) 2006-11-11 2008-05-14 Universitätsklinikum Hamburg-Eppendorf Pouch-like construct comprising mammalian tissue
SE530568C2 (sv) 2006-11-13 2008-07-08 Medtentia Ab Anordning och metod för förbättring av funktionen hos en hjärtklaff
WO2008060553A1 (en) 2006-11-14 2008-05-22 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Transcatheter coronary sinus mitral valve annuloplasty procedure and coronary artery and myocardial protection device
JP2010511469A (ja) 2006-12-05 2010-04-15 バルテック カーディオ，リミティド セグメント化リング配置
CN101641061B (zh) 2006-12-06 2013-12-18 美顿力科尔瓦有限责任公司 用于环锚固的自膨胀瓣膜的经心尖递送的系统和方法
FR2909857B1 (fr) 2006-12-14 2009-03-06 Perouse Soc Par Actions Simpli Endovalve.
EP1935377B1 (en) 2006-12-19 2010-03-24 Sorin Biomedica Cardio S.R.L. Instrument for in situ deployment of cardiac valve prostheses
EP1935378B1 (en) 2006-12-19 2014-09-17 Sorin Group Italia S.r.l. Instrument for in situ positioning of cardiac valve prostheses
JP5238716B2 (ja) 2006-12-19 2013-07-17 セント ジュード メディカル インコーポレイテッド ステント構造及び組織弁小葉を有する人工心臓弁、及び関連する方法
FR2910269B1 (fr) 2006-12-22 2009-02-27 Corevalve Inc Materiel de traitement d'une valve cardiaque,en particulier d'une valve mitrale
US8236045B2 (en) 2006-12-22 2012-08-07 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method of making the same
WO2008085814A2 (en) 2007-01-03 2008-07-17 Mitralsolutions, Inc. Implantable devices for controlling the size and shape of an anatomical structure or lumen
DE602007004180D1 (de) 2007-01-15 2010-02-25 Chang Jen Ping Vorrichtung zur Prüfung der Tüchtigkeit einer Aortenklappe und einer Pulmonalklappe
EP2111190B1 (en) 2007-01-19 2013-10-09 Medtronic, Inc. Stented heart valve devices for atrioventricular valve replacement
CA2676541C (en) 2007-01-26 2015-08-11 Medtronic, Inc. Annuloplasty device for tricuspid valve repair
DE102007005900A1 (de) 2007-02-01 2008-08-07 Endosmart Gesellschaft für innovative Medizintechnik mbH Instrument zum operativen Entfernen einer defekten Herzklappe
EP2111337B1 (en) 2007-02-05 2013-07-03 Boston Scientific Limited Synthetic composite structures
JP5313928B2 (ja) 2007-02-05 2013-10-09 ボストン サイエンティフィック リミテッド 経皮的な弁およびシステム
JP2010517624A (ja) 2007-02-05 2010-05-27 ボストン サイエンティフィック リミテッド 経皮的手技用の弁、システム及び方法
US9415567B2 (en) 2007-02-05 2016-08-16 Boston Scientific Scimed, Inc. Synthetic composite structures
CA2677361C (en) 2007-02-09 2016-04-05 Edwards Lifesciences Corporation Progressively sized annuloplasty rings
US20080195126A1 (en) 2007-02-14 2008-08-14 Jan Otto Solem Suture and method for repairing a heart
CA2677633C (en) 2007-02-15 2015-09-08 Medtronic, Inc. Multi-layered stents and methods of implanting
WO2008101083A2 (en) 2007-02-15 2008-08-21 Cook Incorporated Artificial valve prostheses with a free leaflet portion
EP1958598A1 (de) 2007-02-16 2008-08-20 Universität Zürich Wachstumsfähige, rohrförmige Stützprothese
US9504568B2 (en) 2007-02-16 2016-11-29 Medtronic, Inc. Replacement prosthetic heart valves and methods of implantation
WO2008098777A1 (de) 2007-02-16 2008-08-21 Universität Zürich Rohrförmige stützprothese mit herzklappe insbesondere für aortenklappenersatz
DE102007010305A1 (de) 2007-02-22 2008-08-28 Jotec Gmbh Vorrichtung zum Freisetzen eines selbstexpandierenden Stents in ein Körpergefäß
US8221505B2 (en) 2007-02-22 2012-07-17 Cook Medical Technologies Llc Prosthesis having a sleeve valve
US7753949B2 (en) 2007-02-23 2010-07-13 The Trustees Of The University Of Pennsylvania Valve prosthesis systems and methods
US20080208327A1 (en) 2007-02-27 2008-08-28 Rowe Stanton J Method and apparatus for replacing a prosthetic valve
US8100959B2 (en) 2007-03-09 2012-01-24 Pulmonx Corporation Loading device for a pulmonary implant
US8303622B2 (en) 2007-03-14 2012-11-06 St. Jude Medical, Inc. Heart valve chordae replacement methods and apparatus
FR2913879B1 (fr) 2007-03-21 2009-06-12 Perouse Soc Par Actions Simpli Dispositif de largage d'un implant expansible radialement, necessaire de traitement et procede de largage associe
CN101742975B (zh) 2007-04-13 2013-03-06 耶拿阀门科技公司 用于治疗心脏瓣膜关闭不全或狭窄的医疗装置
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
US8409274B2 (en) 2007-04-26 2013-04-02 St. Jude Medical, Inc. Techniques for attaching flexible leaflets of prosthetic heart valves to supporting structures
US8529620B2 (en) 2007-05-01 2013-09-10 Ottavio Alfieri Inwardly-bowed tricuspid annuloplasty ring
FR2915678B1 (fr) 2007-05-02 2010-04-16 Lapeyre Ind Llc Valve cardiaque prothetique mecanique
US8147504B2 (en) 2007-05-05 2012-04-03 Medtronic, Inc. Apparatus and methods for delivering fasteners during valve replacement
FR2915903B1 (fr) 2007-05-10 2010-06-04 Carpentier Matra Carmat Procede pour la realisation d'un objet hemocompatible de configuration complexe et objet ainsi obtenu.
CA2683193A1 (en) 2007-05-15 2008-11-20 Jenavalve Technology Inc. Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent
US8403979B2 (en) 2007-05-17 2013-03-26 Cook Medical Technologies Llc Monocuspid prosthetic valve having a partial sinus
ATE459307T1 (de) 2007-05-21 2010-03-15 Sala Berardino Della ELEKTROMAGNETISCH SCHLIEßBARES RÜCKSCHLAGVENTIL FÜR BIOLOGISCHE FLÜSSIGKEITPUMPEN
FR2916627B1 (fr) 2007-05-30 2010-09-17 Perouse Lab Necessaire de traitement d'un conduit de circulation du sang
JP5367700B2 (ja) 2007-06-04 2013-12-11 セント ジュード メディカル インコーポレイテッド 人工心臓弁
FR2916959B1 (fr) 2007-06-08 2009-09-04 Perouse Soc Par Actions Simpli Necessaire destine a etre implante dans un conduit de circulation de sang
US9101691B2 (en) 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
AU2008269018B2 (en) 2007-06-26 2014-07-31 St. Jude Medical, Inc. Apparatus and methods for implanting collapsible/expandable prosthetic heart valves
DE102007031146A1 (de) 2007-06-27 2009-01-08 Aesculap Ag Sinusflicken zum Ersatz von defekten Sinus an der Aortenwurzel
DE102007031148A1 (de) 2007-06-27 2009-01-08 Aesculap Ag Aortensinusprothese
EP2014257B1 (en) 2007-07-12 2010-09-08 Sorin Biomedica Cardio S.R.L. Expandable prosthetic valve crimping device
US8663319B2 (en) 2007-07-23 2014-03-04 Hocor Cardiovascular Technologies Llc Methods and apparatus for percutaneous aortic valve replacement
US9308086B2 (en) 2010-09-21 2016-04-12 Hocor Cardiovascular Technologies Llc Method and system for balloon counterpulsation during aortic valve replacement
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US9566178B2 (en) 2010-06-24 2017-02-14 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
DE202008018551U1 (de) 2007-08-21 2015-10-26 Symetis Sa Eine Ersatzklappe
US20090088836A1 (en) 2007-08-23 2009-04-02 Direct Flow Medical, Inc. Translumenally implantable heart valve with formed in place support
WO2009029199A1 (en) 2007-08-24 2009-03-05 St. Jude Medical, Inc. Prosthetic aortic heart valves
US8834551B2 (en) 2007-08-31 2014-09-16 Rex Medical, L.P. Vascular device with valve for approximating vessel wall
US8092363B2 (en) 2007-09-05 2012-01-10 Mardil, Inc. Heart band with fillable chambers to modify heart valve function
EP2185107B1 (en) 2007-09-07 2017-01-25 Edwards Lifesciences Corporation Active holder for annuloplasty ring delivery
US20090105794A1 (en) 2007-09-07 2009-04-23 Ziarno W Andrew Microprocessor controlled delivery system for cardiac valve prosthesis
FR2920664B1 (fr) 2007-09-11 2010-09-10 Perouse Lab Dispositif de traitement d'un conduit de circulation du sang
FR2932376B1 (fr) 2008-06-11 2011-04-01 Perouse Lab Dispositif de traitement d'un conduit de circulation du sang
DE102007043830A1 (de) 2007-09-13 2009-04-02 Lozonschi, Lucian, Madison Herzklappenstent
EP3028670B1 (en) 2007-09-26 2023-12-20 St. Jude Medical, LLC Collapsible prosthetic heart valves
US8136230B2 (en) 2007-10-12 2012-03-20 Spiration, Inc. Valve loader method, system, and apparatus
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
US7981151B2 (en) 2007-10-15 2011-07-19 Edwards Lifesciences Corporation Transcatheter heart valve with micro-anchors
US20090105813A1 (en) 2007-10-17 2009-04-23 Sean Chambers Implantable valve device
US8647381B2 (en) 2007-10-25 2014-02-11 Symetis Sa Stents, valved-stents, and methods and systems for delivery thereof
ATE543461T1 (de) 2007-11-05 2012-02-15 St Jude Medical Falt- und dehnbare herzklappenprothesen mit nicht dehnbaren stent-säulen und wiederentnahmefunktion
US8715337B2 (en) 2007-11-09 2014-05-06 Cook Medical Technologies Llc Aortic valve stent graft
WO2009067432A1 (en) 2007-11-19 2009-05-28 Cook Incorporated Valve frame
DE102007061301A1 (de) 2007-12-10 2009-06-18 Aesculap Ag Ummantelung zur Wiederherstellung der Klappenfunktion variköser Venen und Verwendung der Ummantelung in der Chirurgie
HRP20211382T1 (hr) 2007-12-14 2021-12-24 Edwards Lifesciences Corporation Okvir za pričvršćivanje listića za protetski zalistak
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
EP2072027B1 (en) 2007-12-21 2020-06-17 Medtentia International Ltd Oy pre-annuloplasty device and method
US20090171456A1 (en) 2007-12-28 2009-07-02 Kveen Graig L Percutaneous heart valve, system, and method
JP2011508652A (ja) 2008-01-04 2011-03-17 インターベンショナル アンド サージカル イノベーションズ，エルエルシー 血流制御装置
JP5591120B2 (ja) 2008-01-16 2014-09-17 セント ジュード メディカル インコーポレイテッド 折りたたみ可能／拡張可能な人工心臓弁の送達及び回収システム
EP2254512B1 (en) 2008-01-24 2016-01-06 Medtronic, Inc. Markers for prosthetic heart valves
US9364324B2 (en) 2008-01-24 2016-06-14 Medtronic Vascular, Inc. Infundibular reducer device delivery system and related methods
EP2082690B1 (en) 2008-01-24 2012-06-20 Kardium, Inc. Medical device to assist diastolic function and prevent ventricular enlargement
US8157853B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
EP2254513B1 (en) 2008-01-24 2015-10-28 Medtronic, Inc. Stents for prosthetic heart valves
DK2254514T3 (en) 2008-01-24 2018-12-17 Medtronic Inc STENTS FOR HEART VALVE PROSTHESIS
US7993395B2 (en) 2008-01-25 2011-08-09 Medtronic, Inc. Set of annuloplasty devices with varying anterior-posterior ratios and related methods
EP2249711B1 (en) 2008-02-06 2021-10-06 Ancora Heart, Inc. Multi-window guide tunnel
KR101621486B1 (ko) 2008-02-08 2016-05-16 하트웨어, 인코포레이티드 심실내 배치용 심실보조장치
EP2520252A1 (en) 2008-02-11 2012-11-07 Corassist Cardiovascular Ltd. Ventricular function assisting devices and methods of use thereof
AU2009219415B2 (en) 2008-02-25 2013-01-17 Medtronic Vascular Inc. Infundibular reducer devices
CA2787245A1 (en) 2008-02-26 2009-09-03 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US20090264989A1 (en) 2008-02-28 2009-10-22 Philipp Bonhoeffer Prosthetic heart valve systems
CN103637861B (zh) 2008-02-29 2016-05-25 爱德华兹生命科学公司 用于部署假体装置的可扩展元件
DE102008012438B4 (de) 2008-02-29 2014-12-24 Nvt Ag Mechanische Aortenklappe für die endovaskuläre Implantation
DE102008012113A1 (de) 2008-03-02 2009-09-03 Transcatheter Technologies Gmbh Stent, welcher vom expandierten Zustand erneut im Durchmesser kontrolliert verringerbar ist
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
DE102008015781B4 (de) 2008-03-26 2011-09-29 Malte Neuss Vorrichtung zum Verschluss von Defekten im Gefäßsystem
ATE507801T1 (de) 2008-03-27 2011-05-15 Ab Medica Spa KLAPPENPROTHESE ZUR IMPLANTATION IN KÖRPERGEFÄßE
US7806919B2 (en) 2008-04-01 2010-10-05 Medtronic Vascular, Inc. Double-walled stent system
US8430927B2 (en) 2008-04-08 2013-04-30 Medtronic, Inc. Multiple orifice implantable heart valve and methods of implantation
CA2753027C (en) 2008-04-09 2016-06-14 Georgia Tech Research Corporation Annuloplasty rings and methods for heart valve repair
US8262725B2 (en) 2008-04-16 2012-09-11 Cardiovascular Technologies, Llc Transvalvular intraannular band for valve repair
FR2930137B1 (fr) 2008-04-18 2010-04-23 Corevalve Inc Materiel de traitement d'une valve cardiaque, en particulier d'une valve mitrale.
WO2009130631A2 (en) 2008-04-21 2009-10-29 Simcha Milo Surgical stapling systems
US8323336B2 (en) * 2008-04-23 2012-12-04 Medtronic, Inc. Prosthetic heart valve devices and methods of valve replacement
KR101617052B1 (ko) 2008-04-23 2016-04-29 메드트로닉 인코포레이티드 스텐트 부착 심장 판막 장치
US20090276040A1 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
CA2723881C (en) 2008-05-09 2017-06-06 Edwards Lifesciences Corporation Degenerative valvular disease specific annuloplasty rings
US9061119B2 (en) 2008-05-09 2015-06-23 Edwards Lifesciences Corporation Low profile delivery system for transcatheter heart valve
US8152844B2 (en) 2008-05-09 2012-04-10 Edwards Lifesciences Corporation Quick-release annuloplasty ring holder
US20090287303A1 (en) 2008-05-13 2009-11-19 Edwards Lifesciences Corporation Physiologically harmonized tricuspid annuloplasty ring
US8668668B2 (en) 2008-05-14 2014-03-11 Onset Medical Corporation Expandable iliac sheath and method of use
ES2386239T3 (es) 2008-05-16 2012-08-14 Sorin Biomedica Cardio S.R.L. Prótesis cardiovalvular atraumática
GB0809357D0 (en) 2008-05-22 2008-07-02 Punjabi Prakash Heart valve repair device
CA2726807C (en) 2008-06-05 2016-05-31 Medtronic, Inc. Connection systems for two piece prosthetic heart valve assemblies and methods for making and using them
PT4233799T (pt) 2008-06-06 2024-08-08 Edwards Lifesciences Corp Válvula cardíaca transcateter de baixo perfil
US9192472B2 (en) 2008-06-16 2015-11-24 Valtec Cardio, Ltd. Annuloplasty devices and methods of delivery therefor
WO2009153770A1 (en) 2008-06-20 2009-12-23 Vysera Biomedical Limited Esophageal valve
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
ES2659081T3 (es) 2008-06-20 2018-03-13 Coloplast A/S Un biomaterial
US8206635B2 (en) 2008-06-20 2012-06-26 Amaranth Medical Pte. Stent fabrication via tubular casting processes
WO2010008451A2 (en) 2008-06-23 2010-01-21 Lumen Biomedical, Inc. Embolic protection during percutaneous heart valve replacement and similar procedures
AU2009271574B2 (en) 2008-07-15 2015-05-21 St. Jude Medical, Inc. Axially anchoring collapsible and re-expandable prosthetic heart valves for various disease states
ES2570592T3 (es) 2008-07-15 2016-05-19 St Jude Medical Diseños de manguito colapsable y reexpansible de válvula cardiaca protésica y aplicaciones tecnológicas complementarias
WO2010006627A1 (en) 2008-07-17 2010-01-21 Nvt Ag Cardiac valve prosthesis system
CN104771248B (zh) 2008-07-21 2018-06-05 爱德华兹生命科学卡迪尔克有限责任公司 可重新定位的腔内支撑结构及其应用
EP2313152B1 (en) 2008-07-21 2022-08-31 Bioventrix Cardiac anchor structures
RU2373900C1 (ru) 2008-07-23 2009-11-27 Закрытое Акционерное Общество Научно-Производственное Предприятие "Мединж" Протез клапана сердца
US9232992B2 (en) 2008-07-24 2016-01-12 Aga Medical Corporation Multi-layered medical device for treating a target site and associated method
EP2326264B1 (en) 2008-07-27 2017-11-15 Pi-R-Squared Ltd. Fracturing calcifications in heart valves
BRPI0916696A2 (pt) 2008-07-29 2015-11-17 St Jude Medical Cardiology Div método e sistema para ajuste a longo prazo de um dispositivo de implante
US8337390B2 (en) 2008-07-30 2012-12-25 Cube S.R.L. Intracardiac device for restoring the functional elasticity of the cardiac structures, holding tool for the intracardiac device, and method for implantation of the intracardiac device in the heart
WO2010020660A1 (en) 2008-08-19 2010-02-25 Dsm Ip Assets B.V. Implantable valve prosthesis and method for manufacturing such a valve
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
AU2008360983A1 (en) 2008-08-25 2010-03-04 Cardiokinetix, Inc. Retrievable cardiac devices
US8998981B2 (en) 2008-09-15 2015-04-07 Medtronic, Inc. Prosthetic heart valve having identifiers for aiding in radiographic positioning
EP2358308B1 (en) 2008-09-15 2019-11-27 Medtronic, Inc. Tools for remodeling tissue
US8721714B2 (en) 2008-09-17 2014-05-13 Medtronic Corevalve Llc Delivery system for deployment of medical devices
EP2344075B1 (en) 2008-09-19 2018-12-05 Edwards Lifesciences Corporation Annuloplasty ring configured to receive a percutaneous prosthetic heart valve implantation
EP4218675A3 (en) 2008-09-19 2023-08-30 Edwards Lifesciences Corporation Prosthetic heart valve configured to receive a percutaneous prosthetic heart valve implantation
AU2009295960A1 (en) 2008-09-29 2010-04-01 Cardiaq Valve Technologies, Inc. Heart valve
EP2341871B1 (en) 2008-10-01 2017-03-22 Edwards Lifesciences CardiAQ LLC Delivery system for vascular implant
EP2344090B8 (en) 2008-10-09 2017-11-08 Xsat (Pty) Ltd. A stent deployment device
NL1036038C (en) 2008-10-09 2010-04-14 Univ Eindhoven Tech Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof.
EP2349096B1 (en) 2008-10-10 2021-01-27 MedicalTree Patent Ltd. An improved artificial valve
EP4454553A3 (en) 2008-10-10 2024-11-27 MedicalTree Patent Ltd. An improved artifical valve
ES2949294T3 (es) 2008-10-10 2023-09-27 Medicaltree Patent Ltd Válvula artificial mejorada
JP2012504985A (ja) 2008-10-10 2012-03-01 グット，カルステン，ニルス 埋め込み装置及び埋め込み方法
US8137398B2 (en) 2008-10-13 2012-03-20 Medtronic Ventor Technologies Ltd Prosthetic valve having tapered tip when compressed for delivery
US8449625B2 (en) 2009-10-27 2013-05-28 Edwards Lifesciences Corporation Methods of measuring heart valve annuluses for valve replacement
US8986361B2 (en) 2008-10-17 2015-03-24 Medtronic Corevalve, Inc. Delivery system for deployment of medical devices
AU2009305960B2 (en) 2008-10-20 2013-10-17 Corassist Cardiovascular Ltd. Ventricular function assisting device and a method and apparatus for implanting it
EP2367504B1 (en) 2008-10-30 2014-08-06 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valve delivery system and methods
US9682242B2 (en) 2008-11-14 2017-06-20 Bal Seal Engineering, Inc. Connector with low lead insertion force and method of reducing same
EP2358297B1 (en) 2008-11-21 2019-09-11 Percutaneous Cardiovascular Solutions Pty Limited Heart valve prosthesis
CA2743719C (en) 2008-11-25 2019-03-19 Edwards Lifesciences Corporation Apparatus and method for in situ expansion of prosthetic device
WO2010065912A1 (en) 2008-12-04 2010-06-10 Georgia Tech Research Corporation Method and apparatus for minimally invasive heart valve procedures
US8591573B2 (en) 2008-12-08 2013-11-26 Hector Daniel Barone Prosthetic valve for intraluminal implantation
RU2526567C2 (ru) 2008-12-12 2014-08-27 Конинклейке Филипс Электроникс Н.В. Автоматическое создание ориентиров для замены сердечного клапана
US8177802B2 (en) 2008-12-16 2012-05-15 Medtronic Vascular, Inc. Apparatus for percutaneously creating native tissue venous valves
US8308798B2 (en) 2008-12-19 2012-11-13 Edwards Lifesciences Corporation Quick-connect prosthetic heart valve and methods
WO2010071810A1 (en) 2008-12-19 2010-06-24 Andy Christopher Kiser Methods and devices for endoscopic access to the heart
US8808368B2 (en) 2008-12-22 2014-08-19 Valtech Cardio, Ltd. Implantation of repair chords in the heart
US8911494B2 (en) 2009-05-04 2014-12-16 Valtech Cardio, Ltd. Deployment techniques for annuloplasty ring
EP3848002A1 (en) 2008-12-22 2021-07-14 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
EP2682072A1 (en) 2008-12-23 2014-01-08 Sorin Group Italia S.r.l. Expandable prosthetic valve having anchoring appendages
US8556965B2 (en) 2008-12-31 2013-10-15 Medtronic, Inc. Semi-rigid annuloplasty ring and band
WO2010078603A2 (en) 2009-01-02 2010-07-08 Deep Vein Medical, Inc. Device for regulating blood flow
US8372140B2 (en) 2009-01-07 2013-02-12 Cook Medical Technologies Llc Implantable valve prosthesis with independent frame elements
US9402720B2 (en) 2009-01-12 2016-08-02 Valve Medical Ltd. Modular percutaneous valve structure and delivery method
US8998982B2 (en) 2009-01-12 2015-04-07 Valve Medical Ltd. Method and apparatus for fine adjustment of a percutaneous valve structure
US9681950B2 (en) 2009-01-12 2017-06-20 Valve Medical Ltd. System and method for placing a percutaneous valve device
US9204965B2 (en) 2009-01-14 2015-12-08 Lc Therapeutics, Inc. Synthetic chord
EP2381896B1 (en) 2009-01-22 2015-10-21 St. Jude Medical, Cardiology Division, Inc. Magnetic docking system for the long term adjustment of an implantable device
WO2010085649A1 (en) 2009-01-22 2010-07-29 St. Jude Medical Post-operative adjustment tool, minimally invasive attachment apparatus, and adjustable tricuspid ring
WO2010090721A1 (en) 2009-02-06 2010-08-12 St. Jude Medical, Inc. Adjustable annuloplasty ring support
JP5662353B2 (ja) 2009-02-06 2015-01-28 セント・ジュード・メディカル，インコーポレイテッド 心臓弁輪サイザー
US8574289B2 (en) 2009-02-09 2013-11-05 St. Jude Medical, Cardiology Division, Inc. Inflatable minimally invasive system for delivering and securing an annular implant
CN102316823B (zh) 2009-02-11 2016-06-08 新加坡南洋理工大学 多层外科用假体
US10258471B2 (en) 2009-02-11 2019-04-16 Vdyne, Llc Catheter
DE102009009158B4 (de) 2009-02-16 2010-11-04 Siemens Aktiengesellschaft Lokalisierung eines medizinischen Instruments in einem präinvasiv aufgenommenen Tomographie-Bilddatensatz
BRPI1013346A2 (pt) 2009-02-20 2016-03-29 St Jude Medical ferramenta de crimpar, sistema para substituição de válvula cardíaca protética, e , método para colpasar uma válvula cardíaca protética.
US8109990B2 (en) 2009-02-24 2012-02-07 Cook Medical Technologies Llc Low profile support frame and related intraluminal medical devices
US8348997B2 (en) 2009-02-24 2013-01-08 Medtronic Vascular, Inc. One-way replacement valve
US20100217382A1 (en) 2009-02-25 2010-08-26 Edwards Lifesciences Mitral valve replacement with atrial anchoring
CN102413793B (zh) 2009-02-25 2015-01-28 耶拿阀门科技公司 用于瓣膜假体在病人心脏中的植入部位的定位和锚定的支架
BRPI1008902A2 (pt) 2009-02-27 2016-03-15 St Jude Medical válvula cardíaca protética.
US8021420B2 (en) 2009-03-12 2011-09-20 Medtronic Vascular, Inc. Prosthetic valve delivery system
RU2393818C1 (ru) 2009-03-19 2010-07-10 Закрытое Акционерное Общество Научно-Производственное Предприятие "Мединж" Реимплантируемый протез клапана сердца и инструмент для его установки
US20100262043A1 (en) 2009-03-26 2010-10-14 Sorin Group Usa, Inc. Annuloplasty sizers for minimally invasive procedures
CN101919753A (zh) 2009-03-30 2010-12-22 卡迪万蒂奇医药公司 人工主动脉瓣膜或二尖瓣膜的无缝合移植方法和装置
GB0905444D0 (en) 2009-03-30 2009-05-13 Ucl Business Plc Heart valve prosthesis
WO2010117471A2 (en) 2009-04-10 2010-10-14 Lon Southerland Annest An implantable scaffolding containing an orifice for use with a prosthetic or bio-prosthetic valve
WO2010117367A1 (en) 2009-04-10 2010-10-14 Cardiokinetix, Inc. Sealing and filling ventricular partitioning devices to improve cardiac function
CA2961053C (en) 2009-04-15 2019-04-30 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9968358B2 (en) 2009-04-15 2018-05-15 Microvention, Inc. Implant delivery system
US8512397B2 (en) 2009-04-27 2013-08-20 Sorin Group Italia S.R.L. Prosthetic vascular conduit
CN102458316A (zh) 2009-04-28 2012-05-16 Dc设备公司 治疗心力衰竭的装置、系统和方法
NZ596179A (en) 2009-04-29 2014-05-30 Cleveland Clinic Foundation Apparatus and method for replacing a diseased cardiac valve
US9034034B2 (en) 2010-12-22 2015-05-19 V-Wave Ltd. Devices for reducing left atrial pressure, and methods of making and using same
WO2010128501A1 (en) 2009-05-04 2010-11-11 V-Wave Ltd. Device and method for regulating pressure in a heart chamber
US8523881B2 (en) 2010-07-26 2013-09-03 Valtech Cardio, Ltd. Multiple anchor delivery tool
CN102438551A (zh) 2009-05-08 2012-05-02 皇家飞利浦电子股份有限公司 可植入医疗装置的超声规划和引导
US8403982B2 (en) 2009-05-13 2013-03-26 Sorin Group Italia S.R.L. Device for the in situ delivery of heart valves
EP2250976B1 (en) 2009-05-13 2015-08-26 Sorin Group Italia S.r.l. Device for the in situ delivery of heart valves
EP2250970B1 (en) 2009-05-13 2012-12-26 Sorin Biomedica Cardio S.r.l. Device for surgical interventions
FR2945440B1 (fr) 2009-05-14 2012-12-07 Perouse Lab Dispositif de traitement et necessaire de traitement d'un conduit de circulation du sang
US8075611B2 (en) 2009-06-02 2011-12-13 Medtronic, Inc. Stented prosthetic heart valves
DE102009024648B4 (de) 2009-06-03 2018-05-09 Aesculap Ag Markierte Venen-Ummantelung, insbesondere zur Wiederherstellung der Venenklappenfunktion variköser Venen
US8348998B2 (en) 2009-06-26 2013-01-08 Edwards Lifesciences Corporation Unitary quick connect prosthetic heart valve and deployment system and methods
FR2947716B1 (fr) 2009-07-10 2011-09-02 Cormove Implant prothetique ameliore
US8439970B2 (en) 2009-07-14 2013-05-14 Edwards Lifesciences Corporation Transapical delivery system for heart valves
EP3862046A3 (en) 2009-07-14 2021-10-27 Edwards Lifesciences Corporation Transapical delivery system for heart valves
WO2011006507A2 (en) 2009-07-15 2011-01-20 Technical University Of Denmark Polymer coating comprising 2-methoxyethyl acrylate units synthesized by surface-initiated atom transfer radical polymerization
US9028546B2 (en) 2009-07-17 2015-05-12 Peter Forsell Artificial valve for implantation
JP5716024B2 (ja) 2009-07-22 2015-05-13 ザ テキサス エー アンド エム ユニヴァーシティー システムＴｈｅ Ｔｅｘａｓ Ａ＆Ｍ Ｕｎｉｖｅｒｓｉｔｙ Ｓｙｓｔｅｍ 心臓病態を治療するための補助及びリコイル機能を備える二相性及び動的調整可能サポートデバイス及び方法
US20110022165A1 (en) 2009-07-23 2011-01-27 Edwards Lifesciences Corporation Introducer for prosthetic heart valve
ES2549000T3 (es) 2009-07-27 2015-10-22 Endologix, Inc. Endoprótesis
US8500757B2 (en) 2009-07-28 2013-08-06 Edwards Lifesciences Corporation Surgical puncture cinch and closure system
WO2011022658A1 (en) 2009-08-20 2011-02-24 Cook Incorporated Loading apparatus and system for expandable intraluminal medical devices
JP5744028B2 (ja) 2009-08-27 2015-07-01 メドトロニック，インコーポレイテッド 経カテーテル弁搬送システムおよび方法
CA2772358C (en) 2009-08-28 2018-05-22 3F Therapeutics, Inc. Transapical delivery device and method of use
JP5866668B2 (ja) 2009-08-28 2016-02-17 メドトロニック ３エフ セラピュティックス インコーポレイテッド クリンプ装置及び使用方法
EP2470121B1 (en) 2009-08-28 2021-03-17 3F Therapeutics, Inc. Surgical delivery device and method of use
EP2475328B1 (en) 2009-09-11 2014-08-27 GI Dynamics, Inc. Anchors with open heads
EP3042615B1 (en) 2009-09-15 2024-12-04 Evalve, Inc. Systems and devices for cardiac valve repair
US8562673B2 (en) 2009-09-21 2013-10-22 Medtronic, Inc. Stented transcatheter prosthetic heart valve delivery system and method
EP2482749B1 (en) 2009-10-01 2017-08-30 Kardium Inc. Kit for constricting tissue or a bodily orifice, for example, a mitral valve
WO2011047168A1 (en) 2009-10-14 2011-04-21 Cardiovascular Technologies, Llc Percutaneous transvalvular intraannular band for mitral valve repair
FR2951549B1 (fr) 2009-10-15 2013-08-23 Olivier Schussler Procede d'obtention de bioprotheses medicales implantables
WO2011056578A2 (en) 2009-10-26 2011-05-12 Cardiokinetix, Inc. Ventricular volume reduction
US8277502B2 (en) 2009-10-29 2012-10-02 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US10376359B2 (en) 2009-11-02 2019-08-13 Symetis Sa Aortic bioprosthesis and systems for delivery thereof
GR1007028B (el) 2009-11-11 2010-10-22 Ευσταθιος-Ανδρεας Αγαθος Υποστηρικτης βιοπροσθετικων βαλβιδων με διαγλωχινικο συνδεσμο σχηματος καρδιας
DE102009055969A1 (de) 2009-11-27 2011-06-01 Transcatheter Technologies Gmbh Vorrichtung und Set zum Falten oder Entfalten eines medizinischen Implantats und Verfahren
WO2011067770A1 (en) 2009-12-02 2011-06-09 Valtech Cardio, Ltd. Delivery tool for implantation of spool assembly coupled to a helical anchor
ES2870080T3 (es) 2009-12-08 2021-10-26 Avalon Medical Ltd Dispositivo y sistema para reemplazo de válvula mitral transcatéter
CN102858272B (zh) 2009-12-15 2015-07-15 爱德华兹生命科学公司 治疗脉管通道的膨胀设备
US8869982B2 (en) 2009-12-18 2014-10-28 Edwards Lifesciences Corporation Prosthetic heart valve packaging and deployment system
AU2010331818B2 (en) 2009-12-18 2016-02-18 Coloplast A/S A biomaterial
US20110146361A1 (en) 2009-12-22 2011-06-23 Edwards Lifesciences Corporation Method of Peening Metal Heart Valve Stents
CN102113921A (zh) 2009-12-30 2011-07-06 微创医疗器械(上海)有限公司 一种介入式心脏瓣膜
US20110160838A1 (en) 2009-12-31 2011-06-30 Blanzy Jeffrey S Endoprosthesis containing multi-phase ferrous steel
US9504562B2 (en) 2010-01-12 2016-11-29 Valve Medical Ltd. Self-assembling modular percutaneous valve and methods of folding, assembly and delivery
US8449608B2 (en) 2010-01-22 2013-05-28 Edwards Lifesciences Corporation Tricuspid ring
EP2351540A1 (en) 2010-01-27 2011-08-03 Jönsson, Anders Device and method for reducing cardiac valve regurgitation
US20110190697A1 (en) 2010-02-03 2011-08-04 Circulite, Inc. Vascular introducers having an expandable section
JP5778183B2 (ja) 2010-02-03 2015-09-16 メドトロニック ジービーアイ インコーポレイテッド セミフレキシブル弁形成リング
US9107749B2 (en) 2010-02-03 2015-08-18 Edwards Lifesciences Corporation Methods for treating a heart
US8839957B2 (en) 2010-02-15 2014-09-23 Michael C. Murad Prosthetic heart valve packaging system
US8518106B2 (en) 2010-02-17 2013-08-27 Medtronic, Inc. Catheter assembly with valve crimping accessories
US8292948B2 (en) 2010-02-17 2012-10-23 Medtronic Vascular, Inc. Apparatus and methods for creating a venous valve from autologous tissue
DE102010008362A1 (de) 2010-02-17 2011-08-18 Transcatheter Technologies GmbH, 93053 Medizinisches Implantat, welches aus einem nicht expandierten Zustand expandierbar ist
US8475523B2 (en) 2010-02-17 2013-07-02 Medtronic, Inc. Distal tip assembly for a heart valve delivery catheter
DE102010008382A1 (de) 2010-02-17 2011-08-18 Transcatheter Technologies GmbH, 93053 Verfahren zum Crimpen bzw. Falten eines medizinischen Implantats an einer Einrichtung zum Verbringen oder Einführen desselben unter Einsatz von Zero-Pressure-Crimping sowie Einrichtungen
DE102010008360A1 (de) 2010-02-17 2011-09-29 Transcatheter Technologies Gmbh Medizinisches Implantat, in welchem beim Crimpen bzw. Falten Lücken verbleiben, Verfahren und Einrichtung zum Verbringen
DE102010008338A1 (de) 2010-02-17 2011-08-18 Transcatheter Technologies GmbH, 93053 Einrichtung, vorgesehen, um an einem Katheter befestigt oder mit diesem verbunden zu werden, Katheter und Verfahren
US8926693B2 (en) 2010-02-17 2015-01-06 Medtronic, Inc. Heart valve delivery catheter with safety button
US20110208293A1 (en) 2010-02-23 2011-08-25 Medtronic, Inc. Catheter-Based Heart Valve Therapy System with Sizing Balloon
US9522062B2 (en) 2010-02-24 2016-12-20 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US9414914B2 (en) 2010-02-24 2016-08-16 Medtronic Ventor Technologies Ltd. Catheter assembly with valve crimping accessories
US10433956B2 (en) 2010-02-24 2019-10-08 Medtronic Ventor Technologies Ltd. Mitral prosthesis and methods for implantation
US9226826B2 (en) 2010-02-24 2016-01-05 Medtronic, Inc. Transcatheter valve structure and methods for valve delivery
EP2538878B1 (en) 2010-02-25 2021-11-24 JenaValve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8361144B2 (en) 2010-03-01 2013-01-29 Colibri Heart Valve Llc Percutaneously deliverable heart valve and methods associated therewith
DK3335670T3 (da) 2010-03-05 2022-07-11 Edwards Lifesciences Corp Mekanismer til fastholdelse af klapproteser
US8679404B2 (en) 2010-03-05 2014-03-25 Edwards Lifesciences Corporation Dry prosthetic heart valve packaging system
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
ES2365317B1 (es) 2010-03-19 2012-08-03 Xavier Ruyra Baliarda Banda protésica, en particular para la reparación de una válvula mitral.
CA2793839C (en) 2010-03-23 2018-05-22 Boston Scientific Scimed, Inc. Annuloplasty device
BR122014006876B1 (pt) 2010-03-23 2020-09-29 Edwards Lifesciences Corporation Método para preparar material de membrana de tecido bioprotético
DE102010012677B4 (de) 2010-03-24 2017-08-10 Fehling Instruments Gmbh & Co. Kg Spreizer für die Aortenklappenrekonstruktion
SE535140C2 (sv) 2010-03-25 2012-04-24 Jan Otto Solem En implanterbar anordning, kit och system för förbättring av hjärtfunktionen, innefattande medel för generering av longitudinell rörelse av mitralisklaffen
US9480557B2 (en) 2010-03-25 2016-11-01 Medtronic, Inc. Stents for prosthetic heart valves
SE535690C2 (sv) 2010-03-25 2012-11-13 Jan Otto Solem En implanterbar anordning och kit för hjärtunderstöd, innefattande medel för generering av longitudinell rörelse av mitralisklaffen
EP3527173A3 (en) 2010-03-26 2019-12-11 Thubrikar Aortic Valve Inc. Valve component, frame component and prosthetic valve device including the same for implantation in a body lumen
US9320597B2 (en) 2010-03-30 2016-04-26 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US8998980B2 (en) 2010-04-09 2015-04-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with recapturing feature and method
US8512400B2 (en) 2010-04-09 2013-08-20 Medtronic, Inc. Transcatheter heart valve delivery system with reduced area moment of inertia
US8512401B2 (en) 2010-04-12 2013-08-20 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with funnel recapturing feature and method
US8579963B2 (en) 2010-04-13 2013-11-12 Medtronic, Inc. Transcatheter prosthetic heart valve delivery device with stability tube and method
US8357195B2 (en) 2010-04-15 2013-01-22 Medtronic, Inc. Catheter based annuloplasty system and method
US9833314B2 (en) 2010-04-16 2017-12-05 Abiomed, Inc. Percutaneous valve deployment
US10512537B2 (en) 2010-04-16 2019-12-24 Abiomed, Inc. Flow optimized polymeric heart valve
US8465541B2 (en) 2010-04-19 2013-06-18 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with expandable stability tube
US8764811B2 (en) 2010-04-20 2014-07-01 Medtronic Vascular, Inc. Controlled tip release stent graft delivery system and method
US8623075B2 (en) 2010-04-21 2014-01-07 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method with controlled expansion of prosthetic heart valve
US8876892B2 (en) 2010-04-21 2014-11-04 Medtronic, Inc. Prosthetic heart valve delivery system with spacing
EP3858293A1 (en) 2010-04-21 2021-08-04 Medtronic, Inc. Prosthetic valve with sealing members
US8740976B2 (en) 2010-04-21 2014-06-03 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with flush report
CN102858275A (zh) 2010-04-23 2013-01-02 美敦力公司 用于假体心脏瓣膜的植入的输送系统以及方法
US8568474B2 (en) 2010-04-26 2013-10-29 Medtronic, Inc. Transcatheter prosthetic heart valve post-dilatation remodeling devices and methods
WO2011139747A1 (en) 2010-04-27 2011-11-10 Medtronic Inc. Transcatheter prosthetic heart valve delivery device with biased release features
CN102905647B (zh) 2010-04-27 2015-07-29 美敦力公司 具有被动触发器释放件的经导管假体心脏瓣膜输送装置
CA2792926C (en) 2010-04-29 2018-02-20 Vinay Badhwar Automatic suturing apparatus and methods of use
US8974475B2 (en) 2010-04-30 2015-03-10 Medtronic, Inc. Methods and devices for cardiac valve repair or replacement
CA3303770A1 (en) 2010-05-05 2026-05-13 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
AU2014203064B2 (en) 2010-05-05 2015-06-11 Neovasc Inc. Transcatheter mitral valve prosthesis
CA2793916C (en) 2010-05-10 2016-10-25 Edwards Lifesciences Corporation Prosthetic heart valve
US9554901B2 (en) 2010-05-12 2017-01-31 Edwards Lifesciences Corporation Low gradient prosthetic heart valve
US9433501B2 (en) 2010-05-19 2016-09-06 Direct Flow Medical, Inc. Inflation media for implants
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
SI2387977T1 (sl) 2010-05-20 2014-03-31 Jenavalve Technology Inc. Regus Business Centre Wilmington Downtown Katetrski sistem za vstavljanje razteznega stenta srčne zaklopke v telo pacienta
IT1400327B1 (it) 2010-05-21 2013-05-24 Sorin Biomedica Cardio Srl Dispositivo di supporto per protesi valvolari e corrispondente corredo.
US8790394B2 (en) 2010-05-24 2014-07-29 Valtech Cardio, Ltd. Adjustable artificial chordeae tendineae with suture loops
CA2799459A1 (en) 2010-05-25 2011-12-01 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US9098899B2 (en) 2010-05-27 2015-08-04 Koninklijke Philips N.V. Determining the specific orientation of an object
US9387077B2 (en) 2010-05-27 2016-07-12 Medtronic Vascular Galway Catheter assembly with prosthesis crimping and prosthesis retaining accessories
US9561102B2 (en) 2010-06-02 2017-02-07 Medtronic, Inc. Transcatheter delivery system and method with controlled expansion and contraction of prosthetic heart valve
EP3441045B1 (en) 2010-06-07 2020-07-29 Valtech Cardio, Ltd. Apparatus to draw first and second portions of tissue toward each other
EP2582326B2 (en) 2010-06-21 2024-07-03 Edwards Lifesciences CardiAQ LLC Replacement heart valve
JP5833832B2 (ja) 2010-06-30 2015-12-16 テルモ株式会社 生体移植片移送器具及び生体移植片の移送方法
DK2590595T3 (en) 2010-07-09 2015-12-07 Highlife Sas Transcatheter atrioventricular heart valve prosthesis
EP3552655B1 (en) 2010-07-13 2020-12-23 Loma Vista Medical, Inc. Inflatable medical devices
AU2011279727B2 (en) 2010-07-15 2014-03-27 St. Jude Medical, Inc. Retainers for transcatheter heart valve delivery systems
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
EP2598044B1 (en) 2010-07-27 2019-03-13 Incept, LLC Apparatus for treating neurovascular venous outflow obstruction
ES2471367T3 (es) 2010-07-30 2014-06-26 Institut Quimic De Sarria Implante bioactivo
EP2600798B1 (en) 2010-08-03 2015-10-28 Cook Medical Technologies LLC Two valve caval stent for functional replacement of incompetent tricuspid valve
WO2012019052A2 (en) 2010-08-04 2012-02-09 Micardia Corporation Percutaneous transcatheter repair of heart valves
AU2011292460B2 (en) 2010-08-17 2014-03-13 St. Jude Medical, Inc. Delivery system for collapsible heart valve
US9408694B2 (en) 2010-08-17 2016-08-09 St. Jude Medical, Inc. Tip for medical implant delivery system
WO2012027384A2 (en) 2010-08-23 2012-03-01 Edwards Lifesciences Corporation Color-coded prosthetic valve system and methods for using the same
US9039759B2 (en) 2010-08-24 2015-05-26 St. Jude Medical, Cardiology Division, Inc. Repositioning of prosthetic heart valve and deployment
JP5891228B2 (ja) 2010-08-24 2016-03-22 セント・ジュード・メディカル，インコーポレイテッド 経カテーテル心臓弁送達システム用の段階的展開装置および方法
BR112013004115B1 (pt) 2010-08-24 2021-01-05 Edwards Lifesciences Corporation anel de anuloplastia
WO2012027515A2 (en) 2010-08-24 2012-03-01 Southern Lights Ventures 2002 Limited Biomaterials with enhanced properties and devices made therefrom
CN103189016B (zh) 2010-08-31 2016-08-10 爱德华兹生命科学公司 生理性三尖瓣瓣膜成形环
EP2422748B1 (de) 2010-08-31 2016-01-27 Biotronik AG Medizinisches Implantat, insbesondere Klappenimplantat, zur Implantation in einen tierischen und/oder menschlichen Körper sowie Verfahren, insbesondere Herstellungsverfahren, zur Herstellung einer Implantationsvorrichtung für das medizinische Implantat
CA2809909A1 (en) 2010-09-01 2012-03-08 Julie A. Logan Cardiac valve support structure
WO2012030598A2 (en) 2010-09-01 2012-03-08 Medtronic Vascular Galway Limited Prosthetic valve support structure
US8641757B2 (en) 2010-09-10 2014-02-04 Edwards Lifesciences Corporation Systems for rapidly deploying surgical heart valves
EP3342377B1 (en) 2010-09-10 2022-06-15 Boston Scientific Limited Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device
US10076327B2 (en) 2010-09-14 2018-09-18 Evalve, Inc. Flexible actuator mandrel for tissue apposition systems
DE102010037529A1 (de) 2010-09-14 2012-03-15 Transcatheter Technologies Gmbh Einrichtung, vorgesehen, um an einem Katheter befestigt oder mit diesem verbunden zu werden, Katheter und Verfahren
EP2616007B1 (en) 2010-09-17 2020-06-03 St. Jude Medical, Cardiology Division, Inc. Staged deployment devices for transcatheter heart valve delivery
FR2964855B1 (fr) 2010-09-17 2013-10-18 Ct Hospitalier Regional Universitaire D Amiens Implant destine a etre place dans un passage sanguin auriculo-ventriculaire
US9439795B2 (en) 2010-09-17 2016-09-13 St. Jude Medical, Cardiology Division, Inc. Retainers for transcatheter heart valve delivery systems
WO2012036742A2 (en) 2010-09-17 2012-03-22 St. Jude Medical, Cardiology Division, Inc. Assembly and method for loading a self-expanding collapsible heart valve
JP2013540484A (ja) 2010-09-20 2013-11-07 セント・ジュード・メディカル，カーディオロジー・ディヴィジョン，インコーポレイテッド 折畳み可能な人工弁における弁尖の取付装置
EP2618780B1 (en) 2010-09-20 2017-11-15 St. Jude Medical, Cardiology Division, Inc. Delivery device having a curved shaft and a straightening member for transcatheter aortic valve implantation
WO2012040655A2 (en) 2010-09-23 2012-03-29 Cardiaq Valve Technologies, Inc. Replacement heart valves, delivery devices and methods
CA2810467C (en) 2010-09-24 2019-08-20 Symetis Sa Stent-valve, delivery apparatus and delivery method
US8845720B2 (en) 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
BR112013007253B1 (pt) 2010-09-29 2021-10-05 Taupnumedical Co.,Ltd Dispositivo de proteção tecidual para seio coronariano e válvula tricúspide, dispositivo de distribuição de nó e dispositivo para cerclagem de válvula mitral, contendo o mesmo
WO2012047761A2 (en) 2010-09-30 2012-04-12 Biostable Science Engineering, Inc. Aortic valve devices
EP2621407B1 (en) 2010-09-30 2018-01-17 Biostable Science & Engineering, Inc. Intra-annular mounting frame for aortic valve repair
FI4233795T3 (fi) 2010-10-05 2024-09-09 Edwards Lifesciences Corp Keinosydänläppä
US8284085B2 (en) 2010-10-06 2012-10-09 Texas Instruments Incorporated Pipelined continuous-time sigma delta modulator
JP5995110B2 (ja) 2010-10-21 2016-09-21 メドトロニック，インコーポレイテッド 心室内ロープロファイル補綴僧帽弁
GB201017921D0 (en) 2010-10-22 2010-12-01 Ucl Business Plc Prothesis delivery system
US8562663B2 (en) 2010-10-26 2013-10-22 Medtronic Ventor Technologies Ltd. Devices and methods for loading a prosthesis onto a delivery system
US20120116496A1 (en) 2010-11-05 2012-05-10 Chuter Timothy A Stent structures for use with valve replacements
US20120116498A1 (en) 2010-11-05 2012-05-10 Chuter Timothy A Aortic valve prostheses
IT1402571B1 (it) 2010-11-12 2013-09-13 Ht Consultant Di Giovanni Righini Sistema protesico per valvola cardio-vascolare con struttura di ancoraggio separata
US20120191174A1 (en) 2010-11-16 2012-07-26 Trivascular, Inc. Advanced endovascular graft and delivery system
DE102010051632B4 (de) 2010-11-17 2013-09-12 Hans-Hinrich Sievers Gestentete biologische Herzklappe
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
EP2640316B1 (en) 2010-11-18 2017-03-15 Pavilion Medical Innovations, LLC Tissue restraining devices and methods of use
US8932350B2 (en) 2010-11-30 2015-01-13 Edwards Lifesciences Corporation Reduced dehiscence annuloplasty ring
US9078750B2 (en) 2010-11-30 2015-07-14 Edwards Lifesciences Corporation Ergonomic mitral heart valve holders
CA2819424C (en) 2010-12-14 2020-07-21 Transcatheter Technologies Gmbh Apparatus comprising an aligning device, set and method
US9579197B2 (en) 2010-12-15 2017-02-28 Medtronic Vascular, Inc. Systems and methods for positioning a heart valve using visual markers
DE102010061371A1 (de) 2010-12-20 2012-06-21 Transcatheter Technologies Gmbh Vorrichtung mit individuellen Schaftfasern und Set zum Falten oder Entfalten eines medizinischen Implantats und Verfahren
EP2468215A1 (en) 2010-12-22 2012-06-27 Centre Hospitaller Universitaire Vaudois (CHUV) Annuloplasty ring
US9044221B2 (en) 2010-12-29 2015-06-02 Neochord, Inc. Exchangeable system for minimally invasive beating heart repair of heart valve leaflets
AU2012204392B2 (en) 2011-01-04 2015-06-11 The Cleveland Clinic Foundation Apparatus and method for treating a regurgitant heart valve
US8948848B2 (en) 2011-01-07 2015-02-03 Innovative Cardiovascular Solutions, Llc Angiography catheter
US20140018912A1 (en) 2011-01-11 2014-01-16 Symetis Sa Method and Apparatus Useful for Transcatheter Aortic Valve Implantation
EP2474287A1 (en) 2011-01-11 2012-07-11 Symetis Sa Delivery catheter for stent-valve, and sub-assembly therefor
ES2710002T3 (es) 2011-01-11 2019-04-22 Hans Reiner Figulla Prótesis valvular para reemplazar una válvula auriculoventricular del corazón
US9687342B2 (en) 2011-01-11 2017-06-27 Hans Reiner Figulla Valve prosthesis for replacing an atrioventricular valve of the heart with anchoring element
CA3028172C (en) 2011-01-18 2020-12-22 Loma Vista Medical, Inc. Inflatable medical devices
DE102011009555A1 (de) 2011-01-21 2012-07-26 Aesculap Ag Gefäßprothese mit integrierter Aortenklappe
US8845717B2 (en) 2011-01-28 2014-09-30 Middle Park Medical, Inc. Coaptation enhancement implant, system, and method
EP2670356B1 (en) 2011-01-31 2016-09-28 St. Jude Medical, Inc. Adjustable prosthetic anatomical device holder and handle for the implantation of an annuloplasty ring
WO2012106351A1 (en) 2011-01-31 2012-08-09 St. Jude Medical, Inc. Tool for the adjustment of a prosthetic anatomical device
US9314336B2 (en) 2011-01-31 2016-04-19 St. Jude Medical, Inc. Adjustment assembly for an adjustable prosthetic valve device
EP3106130B1 (en) 2011-01-31 2018-09-05 St. Jude Medical, LLC An adjustment tool for a prosthetic device
EP2670354B1 (en) 2011-01-31 2016-04-27 St. Jude Medical, Inc. Adjustable annuloplasty ring sizing indicator
US9717593B2 (en) 2011-02-01 2017-08-01 St. Jude Medical, Cardiology Division, Inc. Leaflet suturing to commissure points for prosthetic heart valve
EP2670357B1 (en) 2011-02-02 2019-03-20 St. Jude Medical, LLC System for loading a collapsible heart valve into a delivery device
EP2484309B1 (en) 2011-02-02 2019-04-10 Shlomo Gabbay Heart valve prosthesis
AU2012214279A1 (en) 2011-02-10 2013-08-22 Corvia Medical, Inc. Apparatus and methods to create and maintain an intra-atrial pressure relief opening
US20120209375A1 (en) 2011-02-11 2012-08-16 Gilbert Madrid Stability device for use with percutaneous delivery systems
EP2486894B1 (en) 2011-02-14 2021-06-09 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
ES2641902T3 (es) 2011-02-14 2017-11-14 Sorin Group Italia S.R.L. Dispositivo de anclaje sin sutura para prótesis valvulares cardiacas
WO2012112469A2 (en) 2011-02-15 2012-08-23 Medivalve Ltd. Percutaneous positioning device
US9393133B2 (en) 2011-02-18 2016-07-19 Piolax Medical Devices, Inc. Abdominal cavity-vein shunt stent
GB2488530A (en) 2011-02-18 2012-09-05 David J Wheatley Heart valve
EP2677965B1 (en) 2011-02-25 2017-06-21 University of Connecticut Prosthetic heart valve
US9155619B2 (en) 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
PL218575B1 (pl) 2011-02-28 2014-12-31 Fundacja Rozwoju Kardiochirurgii Im Prof Zbigniewa Religi Sposób wytwarzania warstw powierzchniowych na implantach medycznych
US9445898B2 (en) 2011-03-01 2016-09-20 Medtronic Ventor Technologies Ltd. Mitral valve repair
CN103561686B (zh) 2011-03-03 2016-03-30 英派尔科技开发有限公司 用于可膨胀球囊支架的经皮输送的临时灌注通道
EP4119095B1 (en) 2011-03-21 2026-06-03 Cephea Valve Technologies, Inc. Disk-based valve apparatus
EP2688525B1 (en) 2011-03-23 2019-08-21 Daidalos Solutions B.V. Medical instrument, ring prosthesis, stent and stented valve
US10016461B2 (en) 2012-12-03 2018-07-10 The Regents Of The University Of California Apparatus and process for growing a heart valve in three-dimensions
US8900862B2 (en) 2011-03-23 2014-12-02 The Regents Of The University Of California Mesh enclosed tissue constructs
US8961599B2 (en) 2011-04-01 2015-02-24 W. L. Gore & Associates, Inc. Durable high strength polymer composite suitable for implant and articles produced therefrom
US11213393B2 (en) 2011-04-01 2022-01-04 Edwards Lifesciences Corporation Compressible heart valve annulus sizing templates
US8945212B2 (en) 2011-04-01 2015-02-03 W. L. Gore & Associates, Inc. Durable multi-layer high strength polymer composite suitable for implant and articles produced therefrom
BR112013024872A2 (pt) 2011-04-04 2016-12-20 Medical Res Infrastructure & Health Services Fund dispositivo e método para o reparo de válvula do coração
EP3388005B1 (en) 2011-04-20 2020-08-19 The Board of Trustees of the Leland Stanford Junior University Systems for endoluminal valve creation
US9381082B2 (en) 2011-04-22 2016-07-05 Edwards Lifesciences Corporation Devices, systems and methods for accurate positioning of a prosthetic valve
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
EP2520250B1 (en) 2011-05-04 2014-02-19 Medtentia International Ltd Oy Medical device for a cardiac valve implant
EP2520251A1 (en) 2011-05-05 2012-11-07 Symetis SA Method and Apparatus for Compressing Stent-Valves
EP2522307B1 (en) 2011-05-08 2020-09-30 ITSO Medical AB Device for delivery of medical devices to a cardiac valve
EP2522308B1 (de) 2011-05-10 2015-02-25 Biotronik AG Mechanische Transkatheter-Herzklappenprothese
US9144494B2 (en) 2011-05-12 2015-09-29 Medtronic, Inc. Delivery catheter system with micro and macro movement control
US9486604B2 (en) 2011-05-12 2016-11-08 Medtronic, Inc. Packaging and preparation tray for a delivery system
WO2012158543A1 (en) 2011-05-13 2012-11-22 Heartware, Inc. Intravascular blood pump and method of implantation
EP3967268A1 (en) 2011-05-16 2022-03-16 Hlt, Inc. Inversion delivery device for a prosthesis
US8523940B2 (en) 2011-05-17 2013-09-03 Boston Scientific Scimed, Inc. Annuloplasty ring with anchors fixed by curing polymer
US8814932B2 (en) 2011-05-17 2014-08-26 Boston Scientific Scimed, Inc. Annuloplasty ring with piercing wire and segmented wire lumen
US8945209B2 (en) 2011-05-20 2015-02-03 Edwards Lifesciences Corporation Encapsulated heart valve
ES2841108T3 (es) 2011-05-26 2021-07-07 On X Life Tech Inc Manguito de costura de válvula cardíaca
KR20140024905A (ko) 2011-05-27 2014-03-03 코매트릭스 카디오바스컬라 인코포레이티드 멸균된 무세포성 세포외 기질 조성물 및 이의 제조 방법
US20130035757A1 (en) 2011-06-01 2013-02-07 John Zentgraf Minimally invasive repair of heart valve leaflets
PL2724690T3 (pl) 2011-06-01 2017-01-31 Nvt Ag Układ do instalowania protezy zastawki serca
US9402721B2 (en) 2011-06-01 2016-08-02 Valcare, Inc. Percutaneous transcatheter repair of heart valves via trans-apical access
US9101471B2 (en) 2011-06-13 2015-08-11 Edwards Lifesciences Corporation Systems and delivery handles for delivering prosthetic heart valves disposed on valve holders
US20120315260A1 (en) 2011-06-13 2012-12-13 Svetlana A. Ivanova Compositions and Methods to Prevent and Treat Biofilms
US8840664B2 (en) 2011-06-15 2014-09-23 Edwards Lifesciences Corporation Heart valve prosthesis anchoring device and methods
WO2012173995A2 (en) 2011-06-15 2012-12-20 St. Jude Medical, Inc. Multi-layer stent
AU2012272855C1 (en) 2011-06-21 2018-04-05 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
EP2723274B1 (en) 2011-06-23 2017-12-27 Valtech Cardio, Ltd. Closure element for use with annuloplasty structure
WO2013003228A1 (en) 2011-06-27 2013-01-03 University Of Maryland, Baltimore Transapical mitral valve repair device
US9364326B2 (en) 2011-06-29 2016-06-14 Mitralix Ltd. Heart valve repair devices and methods
US9358107B2 (en) 2011-06-30 2016-06-07 Edwards Lifesciences Corporation Systems, dies, and methods for processing pericardial tissue
US8926588B2 (en) 2011-07-05 2015-01-06 Medtronic Vascular, Inc. Steerable delivery catheter
DE102011106928B4 (de) 2011-07-08 2019-02-07 Admedes Schuessler Gmbh Verfahren, Vorrichtung und Verwendung eines Verfahrens zum elektrochemischen Abtragen eines Werkstoffs
DE102011107551B4 (de) 2011-07-11 2015-05-28 Universitätsklinikum Schleswig-Holstein Anuloplastiering
EP2731550B1 (en) 2011-07-12 2016-02-24 Boston Scientific Scimed, Inc. Coupling system for a replacement valve
US8795357B2 (en) 2011-07-15 2014-08-05 Edwards Lifesciences Corporation Perivalvular sealing for transcatheter heart valve
ITMI20111347A1 (it) 2011-07-20 2013-01-21 Agora S R L Struttura modulare di supporto, particolarmente per impianti fotovoltaici.
EP3424468A1 (en) 2011-07-21 2019-01-09 4Tech Inc. Apparatus for tricuspid valve repair using tension
US9339384B2 (en) 2011-07-27 2016-05-17 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US8893370B2 (en) 2011-07-28 2014-11-25 St. Jude Medical, Cardiology Division, Inc. System for loading a collapsible heart valve
WO2013016519A2 (en) 2011-07-28 2013-01-31 St. Jude Medical, Cardiology Division, Inc. System for loading a collapsible heart valve
GB201113060D0 (en) 2011-07-29 2011-09-14 Univ Ulster Tissue scaffold
AU2012290221B2 (en) 2011-07-29 2017-02-23 Carnegie Mellon University Artificial valved conduits for cardiac reconstructive procedures and methods for their production
EP3417813B1 (en) 2011-08-05 2020-05-13 Cardiovalve Ltd Percutaneous mitral valve replacement
WO2013022798A1 (en) 2011-08-05 2013-02-14 California Institute Of Technology Percutaneous heart valve delivery systems
EP2554139A1 (en) 2011-08-05 2013-02-06 Centre Hospitalier Universitaire Vaudois Actuating device for a surgical implant
EP3403616B1 (en) 2011-08-11 2022-05-11 Tendyne Holdings, Inc. Improvements for prosthetic valves and related inventions
WO2013022585A1 (en) 2011-08-11 2013-02-14 St. Jude Medical, Inc. Apparatus and method for heart valve repair
US9060860B2 (en) 2011-08-18 2015-06-23 St. Jude Medical, Cardiology Division, Inc. Devices and methods for transcatheter heart valve delivery
US11185403B2 (en) 2011-08-31 2021-11-30 Cook Medical Technologies Llc Endoluminal prosthesis assembly
EP2564811B1 (en) 2011-08-31 2021-03-10 The Cleveland Clinic Foundation Delivery system for an endoluminal device
JP6010018B2 (ja) 2011-09-09 2016-10-19 新幹工業株式会社 弁付きステント、弁付きステント形成用基材、及び弁付きステントの生産方法
DE102014102725A1 (de) 2014-02-28 2015-09-17 Highlife Sas Transkatheter-Klappenprothese
ES2616030T3 (es) 2011-09-12 2017-06-09 Highlife Sas Sistema de catéter de tratamiento
CA2848251C (en) 2011-09-12 2019-08-06 Highlife Sas Transcatheter valve prosthesis
DE102011054176B4 (de) 2011-09-12 2016-02-04 Highlife Sas Behandlungs-Katheter-System
DE102014102653A1 (de) 2014-02-28 2015-09-03 Highlife Sas Transkatheter-Klappenprothese
US8945177B2 (en) 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US9011468B2 (en) 2011-09-13 2015-04-21 Abbott Cardiovascular Systems Inc. Independent gripper
US9422615B2 (en) 2011-09-16 2016-08-23 W. L. Gore & Associates, Inc. Single step shape memory alloy expansion
US8920493B2 (en) 2011-09-16 2014-12-30 St. Jude Medical, Cardiology Division, Inc. Systems and methods for holding annuloplasty rings
EP2572684B1 (de) 2011-09-23 2016-05-04 Biotronik AG Freigabevorrichtung zum Lösen eines medizinischen Implantats von einem Katheter sowie Katheter mit einer Freigabevorrichtung
US8900295B2 (en) 2011-09-26 2014-12-02 Edwards Lifesciences Corporation Prosthetic valve with ventricular tethers
US9554904B2 (en) 2011-09-28 2017-01-31 Medtronic CV Luxembourg S.a.r.l. Distal tip assembly for a heart valve delivery catheter
BR112014007686A2 (pt) 2011-09-30 2017-04-18 Bioventrix Inc método e sistema para tratamento de coração dentro do paciente
EP2763708B1 (en) 2011-10-05 2022-01-05 Boston Scientific Scimed, Inc. Profile reduction seal for prosthetic heart valve
FR2980968B1 (fr) 2011-10-10 2013-12-27 Assist Publ Hopitaux De Paris Prothese cardiovasculaire en polymere biodegradable comprenant un element tubulaire logeant une valve et procede de fabrication de ladite prothese
US9655720B2 (en) 2011-10-13 2017-05-23 The Research Foundation For The State University Of New York Polymeric heart valve
CA2849030C (en) 2011-10-19 2020-10-27 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
AU2012325809B2 (en) 2011-10-19 2016-01-21 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9827093B2 (en) 2011-10-21 2017-11-28 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US8945146B2 (en) 2011-10-24 2015-02-03 Medtronic, Inc. Delivery system assemblies and associated methods for implantable medical devices
CN102423505B (zh) 2011-10-27 2014-12-10 上海微创医疗器械（集团）有限公司 膜式渗透汽化式固定人工生物瓣的方法及装置
US8986368B2 (en) 2011-10-31 2015-03-24 Merit Medical Systems, Inc. Esophageal stent with valve
US9192496B2 (en) 2011-10-31 2015-11-24 Merit Medical Systems, Inc. Systems and methods for sheathing an implantable device
CN102499993B (zh) 2011-11-01 2014-01-15 上海微创医疗器械（集团）有限公司 一种边缘刚性化人工生物瓣膜的制备方法
WO2013071179A1 (en) 2011-11-10 2013-05-16 Transaortic Medical, Inc. System for deploying a device to a distal location across a diseased vessel
US9131926B2 (en) 2011-11-10 2015-09-15 Boston Scientific Scimed, Inc. Direct connect flush system
EP2591754B1 (en) 2011-11-10 2015-02-25 Medtentia International Ltd Oy A device and a method for improving the function of a heart valve
EP2591755A1 (en) 2011-11-12 2013-05-15 Medtentia International Ltd Oy Device and method for improving fixation of a medical device
US8851286B2 (en) 2011-11-15 2014-10-07 Boston Scientific Scimed Inc. Dual sterilization containment vessel
JP2015501680A (ja) 2011-11-15 2015-01-19 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． キーで固定されるロッキング構造体を備えた医療器具
US8721587B2 (en) 2011-11-17 2014-05-13 Medtronic, Inc. Delivery system assemblies and associated methods for implantable medical devices
FR2982763B1 (fr) 2011-11-17 2015-07-17 Ct Hospitalier Regional Universitaire D Amiens Implant destine a etre place dans un passage de circulation du sang et dispositif de traitement associe
US8951243B2 (en) 2011-12-03 2015-02-10 Boston Scientific Scimed, Inc. Medical device handle
US9480558B2 (en) 2011-12-05 2016-11-01 Medtronic, Inc. Transcatheter valve having reduced seam exposure
EP4413954A3 (en) 2011-12-06 2024-11-20 Aortic Innovations LLC Device for endovascular aortic repair and method of using the same
ES3021845T3 (en) 2011-12-09 2025-05-27 Edwards Lifesciences Corp Prosthetic heart valve having improved commissure supports
US9345574B2 (en) 2011-12-09 2016-05-24 Edwards Lifesciences Corporation Force-based heart valve sizer
JP6153938B2 (ja) 2011-12-12 2017-06-28 デイヴィッド・アロン 心臓弁修復デバイス
ES2606877T3 (es) 2011-12-13 2017-03-28 Boston Scientific Scimed, Inc. Válvula cardíaca descalcificante
US9078645B2 (en) 2011-12-19 2015-07-14 Edwards Lifesciences Corporation Knotless suture anchoring devices and tools for implants
WO2013096644A1 (en) 2011-12-20 2013-06-27 Boston Scientific Scimed, Inc. Apparatus for endovascularly replacing a heart valve
US9510945B2 (en) 2011-12-20 2016-12-06 Boston Scientific Scimed Inc. Medical device handle
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
EP4670679A3 (en) 2011-12-21 2026-03-18 Majoro Cardiac Innovations, LLC Platforms for mitral valve replacement
US9078747B2 (en) 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
AU2012268911B2 (en) 2011-12-22 2014-04-24 Cook Medical Technologies Llc Endoluminal prosthesis comprising a valve replacement and at least one fenestration
WO2013091730A1 (en) 2011-12-23 2013-06-27 Myopowers Medical Technologies Sa Medical device comprising an artificial contractile structure
EP2842517A1 (en) 2011-12-29 2015-03-04 Sorin Group Italia S.r.l. A kit for implanting prosthetic vascular conduits
EP2609894B1 (en) 2011-12-31 2015-04-01 Fundacja Rozwoju Kardiochirurgii Im. Prof. Zbigniewa Religi Heart valve
JP6272781B2 (ja) 2012-01-06 2018-01-31 エンボライン， インコーポレイテッド 統合された塞栓保護デバイス
EP3300697A1 (en) 2012-01-10 2018-04-04 Jennifer K. White Articulated support structure with secondary strut features
EP2620125B1 (en) 2012-01-24 2017-10-11 Medtentia International Ltd Oy An arrangement, a loop-shaped support, a prosthetic heart valve and a method of repairing or replacing a native heart valve
US9610082B2 (en) 2012-01-25 2017-04-04 St. Jude Medical, Inc. Apparatus and method for heart valve repair
FR2986149B1 (fr) 2012-01-26 2014-12-26 Ct Hospitalier Universitaire De Clermont Fd Dispositif de remplacement d'au moins un cordage de la valve mitrale et kit comprenant au moins deux dispositifs
US9226812B2 (en) 2012-01-30 2016-01-05 Kawasumi Laboratories, Inc. Biliary stent
EP2809263B1 (en) 2012-01-31 2017-08-23 Mitral Valve Technologies Sàrl Mitral valve docking devices, systems
EP3108855A1 (en) 2012-02-01 2016-12-28 St. Jude Medical, Inc. Clip delivery system for tissue repair
US20130204360A1 (en) 2012-02-01 2013-08-08 Hlt, Inc. Invertible Tissue Valve And Method
WO2013116617A1 (en) 2012-02-02 2013-08-08 St. Jude Medical, Cardiology Division, Inc. Apparatus and method for heart valve repair
EP3628247B1 (en) 2012-02-07 2022-08-10 Intervene, Inc. System for endoluminal valve creation
EP3281608B1 (en) 2012-02-10 2020-09-16 CVDevices, LLC Medical product comprising a frame and visceral pleura
US10420645B2 (en) 2012-02-15 2019-09-24 Children's Medical Center Corporation Right ventricular papillary approximation
CA3097321A1 (en) 2012-02-22 2013-08-29 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
EP2819618B1 (en) 2012-02-28 2018-05-02 Mvalve Technologies Ltd. Single-ring cardiac valve support
EP2819619B1 (en) 2012-02-29 2019-01-16 ValCare, Inc. Percutaneous annuloplasty system with anterior-posterior adjustment
US9770332B2 (en) 2012-03-06 2017-09-26 Highlife Sas Treatment catheter member with encircling function
JP6001280B2 (ja) 2012-03-09 2016-10-05 学校法人金沢医科大学 心臓矯正ネットの製造方法
JP6084775B2 (ja) 2012-03-09 2017-02-22 学校法人金沢医科大学 心臓矯正ネット
NZ629494A (en) 2012-03-12 2017-02-24 Univ Colorado State Res Found Glycosaminoglycan and synthetic polymer materials for blood-contacting applications
CA2867206A1 (en) 2012-03-14 2013-09-19 Universite Catholique De Louvain Device for excision of heart valve
EP2641569B1 (en) 2012-03-23 2015-01-28 Sorin Group Italia S.r.l. A collapsible valve prosthesis
US9023098B2 (en) 2012-03-28 2015-05-05 Medtronic, Inc. Dual valve prosthesis for transcatheter valve implantation
US8926694B2 (en) 2012-03-28 2015-01-06 Medtronic Vascular Galway Limited Dual valve prosthesis for transcatheter valve implantation
US9066800B2 (en) 2012-03-28 2015-06-30 Medtronic, Inc. Dual valve prosthesis for transcatheter valve implantation
US9101467B2 (en) 2012-03-30 2015-08-11 Medtronic CV Luxembourg S.a.r.l. Valve prosthesis
ES2552382T3 (es) 2012-04-04 2015-11-27 Sorin Group Italia S.R.L. Dispositivo de soporte para prótesis de válvulas cardíacas
CA2869365A1 (en) 2012-04-05 2013-10-10 Mvalve Technologies Ltd. Cardiac valve support structure
US20150080713A1 (en) 2012-04-12 2015-03-19 Medivalve Ltd. Intracorporeal imaging aid (ima)
EP2836171B1 (en) 2012-04-12 2018-10-17 California Institute of Technology Percutaneous heart valve delivery systems
US9999501B2 (en) 2012-04-18 2018-06-19 Medtronic CV Luxembourg S.a.r.l. Valve prosthesis
CN102764169B (zh) 2012-04-19 2015-07-29 杭州启明医疗器械有限公司 人工心脏瓣膜及其瓣膜支架
US9011515B2 (en) 2012-04-19 2015-04-21 Caisson Interventional, LLC Heart valve assembly systems and methods
US9168122B2 (en) 2012-04-26 2015-10-27 Rex Medical, L.P. Vascular device and method for valve leaflet apposition
WO2013163283A2 (en) 2012-04-27 2013-10-31 Cook Medical Technologies Llc Anti-aspiration prosthesis
ITTO20120372A1 (it) * 2012-04-27 2013-10-28 Marcio Scorsin Protesi valvolare cardiaca monocuspide
US9427303B2 (en) 2012-04-27 2016-08-30 Cook Medical Technologies Llc Anti-aspiration valve
US20130289699A1 (en) 2012-04-30 2013-10-31 St. Jude Medical, Cardiology Division, Inc. Aortic valve holder with stent protection and/or ability to decrease valve profile
CA2871153A1 (en) 2012-05-09 2013-11-14 Boston Scientific Scimed, Inc. Reduced profile valve with locking elements
EP3141218B1 (en) 2012-05-15 2023-09-06 Valve Medical Ltd. System for assembling a folded percutaneous valve
EP2849680B1 (en) 2012-05-16 2019-01-09 Edwards Lifesciences Corporation Coaptation element for reducing cardiac valve regurgitation
EP2849678B1 (en) 2012-05-16 2022-08-10 JenaValve Technology, Inc. Catheter delivery system for introducing an expandable heart valve prosthesis and medical device for the treatment of a heart valve defect
CA2871156C (en) 2012-05-16 2020-06-30 Edwards Lifesciences Corporation Devices and methods for reducing cardiac valve regurgitation
AU2013264730B2 (en) 2012-05-20 2018-02-01 Tel Hashomer Medical Research Infrastructure And Services Ltd. Prosthetic mitral valve
US9474600B2 (en) 2012-05-24 2016-10-25 Shanghai Cingular Biotech Corporation Prosthetic heart valve
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9642700B2 (en) 2012-05-31 2017-05-09 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve having a polymeric stent
DE102012010798A1 (de) 2012-06-01 2013-12-05 Universität Duisburg-Essen Implantierbare Vorrichtung zur Verbesserung oder Behebung einer Herzklappeninsuffizienz
US9301835B2 (en) 2012-06-04 2016-04-05 Edwards Lifesciences Corporation Pre-assembled bioprosthetic valve and sealed conduit
FR2991162B1 (fr) 2012-06-05 2015-07-17 Ass Marie Lannelongue Endoprothese, notamment vasculaire ou cardiaque, avec elements thrombogenes
EP2854705B1 (en) 2012-06-05 2020-04-15 Kardiozis Endoprosthesis and delivery device for implanting such endoprosthesis
WO2013184630A1 (en) 2012-06-05 2013-12-12 Merit Medical Systems, Inc. Esophageal stent
CA2874453C (en) 2012-06-06 2021-05-18 Loma Vista Medical, Inc. Inflatable medical devices
US9597205B2 (en) 2012-06-06 2017-03-21 Magenta Medical Ltd. Prosthetic renal valve
CN104507419A (zh) 2012-06-07 2015-04-08 波士顿科学国际有限公司 用于置换原生心脏瓣膜的装置
US9095428B2 (en) 2012-06-08 2015-08-04 Cameron International Corporation Artificial heart system
US9526610B2 (en) 2012-06-12 2016-12-27 Medtronic, Inc. Method and device for percutaneous valve annuloplasty
US9883941B2 (en) 2012-06-19 2018-02-06 Boston Scientific Scimed, Inc. Replacement heart valve
WO2013190344A1 (en) 2012-06-22 2013-12-27 Pierre Squara Heart valve prostheses
US9289292B2 (en) 2012-06-28 2016-03-22 St. Jude Medical, Cardiology Division, Inc. Valve cuff support
US9615920B2 (en) 2012-06-29 2017-04-11 St. Jude Medical, Cardiology Divisions, Inc. Commissure attachment feature for prosthetic heart valve
US9918837B2 (en) 2012-06-29 2018-03-20 St. Jude Medical, Cardiology Division, Inc. System to assist in the release of a collapsible stent from a delivery device
US9241791B2 (en) 2012-06-29 2016-01-26 St. Jude Medical, Cardiology Division, Inc. Valve assembly for crimp profile
US20140005776A1 (en) 2012-06-29 2014-01-02 St. Jude Medical, Cardiology Division, Inc. Leaflet attachment for function in various shapes and sizes
ES2690824T3 (es) 2012-07-02 2018-11-22 Boston Scientific Scimed, Inc. Formación de prótesis valvular cardiaca
US9498202B2 (en) 2012-07-10 2016-11-22 Edwards Lifesciences Corporation Suture securement devices
WO2014011888A1 (en) 2012-07-12 2014-01-16 Boston Scientific Scimed, Inc. Low profile heart valve delivery system and method
EP2874568B1 (en) 2012-07-20 2018-01-10 Cook Medical Technologies LLC Implantable medical device having a sleeve
US9271856B2 (en) 2012-07-25 2016-03-01 Medtronic Vascular Galway Delivery catheter with distal moving capsule for transapical prosthetic heart valve delivery
US9283072B2 (en) 2012-07-25 2016-03-15 W. L. Gore & Associates, Inc. Everting transcatheter valve and methods
US10376360B2 (en) 2012-07-27 2019-08-13 W. L. Gore & Associates, Inc. Multi-frame prosthetic valve apparatus and methods
US9364358B2 (en) 2012-07-27 2016-06-14 Medinol Ltd. Catheter with retractable cover and pressurized fluid
US9254141B2 (en) 2012-08-02 2016-02-09 St. Jude Medical, Inc. Apparatus and method for heart valve repair
ES2735536T3 (es) 2012-08-10 2019-12-19 Sorin Group Italia Srl Una prótesis de válvula y un kit
US9468525B2 (en) 2012-08-13 2016-10-18 Medtronic, Inc. Heart valve prosthesis
CN102805676B (zh) 2012-08-14 2015-06-17 杭州启明医疗器械有限公司 人造瓣膜置换装置的压缩装置
DE102012107465A1 (de) 2012-08-15 2014-05-22 Pfm Medical Ag Implantierbare Einrichtung zur Verwendung im menschlichen und/oder tierischen Körper zum Ersatz einer Organklappe
EP2884906B1 (en) 2012-08-17 2020-05-06 On-X Life Technologies Inc. Biological chord repair system
US9649212B2 (en) 2012-08-30 2017-05-16 Biotronik Ag Release device for releasing a medical implant from a catheter and catheter comprising a release device
US9717595B2 (en) 2012-09-05 2017-08-01 Medtronic Vascular Galway Trans-aortic delivery system with containment capsule centering device
DE102012216742A1 (de) 2012-09-19 2014-03-20 Hans-Hinrich Sievers Herzklappenprothese
WO2014046065A1 (ja) 2012-09-21 2014-03-27 国立大学法人大阪大学 心筋・血管再生デバイスとしての重症心不全治療材
CN105078615B (zh) 2012-09-21 2018-10-09 上海微创心通医疗科技有限公司 用于植入体输送系统的内管组件
US9283078B2 (en) 2012-09-21 2016-03-15 Materialise N.V. Patient-specific intraluminal implants
US9585748B2 (en) 2012-09-25 2017-03-07 Edwards Lifesciences Corporation Methods for replacing a native heart valve and aorta with a prosthetic heart valve and conduit
EP2900150B1 (en) 2012-09-29 2018-04-18 Mitralign, Inc. Plication lock delivery system
EP2712633B1 (de) 2012-10-02 2015-04-29 Biotronik AG Bioprosthetische Komponenten für ein Implantat, insbesondere teilvernetzte biologische Herzklappen
EP2906147A1 (en) 2012-10-09 2015-08-19 Biotronik AG Crimping tool for a prosthetic device and method for crimping a prosthetic device with a crimping tool
FR2996747B1 (fr) 2012-10-11 2015-02-06 Cormove Implant destine a etre insere dans un conduit de circulation du sang
US9295549B2 (en) 2012-10-12 2016-03-29 St. Jude Medical, Cardiology Division, Inc. Valve holder and loading integration
US9801721B2 (en) 2012-10-12 2017-10-31 St. Jude Medical, Cardiology Division, Inc. Sizing device and method of positioning a prosthetic heart valve
FR2996748B1 (fr) 2012-10-12 2015-02-06 Cormove Dispositif de traitement d'un conduit de circulation du sang
US10799348B2 (en) 2012-10-18 2020-10-13 Loma Vista Medical, Inc. Reinforced inflatable medical devices
WO2014062448A1 (en) 2012-10-19 2014-04-24 Boston Scientific Scimed, Inc. Anti-thrombus feature for implanted medical devices
US10376266B2 (en) 2012-10-23 2019-08-13 Valtech Cardio, Ltd. Percutaneous tissue anchor techniques
US9949828B2 (en) 2012-10-23 2018-04-24 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
EP2911611B1 (en) 2012-10-24 2022-12-07 Cook Medical Technologies LLC Anti-reflux prosthesis
FR2997288B1 (fr) 2012-10-25 2015-01-23 Cormove Dispositif de mise en place d'une etancheite autour d'un implant dans un passage de circulation du sang, et necessaire de traitement associe
US9192751B2 (en) 2012-10-26 2015-11-24 Medtronic, Inc. Elastic introducer sheath
DE102012219752A1 (de) 2012-10-29 2014-04-30 Aesculap Ag Stabilisator für Operationen am schlagenden Herzen
US9636441B2 (en) 2012-11-05 2017-05-02 Robert Jarvik Support stent for transvalvular conduit
US20140128964A1 (en) 2012-11-08 2014-05-08 Symetis Sa Stent Seals and Methods for Sealing an Expandable Stent
US20140135907A1 (en) 2012-11-09 2014-05-15 Medtronic CV Luxembourg S.a.r.l. Medical Device Delivery System and Methods of Delivering Medical Devices
US9144493B2 (en) 2012-11-14 2015-09-29 Medtronic Vascular Galway Limited Valve prosthesis deployment assembly and method
FR2998166B1 (fr) 2012-11-16 2016-02-26 Engin Oder Prothese annulaire pour la therapie de la valve mitrale par annulo-plastie
ES2610992T3 (es) 2012-11-20 2017-05-04 Innovheart S.R.L. Dispositivo para desplegar un sistema de alambres guías dentro de una cámara cardíaca para implantar una válvula cardíaca protésica
DK2922500T3 (en) 2012-11-20 2017-02-06 Innovheart S R L PROCESSING PROCEDURES FOR HEALTHCARD REPLACEMENT
US20140142689A1 (en) 2012-11-21 2014-05-22 Didier De Canniere Device and method of treating heart valve malfunction
US11400261B2 (en) 2012-11-21 2022-08-02 Concert Medical, Llc Preformed guidewire
ES2931210T3 (es) 2012-11-21 2022-12-27 Edwards Lifesciences Corp Mecanismos de retención para válvulas cardiacas protésicas
US9199348B2 (en) 2012-11-27 2015-12-01 Medtronic, Inc. Prosthetic valve crimping
WO2014089424A1 (en) 2012-12-07 2014-06-12 Valcare, Inc. Methods, devices, and systems for percutaneously anchoring annuloplasty rings
EP2742911A1 (de) 2012-12-17 2014-06-18 Hans Reiner Figulla Klappenprothese zum Ersatz einer Atrioventricularklappe
US9737398B2 (en) 2012-12-19 2017-08-22 W. L. Gore & Associates, Inc. Prosthetic valves, frames and leaflets and methods thereof
US9101469B2 (en) 2012-12-19 2015-08-11 W. L. Gore & Associates, Inc. Prosthetic heart valve with leaflet shelving
US9398952B2 (en) 2012-12-19 2016-07-26 W. L. Gore & Associates, Inc. Planar zone in prosthetic heart valve leaflet
US10039638B2 (en) 2012-12-19 2018-08-07 W. L. Gore & Associates, Inc. Geometric prosthetic heart valves
US10966820B2 (en) 2012-12-19 2021-04-06 W. L. Gore & Associates, Inc. Geometric control of bending character in prosthetic heart valve leaflets
US9144492B2 (en) 2012-12-19 2015-09-29 W. L. Gore & Associates, Inc. Truncated leaflet for prosthetic heart valves, preformed valve
US10321986B2 (en) 2012-12-19 2019-06-18 W. L. Gore & Associates, Inc. Multi-frame prosthetic heart valve
US9968443B2 (en) 2012-12-19 2018-05-15 W. L. Gore & Associates, Inc. Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet
US9008769B2 (en) 2012-12-21 2015-04-14 Backbeat Medical, Inc. Methods and systems for lowering blood pressure through reduction of ventricle filling
EP2938291B2 (en) 2012-12-27 2023-01-11 Venus MedTech (HangZhou), Inc. Apparatus and set for folding or unfolding a medical implant comprising a clamping mechanism
SG10201609392XA (en) 2012-12-31 2017-01-27 Edwards Lifesciences Corp Post-implant expandable surgical heart valve configurations
DE102013200152A1 (de) 2013-01-08 2014-07-10 AdjuCor GmbH Herzunterstützungsvorrichtung mit einer selbst-expandierenden Schale
US9066801B2 (en) 2013-01-08 2015-06-30 Medtronic, Inc. Valve prosthesis and method for delivery
EP2752170B1 (en) 2013-01-08 2017-02-22 Cook Medical Technologies LLC Multi valve anti-reflux prosthesis
WO2014108903A1 (en) 2013-01-09 2014-07-17 4Tech Inc. Soft tissue anchors
EP2943151B1 (en) 2013-01-10 2017-07-19 Intervene, Inc. System for endoluminal valve creation
FR3001121B1 (fr) 2013-01-18 2016-01-15 Ladjali Mustapha Dr Pince de traitement d'un tissu corporel et necessaire de traitement associe
EP2948103B1 (en) 2013-01-24 2022-12-07 Cardiovalve Ltd Ventricularly-anchored prosthetic valves
EP2948101B1 (en) 2013-01-25 2019-03-13 Medtentia International Ltd Oy A medical device for facilitating selection of an annuloplasty implant
CA2897912C (en) 2013-01-25 2021-11-30 Medtentia International Ltd Oy A system for cardiac valve repair
WO2014114797A1 (en) 2013-01-25 2014-07-31 Medtentia International Ltd Oy Temporary atrium support device
EP2948102B1 (en) 2013-01-25 2019-01-16 Medtentia International Ltd Oy A valve for short time replacement, for taking over the function of and/or for temporary or partial support of a native valve in a heart
CN105050543B (zh) 2013-01-25 2018-03-20 梅德坦提亚国际有限公司 用于收集腱索和/或瓣叶的医疗系统、装置及其方法
US10413401B2 (en) 2013-02-01 2019-09-17 Medtronic CV Luxembourg S.a.r.l. Anti-paravalvular leakage component for a transcatheter valve prosthesis
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
EP2950752B1 (en) 2013-02-04 2022-07-27 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices
BR112015018310A2 (pt) 2013-02-06 2017-07-18 Symetis Sa válvula protética, aparelho de introdução e método de introdução
WO2014130160A1 (en) 2013-02-21 2014-08-28 St. Jude Medical, Cardiology Division, Inc. Transapical passive articulation delivery system design
EP2769681B1 (en) 2013-02-22 2019-08-21 Biotronik AG Release device for detaching a medical implant from an insertion device and an insertion device comprising a release device
EP2769742A1 (en) 2013-02-22 2014-08-27 Cardiatis S.A. MRI visible medical device.
CN104000672B (zh) 2013-02-25 2016-06-15 上海微创心通医疗科技有限公司 心脏瓣膜假体
EP2961358B1 (en) 2013-02-28 2019-06-26 Boston Scientific Scimed, Inc. Implantable medical devices for reduced tissue inflammation
US9155616B2 (en) 2013-02-28 2015-10-13 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with expandable microspheres
EP3427696B1 (en) 2013-03-01 2025-07-02 Cormatrix Cardiovascular, Inc. Anchored cardiovascular valve
EP2964152B1 (en) 2013-03-07 2021-04-28 Medtronic Vascular Galway Prosthesis for transcatheter valve implantation
ITPI20130015A1 (it) 2013-03-07 2014-09-08 S M Scienzia Machinale S R L Apparecchiatura e metodo per la produzione di un oggetto tridimensionale biocompatibile
US9814573B2 (en) 2013-03-08 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Method of preparing a tissue swatch for a bioprosthetic device
CN105246430B (zh) 2013-03-08 2020-07-28 卡内基梅隆大学 可扩展的可植入导管
US9808364B2 (en) 2013-03-11 2017-11-07 Cook Medical Technologies Llc Systems and methods for maintaining perfusion of branch vessels
US9119713B2 (en) 2013-03-11 2015-09-01 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve replacement
US9744032B2 (en) 2013-03-11 2017-08-29 Cook Medical Technologies Llc Endoluminal prosthesis comprising a valve and an axially extendable segment
WO2014164302A1 (en) 2013-03-12 2014-10-09 Edwards Lifesciences Corporation Systems and methods for ensuring safe and rapid deployment of prosthetic heart valves
US8986375B2 (en) 2013-03-12 2015-03-24 Medtronic, Inc. Anti-paravalvular leakage component for a transcatheter valve prosthesis
WO2014164151A1 (en) 2013-03-12 2014-10-09 Medtronic Inc. Heart valve prosthesis
WO2014164832A1 (en) 2013-03-12 2014-10-09 Edwards Lifesciences Corporation Rapidly deployable surgical heart valves
CN105517509B (zh) 2013-03-13 2017-08-08 爱德华兹生命科学卡迪尔克有限责任公司 铰接式连合瓣膜支架和方法
CN105007955B (zh) 2013-03-13 2018-06-22 W.L.戈尔及同仁股份有限公司 适用于植入物的耐用高强度聚合物复合材料及其制品
US9326856B2 (en) 2013-03-14 2016-05-03 St. Jude Medical, Cardiology Division, Inc. Cuff configurations for prosthetic heart valve
CN108852555A (zh) 2013-03-14 2018-11-23 瓣膜医学有限公司 临时的瓣膜和瓣膜-过滤器
CN105163687B (zh) 2013-03-14 2019-08-13 心肺医疗股份有限公司 栓子保护装置和使用方法
US9687346B2 (en) 2013-03-14 2017-06-27 Edwards Lifesciences Corporation Multi-stranded heat set annuloplasty rings
EP2777616B1 (en) 2013-03-14 2020-08-19 Edwards Lifesciences CardiAQ LLC Prosthesis for atraumatically grasping intralumenal tissue
US20140277427A1 (en) 2013-03-14 2014-09-18 Cardiaq Valve Technologies, Inc. Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
WO2014160330A1 (en) 2013-03-14 2014-10-02 Millepede, Llc. Systems and methods for reshaping a heart valve
US9907681B2 (en) 2013-03-14 2018-03-06 4Tech Inc. Stent with tether interface
CA2907185C (en) 2013-03-15 2019-12-17 Hlt, Inc. Low-profile prosthetic valve structure
CA2905544C (en) 2013-03-15 2020-08-18 Symetis Sa Improvements relating to transcatheter stent-valves
US20140276979A1 (en) 2013-03-15 2014-09-18 Lsi Solutions, Inc. Method and devices for securing bidirectional suture loops using coaxial mechanical fasteners
EP2967863B1 (en) 2013-03-15 2018-01-31 Edwards Lifesciences Corporation Valved aortic conduits
EP2967700B1 (en) 2013-03-15 2020-11-25 Valcare, Inc. Systems for delivery of annuloplasty rings
EP2777617B1 (en) 2013-03-15 2022-09-14 Edwards Lifesciences CardiAQ LLC Prosthesis with outer skirt
US8906086B2 (en) 2013-03-15 2014-12-09 Cook Medical Technologies Llc Endovascular stent graft with self-closing perfusion branch
US9232998B2 (en) 2013-03-15 2016-01-12 Cardiosolutions Inc. Trans-apical implant systems, implants and methods
US9289297B2 (en) 2013-03-15 2016-03-22 Cardiosolutions, Inc. Mitral valve spacer and system and method for implanting the same
CA2901008C (en) 2013-03-15 2021-06-22 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9232994B2 (en) 2013-03-15 2016-01-12 Medtronic Vascular Galway Limited Stented prosthetic heart valve and methods for making
CN103190968B (zh) 2013-03-18 2015-06-17 杭州启明医疗器械有限公司 一种支架以及具有该支架的安装稳固的人造瓣膜置换装置
FR2998167B1 (fr) 2013-03-20 2015-01-09 Marco Vola Dispositif pour realiser une annuloplastie par voie transapicale de la valve mitrale
DE102013205519B4 (de) 2013-03-27 2019-05-23 Fehling Instruments Gmbh & Co. Kg Spreizer für den Vorhof des Herzens
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
EP2789312A1 (en) 2013-04-09 2014-10-15 Epygon Sasu Expandable stent-valve and method for manufacturing a stent
FR3004638B1 (fr) 2013-04-19 2015-05-29 Invalv Lab Implant, notamment destine a etre place dans une valve auriculo-ventriculaire cardiaque, comportant un systeme d'ecartement des bras proximaux
EP2986256B1 (en) 2013-04-19 2019-04-10 Strait Access Technologies Holdings (Pty) Ltd A prosthetic heart valve
FR3004917B1 (fr) 2013-04-25 2016-06-10 Bernard Pain Appareil de mesure du diametre d'une valve aortique
JP6557217B2 (ja) 2013-05-01 2019-08-07 アニュメド， インコーポレイテッド 個別化された大動脈弁補綴具
DE102013208038B4 (de) 2013-05-02 2016-09-08 Michael Siegenthaler Katheterbasierendes Herzunterstützungssystem
US9375311B2 (en) 2013-05-03 2016-06-28 Medtronic, Inc. Prosthetic valves and associated appartuses, systems and methods
EP4176841A1 (en) 2013-05-03 2023-05-10 Cormatrix Cardiovascular, Inc. Prosthetic tissue valves
KR101429005B1 (ko) 2013-05-06 2014-08-12 부산대학교 산학협력단 심장판막 고정장치
US9937330B2 (en) 2013-05-07 2018-04-10 Cook Medical Technologies Llc System, method, and kit for providing the diameter of a balloon during treatment
CA2910751C (en) 2013-05-09 2021-02-23 Mitrassist Medical Ltd. Heart valve assistive prosthesis
EP3964168A1 (en) 2013-05-10 2022-03-09 Medtronic, Inc. System for deploying a device to a distal location across a diseased vessel
EP2803335B1 (en) 2013-05-14 2017-09-27 Venus MedTech (HangZhou), Inc. Apparatus for folding or unfolding a medical implant, and implant
WO2014189974A1 (en) 2013-05-20 2014-11-27 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
WO2014189977A1 (en) 2013-05-20 2014-11-27 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
CN105555204B (zh) 2013-05-21 2018-07-10 V-波有限责任公司 用于递送减小左房压力的装置的设备
EP2805695A1 (en) 2013-05-21 2014-11-26 Medtentia International Ltd Oy Medical system for annuloplasty
EP2805678B1 (en) 2013-05-22 2017-05-17 Medtentia International Ltd Oy Stitching device
EP3533417B1 (en) 2013-05-22 2025-01-08 Valcare Medical, Inc. Transcatheter prosthetic valve for mitral or tricuspid valve replacement
EP3003452B1 (en) 2013-05-24 2019-09-11 Bioventrix, Inc. Cardiac tissue penetrating devices
CN104173121B (zh) 2013-05-27 2016-05-25 上海微创心通医疗科技有限公司 用于输送植入体的电动手柄及输送系统
US20140358224A1 (en) 2013-05-30 2014-12-04 Tendyne Holdlings, Inc. Six cell inner stent device for prosthetic mitral valves
FR3006582B1 (fr) 2013-06-05 2015-07-17 Mustapha Ladjali Dispositif de traitement d'un tissu corporel et necessaire de traitement associe
JP6440694B2 (ja) 2013-06-06 2018-12-19 デイヴィッド・アロン 心臓弁の修復および置換
CN105473107B (zh) 2013-06-14 2018-05-11 心脏解决方案有限公司 二尖瓣隔离物及其植入系统和方法
CN105451684B (zh) 2013-06-16 2017-04-19 皮-卡尔迪亚有限公司 经皮栓塞保护套
DE102013106352A1 (de) 2013-06-18 2014-12-18 Universität Zu Lübeck Herzunterstützungssystem sowie Herzunterstützungsverfahren
US9883942B2 (en) 2013-06-18 2018-02-06 St. Jude Medical, Cardiology Division, Inc. Transapical introducer
FR3006884B1 (fr) 2013-06-18 2016-06-24 Laboratoires Invalv Dispositif atraumatique d'introduction d'un element tubulaire creux dans un organe biologique
WO2014204807A1 (en) 2013-06-19 2014-12-24 Aga Medical Corporation Collapsible valve having paravalvular leak protection
US9320841B2 (en) 2013-06-21 2016-04-26 Corvivo, Inc. Ventricular assist device
AU2014302505B2 (en) 2013-06-25 2019-11-28 Tendyne Holdings, Inc. Thrombus management and structural compliance features for prosthetic heart valves
WO2015006575A1 (en) 2013-07-10 2015-01-15 Medtronic Inc. Helical coil mitral valve annuloplasty systems and methods
WO2015006739A1 (en) 2013-07-11 2015-01-15 Edwards Lifesciences Corporation Knotless suture fastener installation system
US9237948B2 (en) 2013-07-11 2016-01-19 Medtronic, Inc. Delivery system with projections
EP2826443B1 (en) 2013-07-16 2017-06-28 Venus MedTech (HangZhou), Inc. Set comprising an apparatus and a medical implant
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
EP3024527B1 (en) 2013-07-22 2021-11-17 Mayo Foundation for Medical Education and Research Device for self-centering a guide catheter
FR3008885B1 (fr) 2013-07-26 2016-12-30 Landanger Dispositif chirurgical notamment pour la pose de prothese de cordage mitrale
EP2918245B1 (en) 2014-03-14 2017-05-03 Venus MedTech (HangZhou), Inc. Heart valve comprising a crown piece interconnected to leaflets, a top cuff and a bottom cuff; and a medical implant
EP2832318B1 (en) 2013-07-31 2017-04-05 Venus MedTech (HangZhou), Inc. Handle assembly for implant delivery apparatus comprising a force limiter, a displacement limiter and/or a brake frame assembly
EP2918246B1 (en) 2014-03-14 2018-08-08 Venus MedTech (HangZhou), Inc. Heart valve assembly comprising twofold sealing
EP2832316B1 (en) 2013-07-31 2017-03-29 Venus MedTech (HangZhou), Inc. Handle assembly for implant delivery apparatus comprising a displacement limiter, a force limiter and/or a brake frame assembly
JP6499653B2 (ja) 2013-07-31 2019-04-10 シーヴィ デヴァイシズ，エルエルシー 単一体のシステムと装置およびその逆行性灌流利用方法
EP2832317B1 (en) 2013-07-31 2017-02-15 Venus MedTech (HangZhou), Inc. Implant delivery device for folding or unfolding a medical implant based on a knot
EP2832315B1 (en) 2013-07-31 2017-11-22 Venus MedTech (HangZhou), Inc. Handle assembly for implant delivery apparatus comprising a brake frame assembly, a force limiter and/or a displacement limiter
JP6465883B2 (ja) 2013-08-01 2019-02-06 テンダイン ホールディングス，インコーポレイテッド 心外膜アンカーデバイス及び方法
EP2835112B1 (en) 2013-08-08 2021-01-27 Sorin Group Italia S.r.l. Heart valve prosthesis
EP3323389B1 (en) 2013-08-14 2020-05-06 Sorin Group Italia S.r.l. Apparatus for chordal replacement
US20150051696A1 (en) 2013-08-14 2015-02-19 Boston Scientific Scimed, Inc. Medical guidewire
EP3545906B1 (en) 2013-08-14 2020-12-23 Mitral Valve Technologies Sàrl Replacement heart valve apparatus
WO2015031124A1 (en) 2013-08-29 2015-03-05 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve with lyophilized tissue
WO2015028209A1 (en) 2013-08-30 2015-03-05 Jenavalve Technology Gmbh Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
ES2706401T3 (es) 2013-08-30 2019-03-28 Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin Estructura saquiforme con actividad paracrina y métodos para su preparación
US10575953B2 (en) 2013-08-30 2020-03-03 Bioventrix, Inc. Heart anchor positioning devices, methods, and systems for treatment of congestive heart failure and other conditions
WO2015038458A1 (en) 2013-09-12 2015-03-19 St. Jude Medical, Cardiology Division, Inc. Stent designs for prosthetic heart valves
US10123870B2 (en) 2013-09-12 2018-11-13 St. Jude Medical, Cardiology Division, Inc. Alignment of an implantable medical device
EP3043755B1 (en) 2013-09-12 2022-10-19 St. Jude Medical, Cardiology Division, Inc. Atraumatic interface in an implant delivery device
GB201316349D0 (en) 2013-09-13 2013-10-30 Ucl Business Plc Vascular implant
CN105722476B (zh) 2013-09-16 2018-07-20 西美蒂斯股份公司 用于压缩/装载支架-瓣膜的方法和装置
EP2853237A1 (en) 2013-09-25 2015-04-01 Universität Zürich Biological heart valve replacement, particularly for pediatric patients, and manufacturing method
WO2015044190A1 (en) 2013-09-27 2015-04-02 Technische Universiteit Eindhoven Controlling tissue engineered heart valve geometry by using predefined inserts during culture
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US20150094803A1 (en) 2013-09-30 2015-04-02 The Cleveland Clinic Foundation Apparatus and method for treating a regurgitant heart valve
EP3052053B1 (en) 2013-10-05 2020-08-12 Sino Medical Sciences Technology, Inc. Device for mitral valve regurgitation method
US10869681B2 (en) 2013-10-17 2020-12-22 Cedars-Sinai Medical Center Device to percutaneously treat heart valve embolization
US9788944B2 (en) 2013-10-21 2017-10-17 St. Jude Medical, Cardiology Division, Inc. Transcatheter valve implantation access sheaths
US20160279297A1 (en) 2013-10-22 2016-09-29 ConcieValve LLC Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis
US10182910B2 (en) 2013-10-23 2019-01-22 Biotronik Ag Method for fitting an implant to a catheter
US9662202B2 (en) 2013-10-24 2017-05-30 Medtronic, Inc. Heart valve prosthesis
US10646333B2 (en) 2013-10-24 2020-05-12 Medtronic, Inc. Two-piece valve prosthesis with anchor stent and valve component
US9414913B2 (en) 2013-10-25 2016-08-16 Medtronic, Inc. Stented prosthetic heart valve
WO2015063118A1 (en) 2013-10-28 2015-05-07 Symetis Sa Stent-valve, delivery apparatus and method of use
CN106562840B (zh) 2013-10-31 2018-06-22 上海微创心通医疗科技有限公司 一种将植入体装载到输送系统中的导引盖和装载系统
EP2870946B1 (en) 2013-11-06 2018-10-31 St. Jude Medical, Cardiology Division, Inc. Paravalvular leak sealing mechanism
EP2870945B1 (en) 2013-11-08 2016-07-06 Nvt Ag Deployment system for vascular implants
CA2934975A1 (en) 2013-11-11 2015-05-14 Edwards Lifesciences Cardiaq Llc Systems and methods for manufacturing a stent frame
US9839765B2 (en) 2013-11-12 2017-12-12 St. Jude Medical, Cardiology Division, Inc. Transfemoral mitral valve repair delivery device
CN105916471A (zh) 2013-11-15 2016-08-31 盖和圣托马斯的Nhs信托基金会 用于心脏假体的信息标志和使用心脏假体的方法
EP3071149B1 (en) 2013-11-19 2022-06-01 St. Jude Medical, Cardiology Division, Inc. Sealing structures for paravalvular leak protection
US9603600B2 (en) 2013-11-20 2017-03-28 James E. Coleman Actuator for deployable implant
US9848880B2 (en) 2013-11-20 2017-12-26 James E. Coleman Adjustable heart valve implant
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
US10098734B2 (en) 2013-12-05 2018-10-16 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US9504565B2 (en) 2013-12-06 2016-11-29 W. L. Gore & Associates, Inc. Asymmetric opening and closing prosthetic valve leaflet
CN111991117B (zh) 2013-12-11 2023-10-24 雪松-西奈医学中心 用于在双孔二尖瓣中经导管二尖瓣置换的装置
KR102471841B1 (ko) 2013-12-19 2022-11-29 백비트 메디컬 엘엘씨 심방 압력을 조절하여 혈압을 조절하는 방법 및 시스템
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
CN103735337B (zh) 2013-12-31 2016-08-17 金仕生物科技（常熟）有限公司 人工心脏瓣膜成形环
CN103750922B (zh) 2013-12-31 2016-07-13 金仕生物科技（常熟）有限公司 制备人工心脏瓣膜瓣叶的方法
US9943408B2 (en) 2014-01-08 2018-04-17 St. Jude Medical, Cardiology Division, Inc. Basket delivery system
US9539090B2 (en) 2014-01-16 2017-01-10 Cook Medical Technologies Llc Transaortic valve access device
EP2896387A1 (en) 2014-01-20 2015-07-22 Mitricares Heart valve anchoring device
US10327890B2 (en) 2014-01-22 2019-06-25 Biotronik Ag Thermochemically treated miniature tubes as semifinished products for vascular stents
EP3096713B1 (en) 2014-01-23 2022-09-21 President and Fellows of Harvard College Engineered polymeric valves, tubular structures and sheets
US9820852B2 (en) 2014-01-24 2017-11-21 St. Jude Medical, Cardiology Division, Inc. Stationary intra-annular halo designs for paravalvular leak (PVL) reduction—active channel filling cuff designs
US9750603B2 (en) 2014-01-27 2017-09-05 Medtronic Vascular Galway Stented prosthetic heart valve with variable stiffness and methods of use
CA2937794A1 (en) 2014-01-28 2015-08-06 Sanford Health Pararenal and thoracic arch stent graft and methods for use
CN105744969B (zh) 2014-01-31 2019-12-31 雪松-西奈医学中心 用于最优主动脉瓣膜复合体成像和对准的猪尾装置
KR102432831B1 (ko) 2014-02-04 2022-08-12 이노브하르트 에세.에레.엘레. 심장 판막용 인공 디바이스
EP3102150B1 (en) 2014-02-07 2023-08-09 C. R. Bard, Inc. Polymer composite-covered stents
EP2904989A1 (en) 2014-02-11 2015-08-12 Kephalios S.A.S. Adjustable annuloplasty device
US9913717B2 (en) 2014-02-14 2018-03-13 Edwards Lifesciences Corporation Percutaneous leaflet augmentation
WO2015126712A1 (en) 2014-02-18 2015-08-27 St. Jude Medical, Cardiology Division, Inc. Bowed runners for paravalvular leak protection
PL4062874T4 (pl) 2014-02-18 2024-03-04 Edwards Lifesciences Corporation Elastyczna ramka dla spojenia
US9949825B2 (en) 2014-02-18 2018-04-24 St. Jude Medical, Cardiology Division, Inc. Bowed runners and corresponding valve assemblies for paravalvular leak protection
EP2907479A1 (en) 2014-02-18 2015-08-19 Medtentia International Ltd Oy A system and a method for delivery of an annuloplasty implant
CN109674560B (zh) 2014-02-21 2022-04-01 米特拉尔维尔福科技有限责任公司 用于递送人工二尖瓣和锚固装置的装置、系统和方法
EP3107497B1 (en) 2014-02-21 2020-07-22 Edwards Lifesciences CardiAQ LLC Delivery device for controlled deployment of a replacement valve
AU2015223169B2 (en) 2014-02-25 2019-08-29 Zain KHALPEY Ventricular assist device and method
AU2015221862B2 (en) 2014-02-28 2019-05-02 Highlife Sas Transcatheter valve prosthesis
AU2015221855B2 (en) 2014-02-28 2019-06-13 Highlife Sas Transcatheter valve prosthesis
EP2918247A1 (en) 2014-03-11 2015-09-16 Epygon Sasu A prosthetic valve and a delivery device
EP2918248A1 (en) 2014-03-11 2015-09-16 Epygon Sasu An expandable stent-valve and a delivery device
EP2918249B1 (de) 2014-03-14 2020-04-29 Venus MedTech (HangZhou), Inc. Supraclaviculäres kathetersystem für einen transseptalen zugang zum linken vorhof und linken ventrikel
US9668861B2 (en) 2014-03-15 2017-06-06 Rex Medical, L.P. Vascular device for treating venous valve insufficiency
GB2527075A (en) 2014-03-17 2015-12-16 Daassist As Percutaneous system, devices and methods
US10390943B2 (en) 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
JP6576944B2 (ja) 2014-03-18 2019-09-18 セント・ジュード・メディカル，カーディオロジー・ディヴィジョン，インコーポレイテッド 僧帽弁置換におけるトグルセル固定
EP2921139B1 (en) 2014-03-18 2018-11-21 Nvt Ag Heartvalve implant
EP2921135B1 (en) 2014-03-18 2017-02-01 Nvt Ag Prosthetic heart valve handling system
JP6411043B2 (ja) 2014-03-20 2018-10-24 学校法人東邦大学 弁尖形成用テンプレート
EP2923665B1 (de) 2014-03-26 2018-10-17 Biotronik AG Kathetervorrichtung zur minimalinvasiven Implantation eines Gefäßimplantats, insbesondere für die interventionelle, kathetergestützte Aortenklappenimplantation
WO2015152980A1 (en) 2014-03-31 2015-10-08 St. Jude Medical, Cardiology Division, Inc. Paravalvular sealing via extended cuff mechanisms
EP3125827B1 (en) 2014-04-01 2021-09-15 Medtronic CV Luxembourg S.à.r.l. Anti-paravalvular leakage component for a transcatheter valve prosthesis
EP2926840B1 (de) 2014-04-02 2018-05-09 Biotronik AG Verfahren zur Aufbereitung von biologischem Gewebe zur trockenen Verwendung in einem Implantat
ES2635438T3 (es) 2014-04-07 2017-10-03 Nvt Ag Dispositivo para su implantación en el corazón de un mamífero
US11116496B2 (en) 2014-04-08 2021-09-14 Lsi Solutions, Inc. Surgical suturing device for a replacement anatomical structure and methods thereof
EP3131502B1 (en) 2014-04-16 2021-07-21 Alma Mater Studiorum - Università di Bologna Heart valve prosthesis with integrated electronic circuit for measuring intravalvular electrical impedance
EP3552585B1 (en) 2014-04-17 2022-10-26 Medtronic Vascular Galway Hinged transcatheter prosthetic heart valve delivery system
US10321987B2 (en) 2014-04-23 2019-06-18 Medtronic, Inc. Paravalvular leak resistant prosthetic heart valve system
FR3020265B1 (fr) 2014-04-24 2019-09-06 Cormove Dispositif de mise en place d'une etancheite autour d'un implant dans un passage de circulation du sang, et necessaire de traitement associe
US10154904B2 (en) 2014-04-28 2018-12-18 Edwards Lifesciences Corporation Intravascular introducer devices
WO2015169870A1 (en) 2014-05-06 2015-11-12 Dsm Ip Assets B.V. Method of making a prosthetic valve and valve obtained therewith
JP6566445B2 (ja) 2014-05-06 2019-08-28 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． 人工弁の製造方法およびそれにより得られる弁
BR112016025723B1 (pt) 2014-05-06 2022-02-22 Dsm Ip Assets B.V. Válvula protética, conjunto de folhetos e método de fabricação da referida válvula protética
US10195025B2 (en) 2014-05-12 2019-02-05 Edwards Lifesciences Corporation Prosthetic heart valve
USRE49792E1 (en) 2014-05-14 2024-01-09 Corcym S.R.L. Implant device and implantation kit
US10130467B2 (en) 2014-05-16 2018-11-20 St. Jude Medical, Cardiology Division, Inc. Subannular sealing for paravalvular leak protection
CN106456330B (zh) 2014-05-21 2021-05-25 奥斯卡·马莱蒂 用于治疗导致影响下肢的逆流的疾病的人工瓣膜
EP3563800B1 (en) 2014-05-21 2023-10-11 SWAT Medical AB Improved embolic protection device
EP3145449B2 (en) 2014-05-21 2023-12-13 St. Jude Medical, Cardiology Division, Inc. Self-expanding heart valves for coronary perfusion and sealing
US10500042B2 (en) 2014-05-22 2019-12-10 St. Jude Medical, Cardiology Division, Inc. Stents with anchoring sections
US9757232B2 (en) 2014-05-22 2017-09-12 Edwards Lifesciences Corporation Crimping apparatus for crimping prosthetic valve with protruding anchors
FR3021208B1 (fr) 2014-05-23 2021-03-12 Thomas Modine Prothese de valve cardiaque mitrale ou tricuspide
US9687345B2 (en) 2014-05-29 2017-06-27 Edwards Lifesciences Cardiaq Llc Prosthesis, delivery device and methods of use
FR3021860A1 (fr) 2014-06-05 2015-12-11 Bernard Pain Dispositif transcatheter pour l'ablation de tissus calcifies au niveau des volets d'une valve aortique
FR3021863A1 (fr) 2014-06-05 2015-12-11 Bernard Pain Dispositif d'introduction transcatheter dans la racine aortique au niveau de la jonction sino tubulaire
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US9855140B2 (en) 2014-06-10 2018-01-02 St. Jude Medical, Cardiology Division, Inc. Stent cell bridge for cuff attachment
FR3021862B1 (fr) 2014-06-10 2016-05-20 Vygon Kit d'operation pour mise en place de valve aortique
US10111749B2 (en) 2014-06-11 2018-10-30 Medtronic Vascular, Inc. Prosthetic valve with flow director
WO2015191946A1 (en) 2014-06-12 2015-12-17 The Cleveland Clinic Foundation Device, system, and method for treating a regurgitant heart valve
ES2693507T3 (es) 2014-06-17 2018-12-12 Consiglio Nazionale Delle Ricerche Un procedimiento de fabricación de una válvula cardíaca hecha de un material de polímero y válvula cardíaca obtenida de este modo
CA2958061A1 (en) 2014-06-18 2015-12-23 Middle Peak Medical, Inc. Mitral valve implants for the treatment of valvular regurgitation
US9801720B2 (en) 2014-06-19 2017-10-31 4Tech Inc. Cardiac tissue cinching
ES2914153T3 (es) 2014-06-24 2022-06-07 Polares Medical Inc Sistemas para anclar un implante
US9700412B2 (en) 2014-06-26 2017-07-11 Mitralix Ltd. Heart valve repair devices for placement in ventricle and delivery systems for implanting heart valve repair devices
WO2016001382A2 (en) 2014-07-02 2016-01-07 Medtentia International Ltd Oy Clip for a medical implant
MX2017000107A (es) 2014-07-03 2017-06-30 Medtentia Int Ltd Oy Sistema para anuloplastia.
CN104055604B (zh) 2014-07-07 2016-06-01 宁波健世生物科技有限公司 一种带锚定装置的心脏瓣膜植入器械
FR3023704B1 (fr) 2014-07-15 2016-08-26 Mustapha Ladjali Dispositif de traitement endovasculaire d'une valve cardiaque en vue d'un remplacement valvulaire percutane
WO2016008551A1 (de) 2014-07-16 2016-01-21 Universitätsklinikum Jena Herzklappenprothese zum perkutanen ersatz einer trikuspidalklappe, set und system mit einer derartigen herzklappenprothese
ES2843250T3 (es) 2014-07-16 2021-07-16 Medira Ag Prótesis valvular cardiaca para la sustitución percutánea de una válvula tricúspide y sistema con una prótesis valvular cardiaca de este tipo
US9180005B1 (en) 2014-07-17 2015-11-10 Millipede, Inc. Adjustable endolumenal mitral valve ring
CN106999174B (zh) 2014-07-17 2019-08-23 核心医疗股份公司 用于心瓣修复的医疗设备及方法
EP2979667B2 (de) 2014-07-30 2020-10-28 Biotronik AG Einführvorrichtung für ein medizinisches implantat in einen menschlichen und/oder tierischen körper
EP3174502B1 (en) 2014-07-30 2022-04-06 Cardiovalve Ltd Apparatus for implantation of an articulatable prosthetic valve
ES2725883T3 (es) 2014-08-01 2019-09-30 Alvimedica Tibbi Ueruenler Sanayi Ve Dis Ticaret A S Prótesis de válvula aórtica, particularmente adecuada para implantación transcatéter
US9801719B2 (en) 2014-08-15 2017-10-31 Edwards Lifesciences Corporation Annulus rings with suture clips
US9808201B2 (en) 2014-08-18 2017-11-07 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
US9737264B2 (en) 2014-08-18 2017-08-22 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
MX2017002885A (es) 2014-09-08 2017-09-28 Medtentia Int Ltd Oy Implante de anuloplastia.
JP5738461B1 (ja) 2014-09-08 2015-06-24 重之 尾崎 弁尖サイザー
US10595999B2 (en) 2014-09-09 2020-03-24 Occlutech Holding Ag Flow regulating device in the heart
US9827094B2 (en) 2014-09-15 2017-11-28 W. L. Gore & Associates, Inc. Prosthetic heart valve with retention elements
GB2536538B (en) 2014-09-17 2018-07-18 Cardiomech As Anchor for implantation in body tissue
EP3000436B1 (de) 2014-09-24 2017-04-05 Alexander Lauten System zum Ersatz einer an einer Entzündung oder einer Infektion erkrankten Klappe des Herzens
EP3054893B1 (en) 2014-09-24 2017-04-12 Sorin Group Italia S.r.l. A holder for heart valve prostheses, corresponding storage arrangement, delivery instrument and kit
ES2676060T3 (es) 2014-09-26 2018-07-16 Nvt Ag Dispositivo implantable para el tratamiento de la regurgitación de la válvula mitral
RU2017114607A (ru) 2014-09-28 2018-10-29 Кардиокинетикс, Инк. Устройства для терапии нарушений функции сердца
US10390950B2 (en) 2014-10-03 2019-08-27 St. Jude Medical, Cardiology Division, Inc. Flexible catheters and methods of forming same
DE102014114762B3 (de) 2014-10-10 2016-03-03 Asanus Medizintechnik Gmbh Aortenklappenklemme und Instrumentensatz zur Aortenklappenrekonstruktion
JP2017530814A (ja) 2014-10-13 2017-10-19 シメティス・ソシエテ・アノニムＳｙｍｅｔｉｓ Ｓａ ステント弁のためのカテーテル送達システム
EP3009104B1 (en) 2014-10-14 2019-11-20 St. Jude Medical, Cardiology Division, Inc. Flexible catheter and methods of forming same
EP4331503A3 (en) 2014-10-14 2024-06-05 Edwards Lifesciences Innovation (Israel) Ltd. Leaflet-restraining techniques
FR3027212A1 (fr) 2014-10-16 2016-04-22 Seguin Jacques Implant intervalvulaire pour valve mitrale
US10105225B2 (en) 2014-10-22 2018-10-23 Medtronic, Inc. Devices, systems and methods for tissue approximation, including approximating mitral valve leaflets
EP3212097B1 (en) 2014-10-30 2018-07-11 Peter Osypka Stiftung Transmyocardial insertion unit
US10213307B2 (en) 2014-11-05 2019-02-26 Medtronic Vascular, Inc. Transcatheter valve prosthesis having an external skirt for sealing and preventing paravalvular leakage
CA2967241C (en) 2014-11-17 2023-01-31 Mitrassist Medical Ltd. Heart valve prosthesis
DE102014223522A1 (de) 2014-11-18 2016-05-19 Hans-Hinrich Sievers Biologische Herzklappenprothese
EP3223873B1 (en) 2014-11-24 2020-04-08 Biotronik AG Sealing structure for heart valve implants
JP6717820B2 (ja) 2014-12-02 2020-07-08 ４テック インコーポレイテッド 偏心組織アンカー
CR20170245A (es) 2014-12-05 2017-09-14 Edwards Lifesciences Corp Cateter dirigible con cable de tracción
CN109758266B (zh) 2014-12-18 2021-01-01 W.L.戈尔及同仁股份有限公司 带有机械联接的瓣叶的假体瓣膜
EP3037064B1 (en) 2014-12-23 2018-03-14 Venus MedTech (HangZhou), Inc. Minimally invasive mitral valve replacement with brim
WO2016098877A1 (ja) 2014-12-19 2016-06-23 国立研究開発法人国立循環器病研究センター 人工弁形成基材及び人工弁
WO2016101991A1 (en) 2014-12-22 2016-06-30 Synergio Ab An implantable hydraulic displacement actuator, system, manufacturing and methods thereof
US10092428B2 (en) 2014-12-30 2018-10-09 Cook Medical Technologies Llc Low profile prosthesis delivery device
US10299928B2 (en) 2015-01-05 2019-05-28 David Alon Heart ventricle remodeling
US9579195B2 (en) 2015-01-13 2017-02-28 Horizon Scientific Corp. Mitral bileaflet valve
WO2016118522A1 (en) 2015-01-21 2016-07-28 Medtronic Inc. Prosthetic valve sizer and assembly including same
CN107427355B (zh) 2015-02-02 2021-08-10 赛姆斯股份公司 支架密封件及其制备方法
JP6636527B2 (ja) 2015-02-03 2020-01-29 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 心膜組織を処理する方法、装置およびシステム
EP3253331B1 (en) 2015-02-05 2021-04-07 Tendyne Holdings, Inc. Prosthetic heart valve with tether and expandable epicardial pad
US10231834B2 (en) 2015-02-09 2019-03-19 Edwards Lifesciences Corporation Low profile transseptal catheter and implant system for minimally invasive valve procedure
US10039637B2 (en) 2015-02-11 2018-08-07 Edwards Lifesciences Corporation Heart valve docking devices and implanting methods
US20160235525A1 (en) 2015-02-12 2016-08-18 Medtronic, Inc. Integrated valve assembly and method of delivering and deploying an integrated valve assembly
CN107530166B (zh) 2015-02-13 2020-01-31 魅尔皮德股份有限公司 使用旋转锚固件的瓣膜置换
JP6813494B2 (ja) 2015-02-13 2021-01-13 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティドＷ．Ｌ． Ｇｏｒｅ ＆ Ａｓｓｏｃｉａｔｅｓ， Ｉｎｃｏｒｐｏｒａｔｅｄ 人工弁用のコヒーレントシングルレイヤ高強度合成ポリマー複合体
US10413400B2 (en) 2015-02-24 2019-09-17 Rijksuniversiteit Groningen Mechanical heart valve prosthesis for the right ventricle
FR3033494B1 (fr) 2015-03-10 2017-03-24 Carmat Endoprothese tissulaire et procede pour sa realisation
US10758349B2 (en) 2015-03-13 2020-09-01 Medtronic Vascular, Inc. Delivery device for prosthetic heart valve with capsule adjustment device
EP4353203B1 (en) 2015-03-20 2026-08-19 JenaValve Technology, Inc. Heart valve prosthesis delivery system
EP3273911A1 (en) 2015-03-24 2018-01-31 St. Jude Medical, Cardiology Division, Inc. Prosthetic mitral valve
CN107157622B (zh) 2015-03-26 2019-12-17 杭州启明医疗器械股份有限公司 使用安全的瓣膜支架以及具有该瓣膜支架的瓣膜置换装置
DE102015206099A1 (de) 2015-04-02 2016-10-06 Hans-Hinrich Sievers Herzklappenprothese
DE102015206097A1 (de) 2015-04-02 2016-10-06 Hans-Hinrich Sievers Herzklappenprothese
DE102015206098B4 (de) 2015-04-02 2018-09-27 Hans-Hinrich Sievers Implantationshilfe für eine biologische Herzklappenprothese sowie Herzklappenprothesensystem
FR3034642B1 (fr) 2015-04-07 2021-01-15 Benjamin Faurie Introducteur pour ensemble de remplacement d'une valve cardiaque ou pour ensemble d'angioplastie coronaire
EP3078350B1 (en) 2015-04-09 2018-01-31 Frid Mind Technologies 3d filter for prevention of stroke
US10314696B2 (en) 2015-04-09 2019-06-11 Boston Scientific Scimed, Inc. Prosthetic heart valves having fiber reinforced leaflets
US10327896B2 (en) 2015-04-10 2019-06-25 Edwards Lifesciences Corporation Expandable sheath with elastomeric cross sectional portions
US10792471B2 (en) 2015-04-10 2020-10-06 Edwards Lifesciences Corporation Expandable sheath
US10368986B2 (en) 2015-04-15 2019-08-06 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system and method
US9931790B2 (en) 2015-04-16 2018-04-03 Siemens Healthcare Gmbh Method and system for advanced transcatheter aortic valve implantation planning
AU2016248314B2 (en) 2015-04-16 2020-05-21 Tendyne Holdings, Inc. Apparatus and methods for delivery, repositioning, and retrieval of transcatheter prosthetic valves
US10064718B2 (en) 2015-04-16 2018-09-04 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
KR101588310B1 (ko) 2015-04-22 2016-01-25 (주)태웅메디칼 심낭막을 이용한 인공심장판막 및 그 제조방법
US9782256B2 (en) 2015-04-27 2017-10-10 Venus Medtech (Hangzhou) Inc Heart valve assembly
EP3087952A1 (en) 2015-04-29 2016-11-02 Kephalios S.A.S. An annuloplasty system and a method for monitoring the effectiveness of an annuloplasty treatment
US10232564B2 (en) 2015-04-29 2019-03-19 Edwards Lifesciences Corporation Laminated sealing member for prosthetic heart valve
CN106175985B (zh) 2015-04-29 2018-08-24 上海微创心通医疗科技有限公司 用于输送植入体的驱动手柄及输送系统
CN114668555A (zh) 2015-04-30 2022-06-28 丝绸之路医药公司 用于经导管主动脉瓣治疗的系统和方法
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
DK3288479T3 (da) 2015-05-01 2022-01-17 Feops Nv Fremgangsmåde og system til bestemmelse af en risiko for hjerteledningsabnormiteter
EP3632378B1 (en) 2015-05-01 2024-05-29 JenaValve Technology, Inc. Device with reduced pacemaker rate in heart valve replacement
US9629720B2 (en) 2015-05-04 2017-04-25 Jacques Seguin Apparatus and methods for treating cardiac valve regurgitation
GB2538072B (en) 2015-05-05 2017-11-15 Strait Access Tech Holdings (Pty) Ltd A non-occlusive dilation and deployment catheter device
WO2016178126A1 (en) 2015-05-05 2016-11-10 The Medical Research Infrastructure And Health Services Fund Of The Tel-Aviv Medical Center Mitral valve implant
DE102015107242B4 (de) 2015-05-08 2022-11-03 Highlife Sas System zum Implantieren eines Implantats um eine umfängliche Gewebestruktur in einem Herz und Verfahren zum Anordnen und Vorbringen eines Implantats auf einem Führungsdraht eines solchen Systems
JP6595210B2 (ja) 2015-05-08 2019-10-23 株式会社日本医療機器開発機構 大動脈弁再建術トレーニングキット
CA2985659A1 (en) 2015-05-12 2016-11-17 Ancora Heart, Inc. Device and method for releasing catheters from cardiac structures
EP4512372B1 (en) 2015-05-14 2026-06-17 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
GB2538749B (en) 2015-05-27 2017-08-02 Univ Dublin City Inflatable balloon
JP6816889B2 (ja) 2015-05-28 2021-01-20 ４テック インコーポレイテッド 引張り部材を有する偏心組織アンカー
EP3302362B1 (en) 2015-05-28 2020-11-11 St. Jude Medical, Cardiology Division, Inc. System for loading a collapsible heart valve having a leaflet restraining member
WO2016196270A1 (en) 2015-06-01 2016-12-08 Edwards Lifesciences Corporation Cardiac valve repair devices configured for percutaneous delivery
RU2723333C2 (ru) 2015-06-04 2020-06-09 Эпигон Атриовентрикулярный клапанный стент с механизмом захвата и удерживания створки нативного клапана
EP3302367B1 (en) 2015-06-08 2023-06-07 Northwestern University Annuloplasty ring for receiving a replacement valve
US10314707B2 (en) 2015-06-09 2019-06-11 Edwards Lifesciences, Llc Asymmetric mitral annuloplasty band
GB2539444A (en) 2015-06-16 2016-12-21 Ucl Business Plc Prosthetic heart valve
CA2991155A1 (en) 2015-06-30 2017-01-05 Robert V. Snyders Lifetime regenerative heart valve
JP6579828B2 (ja) 2015-06-30 2019-09-25 キヤノン株式会社 ズームレンズ及びそれを有する撮像装置
CN107735051B (zh) 2015-07-02 2020-07-31 爱德华兹生命科学公司 适于植入后膨胀的混合心脏瓣膜
US10716671B2 (en) 2015-07-02 2020-07-21 Boston Scientific Scimed, Inc. Prosthetic heart valve composed of composite fibers
US10456246B2 (en) 2015-07-02 2019-10-29 Edwards Lifesciences Corporation Integrated hybrid heart valves
JP6778737B2 (ja) 2015-07-03 2020-11-04 ボストン サイエンティフィック リミテッド 人工弁用バルーンカテーテル
DE102015212699A1 (de) 2015-07-07 2017-01-12 AdjuCor GmbH Implantierbare Vorrichtung zur ortsgenauen Zuführung und Applikation von Substanzen in das Perikard oder auf die Herzoberfläche
US9974650B2 (en) 2015-07-14 2018-05-22 Edwards Lifesciences Corporation Prosthetic heart valve
US10639149B2 (en) 2015-07-16 2020-05-05 St. Jude Medical, Cardiology Division, Inc. Sutureless prosthetic heart valve
ITUB20152409A1 (it) 2015-07-22 2017-01-22 Sorin Group Italia Srl Manicotto valvolare per protesi valvolari e corrispondente dispositivo
EP3328318B1 (en) 2015-07-28 2019-08-21 Boston Scientific Scimed, Inc. Valve delivery system with pinless release mechanism
EP3334354B1 (en) 2015-08-11 2021-03-03 Terumo Corporation System for implant delivery
US10179041B2 (en) 2015-08-12 2019-01-15 Boston Scientific Scimed Icn. Pinless release mechanism
US10368983B2 (en) 2015-08-12 2019-08-06 St. Jude Medical, Cardiology Division, Inc. Collapsible heart valve including stents with tapered struts
US10925726B2 (en) 2015-08-12 2021-02-23 Boston Scientific Scimed, Inc. Everting leaflet delivery system with pivoting
US10709553B2 (en) 2015-08-12 2020-07-14 Boston Scientific Scimed, Inc. V-Clip post with pivoting
US10213301B2 (en) 2015-08-14 2019-02-26 Caisson Interventional, LLC Systems and methods for heart valve therapy
US10179046B2 (en) 2015-08-14 2019-01-15 Edwards Lifesciences Corporation Gripping and pushing device for medical instrument
US9895222B2 (en) 2015-08-17 2018-02-20 Venus Medtech (Hangzhou) Inc. Aortic replacement valve
EP3365349B1 (en) 2015-08-18 2022-06-15 University of Pittsburgh- Of the Commonwealth System of Higher Education Viologen-functionalized porphyrins for reducing biofouling on surfaces
US11357499B2 (en) 2015-08-18 2022-06-14 Lsi Solutions, Inc. Apparatus for mitral valve repair and methods thereof
US11026788B2 (en) 2015-08-20 2021-06-08 Edwards Lifesciences Corporation Loader and retriever for transcatheter heart valve, and methods of crimping transcatheter heart valve
US10631977B2 (en) 2015-08-24 2020-04-28 Edwards Lifesciences Corporation Covering and assembly method for transcatheter valve
JP6993972B2 (ja) 2015-08-25 2022-01-14 イノベイン，インコーポレイティド 人工静脈弁
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
CN108348346B (zh) 2015-08-26 2020-11-06 爱德华兹生命科学公司 受控气囊部署
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
CN108135592B (zh) 2015-09-02 2021-05-14 爱德华兹生命科学公司 用于固定经导管瓣膜至生物假体心脏结构的间隔件
JP2018526109A (ja) 2015-09-03 2018-09-13 セント・ジュード・メディカル，カーディオロジー・ディヴィジョン，インコーポレイテッド 拡張可能な部分を有するイントロデューサシース
US10092324B2 (en) 2015-09-04 2018-10-09 The Trustees Of The University Of Pennsylvania Systems and methods for percutaneous removal of objects from an internal body space
US10080653B2 (en) 2015-09-10 2018-09-25 Edwards Lifesciences Corporation Limited expansion heart valve
EP3347182B1 (en) 2015-09-11 2022-07-13 S.M. Scienzia Machinale S.r.l Apparatus and method for producing a biocompatible three-dimensional object
US10195023B2 (en) 2015-09-15 2019-02-05 Boston Scientific Scimed, Inc. Prosthetic heart valves including pre-stressed fibers
US10478288B2 (en) 2015-09-30 2019-11-19 Clover Life Sciences Inc. Trileaflet mechanical prosthetic heart valve
ES2554296B1 (es) 2015-10-02 2017-01-18 Jose Ignacio ARAMENDI GALLARDO Anillo subaórtico reabsorbible
US10195024B2 (en) 2015-10-07 2019-02-05 Boston Scientific Scimed, Inc. Porcine small intestine submucosa leaflet material
US9872765B2 (en) 2015-10-12 2018-01-23 Venus Medtech (Hangzhou) Inc Mitral valve assembly
WO2017066480A1 (en) 2015-10-14 2017-04-20 Heart Repair Technologies, Inc. Transvalvular intraannular band for mitral valve repair
US10350067B2 (en) 2015-10-26 2019-07-16 Edwards Lifesciences Corporation Implant delivery capsule
JP6873121B2 (ja) 2015-10-28 2021-05-19 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 大動脈弁状態の情報伝達
US10266657B2 (en) 2015-10-29 2019-04-23 Commonwealth Scientific And Industrial Research Organisation Polyurethane/urea compositions
US20170143478A1 (en) 2015-11-02 2017-05-25 Robert S. Schwartz Devices and methods for reducing cardiac valve regurgitation
US9592121B1 (en) 2015-11-06 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US10321996B2 (en) 2015-11-11 2019-06-18 Edwards Lifesciences Corporation Prosthetic valve delivery apparatus having clutch mechanism
CN111329541B (zh) 2015-11-17 2023-09-19 波士顿科学国际有限公司 用于使心脏瓣环重新定形的可植入装置和输送系统
US10143554B2 (en) 2015-12-03 2018-12-04 Medtronic Vascular, Inc. Venous valve prostheses
DE102015121501A1 (de) 2015-12-10 2017-06-14 Biotronik Ag Einführkatheter und Katheteranordnung
JP7002451B2 (ja) 2015-12-15 2022-01-20 ニオバスク ティアラ インコーポレイテッド 経中隔送達システム
US11008676B2 (en) 2015-12-16 2021-05-18 Edwards Lifesciences Corporation Textured woven fabric for use in implantable bioprostheses
EP3184081B1 (en) 2015-12-22 2021-03-24 Medira Ag Prosthetic mitral valve coaptation enhancement device
EP3184082B1 (en) 2015-12-23 2022-08-17 P+F Products + Features Vertriebs GmbH Stent for a surgical valve
AU2016380259B2 (en) 2015-12-28 2020-10-22 Tendyne Holdings, Inc. Atrial pocket closures for prosthetic heart valves
CA3010324A1 (en) 2015-12-30 2017-07-06 Caisson Interventional, LLC Systems and methods for heart valve therapy
US10426619B2 (en) 2015-12-30 2019-10-01 Avvie Gmbh Implant and method for improving coaptation of an atrioventricular valve
AU2017207775A1 (en) 2016-01-14 2018-07-26 Cardiatis S.A. Implantable prosthesis for thoracic aortic disease involving aortic valve dysfunction
CA3011791C (en) 2016-01-22 2023-12-05 Medtentia International Ltd Oy Annuloplasty implant
EP3409454B1 (en) 2016-01-25 2023-03-01 Ricoh Company, Ltd. Three-dimensional molded object, method for producing three-dimensional molded object, material set for three-dimensional molding, and hydrogel precursor liquid
US20170209268A1 (en) 2016-01-27 2017-07-27 Medtronic, Inc. Systems and methods for repositioning a fully deployed valve assembly
US10342660B2 (en) 2016-02-02 2019-07-09 Boston Scientific Inc. Tensioned sheathing aids
JP2019503813A (ja) 2016-02-04 2019-02-14 ミリピード， インコーポレイテッドＭｉｌｌｉｐｅｄｅ， Ｉｎｃ． 僧帽弁反転プロテーゼ
US10363130B2 (en) 2016-02-05 2019-07-30 Edwards Lifesciences Corporation Devices and systems for docking a heart valve
AU2017218708B2 (en) 2016-02-08 2022-02-03 Innoventric Ltd. Treatment of tricuspid insufficiency
US10376681B2 (en) 2016-02-29 2019-08-13 Edwards Lifesciences Corporation Vacuum-based compliance restoration
EP3213714A1 (de) 2016-03-03 2017-09-06 Biotronik AG Einführkatheter und katheteranordnung
DE102016103843A1 (de) 2016-03-03 2017-09-07 Biotronik Ag Reduktion von paravalvulärer Leckage durch kontrollierten Thrombusaufbau
US10779941B2 (en) 2016-03-08 2020-09-22 Edwards Lifesciences Corporation Delivery cylinder for prosthetic implant
US10398549B2 (en) 2016-03-15 2019-09-03 Abbott Cardiovascular Systems Inc. System and method for transcatheter heart valve platform
CA3020049A1 (en) 2016-03-22 2017-09-28 Assistance Publique-Hopitaux De Paris Vascular valved prosthesis and manufacturing method
WO2017165810A1 (en) 2016-03-25 2017-09-28 Phillip Laby Fluid-actuated sheath displacement and articulation behavior improving systems, devices, and methods for catheters, continuum manipulators, and other uses
GB2548891B (en) 2016-03-31 2018-07-04 I Birdi Ltd A prosthetic device for mitral valve repair
DE102016106575A1 (de) 2016-04-11 2017-10-12 Biotronik Ag Herzklappenprothese
US10159569B2 (en) 2016-04-12 2018-12-25 Lars Erickson Minimally invasive atrio-ventricular valve treatment by chordae adjustment
CN105852916B (zh) 2016-04-14 2018-02-06 上海甲悦医疗器械有限公司 一种经心尖植入的二尖瓣柔性闭合板阻塞体及植入方法
US10624743B2 (en) 2016-04-22 2020-04-21 Edwards Lifesciences Corporation Beating-heart mitral valve chordae replacement
US10485658B2 (en) 2016-04-22 2019-11-26 Backbeat Medical, Inc. Methods and systems for controlling blood pressure
US10405974B2 (en) 2016-04-26 2019-09-10 Boston Scientific Scimed, Inc. Replacement heart valve with improved stitching
WO2017190161A1 (en) 2016-04-27 2017-11-02 Strait Access Technologies Holdings (Pty) Ltd Expandable stent and methods of crimping and expanding such stent
US10406011B2 (en) 2016-04-28 2019-09-10 Medtronic Vascular, Inc. Implantable medical device delivery system
US10231829B2 (en) 2016-05-04 2019-03-19 Boston Scientific Scimed Inc. Leaflet stitching backer
US10172710B2 (en) 2016-05-10 2019-01-08 William Joseph Drasler Two component mitral valve
US10583005B2 (en) 2016-05-13 2020-03-10 Boston Scientific Scimed, Inc. Medical device handle
EP3454794B1 (en) 2016-05-13 2021-04-14 St. Jude Medical, Cardiology Division, Inc. Systems for device implantation
US20170325952A1 (en) 2016-05-13 2017-11-16 Boston Scientific Scimed, Inc. Implant release system
WO2017195125A1 (en) 2016-05-13 2017-11-16 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
EP3454785B1 (en) 2016-05-13 2021-11-17 St. Jude Medical, Cardiology Division, Inc. Heart valve with stent having varying cell densities
WO2017199085A2 (en) 2016-05-16 2017-11-23 Valve Medical Ltd. Inverting temporary valve sheath
ES2873887T3 (es) 2016-05-16 2021-11-04 Elixir Medical Corp Liberación de stent
US10201416B2 (en) 2016-05-16 2019-02-12 Boston Scientific Scimed, Inc. Replacement heart valve implant with invertible leaflets
US11116630B2 (en) 2016-05-16 2021-09-14 Boston Scientific Scimed, Inc. Sheathing aid
EP3457990B1 (en) 2016-05-17 2022-11-30 Boston Scientific Scimed, Inc. Replacement heart valve implant with inflow stitching
WO2017200920A1 (en) 2016-05-19 2017-11-23 Boston Scientific Scimed, Inc. Prosthetic valves, valve leaflets and related methods
JP6987790B2 (ja) 2016-06-02 2022-01-05 メドトロニック ヴァスキュラー インコーポレイテッド 隔壁貫通孔閉鎖先端アセンブリを備えた経カテーテル弁送達システム
EP3463120B1 (en) 2016-06-03 2022-07-27 Intervene, Inc. Devices for manipulating blood vessel walls and associated systems
EP3471662B1 (en) 2016-06-15 2022-08-03 Corcym S.r.l. Two-part mitral valve
DE102016111323A1 (de) 2016-06-21 2017-12-21 Biotronik Ag Einführkatheter und Katheteranordnung
US10639147B2 (en) 2016-06-24 2020-05-05 Edwards Lifesciences Corporation System and method for crimping a prosthetic valve
JP6968113B2 (ja) 2016-06-30 2021-11-17 テンダイン ホールディングス，インコーポレイテッド 人工心臓弁の経心尖送達装置
CN107550524B (zh) 2016-07-01 2020-01-03 先健科技(深圳)有限公司 输送装置
KR20190037233A (ko) 2016-07-06 2019-04-05 더 메서디스트 하스피틀 애뉼러-심실 커플링 메커니즘을 포함하는 인공 승모판막
US10736632B2 (en) 2016-07-06 2020-08-11 Evalve, Inc. Methods and devices for valve clip excision
US10973638B2 (en) 2016-07-07 2021-04-13 Edwards Lifesciences Corporation Device and method for treating vascular insufficiency
GB201611910D0 (en) 2016-07-08 2016-08-24 Valtech Cardio Ltd Adjustable annuloplasty device with alternating peaks and troughs
US10828150B2 (en) 2016-07-08 2020-11-10 Edwards Lifesciences Corporation Docking station for heart valve prosthesis
CN109414326B (zh) 2016-07-12 2021-02-26 美敦力股份有限公司 用于管控流体流动的人工瓣膜
GB201612180D0 (en) 2016-07-13 2016-08-24 Ucl Business Plc Bioprosthetic heart valve
US10058426B2 (en) 2016-07-20 2018-08-28 Abbott Cardiovascular Systems Inc. System for tricuspid valve repair
US10478304B2 (en) 2016-07-20 2019-11-19 Abbott Cardiovascular Systems Inc. Independent system for tricuspid valve repair
US10350062B2 (en) 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
CN106175986B (zh) 2016-07-26 2017-12-01 复旦大学附属中山医院 一种瓣膜夹合器
US10758382B2 (en) 2016-07-27 2020-09-01 Sainath Intellectual Property, LLC Stent with one-way sock valve
US10974027B2 (en) 2016-07-29 2021-04-13 Cephea Valve Technologies, Inc. Combination steerable catheter and systems
US11324495B2 (en) 2016-07-29 2022-05-10 Cephea Valve Technologies, Inc. Systems and methods for delivering an intravascular device to the mitral annulus
US10646689B2 (en) 2016-07-29 2020-05-12 Cephea Valve Technologies, Inc. Mechanical interlock for catheters
US11096781B2 (en) 2016-08-01 2021-08-24 Edwards Lifesciences Corporation Prosthetic heart valve
CN120918849A (zh) 2016-08-10 2025-11-11 卡迪尔维尔福股份有限公司 具有同轴框架的人工瓣膜
US10383725B2 (en) 2016-08-11 2019-08-20 4C Medical Technologies, Inc. Heart chamber prosthetic valve implant with base, mesh and dome sections with single chamber anchoring for preservation, supplementation and/or replacement of native valve function
CN109640836A (zh) 2016-08-18 2019-04-16 4科技有限公司 带有用于插入心包腔中的柔性尖端的组织锚
WO2018039543A1 (en) 2016-08-26 2018-03-01 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with paravalvular leak mitigation features
CR20190069A (es) 2016-08-26 2019-05-14 Edwards Lifesciences Corp Valvulas y sistemas de acoplamiento de valvulas corazon
CN109843219B (zh) 2016-08-26 2022-04-05 爱德华兹生命科学公司 多部分置换心脏瓣膜假体
US10751485B2 (en) 2016-08-29 2020-08-25 Cephea Valve Technologies, Inc. Methods, systems, and devices for sealing and flushing a delivery system
US10575946B2 (en) 2016-09-01 2020-03-03 Medtronic Vascular, Inc. Heart valve prosthesis and separate support flange for attachment thereto
US10456249B2 (en) 2016-09-15 2019-10-29 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with paravalvular leak mitigation features
EP3512465B1 (en) 2016-09-15 2021-09-01 Cardiac Implants LLC An apparatus for delivering a cardiac annulus ring
US10052201B2 (en) 2016-09-21 2018-08-21 Peijia Medical Co., Ltd. Valved stent for mitral and tricuspid heart valve replacement
US10575944B2 (en) 2016-09-22 2020-03-03 Edwards Lifesciences Corporation Prosthetic heart valve with reduced stitching
US10874512B2 (en) 2016-10-05 2020-12-29 Cephea Valve Technologies, Inc. System and methods for delivering and deploying an artificial heart valve within the mitral annulus
ES2892273T3 (es) 2016-10-07 2022-02-03 Electroducer Conjunto de sustitución de una válvula cardíaca o de un conjunto de angioplastia coronaria
FR3057154B1 (fr) 2016-10-07 2018-10-19 Electroducer Electrode transcutanee pour ensemble de remplacement d'une valve cardiaque ou ensemble d'angioplastie coronaire comprenant un catheter de delivrance ou un introducteur
EP3311774B1 (en) 2016-10-19 2022-05-11 P+F Products + Features Vertriebs GmbH Self-expandable atrioventricular valve and system of cardiac valves
CN107374782B (zh) 2016-10-20 2023-04-18 上海微创心通医疗科技有限公司 植入体输送装置
DE202016105963U1 (de) 2016-10-24 2018-01-25 Nvt Ag Intraluminale Gefäßprothese zur Implantation in das Herz oder Herzgefäße eines Patienten
KR102282985B1 (ko) 2016-10-31 2021-07-30 카디악 임플란츠 엘엘씨 심장 판막 고리 상으로의 설치 전에 수축 코드 또는 환형 링의 위치를 드러내기 위한 가요성 방사선 불투과성 돌출부
US10722356B2 (en) 2016-11-03 2020-07-28 Edwards Lifesciences Corporation Prosthetic mitral valve holders
US9999502B2 (en) 2016-11-04 2018-06-19 Highlife Sas Transcather valve prosthesis
US11376121B2 (en) 2016-11-04 2022-07-05 Highlife Sas Transcatheter valve prosthesis
US10653862B2 (en) 2016-11-07 2020-05-19 Edwards Lifesciences Corporation Apparatus for the introduction and manipulation of multiple telescoping catheters
US10869991B2 (en) 2016-11-09 2020-12-22 Medtronic Vascular, Inc. Telescoping catheter
US10363138B2 (en) 2016-11-09 2019-07-30 Evalve, Inc. Devices for adjusting the curvature of cardiac valve structures
DE102016013480A1 (de) 2016-11-11 2018-05-17 Peter Osypka Stiftung Vorrichtung zur Ballondilatation einer verengten Herzklappe
US10398553B2 (en) 2016-11-11 2019-09-03 Evalve, Inc. Opposing disk device for grasping cardiac valve tissue
FR3058632B1 (fr) 2016-11-14 2019-01-25 Laboratoires Invalv Dispositif de traitement d'une valve biologique avec organe de poussee de la valve
FR3058631B1 (fr) 2016-11-14 2019-01-25 Laboratoires Invalv Implant de traitement d'une valve biologique
US10959841B2 (en) 2016-11-15 2021-03-30 Hancock Jaffe Laboratories, Inc. Implantable vein frame
US20180133006A1 (en) 2016-11-15 2018-05-17 Medtronic Vascular, Inc. Stabilization and advancement system for direct aortic transcatheter aortic valve implantation
US10426616B2 (en) 2016-11-17 2019-10-01 Evalve, Inc. Cardiac implant delivery system
WO2018098015A1 (en) 2016-11-22 2018-05-31 Boston Scientific Scimed, Inc. Medical device shaft resistant to compression and/or tension
EP3544548B1 (en) 2016-11-23 2020-12-16 St. Jude Medical, Cardiology Division, Inc. Tissue heart valve (thv) humidor packaging system
US10548614B2 (en) 2016-11-29 2020-02-04 Evalve, Inc. Tricuspid valve repair system
EP3547966B1 (en) 2016-12-01 2021-01-20 Boston Scientific Scimed, Inc. Heart valve remodeling device
FR3060292B1 (fr) 2016-12-15 2019-01-25 Cmi'nov Dispositif pour realiser ou preparer une annuloplastie mitrale par voie transfemorale
EP4218672B1 (en) 2016-12-16 2026-04-01 Edwards Lifesciences Corporation Deployment systems and tools for delivering an anchoring device for a prosthetic valve
EP4653036A3 (en) 2016-12-20 2026-02-11 Edwards Lifesciences Corporation Systems and mechanisms for deploying a docking device for a replacement heart valve
EP3342355B1 (en) 2016-12-29 2020-04-22 Medtentia International Ltd Oy Medical securing device for securing an object with a securing member
CN110402113B (zh) 2017-01-11 2023-02-17 维兰德.K.沙马 心脏分流装置和输送系统
US10463517B2 (en) 2017-01-16 2019-11-05 Cook Medical Technologies Llc Controlled expansion stent graft delivery system
US11185406B2 (en) 2017-01-23 2021-11-30 Edwards Lifesciences Corporation Covered prosthetic heart valve
CA3051272C (en) 2017-01-23 2023-08-22 Cephea Valve Technologies, Inc. Replacement mitral valves
WO2018142275A1 (en) 2017-02-02 2018-08-09 Valfix Medical Ltd. Percutaneous valve repair and replacement
EP3579761A2 (en) 2017-02-08 2019-12-18 4Tech Inc. Post-implantation tensioning in cardiac implants
DE102017202159A1 (de) 2017-02-10 2018-08-16 Tribio Gmbh Biologische Transkatheterklappe
US10492779B2 (en) 2017-02-20 2019-12-03 Edwards Lifesciences Corporation Suturing devices for heart valve surgery
EP3372198B1 (en) 2017-03-06 2019-06-19 AVVie GmbH Implant for improving coaptation of an atrioventricular valve
US10631968B2 (en) 2017-03-06 2020-04-28 Edwards Lifesciences Corporation Humidity-management packaging systems and methods
US10799685B2 (en) 2017-03-09 2020-10-13 Edwards Lifesciences Corporation Expandable sheath with longitudinally extending reinforcing members
EP3592289B1 (en) 2017-03-09 2021-07-07 Medtronic Vascular Inc. Tension management devices for stented prosthesis delivery device
FR3063631B1 (fr) 2017-03-13 2019-03-22 Cmi'nov Dispositif de reparation des cordages de la valve mitrale d'un cœur par voie transfemorale
EP4385532A3 (en) 2017-03-14 2024-10-23 Shape Memory Medical, Inc. Shape memory polymer foams to seal space around valves
WO2018175619A1 (en) 2017-03-22 2018-09-27 Edwards Lifesciences Corporation System and method for implanting and securing a bioprosthetic device to wet tissue
CN110678149B (zh) 2017-03-27 2021-12-21 楚利福医疗有限公司 包括对接元件的用于治疗病变二尖瓣的设备
DE102017002974B4 (de) 2017-03-28 2024-08-08 Immanuel Albertinen Diakonie Ggmbh Herzklappen-Implantat, geeignet für den Einsatz in der minimal-invasiven Chirurgie zur Reparatur einer Herzklappe und/oder eines Herzklappensegels am schlagenden Herzen und Herzklappen-lmplantat-System
AU2018248410B2 (en) 2017-04-05 2020-07-09 Opus Medical Therapies, LLC Transcatheter atrial sealing skirt, anchor, and tether and methods of implantation
WO2018187753A1 (en) 2017-04-06 2018-10-11 Harpoon Medical, Inc. Distal anchor apparatus and methods for mitral valve repair
KR102693748B1 (ko) 2017-04-18 2024-08-13 에드워즈 라이프사이언시스 코포레이션 심장 판막 밀봉 장치 및 그를 위한 전달 장치
US11224511B2 (en) 2017-04-18 2022-01-18 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
EP3619136B1 (en) 2017-05-02 2021-04-21 Medtronic Vascular Inc. Packaging for dry tissue prosthetic heart valve
US10959846B2 (en) 2017-05-10 2021-03-30 Edwards Lifesciences Corporation Mitral valve spacer device
IT201700052909A1 (it) 2017-05-16 2018-11-16 Star Tric S R L Protesi articolata per valvola tricuspide o mitrale e relativo dispositivo di afferraggio
IL309520B2 (en) 2017-05-31 2026-02-01 Edwards Lifesciences Corp Sealing component for heart valve bushing
EP3634255B1 (en) 2017-06-08 2020-08-12 4Tech Inc. Tissue anchor with tether stop
EP3417831B2 (en) 2017-06-19 2023-05-24 HVR Cardio Oy Delivery device for an annuloplasty implant
EP4122507B1 (en) 2017-06-29 2024-04-17 St. Jude Medical, Cardiology Division, Inc. Method of preparing calcification-resistant bioprosthetic heart valve
US11311699B2 (en) 2017-06-30 2022-04-26 Giora Weisz Multi-dimensional navigation within a body chamber
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
CA3067150A1 (en) 2017-07-06 2019-01-10 Edwards Lifesciences Corporation Steerable rail delivery system
US10485650B2 (en) 2017-07-19 2019-11-26 Cook Medical Technologies Llc Endoluminal prosthesis
EP4085853B1 (en) 2017-07-31 2024-07-24 Boston Scientific Scimed, Inc. Introducer system with expandable capabilities
DE202017104793U1 (de) 2017-08-09 2018-11-14 Nvt Ag Ladesystem für Herzklappenprothesen
US10973628B2 (en) 2017-08-18 2021-04-13 Edwards Lifesciences Corporation Pericardial sealing member for prosthetic heart valve
US10722353B2 (en) 2017-08-21 2020-07-28 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
IL254099B (en) 2017-08-22 2021-02-28 Geonovation Medical Tech Ltd Collapsible one-way valve bushing
EP3672532B1 (en) 2017-08-26 2022-08-03 Transmural Systems LLC Implantable cardiac pacing system
WO2019055214A1 (en) 2017-09-12 2019-03-21 Boston Scientific Scimed, Inc. PERCUTANEOUS RELOCATION OF PAPILLARY MUSCLE
WO2019055527A1 (en) 2017-09-13 2019-03-21 Mayo Foundation For Medical Education And Research METHODS AND DEVICES FOR ATTACHING EPICARDIC DEVICES
US10856982B2 (en) 2017-09-19 2020-12-08 St. Jude Medical, Cardiology Division, Inc. Transapical mitral valve delivery system
EP3668450B1 (en) 2017-09-22 2021-07-14 Boston Scientific Scimed, Inc. Dome structure for improved left ventricle function
US20190091013A1 (en) 2017-09-22 2019-03-28 St. Jude Medical, Cardiology Division, Inc. Prosthetic Heart Valve with Atraumatic Aortic Portion
FR3071716B1 (fr) 2017-10-04 2023-02-24 Mdb Texinov Insert textile a finalite medicale et son procede de fabrication
FR3072013B1 (fr) 2017-10-09 2019-09-27 Cmi'nov Dispositif de suture d'une prothese valvulaire cardiaque
EP3470105B1 (de) 2017-10-13 2020-04-22 BIOTRONIK SE & Co. KG Einführelement für eine medizinische einführeinrichtung
US9895226B1 (en) 2017-10-19 2018-02-20 Mitral Tech Ltd. Techniques for use with prosthetic valve leaflets
US10426473B2 (en) 2017-10-19 2019-10-01 Abbott Cardiovascular Systems Inc. System and method for plicating a heart valve
EP3498224B1 (en) 2017-10-19 2021-12-08 Shanghai HanYu Medical Technology Co., Ltd Valve clip device
EP3697346B1 (en) 2017-10-20 2022-01-19 Boston Scientific Scimed, Inc. Heart valve repair implant for treating tricuspid regurgitation
EP3476366B1 (en) 2017-10-27 2020-12-16 Medtentia International Ltd Oy Annuloplasty implant
US10912664B2 (en) 2017-11-21 2021-02-09 Cook Medical Technologies, LLC Stent with induction responsive muscles that facilitate implantation adjustments
KR102053451B1 (ko) 2017-11-24 2020-01-08 (주) 타우피엔유메디칼 서클라지 심방 제세동장치
EP3498223A1 (en) 2017-12-13 2019-06-19 Epygon Crimping device for collapsible valves
CN108065970B (zh) 2017-12-14 2019-06-25 谭雄进 一种可多次调节的人工腱索固定组件
JP7609637B2 (ja) 2018-01-08 2025-01-07 エイチブイアール カーディオ オーイー 弁輪形成デバイス
IT201800000671A1 (it) 2018-01-10 2019-07-10 Matteo Montorfano Dispositivo di inserimento di un filo di guida in un vaso sanguigno
PT3740162T (pt) 2018-01-19 2022-04-05 Edwards Lifesciences Corp Válvula cardíaca protética coberta
US20200397426A1 (en) 2018-01-27 2020-12-24 Lsi Solutions, Inc. Prosthetic suturing device and methods thereof
DE102018102940B4 (de) 2018-02-09 2019-10-31 Francisco Javier Carrero Gomez Vorrichtung zur Prüfung der Funktion einer Aortenklappe
EP3527170B1 (en) 2018-02-20 2020-11-18 Institut National des Sciences Appliquées de Lyon Device for assisting a practitioner in adjusting the length of an artificial chordae implanted in an atrio-ventricular heart valve
WO2019165394A1 (en) 2018-02-26 2019-08-29 Boston Scientific Scimed, Inc. Embedded radiopaque marker in adaptive seal
EP4218669B1 (en) 2018-03-27 2026-08-12 Maduro Discovery, LLC Accessory device to provide neuroprotection during interventional procedures
FR3079404B1 (fr) 2018-03-29 2020-03-06 Electroducer Ensemble de remplacement d’une valve cardiaque avec assistance de stimulation par voie arterielle ou veineuse peripherique
US11234812B2 (en) 2018-04-18 2022-02-01 St. Jude Medical, Cardiology Division, Inc. Methods for surgical valve expansion
EP3787561B1 (en) 2018-04-30 2022-03-16 Edwards Lifesciences Corporation Devices for crimping prosthetic implants
US11026787B2 (en) 2018-04-30 2021-06-08 St. Jude Medical, Cardiology Division, Inc. Heart valve holder
CN112055573B (zh) 2018-05-07 2024-02-27 美敦力瓦斯科尔勒公司 对湿储存植入物进行灭菌的组合件和方法
WO2019223975A1 (en) 2018-05-21 2019-11-28 Medtentia International Ltd Oy Annuloplasty device
WO2019226803A1 (en) 2018-05-22 2019-11-28 Boston Scientific Scimed, Inc. Percutaneous papillary muscle relocation
CA3101165A1 (en) 2018-05-23 2019-11-28 Sorin Group Italia S.R.L. A cardiac valve prosthesis
CN112384174B (zh) 2018-05-23 2024-02-27 恪心有限责任公司 原位递送心脏瓣膜假体的装置
EP3581232B1 (en) 2018-06-11 2021-02-17 Dentsply IH AB Urethral stent and bladder control assembly comprising such a urethral stent
WO2020033146A1 (en) 2018-08-06 2020-02-13 Thubrikar Aortic Valve, Inc. Apparatus and method for delivery of a prosthetic valve device
JP2022502095A (ja) 2018-08-07 2022-01-11 ４テック インコーポレイテッド 心臓埋め込みにおける埋め込み後の張力付与
EP3620133A1 (en) 2018-09-07 2020-03-11 AVVie GmbH Implant for improving coaptation of an artrioventricular valve
FR3085835B1 (fr) 2018-09-13 2020-08-28 Univ Compiegne Tech Implant pour valve cardiaque
US11395738B2 (en) 2018-09-25 2022-07-26 Truleaf Medical Ltd. Docking elements
WO2020072268A1 (en) 2018-10-04 2020-04-09 Stryker Corporation Medical implant delivery system
EP4406510A3 (de) 2018-10-10 2024-10-02 Devie Medical GmbH Implantat zur behandlung und/oder zum ersatz einer entzündeten, thrombosierten oder degenerierten herzklappe
DE102018126828A1 (de) 2018-10-26 2020-04-30 Nvt Ag Herzklappenprothese
US20220015904A1 (en) 2018-11-29 2022-01-20 Cardiomech As Device for Heart Repair
WO2020126001A1 (de) 2018-12-20 2020-06-25 Medizinische Universität Wien Stentgraft und vorrichtung zum zuführen und setzen eines solchen stentgrafts in die aorta ascendens
CN111437065A (zh) 2019-01-17 2020-07-24 TauPNU医疗有限公司 位置可调节的三尖瓣返流手术用器械
US10898329B2 (en) 2019-01-25 2021-01-26 Edwards Lifesciences Corporation Testing apparatus for prosthetic device
JP7075606B2 (ja) 2019-02-26 2022-05-26 株式会社ｉＣｏｒＮｅｔ研究所 心臓サポートネット及び植込み型除細動器
US11491006B2 (en) 2019-04-10 2022-11-08 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
US11452599B2 (en) 2019-05-02 2022-09-27 Twelve, Inc. Fluid diversion devices for hydraulic delivery systems and associated methods
EP3908228B1 (en) 2020-03-17 2022-08-24 Cardiovalve Ltd. Leaflet-grouping system
US11690717B2 (en) 2020-03-30 2023-07-04 Lepu Medical Technology (Beijing) Co., Ltd. Heart valve clamp
US11318013B2 (en) 2020-04-21 2022-05-03 Medtronic, Inc. Compact prosthetic heart valve device
EP3912595B1 (en) 2020-05-19 2023-01-04 AVVie GmbH Implant for improving coaptation of an atrioventricular valve

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040117009A1 (en) 2002-09-23 2004-06-17 Cali Douglas S. Prosthetic mitral valve
US20060293745A1 (en) * 2004-01-23 2006-12-28 Carpentier Alain F Anatomically approximate prosthetic mitral heart valve
US7871435B2 (en) 2004-01-23 2011-01-18 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
US20060259136A1 (en) * 2005-05-13 2006-11-16 Corevalve Sa Heart valve prosthesis and methods of manufacture and use
WO2011069048A2 (en) 2009-12-04 2011-06-09 Edward Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US20120239143A1 (en) 2010-09-30 2012-09-20 BioStable Science & Engineering, Inc. Non-Axisymmetric Aortic Valve Devices
US20140257467A1 (en) 2013-03-11 2014-09-11 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
WO2017127939A1 (en) 2016-01-29 2017-08-03 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
CA3007670A1 (en) 2016-01-29 2017-08-03 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
CN108882981A (zh) 2016-01-29 2018-11-23 内奥瓦斯克迪亚拉公司 用于防止流出阻塞的假体瓣膜

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"European Application Serial No. 17743534.4, Extended European Search Report dated May 24, 2019", 8 pgs.
"International Application Serial No. PCT/CA2017/050097, International Preliminary Report on Patentability dated Aug. 9, 2018", 9 pgs.
"International Application Serial No. PCT/CA2017/050097, Written Opinion dated Jun. 12, 2017", 7 pgs.
International Search Report dated Jun. 12, 2017 for International Application No. PCT/CA2017/050097.

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11589984B2 (en) 2009-03-30 2023-02-28 Jc Medical, Inc. Devices and methods for delivery of valve prostheses
US11446144B2 (en) 2009-03-30 2022-09-20 Jc Medical, Inc. Devices and methods for delivery of valve prostheses
US11510769B2 (en) 2013-03-14 2022-11-29 Jc Medical, Inc. Embolic protection devices and methods of use
US12440324B2 (en) 2013-03-14 2025-10-14 Jc Medical, Inc. Embolic protection devices and methods of use
US11259923B2 (en) 2013-03-14 2022-03-01 Jc Medical, Inc. Methods and devices for delivery of a prosthetic valve
US11938024B2 (en) 2013-03-14 2024-03-26 Jc Medical, Inc. Methods and devices for delivery of a prosthetic valve
US11406497B2 (en) 2013-03-14 2022-08-09 Jc Medical, Inc. Heart valve prosthesis
US12193932B2 (en) 2016-01-29 2025-01-14 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
US11793640B2 (en) 2017-08-25 2023-10-24 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US10856984B2 (en) * 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US12220314B2 (en) 2018-01-07 2025-02-11 Jc Medical, Inc. Heart valve prosthesis placement for low coronary ostia height
US11285001B2 (en) 2018-01-07 2022-03-29 Jc Medical, Inc. Heart valve prosthesis delivery system
USD968607S1 (en) 2018-01-07 2022-11-01 Jc Medical, Inc. Prosthetic heart valve
US11819407B2 (en) 2018-01-07 2023-11-21 Jc Medical, Inc. Heart valve prosthesis delivery system
US11331184B2 (en) 2018-01-07 2022-05-17 Jc Medical, Inc. Methods and devices for delivery of a prosthetic valve
USD1117764S1 (en) 2018-01-07 2026-03-10 Jc Medical, Inc. Prosthetic heart valve
US12059349B2 (en) 2018-01-07 2024-08-13 Jc Medical, Inc. Heart valve prosthesis
US11357626B2 (en) 2018-01-07 2022-06-14 Jc Medical, Inc. Heart valve prosthesis delivery system
US12485007B2 (en) 2018-01-07 2025-12-02 Jc Medical, Inc. Heart valve prosthesis
US12376962B2 (en) 2018-01-07 2025-08-05 Jc Medical, Inc. Methods and devices for delivery of a prosthetic valve
US11253363B2 (en) 2018-01-07 2022-02-22 Jc Medical Inc. Heart valve prosthesis
US12478470B2 (en) 2018-01-07 2025-11-25 Jc Medical, Inc. Valve-in-valve delivery of a heart valve prosthesis
US11491006B2 (en) 2019-04-10 2022-11-08 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
US12036117B2 (en) 2019-04-10 2024-07-16 Neovasc Tiara Inc. Prosthetic valve with natural blood flow

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